Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.
Identifieur interne : 001C06 ( Main/Exploration ); précédent : 001C05; suivant : 001C07Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum.
Auteurs : Apiwat Baramee [France] ; Alexandra Coppin [France] ; Marlène Mortuaire [France] ; Lydie Pelinski [France] ; Stanislas Tomavo [France] ; Jacques Brocard [France]Source :
- Bioorganic and Medicinal Chemistry [ 0968-0896 ] ; 2006.
Abstract
Fourteen ferrocenyl aminohydroxynaphthoquinones, analogues of atovaquone, were synthesized from the hydroxynaphthoquinone core. These novel atovaquone derivatives were tested for their in vitro activity against two apicomplexan parasites of medical importance, Toxoplasma gondii and Plasmodium falciparum, including resistant strains to atovaquone (T. gondii) and chloroquine (P. falciparum). Three of these ferrocenic atovaquone derivatives composed of the hydroxynaphthoquinone core plus an amino-ferrocenic group and an aliphatic chain with 6-8 carbon atoms were found to be significantly active against T. gondii. Moreover, these novel compounds were also effective against the atovaquone-resistant strain of T. gondii (Ato(R)).
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Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000226
- to stream Hal, to step Curation: 000226
- to stream Hal, to step Checkpoint: 000229
- to stream Main, to step Merge: 001E14
- to stream Main, to step Curation: 001C06
Le document en format XML
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<author><name sortKey="Tomavo, Stanislas" sort="Tomavo, Stanislas" uniqKey="Tomavo S" first="Stanislas" last="Tomavo">Stanislas Tomavo</name>
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<author><name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name>
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<series><title level="j">Bioorganic and Medicinal Chemistry</title>
<idno type="ISSN">0968-0896</idno>
<imprint><date type="datePub">2006</date>
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<profileDesc><textClass><keywords scheme="mix" xml:lang="it"><term>Anti-malaria activity</term>
<term>Atovaquone</term>
<term>Ferrocene</term>
<term>Toxoplasmosis</term>
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<front><div type="abstract" xml:lang="en"> <p>Fourteen ferrocenyl aminohydroxynaphthoquinones, analogues of atovaquone, were synthesized from the hydroxynaphthoquinone core. These novel atovaquone derivatives were tested for their in vitro activity against two apicomplexan parasites of medical importance, Toxoplasma gondii and Plasmodium falciparum, including resistant strains to atovaquone (T. gondii) and chloroquine (P. falciparum). Three of these ferrocenic atovaquone derivatives composed of the hydroxynaphthoquinone core plus an amino-ferrocenic group and an aliphatic chain with 6-8 carbon atoms were found to be significantly active against T. gondii. Moreover, these novel compounds were also effective against the atovaquone-resistant strain of T. gondii (Ato(R)).</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
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<tree><country name="France"><noRegion><name sortKey="Baramee, Apiwat" sort="Baramee, Apiwat" uniqKey="Baramee A" first="Apiwat" last="Baramee">Apiwat Baramee</name>
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<name sortKey="Brocard, Jacques" sort="Brocard, Jacques" uniqKey="Brocard J" first="Jacques" last="Brocard">Jacques Brocard</name>
<name sortKey="Coppin, Alexandra" sort="Coppin, Alexandra" uniqKey="Coppin A" first="Alexandra" last="Coppin">Alexandra Coppin</name>
<name sortKey="Mortuaire, Marlene" sort="Mortuaire, Marlene" uniqKey="Mortuaire M" first="Marlène" last="Mortuaire">Marlène Mortuaire</name>
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<name sortKey="Tomavo, Stanislas" sort="Tomavo, Stanislas" uniqKey="Tomavo S" first="Stanislas" last="Tomavo">Stanislas Tomavo</name>
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