Original quinazoline derivatives displaying antiplasmodial properties
Identifieur interne : 001609 ( Main/Exploration ); précédent : 001608; suivant : 001610Original quinazoline derivatives displaying antiplasmodial properties
Auteurs : Youssef Kabri [France] ; Nadine Azas [France] ; Aurélien Dumètre [France] ; Sébastien Hutter [France] ; Michèle Laget [France] ; Pierre Verhaeghe [France] ; Armand Gellis [France] ; Patrice Vanelle [France]Source :
- European Journal of Medicinal Chemistry [ 0223-5234 ] ; 2010-02.
Abstract
The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.). Among the fourteen tested molecules, two exhibited both significant antiplasmodial activity (IC(50) = 0.95 and 1.3 mu M) and low toxicity (IC(50) \textgreater 100 or 125 mu M), compared with two reference drugs: chloroquine and doxycycline. The structure activity relationships establish that the molecular scaffold which exerts the best profile is the 6-nitro-2-(tosylmethyl)-N-(3-substituted-phenyl)-quinazolin-4-amine. The hit molecules were finally investigated regarding their potential action toward two other protozoa, Leishmania donovani and Toxoplasma gondii, showing that these molecules display a selective antiplasmodial activity. (C) 2009 Elsevier Masson SAS. All rights reserved.
Url:
DOI: 10.1016/j.ejmech.2009.11.005
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000177
- to stream Hal, to step Curation: 000177
- to stream Hal, to step Checkpoint: 000184
- to stream Main, to step Merge: 001611
- to stream Main, to step Curation: 001609
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Original quinazoline derivatives displaying antiplasmodial properties</title>
<author><name sortKey="Kabri, Youssef" sort="Kabri, Youssef" uniqKey="Kabri Y" first="Youssef" last="Kabri">Youssef Kabri</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-258556" status="VALID"> <idno type="RNSR">201220354B</idno>
<orgName>Institut de Chimie Radicalaire</orgName>
<orgName type="acronym">ICR</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Avenue Escadrille Normandie-Niemen Service D42 13397 Marseille cedex 20</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://icr-amu.cnrs.fr/</ref>
</desc>
<listRelation> <relation name="UMR7273" active="#struct-198056" type="direct"></relation>
<relation name="UMR7273" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7273" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7273" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Azas, Nadine" sort="Azas, Nadine" uniqKey="Azas N" first="Nadine" last="Azas">Nadine Azas</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Dumetre, Aurelien" sort="Dumetre, Aurelien" uniqKey="Dumetre A" first="Aurélien" last="Dumètre">Aurélien Dumètre</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Hutter, Sebastien" sort="Hutter, Sebastien" uniqKey="Hutter S" first="Sébastien" last="Hutter">Sébastien Hutter</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Laget, Michele" sort="Laget, Michele" uniqKey="Laget M" first="Michèle" last="Laget">Michèle Laget</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Verhaeghe, Pierre" sort="Verhaeghe, Pierre" uniqKey="Verhaeghe P" first="Pierre" last="Verhaeghe">Pierre Verhaeghe</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno>
<idno type="ISNI">0000 0004 0638 384X</idno>
<idno type="RNSR">197417418A</idno>
<orgName>Laboratoire de chimie de coordination</orgName>
<orgName type="acronym">LCC</orgName>
<date type="start">1974-01-01</date>
<desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.lcc-toulouse.fr</ref>
</desc>
<listRelation> <relation active="#struct-448187" type="direct"></relation>
<relation active="#struct-443875" type="indirect"></relation>
<relation active="#struct-217752" type="direct"></relation>
<relation active="#struct-159253" type="direct"></relation>
<relation active="#struct-67872" type="indirect"></relation>
<relation name="FR2599" active="#struct-441569" type="direct"></relation>
<relation name="UPR8241" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno>
<idno type="ISNI">0000000121766169</idno>
<orgName>Institut National Polytechnique (Toulouse)</orgName>
<orgName type="acronym">Toulouse INP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-443875" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName>
<desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno>
<idno type="ISNI">0000000121617331</idno>
<orgName>Université Toulouse III - Paul Sabatier</orgName>
