Necrotizing fasciitis in rheumatic diseases
Identifieur interne : 001C95 ( Main/Exploration ); précédent : 001C94; suivant : 001C96Necrotizing fasciitis in rheumatic diseases
Auteurs : M Y Mok ; S Y Wong [Hong Kong] ; T M Chan [Hong Kong] ; W M Tang [Hong Kong] ; W S Wong [Hong Kong] ; C S Lau [Hong Kong]Source :
- Lupus [ 0961-2033 ] ; 2006-06.
English descriptors
- Teeft :
- Aeromonas, Aeromonas caviae, Aeromonas hydrophila, Clindamycin, Debridement, Diabetes mellitus, Fasciitis, Haemolytic, High fever, Hong kong, Hydrophila, Immunocompromised hosts, Intravascular coagulopathy, Knee amputation, Lupus, Lupus nephritis, Multiple haemorrhagic bullae, Necrotic tissue, Necrotising, Necrotising fasciitis, Necrotizing, Necrotizing fasciitis, Oral route, Organ involvement, Penicillin, Perineal region, Prednisolone, Protein hours, Pyogenes, Queen mary hospital, Rheum disease, Rheumatic diseases, Rheumatoid arthritis, Septic arthritis, Septic shock, Serratia marcescens, Shock syndrome, Streptococcus, Streptococcus pyogenes, Surg, Surgical debridement, Systemic lupus erythematosus, University department.
Abstract
Necrotizing fasciitis is an uncommon but life-threatening complication in immunocompromised hosts. We reported four patients with rheumatic diseases complicated by necrotizing fasciitis and reviewed 14 others from literature search. Most patients were on corticosteroid treatment. Septic shock, disseminated intravascular coagulopathy and acute renal deterioration were common giving rise to an overall mortality rate of 27.8%. Septic arthritis may also complicate the condition. Statistical analysis on the series showed the lack of major surgical debridement as the only risk factor associated with increased mortality (RR 7.5, 95% CI 2.1-27.3, P = 0.01). Timely debridement of necrotic tissue is important for reducing mortality.
Url:
DOI: 10.1191/0961203306lu2314cr
Affiliations:
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hydrophila</term><term>Clindamycin</term><term>Debridement</term><term>Diabetes mellitus</term><term>Fasciitis</term><term>Haemolytic</term><term>High fever</term><term>Hong kong</term><term>Hydrophila</term><term>Immunocompromised hosts</term><term>Intravascular coagulopathy</term><term>Knee amputation</term><term>Lupus</term><term>Lupus nephritis</term><term>Multiple haemorrhagic bullae</term><term>Necrotic tissue</term><term>Necrotising</term><term>Necrotising fasciitis</term><term>Necrotizing</term><term>Necrotizing fasciitis</term><term>Oral route</term><term>Organ involvement</term><term>Penicillin</term><term>Perineal region</term><term>Prednisolone</term><term>Protein hours</term><term>Pyogenes</term><term>Queen mary hospital</term><term>Rheum disease</term><term>Rheumatic diseases</term><term>Rheumatoid arthritis</term><term>Septic arthritis</term><term>Septic shock</term><term>Serratia marcescens</term><term>Shock syndrome</term><term>Streptococcus</term><term>Streptococcus pyogenes</term><term>Surg</term><term>Surgical debridement</term><term>Systemic lupus erythematosus</term><term>University department</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Necrotizing fasciitis is an uncommon but life-threatening complication in immunocompromised hosts. We reported four patients with rheumatic diseases complicated by necrotizing fasciitis and reviewed 14 others from literature search. Most patients were on corticosteroid treatment. Septic shock, disseminated intravascular coagulopathy and acute renal deterioration were common giving rise to an overall mortality rate of 27.8%. Septic arthritis may also complicate the condition. Statistical analysis on the series showed the lack of major surgical debridement as the only risk factor associated with increased mortality (RR 7.5, 95% CI 2.1-27.3, P = 0.01). Timely debridement of necrotic tissue is important for reducing mortality.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country></list><tree><noCountry><name sortKey="Mok, M Y" sort="Mok, M Y" uniqKey="Mok M" first="M Y" last="Mok">M Y Mok</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Wong, S Y" sort="Wong, S Y" uniqKey="Wong S" first="S Y" last="Wong">S Y Wong</name></noRegion><name sortKey="Chan, T M" sort="Chan, T M" uniqKey="Chan T" first="T M" last="Chan">T M Chan</name><name sortKey="Lau, C S" sort="Lau, C S" uniqKey="Lau C" first="C S" last="Lau">C S Lau</name><name sortKey="Tang, W M" sort="Tang, W M" uniqKey="Tang W" first="W M" last="Tang">W M Tang</name><name sortKey="Wong, W S" sort="Wong, W S" uniqKey="Wong W" first="W S" last="Wong">W S Wong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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