Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone A
Identifieur interne : 001581 ( Main/Exploration ); précédent : 001580; suivant : 001582Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone A
Auteurs : L. Monzote [Cuba] ; O. Cuesta-Rubio [Cuba] ; A. Matheeussen [Belgique] ; T. Van Assche [Belgique] ; L. Maes [Belgique] ; P. Cos [Belgique]Source :
- Phytotherapy Research [ 0951-418X ] ; 2011-03.
English descriptors
- Teeft :
- Albicans, Allanblackia monticola, Animal models, Antibacterial activity, Antileishmanial activity, Antimicrob agents chemother, Antimicrobial, Antimicrobial activity, Antimicrobial effect, Antimicrobial evaluation, Antitrypanosomal activity, Assay, Aureus, Benzophenones, Biological activity, Biological properties, Candida albicans, Clusia rosea, Clusiaceae family, Coli, Considerable attention, Derivative, Escherichia coli, Falciparum, Garcinia, Garcinia aristata, Guttiferone, Highest activity, Important role, Infantum amastigotes, Infectious diseases, Inhibition growth, John wiley sons, Moderate activity, Natural products, Nemorosone, Parasite, Parasite growth, Pharmacological point, Polyisoprenylated, Polyisoprenylated benzophenones, Polyisoprenylated benzophenones nemorosone, Prediluted compounds, Prenyl groups, Previous studies, Protozoan parasites, Room temperature, Rubrum, Sodium hydrogen carbonate, Standard deviation, Symphonia globulifera, Test plates, Total parasite burden, Tovomitopsis saldanhae, Wide panel.
Abstract
Polyisoprenylated benzophenones have been isolated from plants, particularly in the Clusiaceae family, and their biological properties recently have received considerable attention from a pharmacological point of view. The aim of the study was to investigate the polyisoprenylated benzophenones, nemorosone and guttiferone A, for their antimicrobial effect against a panel of bacteria, fungi and protozoan parasites. They showed a moderate activity against the Gram‐positive bacterium Staphylococcus aureus, while no activity was demonstrated against Escherichia coli and the fungi Trichophyton rubrum and Candida albicans. An interesting activity was found for Plasmodium falciparum with IC50 values lower than 1 μm, while cytotoxicity on MRC‐5 cells revealed CC50 values of 15.5 and 12.0 μm, respectively, for nemorosone and guttiferone A. Copyright © 2011 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.3401
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001511
- to stream Istex, to step Curation: 001511
- to stream Istex, to step Checkpoint: 000557
- to stream Main, to step Merge: 001583
- to stream Main, to step Curation: 001581
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone A</title><author><name sortKey="Monzote, L" sort="Monzote, L" uniqKey="Monzote L" first="L." last="Monzote">L. Monzote</name></author><author><name sortKey="Cuesta Ubio, O" sort="Cuesta Ubio, O" uniqKey="Cuesta Ubio O" first="O." last="Cuesta-Rubio">O. Cuesta-Rubio</name></author><author><name sortKey="Matheeussen, A" sort="Matheeussen, A" uniqKey="Matheeussen A" first="A." last="Matheeussen">A. Matheeussen</name></author><author><name sortKey="Van Assche, T" sort="Van Assche, T" uniqKey="Van Assche T" first="T." last="Van Assche">T. Van Assche</name></author><author><name sortKey="Maes, L" sort="Maes, L" uniqKey="Maes L" first="L." last="Maes">L. Maes</name></author><author><name sortKey="Cos, P" sort="Cos, P" uniqKey="Cos P" first="P." last="Cos">P. Cos</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FF1142BFA9B6A3C0177468310386E0BA22561F65</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ptr.3401</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-NT20L7WX-3/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001511</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001511</idno><idno type="wicri:Area/Istex/Curation">001511</idno><idno type="wicri:Area/Istex/Checkpoint">000557</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000557</idno><idno type="wicri:doubleKey">0951-418X:2011:Monzote L:antimicrobial:evaluation:of</idno><idno type="wicri:Area/Main/Merge">001583</idno><idno type="wicri:Area/Main/Curation">001581</idno><idno type="wicri:Area/Main/Exploration">001581</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone A</title><author><name sortKey="Monzote, L" sort="Monzote, L" uniqKey="Monzote L" first="L." last="Monzote">L. Monzote</name><affiliation wicri:level="1"><country xml:lang="fr">Cuba</country><wicri:regionArea>Department of Parasitology, Institute of Tropical Medicine ‘Pedro Kouri’, Havana City</wicri:regionArea><wicri:noRegion>Havana City</wicri:noRegion></affiliation></author><author><name sortKey="Cuesta Ubio, O" sort="Cuesta Ubio, O" uniqKey="Cuesta Ubio O" first="O." last="Cuesta-Rubio">O. Cuesta-Rubio</name><affiliation wicri:level="1"><country xml:lang="fr">Cuba</country><wicri:regionArea>Department of Chemistry, Institute of Pharmacy and Food, Havana University</wicri:regionArea><wicri:noRegion>Havana University</wicri:noRegion></affiliation></author><author><name sortKey="Matheeussen, A" sort="Matheeussen, A" uniqKey="Matheeussen A" first="A." last="Matheeussen">A. Matheeussen</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University</wicri:regionArea><wicri:noRegion>Antwerp University</wicri:noRegion></affiliation></author><author><name sortKey="Van Assche, T" sort="Van Assche, T" uniqKey="Van Assche T" first="T." last="Van Assche">T. Van