ChloroquineV1, Main, Exploration, bibRecord, 001621

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine.

Identifieur interne : 001621 ( Main/Exploration ); précédent : 001620; suivant : 001622

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine.

Auteurs : M. Lusakibanza ; G. Mesia ; G. Tona ; S. Karemere ; A. Lukuka ; M. Tits ; L. Angenot ; M. Frédérich

Source :

Journal of ethnopharmacology [ 1872-7573 ] ; 2010.

RBID : pubmed:20430094

Descripteurs français

KwdFr :
- Animaux, Antipaludiques (effets indésirables), Antipaludiques (isolement et purification), Antipaludiques (pharmacologie), Concentration inhibitrice 50, Extraits de plantes (effets indésirables), Extraits de plantes (isolement et purification), Extraits de plantes (pharmacologie), Fibroblastes (), Humains, Lignée cellulaire, Lignées consanguines de souris, Modèles animaux de maladie humaine, Médecine traditionnelle africaine, Paludisme (microbiologie), Paludisme (traitement médicamenteux), Plantes médicinales (), Plasmodium berghei (), Plasmodium berghei (pathogénicité), Plasmodium falciparum (), République démocratique du Congo, Souris, Survie cellulaire (), Techniques de culture cellulaire.
MESH :
- effets indésirables : Antipaludiques, Extraits de plantes.
- isolement et purification : Antipaludiques, Extraits de plantes.
- microbiologie : Paludisme.
- pathogénicité : Plasmodium berghei.
- pharmacologie : Antipaludiques, Extraits de plantes.
- traitement médicamenteux : Paludisme.
- Animaux, Concentration inhibitrice 50, Fibroblastes, Humains, Lignée cellulaire, Lignées consanguines de souris, Modèles animaux de maladie humaine, Médecine traditionnelle africaine, Plantes médicinales, Plasmodium berghei, Plasmodium falciparum, République démocratique du Congo, Souris, Survie cellulaire, Techniques de culture cellulaire.

English descriptors

KwdEn :
- Animals, Antimalarials (adverse effects), Antimalarials (isolation & purification), Antimalarials (pharmacology), Cell Culture Techniques, Cell Line, Cell Survival (drug effects), Democratic Republic of the Congo, Disease Models, Animal, Fibroblasts (drug effects), Humans, Inhibitory Concentration 50, Malaria (drug therapy), Malaria (microbiology), Medicine, African Traditional, Mice, Mice, Inbred Strains, Plant Extracts (adverse effects), Plant Extracts (isolation & purification), Plant Extracts (pharmacology), Plants, Medicinal (chemistry), Plasmodium berghei (drug effects), Plasmodium berghei (pathogenicity), Plasmodium falciparum (drug effects).
MESH :
- chemical , adverse effects : Antimalarials, Plant Extracts.
- chemical , isolation & purification : Antimalarials, Plant Extracts.
- chemical , pharmacology : Antimalarials, Plant Extracts.
- geographic : Democratic Republic of the Congo.
- chemistry : Plants, Medicinal.
- drug effects : Cell Survival, Fibroblasts, Plasmodium berghei, Plasmodium falciparum.
- drug therapy : Malaria.
- microbiology : Malaria.
- pathogenicity : Plasmodium berghei.
- Animals, Cell Culture Techniques, Cell Line, Disease Models, Animal, Humans, Inhibitory Concentration 50, Medicine, African Traditional, Mice, Mice, Inbred Strains.

Abstract

The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo and focusing on plants used traditionally to treat malaria. The in vivo antimalarial activity of aqueous and methanolic extracts active in vitro was also determined in mice infected by Plasmodium berghei berghei.

DOI: 10.1016/j.jep.2010.04.007
PubMed: 20430094

Affiliations:

Le document en format XML

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<affiliation><nlm:affiliation>University of Kinshasa, Faculty of Pharmaceuticals Sciences, Kinshasa XI, Democratic Republic of Congo.</nlm:affiliation>
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<term>Cell Line</term>
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<term>Plasmodium berghei (pathogénicité)</term>
<term>Plasmodium falciparum ()</term>
<term>République démocratique du Congo</term>
<term>Souris</term>
<term>Survie cellulaire ()</term>
<term>Techniques de culture cellulaire</term>
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<front><div type="abstract" xml:lang="en">The in vitro antiplasmodial activity and cytotoxicity of methanolic and dichloromethane extracts from five Congolese plants were evaluated. The plants were selected following an ethnobotanical survey conducted in D.R. Congo and focusing on plants used traditionally to treat malaria. The in vivo antimalarial activity of aqueous and methanolic extracts active in vitro was also determined in mice infected by Plasmodium berghei berghei.</div>
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Serveur d'exploration Chloroquine

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine.

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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