Serveur d'exploration Chloroquine

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Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand.

Identifieur interne : 001465 ( Main/Exploration ); précédent : 001464; suivant : 001466

Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand.

Auteurs : Marcus Rijken [Thaïlande] ; Machteld Boel [Thaïlande] ; Bruce Russell [Singapour] ; Mallika Imwong [Thaïlande] ; Mara Leimanis [Thaïlande] ; Aung Phyo [Thaïlande] ; Atis Muehlenbachs [États-Unis] ; Niklas Lindegardh [Royaume-Uni] ; Rose Mcgready [Thaïlande] ; Laurent Rénia [Singapour] ; Georges Snounou [Singapour] ; Pratap Singhasivanon [Thaïlande] ; François Nosten [Thaïlande]

Source :

RBID : Hal:inserm-00654581

Abstract

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.


Url:
DOI: 10.1186/1475-2875-10-113


Affiliations:


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<name sortKey="Snounou, Georges" sort="Snounou, Georges" uniqKey="Snounou G" first="Georges" last="Snounou">Georges Snounou</name>
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<country>Singapour</country>
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<author>
<name sortKey="Singhasivanon, Pratap" sort="Singhasivanon, Pratap" uniqKey="Singhasivanon P" first="Pratap" last="Singhasivanon">Pratap Singhasivanon</name>
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<orgName>Faculty of Tropical Medicine</orgName>
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<addrLine>Faculty of Tropical Medicine, Bangkok 10400</addrLine>
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<orgName>Mahidol University [Bangkok]</orgName>
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<address>
<addrLine>999 Phuttamonthon 4 Road, Salaya, Nakhon Pathom 73170 Thailand</addrLine>
<country key="TH"></country>
</address>
<ref type="url">https://mahidol.ac.th/</ref>
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</hal:affiliation>
<country>Thaïlande</country>
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</author>
<author>
<name sortKey="Nosten, Francois" sort="Nosten, Francois" uniqKey="Nosten F" first="François" last="Nosten">François Nosten</name>
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<hal:affiliation type="laboratory" xml:id="struct-560954" status="VALID">
<orgName>Shoklo Malaria Research Unit [Mae Sot, Thailand]</orgName>
<orgName type="acronym">Faculty of Tropical Medicine</orgName>
<desc>
<address>
<addrLine>Tak Province</addrLine>
<country key="TH"></country>
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<orgName>Mahidol University [Bangkok]</orgName>
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<address>
<addrLine>999 Phuttamonthon 4 Road, Salaya, Nakhon Pathom 73170 Thailand</addrLine>
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<orgName>Mahidol Oxford Tropical Medicine Research Unit </orgName>
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<addrLine>420/6 Rajvithi Road, Rajthevee, Bangkok 10400</addrLine>
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<ref type="url">http://www.tropmedres.ac/home</ref>
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<orgName>University of Oxford [Oxford]</orgName>
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<addrLine>Wellington Square, Oxford OX1 2JD</addrLine>
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<ref type="url">http://www.ox.ac.uk/</ref>
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<orgName>Wellcome Trust</orgName>
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<country>Thaïlande</country>
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</analytic>
<idno type="DOI">10.1186/1475-2875-10-113</idno>
<series>
<title level="j">Malaria Journal</title>
<idno type="ISSN">1475-2875</idno>
<imprint>
<date type="datePub">2011</date>
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<front>
<div type="abstract" xml:lang="en">
<p>Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations. A growth restricted infant was delivered. Poor susceptibility to CQ was confirmed in-vitro and molecular genotyping was strongly suggestive of true recrudescence of P. vivax. This is the first clinically and laboratory confirmed case of two high-grade CQ resistant vivax parasite strains from Thailand.</p>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>Thaïlande</li>
<li>États-Unis</li>
</country>
</list>
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<name sortKey="Rijken, Marcus" sort="Rijken, Marcus" uniqKey="Rijken M" first="Marcus" last="Rijken">Marcus Rijken</name>
</noRegion>
<name sortKey="Boel, Machteld" sort="Boel, Machteld" uniqKey="Boel M" first="Machteld" last="Boel">Machteld Boel</name>
<name sortKey="Imwong, Mallika" sort="Imwong, Mallika" uniqKey="Imwong M" first="Mallika" last="Imwong">Mallika Imwong</name>
<name sortKey="Leimanis, Mara" sort="Leimanis, Mara" uniqKey="Leimanis M" first="Mara" last="Leimanis">Mara Leimanis</name>
<name sortKey="Mcgready, Rose" sort="Mcgready, Rose" uniqKey="Mcgready R" first="Rose" last="Mcgready">Rose Mcgready</name>
<name sortKey="Nosten, Francois" sort="Nosten, Francois" uniqKey="Nosten F" first="François" last="Nosten">François Nosten</name>
<name sortKey="Phyo, Aung" sort="Phyo, Aung" uniqKey="Phyo A" first="Aung" last="Phyo">Aung Phyo</name>
<name sortKey="Singhasivanon, Pratap" sort="Singhasivanon, Pratap" uniqKey="Singhasivanon P" first="Pratap" last="Singhasivanon">Pratap Singhasivanon</name>
</country>
<country name="Singapour">
<noRegion>
<name sortKey="Russell, Bruce" sort="Russell, Bruce" uniqKey="Russell B" first="Bruce" last="Russell">Bruce Russell</name>
</noRegion>
<name sortKey="Renia, Laurent" sort="Renia, Laurent" uniqKey="Renia L" first="Laurent" last="Rénia">Laurent Rénia</name>
<name sortKey="Snounou, Georges" sort="Snounou, Georges" uniqKey="Snounou G" first="Georges" last="Snounou">Georges Snounou</name>
</country>
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<name sortKey="Muehlenbachs, Atis" sort="Muehlenbachs, Atis" uniqKey="Muehlenbachs A" first="Atis" last="Muehlenbachs">Atis Muehlenbachs</name>
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</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Lindegardh, Niklas" sort="Lindegardh, Niklas" uniqKey="Lindegardh N" first="Niklas" last="Lindegardh">Niklas Lindegardh</name>
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</country>
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</affiliations>
</record>

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