Diagnostic approach and treatment of cutaneous lupus erythematosus
Identifieur interne : 001A10 ( Main/Exploration ); précédent : 001A09; suivant : 001A11Diagnostic approach and treatment of cutaneous lupus erythematosus
Auteurs : Michael Sticherling [Allemagne] ; Gisela Bonsmann [Allemagne] ; Annegret Kuhn [Allemagne]Source :
- JDDG: Journal der Deutschen Dermatologischen Gesellschaft [ 1610-0379 ] ; 2008-01.
English descriptors
- Teeft :
- Adjuvant basis, Agents azathioprine, Antimalarial, Basal tests, Basement membrane zone, Biopsy, Body weight, Butterfly erythema, Calcineurin inhibitors, Case reports, Clinical findings, Clinical studies, Collagen fibers, Complement factors, Complete blood count, Corticosteroid dose, Creatinine clearance, Cutaneous, Cutaneous lupus erythematosus, Cutaneous lupus erythematosus disease area, Cutaneous manifestations, Diagnostic approach, Diagnostic procedures, Direct immunofluorescence, Disease activity, Erythematosus, First choice, First signs, Further differentiation, Glomerular filtration rate, Glucocorticosteroids, Hydroxychloroquine, Hyperkeratotic lesions, Ideal body weight, Immunofluorescence, Indirect immunofluorescence, Individualized fashion, Inflammatory, Inflammatory activity, Inflammatory disease, Interface dermatitis, Interface dermatitis histologically, Intravenous immunoglobulins, Jddg, Laboratory tests, Lesion, Liver enzymes, Lupus, Lupus erythematosus, Methotrexate, Mycophenolate mofetil, Neutrophilic granulocytes, Organ involvement, Photoprovocation testing, Photoprovokationstestung sollte, Potential side effects, Protection products, Renal function parameters, Rheumatoid arthritis, Rheumatoid factor, Scle, Serum creatinine, Serum urea, Severity index, Sich, Side effects, Skin biopsies, Skin biopsy, Skin lesions, Skin manifestations, Special tests, Stain mucin deposition, Subtype, Subtypes, Such cases, Systemic, Systemic administration, Systemic glucocorticosteroids, Systemic lupus erythematosus, Systemic manifestation, Systemic organ involvement, Systemic therapy, Technical investigations, Topical therapy, Trifft nicht, Urine collection, Various criteria, Various subtypes, Week intervals.
Abstract
Cutaneous lupus erythematosus (CLE) is a heterogeneous disorder with a wide range of skin manifestations. In the second part of this review, diagnostic procedures and treatment options in CLE are summarized.The diagnosis of the various subtypes of CLE is based on patients's history,clinical findings,laboratory features, and histological and immunofluorescent examinations of skin biopsies. In case of systemic organ involvement, further adequate technical investigations are necessary. The therapy has to be adjusted to the subtype of CLE and its inflammatory activity as well as the extent of skin involvement. The skin manifestations of CLE are primarily treated by topical therapy, such as glucocorticosteroids, in combination with antimalarials. The response of CLE to immunosuppressive drugs that control organ involvement in systemic lupus erythematosus is often disappointing. Recent advances in biotechnology resulted in the development of several novel systemic agents for the treatment of autoimmune diseases; however, controlled clinical trials are still necessary for the approval of new therapies in CLE.
Url:
DOI: 10.1111/j.1610-0387.2007.06557.x
Affiliations:
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tests</term><term>Basement membrane zone</term><term>Biopsy</term><term>Body weight</term><term>Butterfly erythema</term><term>Calcineurin inhibitors</term><term>Case reports</term><term>Clinical findings</term><term>Clinical studies</term><term>Collagen fibers</term><term>Complement factors</term><term>Complete blood count</term><term>Corticosteroid dose</term><term>Creatinine clearance</term><term>Cutaneous</term><term>Cutaneous lupus erythematosus</term><term>Cutaneous lupus erythematosus disease area</term><term>Cutaneous manifestations</term><term>Diagnostic approach</term><term>Diagnostic procedures</term><term>Direct immunofluorescence</term><term>Disease activity</term><term>Erythematosus</term><term>First choice</term><term>First signs</term><term>Further differentiation</term><term>Glomerular filtration rate</term><term>Glucocorticosteroids</term><term>Hydroxychloroquine</term><term>Hyperkeratotic lesions</term><term>Ideal body weight</term><term>Immunofluorescence</term><term>Indirect immunofluorescence</term><term>Individualized fashion</term><term>Inflammatory</term><term>Inflammatory activity</term><term>Inflammatory disease</term><term>Interface dermatitis</term><term>Interface dermatitis histologically</term><term>Intravenous immunoglobulins</term><term>Jddg</term><term>Laboratory tests</term><term>Lesion</term><term>Liver enzymes</term><term>Lupus</term><term>Lupus erythematosus</term><term>Methotrexate</term><term>Mycophenolate mofetil</term><term>Neutrophilic granulocytes</term><term>Organ involvement</term><term>Photoprovocation testing</term><term>Photoprovokationstestung sollte</term><term>Potential side effects</term><term>Protection products</term><term>Renal function parameters</term><term>Rheumatoid arthritis</term><term>Rheumatoid factor</term><term>Scle</term><term>Serum creatinine</term><term>Serum urea</term><term>Severity index</term><term>Sich</term><term>Side effects</term><term>Skin biopsies</term><term>Skin biopsy</term><term>Skin lesions</term><term>Skin manifestations</term><term>Special tests</term><term>Stain mucin deposition</term><term>Subtype</term><term>Subtypes</term><term>Such cases</term><term>Systemic</term><term>Systemic administration</term><term>Systemic glucocorticosteroids</term><term>Systemic lupus erythematosus</term><term>Systemic manifestation</term><term>Systemic organ involvement</term><term>Systemic therapy</term><term>Technical investigations</term><term>Topical therapy</term><term>Trifft nicht</term><term>Urine collection</term><term>Various criteria</term><term>Various subtypes</term><term>Week intervals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cutaneous lupus erythematosus (CLE) is a heterogeneous disorder with a wide range of skin manifestations. In the second part of this review, diagnostic procedures and treatment options in CLE are summarized.The diagnosis of the various subtypes of CLE is based on patients's history,clinical findings,laboratory features, and histological and immunofluorescent examinations of skin biopsies. In case of systemic organ involvement, further adequate technical investigations are necessary. The therapy has to be adjusted to the subtype of CLE and its inflammatory activity as well as the extent of skin involvement. The skin manifestations of CLE are primarily treated by topical therapy, such as glucocorticosteroids, in combination with antimalarials. The response of CLE to immunosuppressive drugs that control organ involvement in systemic lupus erythematosus is often disappointing. Recent advances in biotechnology resulted in the development of several novel systemic agents for the treatment of autoimmune diseases; however, controlled clinical trials are still necessary for the approval of new therapies in CLE.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Sticherling, Michael" sort="Sticherling, Michael" uniqKey="Sticherling M" first="Michael" last="Sticherling">Michael Sticherling</name></noRegion><name sortKey="Bonsmann, Gisela" sort="Bonsmann, Gisela" uniqKey="Bonsmann G" first="Gisela" last="Bonsmann">Gisela Bonsmann</name><name sortKey="Kuhn, Annegret" sort="Kuhn, Annegret" uniqKey="Kuhn A" first="Annegret" last="Kuhn">Annegret Kuhn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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