<orgName type="acronym">UT3</orgName>
<desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-tlse3.fr/</ref>
</desc>
<listRelation> <relation active="#struct-443875" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno>
<idno type="ISNI">0000 0004 4686 8315</idno>
<idno type="RNSR">200310667L</idno>
<orgName>Institut de Chimie de Toulouse</orgName>
<orgName type="acronym">ICT-FR 2599</orgName>
<desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://ict.ups-tlse.fr/</ref>
</desc>
<listRelation> <relation active="#struct-67872" type="direct"></relation>
<relation active="#struct-217752" type="direct"></relation>
<relation active="#struct-443875" type="indirect"></relation>
<relation name="FR2599" active="#struct-441569" type="direct"></relation>
<relation active="#struct-448187" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Gellis, Armand" sort="Gellis, Armand" uniqKey="Gellis A" first="Armand" last="Gellis">Armand Gellis</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-258556" status="VALID"> <idno type="RNSR">201220354B</idno>
<orgName>Institut de Chimie Radicalaire</orgName>
<orgName type="acronym">ICR</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Avenue Escadrille Normandie-Niemen Service D42 13397 Marseille cedex 20</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://icr-amu.cnrs.fr/</ref>
</desc>
<listRelation> <relation name="UMR7273" active="#struct-198056" type="direct"></relation>
<relation name="UMR7273" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7273" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7273" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Vanelle, Patrice" sort="Vanelle, Patrice" uniqKey="Vanelle P" first="Patrice" last="Vanelle">Patrice Vanelle</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-258556" status="VALID"> <idno type="RNSR">201220354B</idno>
<orgName>Institut de Chimie Radicalaire</orgName>
<orgName type="acronym">ICR</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Avenue Escadrille Normandie-Niemen Service D42 13397 Marseille cedex 20</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://icr-amu.cnrs.fr/</ref>
</desc>
<listRelation> <relation name="UMR7273" active="#struct-198056" type="direct"></relation>
<relation name="UMR7273" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7273" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7273" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-01460232</idno>
<idno type="halId">hal-01460232</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-01460232</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-01460232</idno>
<idno type="doi">10.1016/j.ejmech.2009.11.005</idno>
<date when="2010-02">2010-02</date>
<idno type="wicri:Area/Hal/Corpus">000177</idno>
<idno type="wicri:Area/Hal/Curation">000177</idno>
<idno type="wicri:Area/Hal/Checkpoint">000184</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000184</idno>
<idno type="wicri:doubleKey">0223-5234:2010:Kabri Y:original:quinazoline:derivatives</idno>
<idno type="wicri:Area/Main/Merge">001611</idno>
<idno type="wicri:Area/Main/Curation">001609</idno>
<idno type="wicri:Area/Main/Exploration">001609</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Original quinazoline derivatives displaying antiplasmodial properties</title>
<author><name sortKey="Kabri, Youssef" sort="Kabri, Youssef" uniqKey="Kabri Y" first="Youssef" last="Kabri">Youssef Kabri</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-258556" status="VALID"> <idno type="RNSR">201220354B</idno>
<orgName>Institut de Chimie Radicalaire</orgName>
<orgName type="acronym">ICR</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Avenue Escadrille Normandie-Niemen Service D42 13397 Marseille cedex 20</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://icr-amu.cnrs.fr/</ref>
</desc>
<listRelation> <relation name="UMR7273" active="#struct-198056" type="direct"></relation>
<relation name="UMR7273" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7273" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7273" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Azas, Nadine" sort="Azas, Nadine" uniqKey="Azas N" first="Nadine" last="Azas">Nadine Azas</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Dumetre, Aurelien" sort="Dumetre, Aurelien" uniqKey="Dumetre A" first="Aurélien" last="Dumètre">Aurélien Dumètre</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Hutter, Sebastien" sort="Hutter, Sebastien" uniqKey="Hutter S" first="Sébastien" last="Hutter">Sébastien Hutter</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Laget, Michele" sort="Laget, Michele" uniqKey="Laget M" first="Michèle" last="Laget">Michèle Laget</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-220808" status="OLD"> <idno type="RNSR">200817410U</idno>
