Abnormal mechanical properties of larger arteries in postmenopausal women with systemic lupus erythematosus
Identifieur interne : 002026 ( Main/Exploration ); précédent : 002025; suivant : 002027Abnormal mechanical properties of larger arteries in postmenopausal women with systemic lupus erythematosus
Auteurs : J. Brodszki [Suède] ; C. Bengtsson [Suède] ; T. L Nne [Suède] ; O. Nived [Suède] ; G. Sturfelt [Suède] ; K. Maršál [Suède]Source :
- Lupus [ 0961-2033 ] ; 2004-12.
English descriptors
- Teeft :
- Abdominal aorta, Abpi, Antihypertensive drugs, Antimalarial, Antimalarial drugs, Aortic, Aortic stiffness, Aric study, Arterial, Arterial blood pressure, Arterial pressure, Arterial stiffening, Arterial stiffness, Arterial wall properties, Arthritis rheum, Atherosclerosis, Atherosclerosis risk, Atherosclerotic, Atherosclerotic lesions, Blood pressure, Brodszki, Cardiovascular, Cardiovascular disease, Carotid, Carotid artery, Cholesterol levels, Common carotid artery, Cumulative organ damage, Damage index, Diabetes mellitus, Elastin, Erythematosus, Healthy controls, Immunological mechanisms, Larger arteries, Larger vessel diameters, Limited knowledge, Linear array ultrasound probes, Lower aortic stiffness, Lund, Lund university, Lupus, Lupus erythematosus, Mechanical properties, Myocardial infarction, Normal abpi, Normal appearance, Other mechanisms, Patient group, Plaque, Popliteal, Popliteal artery, Popliteal stiffness, Postmenopausal, Postmenopausal women, Potential defects, Pressure index, Pulsatile diameter changes, Pulse wave velocity, Real time ultrasound scanner, Rheum, Risk factors, Semin arthritis rheum, Serum antielastin antibodies, Southern sweden, Stiffness, Systemic, Systemic lupus erythematosus, Systolic, Systolic pressure, Ultrasound, Ultrasound probe, University hospital, Vascular, Vascular pathology, Vascular properties, Vascular stiffness, Vasculitis, Vessel diameters, Vessel wall, Vessel walls.
Abstract
There is limited knowledge of potential defects in arterial wall properties in female systemic lupus erythematosus (SLE) patients without manifest cardiovascular disease (CVD) and significant atherosclerotic lesions. The aim of the present study was to investigate the mechanical properties of larger vessels in these patients and to compare them with healthy controls. B-mode ultrasound was used to assess vessel wall structure and to exclude presence of plaque. The ankle/brachial pressure index was measured to exclude occlusive arterial disease. An ultrasound echo-tracking system was used to determine stiffness of the abdominal aorta, common carotid artery (CCA) and popliteal artery (PA) in 39 female patientswith SLE and 55 female, healthy controls. SLE had an independent effect on stiffening of the CCA (P = 0.01) and PA (P = 0.005). In addition, larger vessel diameters were observed in the CCA (P = 0.002) after adjustments for the effects of mean arterial pressure and age. Thus, this investigation demonstrated an increased arterial stiffness and signs of premature vascular ageing in the SLE patients without manifest cardiovascular disease and without significant atherosclerotic lesions. The results of this study indicate that other mechanisms besides atherosclerosis might be involved in the pathogenesis of arterial stiffening in SLE patients.
Url:
DOI: 10.1191/0961203304lu2033oa
Affiliations:
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<term>Antimalarial drugs</term>
<term>Aortic</term>
<term>Aortic stiffness</term>
<term>Aric study</term>
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<term>Arterial blood pressure</term>
<term>Arterial pressure</term>
<term>Arterial stiffening</term>
<term>Arterial stiffness</term>
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<term>Arthritis rheum</term>
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<term>Atherosclerotic lesions</term>
<term>Blood pressure</term>
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<term>Damage index</term>
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<term>Immunological mechanisms</term>
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<term>Larger vessel diameters</term>
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<term>Lund university</term>
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<term>Mechanical properties</term>
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<term>Postmenopausal women</term>
<term>Potential defects</term>
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<term>Pulsatile diameter changes</term>
<term>Pulse wave velocity</term>
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<term>Risk factors</term>
<term>Semin arthritis rheum</term>
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<term>Stiffness</term>
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<term>Ultrasound probe</term>
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<term>Vascular pathology</term>
<term>Vascular properties</term>
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<front><div type="abstract" xml:lang="en">There is limited knowledge of potential defects in arterial wall properties in female systemic lupus erythematosus (SLE) patients without manifest cardiovascular disease (CVD) and significant atherosclerotic lesions. The aim of the present study was to investigate the mechanical properties of larger vessels in these patients and to compare them with healthy controls. B-mode ultrasound was used to assess vessel wall structure and to exclude presence of plaque. The ankle/brachial pressure index was measured to exclude occlusive arterial disease. An ultrasound echo-tracking system was used to determine stiffness of the abdominal aorta, common carotid artery (CCA) and popliteal artery (PA) in 39 female patientswith SLE and 55 female, healthy controls. SLE had an independent effect on stiffening of the CCA (P = 0.01) and PA (P = 0.005). In addition, larger vessel diameters were observed in the CCA (P = 0.002) after adjustments for the effects of mean arterial pressure and age. Thus, this investigation demonstrated an increased arterial stiffness and signs of premature vascular ageing in the SLE patients without manifest cardiovascular disease and without significant atherosclerotic lesions. The results of this study indicate that other mechanisms besides atherosclerosis might be involved in the pathogenesis of arterial stiffening in SLE patients.</div>
</front>
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