Drug exposure, pregnancy outcome and fetal and childhood development occurring in the offspring of mothers with systemic lupus erythematosus and other chronic autoimmune diseases
Identifieur interne : 001D43 ( Main/Exploration ); précédent : 001D42; suivant : 001D44Drug exposure, pregnancy outcome and fetal and childhood development occurring in the offspring of mothers with systemic lupus erythematosus and other chronic autoimmune diseases
Auteurs : A. Parke [États-Unis]Source :
- Lupus [ 0961-2033 ] ; 2006-11.
English descriptors
- Teeft :
- Abnormality, Antiphospholipid, Antiphospholipid antibody syndrome, Antiphospholipid syndrome, Arthritis rheum, Autoimmune, Autoimmune disease, Autoimmune diseases, Birth weight, Childhood effects, Clinical thrombotic events, Coll cardiol, Congenital, Congenital heart block, Connecticut health center, Current recommendation, Defective placentation, Developmental abnormalities, Disease activity, Erythematosus, Fetal, Fetal loss, Foreign compounds, Heart block, Hydroxychloroquine, Immunosuppressive, Immunosuppressive agents, Immunosuppressive drugs, Immunosuppressive medications, Intra utero exposure, Long term, Long term consequences, Long term effects, Lupus, Maternal, Maternal disease, Multiple antenatal courses, Multiple sclerosis, Neonatal, Neonatal lupus syndrome, Other hand, Parke, Placental, Postpartum period, Pregnancy, Pregnancy outcome, Pregnancy outcomes, Prematurity, Prenatal exposure, Recent studies, Renal transplantation, Syndrome, Systemic, Systemic lupus erythematosus, Term effects, Tissue deposition, Transplacental passage, Transplant, Xenobiotic agents, Young women.
Abstract
Most autoimmune diseases occur more commonly in females and many of these young women wish to become mothers. For pregnancy to proceed successfully immunomodulation and physiological changes preparing the reproductive system need to occur. Pregnancy occurring in a chronically ill mother who requires medications in order to maintain her own health and who may have already incurred significant organ pathology gives rise to several problems and so four questions arise: 1) What will be the effect of the pregnancy on the underlying disease? 2) What will be the effect of the disease on the outcome of pregnancy? 3) How to manage the disease, just prior to, throughout and immediately after the pregnancy? 4) The long term fetal and childhood effects of maternal disease and its management. This paper reviews the current literature pertaining to these questions in patients with systemic lupus erythematosus (SLE) and other chronic rheumatic and autoimmune diseases.
Url:
DOI: 10.1177/0961203306071003
Affiliations:
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Parke</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Rheumatology, University of Connecticut Health Center, 263 Farmington Ave, MC 5353 Farmington, CT 06030</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Lupus</title><idno type="ISSN">0961-2033</idno><idno type="eISSN">1477-0962</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage CA: Thousand Oaks, CA</pubPlace><date type="published" when="2006-11">2006-11</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="808">808</biblScope><biblScope unit="page" to="813">813</biblScope></imprint><idno type="ISSN">0961-2033</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0961-2033</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term><term>Antiphospholipid</term><term>Antiphospholipid antibody syndrome</term><term>Antiphospholipid syndrome</term><term>Arthritis rheum</term><term>Autoimmune</term><term>Autoimmune disease</term><term>Autoimmune diseases</term><term>Birth weight</term><term>Childhood effects</term><term>Clinical thrombotic events</term><term>Coll cardiol</term><term>Congenital</term><term>Congenital heart block</term><term>Connecticut health center</term><term>Current recommendation</term><term>Defective placentation</term><term>Developmental abnormalities</term><term>Disease activity</term><term>Erythematosus</term><term>Fetal</term><term>Fetal loss</term><term>Foreign compounds</term><term>Heart block</term><term>Hydroxychloroquine</term><term>Immunosuppressive</term><term>Immunosuppressive agents</term><term>Immunosuppressive drugs</term><term>Immunosuppressive medications</term><term>Intra utero exposure</term><term>Long term</term><term>Long term consequences</term><term>Long term effects</term><term>Lupus</term><term>Maternal</term><term>Maternal disease</term><term>Multiple antenatal courses</term><term>Multiple sclerosis</term><term>Neonatal</term><term>Neonatal lupus syndrome</term><term>Other hand</term><term>Parke</term><term>Placental</term><term>Postpartum period</term><term>Pregnancy</term><term>Pregnancy outcome</term><term>Pregnancy outcomes</term><term>Prematurity</term><term>Prenatal exposure</term><term>Recent studies</term><term>Renal transplantation</term><term>Syndrome</term><term>Systemic</term><term>Systemic lupus erythematosus</term><term>Term effects</term><term>Tissue deposition</term><term>Transplacental passage</term><term>Transplant</term><term>Xenobiotic agents</term><term>Young women</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most autoimmune diseases occur more commonly in females and many of these young women wish to become mothers. For pregnancy to proceed successfully immunomodulation and physiological changes preparing the reproductive system need to occur. Pregnancy occurring in a chronically ill mother who requires medications in order to maintain her own health and who may have already incurred significant organ pathology gives rise to several problems and so four questions arise: 1) What will be the effect of the pregnancy on the underlying disease? 2) What will be the effect of the disease on the outcome of pregnancy? 3) How to manage the disease, just prior to, throughout and immediately after the pregnancy? 4) The long term fetal and childhood effects of maternal disease and its management. This paper reviews the current literature pertaining to these questions in patients with systemic lupus erythematosus (SLE) and other chronic rheumatic and autoimmune diseases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Parke, A" sort="Parke, A" uniqKey="Parke A" first="A" last="Parke">A. Parke</name></region><name sortKey="Parke, A" sort="Parke, A" uniqKey="Parke A" first="A" last="Parke">A. Parke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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