Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents
Identifieur interne : 001653 ( Main/Exploration ); précédent : 001652; suivant : 001654Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents
Auteurs : Devdutt Chaturvedi [Inde] ; Abhishek Goswami [Inde] ; Partha Pratim Saikia [Inde] ; Nabin C. Barua [Inde] ; Paruchuri G. Rao [Inde]Source :
- Chemical Society Reviews [ 0306-0012 ] ; 2010.
English descriptors
- Teeft :
- Acetal, Alcohol dimer, Aldehyde, Analogue, Anticancer, Antimalarial, Antimalarial activity, Artemether, Artemisinin, Artemisinin derivatives, Artemisinin dimers, Artemisinin units, Artemisinins, Artemisitene, Artesunate, Artesunic, Artesunic acid, Berghei, Bioorg, Cancer cells, Carba, Carba dimers, Cell proliferation, Chem, Chloroquine, Compound, Cytotoxicity, Derivative, Dihydroartemisinin, Dimer, Diverse panel, Endoperoxide, Endoperoxide linkage, Ester, Ether, Falciparum, Human cancer cell lines, Isomer, Jorhat, Lett, Linker, Malaria, Malaria parasites, Parasite, Posner, Quinine, Reagent, Royal society, Shapiro, Short half life, Tetramers, Trimer, Trioxane, Trioxane dimers, Various kinds.
Abstract
In this tutorial review, an effort towards presentation of a comprehensive account of the recent developments on various kinds of artemisinin derivatives including artemisinin dimers, trimers and tetramers has been made and their efficacy towards malaria parasites and different cancer cells lines was compared with that of artemisinins, and various other anti-malarial and anti-cancer drugs. It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.
Url:
DOI: 10.1039/b816679j
Affiliations:
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