Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes
Identifieur interne : 001492 ( Main/Exploration ); précédent : 001491; suivant : 001493Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes
Auteurs : V. Neves [Royaume-Uni] ; H. M. Coley [Royaume-Uni] ; J. Mcfadden [Royaume-Uni] ; S. R. P. Silva [Royaume-Uni]Source :
- Carbon Nanostructures
Abstract
Abstract: Carbon nanotubes (CNTs) exhibit unique size, shape and physical properties, which make them promising candidates for biomedical applications. In particular, carbon nanotubes have been intensively studied for conjugation with pre-existing therapeutic agents for more effective targeting, as a result of their ability to cross cell membranes. However, to utilise them effectively in biological systems it is extremely important to understand how they behave at the cellular level and their distribution in vivo. Additionally, in order to consider carbon nanotubes as candidate delivery systems of therapeutic agents it is important to ascertain their fate in vivo, but also take into account many factors, such as solubility, stability and clearance. Issues surrounding their short term and long term safety are currently the subject of toxicology testing. Herein, we propose to summarize the main findings on the uptake, trafficking and biodistribution of carbon nanotubes, with special focus on functionalized carbon nanotubes for delivery of therapeutic agents.
Url:
DOI: 10.1007/978-3-642-14802-6_9
Affiliations:
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Mcfadden</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH, Guildford</wicri:regionArea><wicri:noRegion>Guildford</wicri:noRegion></affiliation></author><author><name sortKey="Silva, S R P" sort="Silva, S R P" uniqKey="Silva S" first="S. R. P." last="Silva">S. R. P. Silva</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH, Guildford</wicri:regionArea><wicri:noRegion>Guildford</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="s" type="main" xml:lang="en">Carbon Nanostructures</title><title level="s" type="abbrev">Carbon Nanostructures</title></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Carbon nanotubes (CNTs) exhibit unique size, shape and physical properties, which make them promising candidates for biomedical applications. In particular, carbon nanotubes have been intensively studied for conjugation with pre-existing therapeutic agents for more effective targeting, as a result of their ability to cross cell membranes. However, to utilise them effectively in biological systems it is extremely important to understand how they behave at the cellular level and their distribution in vivo. Additionally, in order to consider carbon nanotubes as candidate delivery systems of therapeutic agents it is important to ascertain their fate in vivo, but also take into account many factors, such as solubility, stability and clearance. Issues surrounding their short term and long term safety are currently the subject of toxicology testing. Herein, we propose to summarize the main findings on the uptake, trafficking and biodistribution of carbon nanotubes, with special focus on functionalized carbon nanotubes for delivery of therapeutic agents.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Neves, V" sort="Neves, V" uniqKey="Neves V" first="V." last="Neves">V. Neves</name></noRegion><name sortKey="Coley, H M" sort="Coley, H M" uniqKey="Coley H" first="H. M." last="Coley">H. M. Coley</name><name sortKey="Mcfadden, J" sort="Mcfadden, J" uniqKey="Mcfadden J" first="J." last="Mcfadden">J. Mcfadden</name><name sortKey="Neves, V" sort="Neves, V" uniqKey="Neves V" first="V." last="Neves">V. Neves</name><name sortKey="Silva, S R P" sort="Silva, S R P" uniqKey="Silva S" first="S. R. P." last="Silva">S. R. P. Silva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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