ChloroquineV1, Main, Exploration, bibRecord, 002464

Enhanced Pneumocystis carinii activity of new primaquine analogues

Identifieur interne : 002464 ( Main/Exploration ); précédent : 002463; suivant : 002465

Enhanced Pneumocystis carinii activity of new primaquine analogues

Auteurs : Thomas E. Goodwin [États-Unis] ; Carole J. Boylan [États-Unis] ; William L. Current [États-Unis] ; John C. Byrd [États-Unis] ; Clint B. Edwards [États-Unis] ; Danny A. Fuller [États-Unis] ; Jennifer L. Green [États-Unis] ; Christine D. Larocca [États-Unis] ; Kevin D. Raney [États-Unis] ; Ashley S. Ross [États-Unis] ; W. Andrew Tucker [États-Unis]

Source :

Bioorganic & Medicinal Chemistry Letters [ 0960-894X ] ; 2000.

RBID : ISTEX:2A325AE232BC9BBE05BAB9BA2649DC22773BAADD

English descriptors

Teeft :
- Agents chemother, Analogue, Antimicrob, Bioassay, Carinii, Carinii infections, Chem, Chemother, Chloroquine, Cyst, Drinking water, Elsevier science, Free base, Fumarate, Fumarate salts, Hendrix college, Immunosuppressed, Immunosuppressed rats, Infection scores, Intraperitoneal, Intraperitoneally, Lett, Logarithmic representation, Lung homogenates, Malaria bioassays, Microscopic evaluation, Primaquine, Primaquine analogue, Primaquine analogues, Queener, Tissue schizonticides.

Abstract

Abstract: New analogues of the venerable antimalarial drug primaquine have been synthesized and bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among immunosuppressed patients. Two of these new compounds are significantly more active than primaquine itself, and provide new information for future drug design and development in this area.

Url:

https://api.istex.fr/ark:/67375/6H6-TQHF9FLT-V/fulltext.pdf

DOI: 10.1016/S0960-894X(00)00436-4

Affiliations:

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to stream Istex, to step Corpus: 000C97
to stream Istex, to step Curation: 000C97
to stream Istex, to step Checkpoint: 001281
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Le document en format XML

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<term>Carinii infections</term>
<term>Chem</term>
<term>Chemother</term>
<term>Chloroquine</term>
<term>Cyst</term>
<term>Drinking water</term>
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<term>Free base</term>
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<term>Intraperitoneal</term>
<term>Intraperitoneally</term>
<term>Lett</term>
<term>Logarithmic representation</term>
<term>Lung homogenates</term>
<term>Malaria bioassays</term>
<term>Microscopic evaluation</term>
<term>Primaquine</term>
<term>Primaquine analogue</term>
<term>Primaquine analogues</term>
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<front><div type="abstract" xml:lang="en">Abstract: New analogues of the venerable antimalarial drug primaquine have been synthesized and bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among immunosuppressed patients. Two of these new compounds are significantly more active than primaquine itself, and provide new information for future drug design and development in this area.</div>
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Enhanced Pneumocystis carinii activity of new primaquine analogues

Enhanced Pneumocystis carinii activity of new primaquine analogues

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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