Assche</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University</wicri:regionArea><wicri:noRegion>Antwerp University</wicri:noRegion></affiliation></author><author><name sortKey="Maes, L" sort="Maes, L" uniqKey="Maes L" first="L." last="Maes">L. Maes</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University</wicri:regionArea><wicri:noRegion>Antwerp University</wicri:noRegion></affiliation></author><author><name sortKey="Cos, P" sort="Cos, P" uniqKey="Cos P" first="P." last="Cos">P. Cos</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University</wicri:regionArea><wicri:noRegion>Antwerp University</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Belgique</country></affiliation><affiliation wicri:level="4"><orgName type="university">Université d'Anvers</orgName><country>Belgique</country><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Belgique</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Phytotherapy Research</title><title level="j" type="alt">PHYTOTHERAPY RESEARCH</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="458">458</biblScope><biblScope unit="page" to="462">462</biblScope><biblScope unit="page-count">5</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2011-03">2011-03</date></imprint><idno type="ISSN">0951-418X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Albicans</term><term>Allanblackia monticola</term><term>Animal models</term><term>Antibacterial activity</term><term>Antileishmanial activity</term><term>Antimicrob agents chemother</term><term>Antimicrobial</term><term>Antimicrobial activity</term><term>Antimicrobial effect</term><term>Antimicrobial evaluation</term><term>Antitrypanosomal activity</term><term>Assay</term><term>Aureus</term><term>Benzophenones</term><term>Biological activity</term><term>Biological properties</term><term>Candida albicans</term><term>Clusia rosea</term><term>Clusiaceae family</term><term>Coli</term><term>Considerable attention</term><term>Derivative</term><term>Escherichia coli</term><term>Falciparum</term><term>Garcinia</term><term>Garcinia aristata</term><term>Guttiferone</term><term>Highest activity</term><term>Important role</term><term>Infantum amastigotes</term><term>Infectious diseases</term><term>Inhibition growth</term><term>John wiley sons</term><term>Moderate activity</term><term>Natural products</term><term>Nemorosone</term><term>Parasite</term><term>Parasite growth</term><term>Pharmacological point</term><term>Polyisoprenylated</term><term>Polyisoprenylated benzophenones</term><term>Polyisoprenylated benzophenones nemorosone</term><term>Prediluted compounds</term><term>Prenyl groups</term><term>Previous studies</term><term>Protozoan parasites</term><term>Room temperature</term><term>Rubrum</term><term>Sodium hydrogen carbonate</term><term>Standard deviation</term><term>Symphonia globulifera</term><term>Test plates</term><term>Total parasite burden</term><term>Tovomitopsis saldanhae</term><term>Wide panel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Polyisoprenylated benzophenones have been isolated from plants, particularly in the Clusiaceae family, and their biological properties recently have received considerable attention from a pharmacological point of view. The aim of the study was to investigate the polyisoprenylated benzophenones, nemorosone and guttiferone A, for their antimicrobial effect against a panel of bacteria, fungi and protozoan parasites. They showed a moderate activity against the Gram‐positive bacterium Staphylococcus aureus, while no activity was demonstrated against Escherichia coli and the fungi Trichophyton rubrum and Candida albicans. An interesting activity was found for Plasmodium falciparum with IC50 values lower than 1 μm, while cytotoxicity on MRC‐5 cells revealed CC50 values of 15.5 and 12.0 μm, respectively, for nemorosone and guttiferone A. Copyright © 2011 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Cuba</li></country><region><li>Province d'Anvers</li><li>Région flamande</li></region><settlement><li>Anvers</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><country name="Cuba"><noRegion><name sortKey="Monzote, L" sort="Monzote, L" uniqKey="Monzote L" first="L." last="Monzote">L. Monzote</name></noRegion><name sortKey="Cuesta Ubio, O" sort="Cuesta Ubio, O" uniqKey="Cuesta Ubio O" first="O." last="Cuesta-Rubio">O. Cuesta-Rubio</name></country><country name="Belgique"><noRegion><name sortKey="Matheeussen, A" sort="Matheeussen, A" uniqKey="Matheeussen A" first="A." last="Matheeussen">A. Matheeussen</name></noRegion><name sortKey="Cos, P" sort="Cos, P" uniqKey="Cos P" first="P." last="Cos">P. Cos</name><name sortKey="Cos, P" sort="Cos, P" uniqKey="Cos P" first="P." last="Cos">P. Cos</name><name sortKey="Cos, P" sort="Cos, P" uniqKey="Cos P" first="P." last="Cos">P. Cos</name><name sortKey="Cos, P" sort="Cos, P" uniqKey="Cos P" first="P." last="Cos">P. Cos</name><name sortKey="Maes, L" sort="Maes, L" uniqKey="Maes L" first="L." last="Maes">L. Maes</name><name sortKey="Van Assche, T" sort="Van Assche, T" uniqKey="Van Assche T" first="T." last="Van Assche">T. Van Assche</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001581 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001581 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:FF1142BFA9B6A3C0177468310386E0BA22561F65
|texte= Antimicrobial Evaluation of the Polyisoprenylated Benzophenones Nemorosone and Guttiferone A
}}
| This area was generated with Dilib version V0.6.33. |  |