An unusual central nervous system involvement in rheumatoid arthritis: combination of pachymeningitis and cerebral vasculitis
Identifieur interne : 001A28 ( Main/Exploration ); précédent : 001A27; suivant : 001A29An unusual central nervous system involvement in rheumatoid arthritis: combination of pachymeningitis and cerebral vasculitis
Auteurs : Asl Kurne [Turquie] ; Rana Karabudak [Turquie] ; Ömer Karadag [Turquie] ; Gül Yalcin-Cakmakli [Turquie] ; Kader Karli-Oguz [Turquie] ; Kivilcim Yavuz [Turquie] ; Meral Calgüneri [Turquie] ; Mehmet Akif Topcuoglu [Turquie]Source :
- Rheumatology International [ 0172-8172 ] ; 2009-09-01.
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Abstract
Abstract: Severe primary central nervous system (CNS) involvement such as vasculitis and pachymeningitis can rarely occur in rheumatoid arthritis (RA) even in the absence of systemic disease activation. The authors illustrate a female patient with well-controlled RA who presented with headaches, encephalopathy, seizures and relapsing focal neurological deficits. Primary rheumatoid cerebral vasculitis and pachymeningitis were diagnosed based on suggestive brain magnetic resonance (MR) imaging, MR angiography, cerebrospinal fluid analysis and cerebral angiography. MR showed abnormal leptomeningeal enhancement and hyperintense FLAIR signal in the cortical subarachnoid spaces consistent with pachymeningitis. Cerebral angiography findings were consistent with vasculitis. Aggressive treatment resulted in significant clinicoradiological resolution. Cerebral vasculitis is a rare but certain manifestation of RA. This complication can be diagnosed in the presence of suggestive angiographic and CSF findings. The condition may be steroid resistant, and needs to be treated more aggressively.
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DOI: 10.1007/s00296-008-0810-6
Affiliations:
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type="published" when="2009-09-01">2009-09-01</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1349">1349</biblScope><biblScope unit="page" to="1353">1353</biblScope></imprint><idno type="ISSN">0172-8172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0172-8172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiography</term><term>Biopsy</term><term>Magnetic resonance imaging</term><term>Pachymeningitis</term><term>Rheumatoid arthritis</term><term>Steroid</term><term>Vasculitis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Severe primary central nervous system (CNS) involvement such as vasculitis and pachymeningitis can rarely occur in rheumatoid arthritis (RA) even in the absence of systemic disease activation. The authors illustrate a female patient with well-controlled RA who presented with headaches, encephalopathy, seizures and relapsing focal neurological deficits. Primary rheumatoid cerebral vasculitis and pachymeningitis were diagnosed based on suggestive brain magnetic resonance (MR) imaging, MR angiography, cerebrospinal fluid analysis and cerebral angiography. MR showed abnormal leptomeningeal enhancement and hyperintense FLAIR signal in the cortical subarachnoid spaces consistent with pachymeningitis. Cerebral angiography findings were consistent with vasculitis. Aggressive treatment resulted in significant clinicoradiological resolution. Cerebral vasculitis is a rare but certain manifestation of RA. This complication can be diagnosed in the presence of suggestive angiographic and CSF findings. The condition may be steroid resistant, and needs to be treated more aggressively.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Kurne, Asl" sort="Kurne, Asl" uniqKey="Kurne A" first="Asl" last="Kurne">Asl Kurne</name></noRegion><name sortKey="Calguneri, Meral" sort="Calguneri, Meral" uniqKey="Calguneri M" first="Meral" last="Calgüneri">Meral Calgüneri</name><name sortKey="Karabudak, Rana" sort="Karabudak, Rana" uniqKey="Karabudak R" first="Rana" last="Karabudak">Rana Karabudak</name><name sortKey="Karadag, Omer" sort="Karadag, Omer" uniqKey="Karadag O" first="Ömer" last="Karadag">Ömer Karadag</name><name sortKey="Karli Oguz, Kader" sort="Karli Oguz, Kader" uniqKey="Karli Oguz K" first="Kader" last="Karli-Oguz">Kader Karli-Oguz</name><name sortKey="Topcuoglu, Mehmet Akif" sort="Topcuoglu, Mehmet Akif" uniqKey="Topcuoglu M" first="Mehmet Akif" last="Topcuoglu">Mehmet Akif Topcuoglu</name><name sortKey="Yalcin Cakmakli, Gul" sort="Yalcin Cakmakli, Gul" uniqKey="Yalcin Cakmakli G" first="Gül" last="Yalcin-Cakmakli">Gül Yalcin-Cakmakli</name><name sortKey="Yavuz, Kivilcim" sort="Yavuz, Kivilcim" uniqKey="Yavuz K" first="Kivilcim" last="Yavuz">Kivilcim Yavuz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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