The Topoisomerases of Protozoan Parasites
Identifieur interne : 002439 ( Main/Exploration ); précédent : 002438; suivant : 002440The Topoisomerases of Protozoan Parasites
Auteurs : S. J Cheesman [Royaume-Uni]Source :
- Parasitology Today [ 0169-4758 ] ; 2000.
English descriptors
- Teeft :
- Agents chemother, Bacterial topoisomerase, Biochem, Camptothecin, Cell cycle, Cellular localisation, Cleavable, Cleavage, Core domain, Cryptosporidium parvum, Crystal structure, Divalent cations, Donovani, Donovani type, Drug targets, Duplex, Encoding, Enzyme, Enzyme activity, Enzymes function, Escherichia coli, Eukaryotic, Eukaryotic topoisomerase, Eukaryotic topoisomerases, Falciparum, Falciparum malaria, Gene encoding topoisomerase, Gene expression, Gyrase, Higher eukaryotes, Human enzyme, Human homologues, Human topoisomerase, Inhibitor, Kinetoplast, Kinetoplast leishmania donovani, Leishmania, Leishmania donovani, Malaria parasites, Malarial parasite plasmodium falciparum, Mammalian cells, Mrna, Nuclear extracts, Nucleic acids, Parasite, Parasite growth, Parasitol, Parasitology, Parasitology today, Pentavalent antimonials, Plasmodium, Plasmodium falciparum, Promoter activity, Protozoan, Protozoan parasites, Protozoan sources, Protozoan topoisomerases, Reaction cycles, Recent years, Regulatory domain, Schematic representation, Schizont, Schizont stages, Top2, Top2 gene, Topoisomerase, Topoisomerase activity, Topoisomerase genes, Topoisomerase inhibitors, Topoisomerase poisons, Topoisomerases, Transient breaks, Trophozoite, Trypanosoma brucei, Ultrastructural changes, Untranslated region.
Abstract
Abstract: Protozoan parasites are responsible for a wide range of debilitating and fatal diseases that are proving notoriously difficult to treat. Many of the standard chemotherapies in use today are expensive, have toxic side effects and, in some cases have marginal efficacy because of the emergence of drug-resistant parasites. In the search for more effective treatments, protozoan topoisomerases are now being considered as potential drug targets, building on the clinical success of anticancer and antibacterial agents that target human and bacterial topoisomerases. In this review, Sandra Cheesman explores progress in this relatively new but potentially important field of research.
Url:
DOI: 10.1016/S0169-4758(00)01697-5
Affiliations:
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J Cheesman</name><affiliation wicri:level="4"><country>Royaume-Uni</country><wicri:regionArea>Institute of Cell and Molecular Biology, the University of Edinburgh, Darwin Building, King's Buildings, Mayfield Road, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Parasitology Today</title><title level="j" type="abbrev">PARTOD</title><idno type="ISSN">0169-4758</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="277">277</biblScope><biblScope unit="page" to="281">281</biblScope></imprint><idno type="ISSN">0169-4758</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0169-4758</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Agents chemother</term><term>Bacterial topoisomerase</term><term>Biochem</term><term>Camptothecin</term><term>Cell cycle</term><term>Cellular localisation</term><term>Cleavable</term><term>Cleavage</term><term>Core domain</term><term>Cryptosporidium parvum</term><term>Crystal structure</term><term>Divalent cations</term><term>Donovani</term><term>Donovani type</term><term>Drug targets</term><term>Duplex</term><term>Encoding</term><term>Enzyme</term><term>Enzyme activity</term><term>Enzymes function</term><term>Escherichia coli</term><term>Eukaryotic</term><term>Eukaryotic topoisomerase</term><term>Eukaryotic topoisomerases</term><term>Falciparum</term><term>Falciparum malaria</term><term>Gene encoding topoisomerase</term><term>Gene expression</term><term>Gyrase</term><term>Higher eukaryotes</term><term>Human enzyme</term><term>Human homologues</term><term>Human topoisomerase</term><term>Inhibitor</term><term>Kinetoplast</term><term>Kinetoplast leishmania donovani</term><term>Leishmania</term><term>Leishmania donovani</term><term>Malaria parasites</term><term>Malarial parasite plasmodium falciparum</term><term>Mammalian cells</term><term>Mrna</term><term>Nuclear extracts</term><term>Nucleic acids</term><term>Parasite</term><term>Parasite growth</term><term>Parasitol</term><term>Parasitology</term><term>Parasitology today</term><term>Pentavalent antimonials</term><term>Plasmodium</term><term>Plasmodium falciparum</term><term>Promoter activity</term><term>Protozoan</term><term>Protozoan parasites</term><term>Protozoan sources</term><term>Protozoan topoisomerases</term><term>Reaction cycles</term><term>Recent years</term><term>Regulatory domain</term><term>Schematic representation</term><term>Schizont</term><term>Schizont stages</term><term>Top2</term><term>Top2 gene</term><term>Topoisomerase</term><term>Topoisomerase activity</term><term>Topoisomerase genes</term><term>Topoisomerase inhibitors</term><term>Topoisomerase poisons</term><term>Topoisomerases</term><term>Transient breaks</term><term>Trophozoite</term><term>Trypanosoma brucei</term><term>Ultrastructural changes</term><term>Untranslated region</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Protozoan parasites are responsible for a wide range of debilitating and fatal diseases that are proving notoriously difficult to treat. Many of the standard chemotherapies in use today are expensive, have toxic side effects and, in some cases have marginal efficacy because of the emergence of drug-resistant parasites. In the search for more effective treatments, protozoan topoisomerases are now being considered as potential drug targets, building on the clinical success of anticancer and antibacterial agents that target human and bacterial topoisomerases. In this review, Sandra Cheesman explores progress in this relatively new but potentially important field of research.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Cheesman, S J" sort="Cheesman, S J" uniqKey="Cheesman S" first="S. J" last="Cheesman">S. J Cheesman</name></region><name sortKey="Cheesman, S J" sort="Cheesman, S J" uniqKey="Cheesman S" first="S. J" last="Cheesman">S. J Cheesman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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