Review on supermolecules as chemical drugs
Identifieur interne : 001822 ( Main/Exploration ); précédent : 001821; suivant : 001823Review on supermolecules as chemical drugs
Auteurs : Chenghe Zhou [République populaire de Chine] ; Linling Gan [République populaire de Chine] ; Yiyi Zhang [République populaire de Chine] ; Feifei Zhang [République populaire de Chine] ; Guangzhou Wang [République populaire de Chine] ; Lei Jin [République populaire de Chine] ; Rongxia Geng [République populaire de Chine]Source :
- Science in China Series B: Chemistry [ 1006-9291 ] ; 2009-04-01.
English descriptors
- KwdEn :
Abstract
Abstract: Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs, i.e. supramolecular chemical drugs or supramolecular drugs, which might have the excellences of lower cost, shorter period, higher potential as clinical drugs for their successful research and development, may possess higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances, lower toxicity, less adverse effect, and better curative effects as well as safety, and therefore exhibit wide potential application. These overwhelming advantages have drawn enormous special attention. This paper gives the definition of supramolecular drugs, proposes the concept of supramolecular chemical drugs, and systematically reviews the recent advances in the research and development of supermolecules, including organic and inorganic complex ones as chemical drugs in the area of antitumor, anti-inflammatory, analgesic, antimalarial, antibacterial, antifungal, antivirus, anti-epileptic, cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented.
Url:
DOI: 10.1007/s11426-009-0103-2
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001E84
- to stream Istex, to step Curation: 001E84
- to stream Istex, to step Checkpoint: 000747
- to stream Main, to step Merge: 001826
- to stream Main, to step Curation: 001822
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Review on supermolecules as chemical drugs</title><author><name sortKey="Zhou, Chenghe" sort="Zhou, Chenghe" uniqKey="Zhou C" first="Chenghe" last="Zhou">Chenghe Zhou</name></author><author><name sortKey="Gan, Linling" sort="Gan, Linling" uniqKey="Gan L" first="Linling" last="Gan">Linling Gan</name></author><author><name sortKey="Zhang, Yiyi" sort="Zhang, Yiyi" uniqKey="Zhang Y" first="Yiyi" last="Zhang">Yiyi Zhang</name></author><author><name sortKey="Zhang, Feifei" sort="Zhang, Feifei" uniqKey="Zhang F" first="Feifei" last="Zhang">Feifei Zhang</name></author><author><name sortKey="Wang, Guangzhou" sort="Wang, Guangzhou" uniqKey="Wang G" first="Guangzhou" last="Wang">Guangzhou Wang</name></author><author><name sortKey="Jin, Lei" sort="Jin, Lei" uniqKey="Jin L" first="Lei" last="Jin">Lei Jin</name></author><author><name sortKey="Geng, Rongxia" sort="Geng, Rongxia" uniqKey="Geng R" first="Rongxia" last="Geng">Rongxia Geng</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AF074D41B1B94AB672F189F40CAEAA927AF416D6</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1007/s11426-009-0103-2</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-3F1R29B5-J/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001E84</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001E84</idno><idno type="wicri:Area/Istex/Curation">001E84</idno><idno type="wicri:Area/Istex/Checkpoint">000747</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000747</idno><idno type="wicri:doubleKey">1006-9291:2009:Zhou C:review:on:supermolecules</idno><idno type="wicri:Area/Main/Merge">001826</idno><idno type="wicri:Area/Main/Curation">001822</idno><idno type="wicri:Area/Main/Exploration">001822</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Review on supermolecules as chemical drugs</title><author><name sortKey="Zhou, Chenghe" sort="Zhou, Chenghe" uniqKey="Zhou C" first="Chenghe" last="Zhou">Chenghe Zhou</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Chemistry and Chemical Engineering, Southwest University, 400715, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author><author><name sortKey="Gan, Linling" sort="Gan, Linling" uniqKey="Gan L" first="Linling" last="Gan">Linling Gan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmaceutical Sciences, Southwest University, 400715, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yiyi" sort="Zhang, Yiyi" uniqKey="Zhang