New Manzamine Alkaloids with Potent Activity against Infectious Diseases
Identifieur interne : 002266 ( Main/Exploration ); précédent : 002265; suivant : 002267New Manzamine Alkaloids with Potent Activity against Infectious Diseases
Auteurs : K. A. El Sayed [États-Unis] ; M. Kelly [États-Unis] ; U. A. K. Kara [États-Unis] ; K. K. H. Ang [États-Unis] ; I. Katsuyama [États-Unis] ; D. C. Dunbar [États-Unis] ; A. A. Khan [États-Unis] ; M. T. Hamann [États-Unis]Source :
- Journal of the American Chemical Society [ 0002-7863 ] ; 2001.
Abstract
The isolation of the new enantiomers of 8-hydroxymanzamine A (1), manzamine F (2), along with the unprecedented manzamine dimer, neo-kauluamine from an undescribed genus of Indo-Pacific sponge (family Petrosiidae, order Haplosclerida) is reported. The relative stereochemistry of neo-kauluamine was established through detailed analysis of NOE-correlations combined with molecular modeling. The significance of the manzamines as in vivo antimalarial agents with superior activity to the clinically used drugs artemisinin and chloroquine is discussed along with the activity in vitro against the AIDS-opportunistic infectious diseases tuberculosis and toxoplasmosis. Reexamination of the sponges identified as Prianos, and Pachypellina, in earlier publications has confirmed that these are members of the same genus as the sponge described here, but differ at the species level.
Url:
DOI: 10.1021/ja002073o
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000E45
- to stream Istex, to step Curation: 000E45
- to stream Istex, to step Checkpoint: 001089
- to stream Main, to step Merge: 002290
- to stream Main, to step Curation: 002266
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>New Manzamine Alkaloids with Potent Activity against Infectious Diseases</title><author><name sortKey="El Sayed, K A" sort="El Sayed, K A" uniqKey="El Sayed K" first="K. A." last="El Sayed">K. A. El Sayed</name></author><author><name sortKey="Kelly, M" sort="Kelly, M" uniqKey="Kelly M" first="M." last="Kelly">M. Kelly</name></author><author><name sortKey="Kara, U A K" sort="Kara, U A K" uniqKey="Kara U" first="U. A. K." last="Kara">U. A. K. Kara</name></author><author><name sortKey="Ang, K K H" sort="Ang, K K H" uniqKey="Ang K" first="K. K. H." last="Ang">K. K. H. Ang</name></author><author><name sortKey="Katsuyama, I" sort="Katsuyama, I" uniqKey="Katsuyama I" first="I." last="Katsuyama">I. Katsuyama</name></author><author><name sortKey="Dunbar, D C" sort="Dunbar, D C" uniqKey="Dunbar D" first="D. C." last="Dunbar">D. C. Dunbar</name></author><author><name sortKey="Khan, A A" sort="Khan, A A" uniqKey="Khan A" first="A. A." last="Khan">A. A. Khan</name></author><author><name sortKey="Hamann, M T" sort="Hamann, M T" uniqKey="Hamann M" first="M. T." last="Hamann">M. T. Hamann</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AAE58B1F3B604C75CD681D30CAC02F7E15341B9C</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1021/ja002073o</idno><idno type="url">https://api.istex.fr/ark:/67375/TPS-VWP8BS01-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000E45</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E45</idno><idno type="wicri:Area/Istex/Curation">000E45</idno><idno type="wicri:Area/Istex/Checkpoint">001089</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001089</idno><idno type="wicri:doubleKey">0002-7863:2001:El Sayed K:new:manzamine:alkaloids</idno><idno type="wicri:Area/Main/Merge">002290</idno><idno type="wicri:Area/Main/Curation">002266</idno><idno type="wicri:Area/Main/Exploration">002266</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">New Manzamine Alkaloids with Potent Activity against Infectious
Diseases</title><author><name sortKey="El Sayed, K A" sort="El Sayed, K A" uniqKey="El Sayed K" first="K. A." last="El Sayed">K. A. El Sayed</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma"> University of Mississippi.</wicri:noCountry></affiliation></author><author><name sortKey="Kelly, M" sort="Kelly, M" uniqKey="Kelly M" first="M." last="Kelly">M. Kelly</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma"> National Institute of Water & Atmospheric Research.</wicri:noCountry></affiliation></author><author><name sortKey="Kara, U A K" sort="Kara, U A K" uniqKey="Kara U" first="U. A. K." last="Kara">U. A. K. Kara</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma"> National University of Singapore.