Antimalarial drugs inhibit the acetylcholine-receptor-operated potassium current in atrial myocytes.
Identifieur interne : 002160 ( Main/Exploration ); précédent : 002159; suivant : 002161Antimalarial drugs inhibit the acetylcholine-receptor-operated potassium current in atrial myocytes.
Auteurs : Yukio Hara [Japon] ; Keiichiro KizakiSource :
- Heart, lung & circulation [ 1443-9506 ] ; 2002.
Abstract
It has been reported that halofantrine, an antimalarial drug, was associated with electrocardiographic prolongation of the QT interval and ventricular arrhythmias. Inhibition of the delayed rectifier potassium channel, a voltage-gated potassium channel, by halofantrine was the likely underlying cellular mechanism for this cardiotoxicity. However, influences of anti-malarial drugs on the ligand-gated potassium channels have not been well-documented. The influences of three different antimalarial drugs, chloroquine, primaquine and pyrimethamine, on the acetylcholine-receptor-operated potassium current (I(K.ACh)), a ligand-gated potassium current, were compared with the effect of quinidine in isolated guinea pig atrial myocytes using patch-clamp techniques.
DOI: 10.1046/j.1443-9506.2002.00128.x
PubMed: 16352079
Affiliations:
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