<orgName>Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques</orgName>
<orgName type="acronym">IP-TPT</orgName>
<date type="start">2008-01-01</date>
<date type="end">2017-12-31</date>
<desc> <address> <addrLine>Faculté de Pharmacie27 bd Jean Moulin CS 3006413385 Marseille </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://pharmacie.univ-amu.fr/umr-md3</ref>
</desc>
<listRelation> <relation name="UMR MD3" active="#struct-300092" type="direct"></relation>
<relation name="UMR MD3" active="#struct-300073" type="direct"></relation>
<relation name="UMR MD3" active="#struct-198056" type="direct"></relation>
<relation name="UMR MD3" active="#struct-67872" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR MD3" active="#struct-300092" type="direct"><org type="institution" xml:id="struct-300092" status="VALID"> <orgName>Service de Santé des Armées</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-300073" type="direct"><org type="institution" xml:id="struct-300073" status="VALID"> <orgName>Assistance Publique - Hôpitaux de Marseille</orgName>
<orgName type="acronym">APHM</orgName>
<desc> <address> <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://fr.ap-hm.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR MD3" active="#struct-67872" type="direct"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Verhaeghe, Pierre" sort="Verhaeghe, Pierre" uniqKey="Verhaeghe P" first="Pierre" last="Verhaeghe">Pierre Verhaeghe</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-461" status="VALID"> <idno type="IdRef">190242221</idno>
<idno type="ISNI">0000 0004 0638 384X</idno>
<idno type="RNSR">197417418A</idno>
<orgName>Laboratoire de chimie de coordination</orgName>
<orgName type="acronym">LCC</orgName>
<date type="start">1974-01-01</date>
<desc> <address> <addrLine>205 Route de Narbonne 31077 TOULOUSE CEDEX 4</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.lcc-toulouse.fr</ref>
</desc>
<listRelation> <relation active="#struct-448187" type="direct"></relation>
<relation active="#struct-443875" type="indirect"></relation>
<relation active="#struct-217752" type="direct"></relation>
<relation active="#struct-159253" type="direct"></relation>
<relation active="#struct-67872" type="indirect"></relation>
<relation name="FR2599" active="#struct-441569" type="direct"></relation>
<relation name="UPR8241" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-448187" type="direct"><org type="institution" xml:id="struct-448187" status="VALID"> <idno type="IdRef">026388820</idno>
<idno type="ISNI">0000000121766169</idno>
<orgName>Institut National Polytechnique (Toulouse)</orgName>
<orgName type="acronym">Toulouse INP</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-443875" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-443875" type="indirect"><org type="regroupinstitution" xml:id="struct-443875" status="VALID"> <orgName>Université Fédérale Toulouse Midi-Pyrénées</orgName>
<desc> <address> <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <idno type="IdRef">026404672</idno>
<idno type="ISNI">0000000121617331</idno>
<orgName>Université Toulouse III - Paul Sabatier</orgName>
<orgName type="acronym">UT3</orgName>
<desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-tlse3.fr/</ref>
</desc>
<listRelation> <relation active="#struct-443875" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-159253" type="direct"><org type="regrouplaboratory" xml:id="struct-159253" status="VALID"> <idno type="IdRef">240309472</idno>
<idno type="ISNI">0000 0004 4686 8315</idno>
<idno type="RNSR">200310667L</idno>
<orgName>Institut de Chimie de Toulouse</orgName>
<orgName type="acronym">ICT-FR 2599</orgName>
<desc> <address> <addrLine>118 Route de Narbonne 31062 Toulouse cédex 9</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://ict.ups-tlse.fr/</ref>
</desc>
<listRelation> <relation active="#struct-67872" type="direct"></relation>
<relation active="#struct-217752" type="direct"></relation>
<relation active="#struct-443875" type="indirect"></relation>
<relation name="FR2599" active="#struct-441569" type="direct"></relation>
<relation active="#struct-448187" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-67872" type="indirect"><org type="institution" xml:id="struct-67872" status="VALID"> <orgName>Institut de Recherche pour le Développement</orgName>