</wicri:noCountry></affiliation></author><author><name sortKey="Ang, K K H" sort="Ang, K K H" uniqKey="Ang K" first="K. K. H." last="Ang">K. K. H. Ang</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma"> National University of Singapore.</wicri:noCountry></affiliation></author><author><name sortKey="Katsuyama, I" sort="Katsuyama, I" uniqKey="Katsuyama I" first="I." last="Katsuyama">I. Katsuyama</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma"> University of Mississippi.</wicri:noCountry></affiliation></author><author><name sortKey="Dunbar, D C" sort="Dunbar, D C" uniqKey="Dunbar D" first="D. C." last="Dunbar">D. C. Dunbar</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma"> University of Mississippi.</wicri:noCountry></affiliation></author><author><name sortKey="Khan, A A" sort="Khan, A A" uniqKey="Khan A" first="A. A." last="Khan">A. A. Khan</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma"> Palo Alto Medical Foundation.</wicri:noCountry></affiliation></author><author><name sortKey="Hamann, M T" sort="Hamann, M T" uniqKey="Hamann M" first="M. T." last="Hamann">M. T. Hamann</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Contribution from the Department of Pharmacognosy, NCDNP, University of Mississippi, University,Mississippi, National Institute of Water and Atmospheric Research Ltd. Auckland, New Zealand;Molecular Parasitology Laboratory, School of Biological Sciences, National University of Singapore;Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation,Palo Alto</wicri:cityArea></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the American Chemical Society</title><title level="j" type="abbrev">J. Am. Chem. Soc.</title><idno type="ISSN">0002-7863</idno><idno type="eISSN">1520-5126</idno><imprint><publisher>American Chemical Society</publisher><date type="e-published" when="2001-02-10">2001</date><date when="2001-03-07">2001</date><biblScope unit="vol">123</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1804">1804</biblScope><biblScope unit="page" to="1808">1808</biblScope></imprint><idno type="ISSN">0002-7863</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-7863</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The isolation of the new enantiomers of 8-hydroxymanzamine A (1), manzamine F (2), along with the unprecedented manzamine dimer, neo-kauluamine from an undescribed genus of Indo-Pacific sponge (family Petrosiidae, order Haplosclerida) is reported. The relative stereochemistry of neo-kauluamine was established through detailed analysis of NOE-correlations combined with molecular modeling. The significance of the manzamines as in vivo antimalarial agents with superior activity to the clinically used drugs artemisinin and chloroquine is discussed along with the activity in vitro against the AIDS-opportunistic infectious diseases tuberculosis and toxoplasmosis. Reexamination of the sponges identified as Prianos, and Pachypellina, in earlier publications has confirmed that these are members of the same genus as the sponge described here, but differ at the species level.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="El Sayed, K A" sort="El Sayed, K A" uniqKey="El Sayed K" first="K. A." last="El Sayed">K. A. El Sayed</name></region><name sortKey="Ang, K K H" sort="Ang, K K H" uniqKey="Ang K" first="K. K. H." last="Ang">K. K. H. Ang</name><name sortKey="Dunbar, D C" sort="Dunbar, D C" uniqKey="Dunbar D" first="D. C." last="Dunbar">D. C. Dunbar</name><name sortKey="Hamann, M T" sort="Hamann, M T" uniqKey="Hamann M" first="M. T." last="Hamann">M. T. Hamann</name><name sortKey="Hamann, M T" sort="Hamann, M T" uniqKey="Hamann M" first="M. T." last="Hamann">M. T. Hamann</name><name sortKey="Kara, U A K" sort="Kara, U A K" uniqKey="Kara U" first="U. A. K." last="Kara">U. A. K. Kara</name><name sortKey="Katsuyama, I" sort="Katsuyama, I" uniqKey="Katsuyama I" first="I." last="Katsuyama">I. Katsuyama</name><name sortKey="Kelly, M" sort="Kelly, M" uniqKey="Kelly M" first="M." last="Kelly">M. Kelly</name><name sortKey="Khan, A A" sort="Khan, A A" uniqKey="Khan A" first="A. A." last="Khan">A. A. Khan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002266 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002266 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:AAE58B1F3B604C75CD681D30CAC02F7E15341B9C
|texte= New Manzamine Alkaloids with Potent Activity against Infectious Diseases
}}
| This area was generated with Dilib version V0.6.33. |  |