Malignancy-associated multicentric reticulohistiocytosis
Identifieur interne : 001851 ( Main/Exploration ); précédent : 001850; suivant : 001852Malignancy-associated multicentric reticulohistiocytosis
Auteurs : Boutros El-Haddad [États-Unis] ; Dalia Hammoud [États-Unis] ; Timothy Shaver [États-Unis] ; Shadi Shahouri [États-Unis]Source :
- Rheumatology International [ 0172-8172 ] ; 2011-09-01.
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Abstract
Abstract: Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.
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DOI: 10.1007/s00296-009-1287-7
Affiliations:
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type="abstract" xml:lang="en">Abstract: Multicentric reticulohistiocytosis (MR) is a rare systemic disorder of unknown etiology. Up to 25% of patients with MR have associated malignancies. We are reporting a case of a patient with MR who initially had an excellent clinical response to oral methotrexate and prednisone. Subsequent attempts of prednisone taper failed because of disease flare-up. Workup for associated malignancy revealed localized squamous cell carcinoma of the lung. The tumor was resected; methotrexate and prednisone were tapered and discontinued with complete remission of MR. A review of literature and the new advances and treatment modalities for MR is provided.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kansas</li></region></list><tree><country name="États-Unis"><region name="Kansas"><name sortKey="El Haddad, Boutros" sort="El Haddad, Boutros" uniqKey="El Haddad B" first="Boutros" last="El-Haddad">Boutros El-Haddad</name></region><name sortKey="Hammoud, Dalia" sort="Hammoud, Dalia" uniqKey="Hammoud D" first="Dalia" last="Hammoud">Dalia Hammoud</name><name sortKey="Hammoud, Dalia" sort="Hammoud, Dalia" uniqKey="Hammoud D" first="Dalia" last="Hammoud">Dalia Hammoud</name><name sortKey="Shahouri, Shadi" sort="Shahouri, Shadi" uniqKey="Shahouri S" first="Shadi" last="Shahouri">Shadi Shahouri</name><name sortKey="Shaver, Timothy" sort="Shaver, Timothy" uniqKey="Shaver T" first="Timothy" last="Shaver">Timothy Shaver</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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