<orgName type="acronym">IRD</orgName>
<desc> <address> <addrLine>SiègeLe Sextant 44, bd de DunkerqueCS 9000913572 Marseille cedex 02</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ird.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="FR2599" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UPR8241" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Gellis, Armand" sort="Gellis, Armand" uniqKey="Gellis A" first="Armand" last="Gellis">Armand Gellis</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-258556" status="VALID"> <idno type="RNSR">201220354B</idno>
<orgName>Institut de Chimie Radicalaire</orgName>
<orgName type="acronym">ICR</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Avenue Escadrille Normandie-Niemen Service D42 13397 Marseille cedex 20</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://icr-amu.cnrs.fr/</ref>
</desc>
<listRelation> <relation name="UMR7273" active="#struct-198056" type="direct"></relation>
<relation name="UMR7273" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7273" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7273" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Vanelle, Patrice" sort="Vanelle, Patrice" uniqKey="Vanelle P" first="Patrice" last="Vanelle">Patrice Vanelle</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-258556" status="VALID"> <idno type="RNSR">201220354B</idno>
<orgName>Institut de Chimie Radicalaire</orgName>
<orgName type="acronym">ICR</orgName>
<date type="start">2012</date>
<desc> <address> <addrLine>Avenue Escadrille Normandie-Niemen Service D42 13397 Marseille cedex 20</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://icr-amu.cnrs.fr/</ref>
</desc>
<listRelation> <relation name="UMR7273" active="#struct-198056" type="direct"></relation>
<relation name="UMR7273" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle name="UMR7273" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"> <idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc> <address> <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7273" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.ejmech.2009.11.005</idno>
<series><title level="j">European Journal of Medicinal Chemistry</title>
<idno type="ISSN">0223-5234</idno>
<imprint><date type="datePub">2010-02</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.). Among the fourteen tested molecules, two exhibited both significant antiplasmodial activity (IC(50) = 0.95 and 1.3 mu M) and low toxicity (IC(50) \textgreater 100 or 125 mu M), compared with two reference drugs: chloroquine and doxycycline. The structure activity relationships establish that the molecular scaffold which exerts the best profile is the 6-nitro-2-(tosylmethyl)-N-(3-substituted-phenyl)-quinazolin-4-amine. The hit molecules were finally investigated regarding their potential action toward two other protozoa, Leishmania donovani and Toxoplasma gondii, showing that these molecules display a selective antiplasmodial activity. (C) 2009 Elsevier Masson SAS. All rights reserved.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Kabri, Youssef" sort="Kabri, Youssef" uniqKey="Kabri Y" first="Youssef" last="Kabri">Youssef Kabri</name>
</region>
<name sortKey="Azas, Nadine" sort="Azas, Nadine" uniqKey="Azas N" first="Nadine" last="Azas">Nadine Azas</name>
<name sortKey="Dumetre, Aurelien" sort="Dumetre, Aurelien" uniqKey="Dumetre A" first="Aurélien" last="Dumètre">Aurélien Dumètre</name>
<name sortKey="Gellis, Armand" sort="Gellis, Armand" uniqKey="Gellis A" first="Armand" last="Gellis">Armand Gellis</name>
<name sortKey="Hutter, Sebastien" sort="Hutter, Sebastien" uniqKey="Hutter S" first="Sébastien" last="Hutter">Sébastien Hutter</name>
<name sortKey="Laget, Michele" sort="Laget, Michele" uniqKey="Laget M" first="Michèle" last="Laget">Michèle Laget</name>
<name sortKey="Vanelle, Patrice" sort="Vanelle, Patrice" uniqKey="Vanelle P" first="Patrice" last="Vanelle">Patrice Vanelle</name>
<name sortKey="Verhaeghe, Pierre" sort="Verhaeghe, Pierre" uniqKey="Verhaeghe P" first="Pierre" last="Verhaeghe">Pierre Verhaeghe</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001609 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001609 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= Hal:hal-01460232 |texte= Original quinazoline derivatives displaying antiplasmodial properties }}
This area was generated with Dilib version V0.6.33. |