Y" first="Yiyi" last="Zhang">Yiyi Zhang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Chemistry and Chemical Engineering, Southwest University, 400715, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Feifei" sort="Zhang, Feifei" uniqKey="Zhang F" first="Feifei" last="Zhang">Feifei Zhang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Chemistry and Chemical Engineering, Southwest University, 400715, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Guangzhou" sort="Wang, Guangzhou" uniqKey="Wang G" first="Guangzhou" last="Wang">Guangzhou Wang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Chemistry and Chemical Engineering, Southwest University, 400715, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Lei" sort="Jin, Lei" uniqKey="Jin L" first="Lei" last="Jin">Lei Jin</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Pharmaceutical Sciences, Southwest University, 400715, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Geng, Rongxia" sort="Geng, Rongxia" uniqKey="Geng R" first="Rongxia" last="Geng">Rongxia Geng</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Chemistry and Chemical Engineering, Southwest University, 400715, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Science in China Series B: Chemistry</title><title level="j" type="abbrev">Sci. China Ser. B-Chem.</title><idno type="ISSN">1006-9291</idno><idno type="eISSN">1862-2771</idno><imprint><publisher>SP Science in China Press</publisher><pubPlace>Heidelberg</pubPlace><date type="published" when="2009-04-01">2009-04-01</date><biblScope unit="volume">52</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="415">415</biblScope><biblScope unit="page" to="458">458</biblScope></imprint><idno type="ISSN">1006-9291</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1006-9291</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>anti-inflammatory</term><term>antibacterial</term><term>anticancer</term><term>antifungal</term><term>antivirus</term><term>cardiovascular agent</term><term>complex</term><term>cyclodextrin</term><term>magnetic resonance imaging agent</term><term>porphyrin</term><term>supramolecular chemistry</term><term>supramolecular drug</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs, i.e. supramolecular chemical drugs or supramolecular drugs, which might have the excellences of lower cost, shorter period, higher potential as clinical drugs for their successful research and development, may possess higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances, lower toxicity, less adverse effect, and better curative effects as well as safety, and therefore exhibit wide potential application. These overwhelming advantages have drawn enormous special attention. This paper gives the definition of supramolecular drugs, proposes the concept of supramolecular chemical drugs, and systematically reviews the recent advances in the research and development of supermolecules, including organic and inorganic complex ones as chemical drugs in the area of antitumor, anti-inflammatory, analgesic, antimalarial, antibacterial, antifungal, antivirus, anti-epileptic, cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Chenghe" sort="Zhou, Chenghe" uniqKey="Zhou C" first="Chenghe" last="Zhou">Chenghe Zhou</name></noRegion><name sortKey="Gan, Linling" sort="Gan, Linling" uniqKey="Gan L" first="Linling" last="Gan">Linling Gan</name><name sortKey="Geng, Rongxia" sort="Geng, Rongxia" uniqKey="Geng R" first="Rongxia" last="Geng">Rongxia Geng</name><name sortKey="Jin, Lei" sort="Jin, Lei" uniqKey="Jin L" first="Lei" last="Jin">Lei Jin</name><name sortKey="Wang, Guangzhou" sort="Wang, Guangzhou" uniqKey="Wang G" first="Guangzhou" last="Wang">Guangzhou Wang</name><name sortKey="Zhang, Feifei" sort="Zhang, Feifei" uniqKey="Zhang F" first="Feifei" last="Zhang">Feifei Zhang</name><name sortKey="Zhang, Yiyi" sort="Zhang, Yiyi" uniqKey="Zhang Y" first="Yiyi" last="Zhang">Yiyi Zhang</name><name sortKey="Zhou, Chenghe" sort="Zhou, Chenghe" uniqKey="Zhou C" first="Chenghe" last="Zhou">Chenghe Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001822 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001822 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:AF074D41B1B94AB672F189F40CAEAA927AF416D6
|texte= Review on supermolecules as chemical drugs
}}
| This area was generated with Dilib version V0.6.33. |  |