Efficacy of eosin B as a new antimalarial drug in a murine model.
Identifieur interne : 001456 ( Main/Exploration ); précédent : 001455; suivant : 001457Efficacy of eosin B as a new antimalarial drug in a murine model.
Auteurs : Zahra Zamani [Iran] ; Alireza Sadeghi Tafreshi [Iran] ; Hossein Nahrevanian [Iran] ; Behzad Lame-Rad [Iran] ; Fatemeh Pourfallah [Iran] ; Hossein Eslamifar [Iran] ; Sedigheh Sadeghi [Iran] ; Farideh Vahabi [Iran] ; Ayda Iravani [Iran] ; Mohammad Arjmand [Iran]Source :
- Malaria Research and Treatment [ 2090-8075 ] ; 2011-11-30.
Abstract
The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro. It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmodium berghei murine malaria. Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei. Both the doses of eosin B 400 mg/kg and 800 mg/kg gave better results than the controls which were 40 mg/kg chloroquine and 100 mg/kg of arteether with P < 0.005 significance. Percentage suppressive activity by Peter's test of eosin B was better, though at a higher dose than both the controls. Survival rate of mice receiving the higher dose of eosin B was longer than that of the controls. When administered twice daily, the mice were fully cured after 4 days. Eosin B seems to be a promising drug exhibiting good antimalarial effects in the murine model of the disease.
Url:
DOI: 10.1155/2012/381724
Affiliations:
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Le document en format XML
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<author><name sortKey="Arjmand, Mohammad" sort="Arjmand, Mohammad" uniqKey="Arjmand M" first="Mohammad" last="Arjmand">Mohammad Arjmand</name>
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<idno type="DOI">10.1155/2012/381724</idno>
<series><title level="j">Malaria Research and Treatment</title>
<idno type="ISSN">2090-8075</idno>
<imprint><date type="datePub">2011-11-30</date>
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<front><div type="abstract" xml:lang="en"> <p>The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro. It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmodium berghei murine malaria. Eosin B was administered in 2 different doses by either the oral or parenteral route, once or twice daily to mice infected with Plasmodium berghei. Both the doses of eosin B 400 mg/kg and 800 mg/kg gave better results than the controls which were 40 mg/kg chloroquine and 100 mg/kg of arteether with P < 0.005 significance. Percentage suppressive activity by Peter's test of eosin B was better, though at a higher dose than both the controls. Survival rate of mice receiving the higher dose of eosin B was longer than that of the controls. When administered twice daily, the mice were fully cured after 4 days. Eosin B seems to be a promising drug exhibiting good antimalarial effects in the murine model of the disease.</p>
</div>
</front>
</TEI>
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<name sortKey="Arjmand, Mohammad" sort="Arjmand, Mohammad" uniqKey="Arjmand M" first="Mohammad" last="Arjmand">Mohammad Arjmand</name>
<name sortKey="Eslamifar, Hossein" sort="Eslamifar, Hossein" uniqKey="Eslamifar H" first="Hossein" last="Eslamifar">Hossein Eslamifar</name>
<name sortKey="Iravani, Ayda" sort="Iravani, Ayda" uniqKey="Iravani A" first="Ayda" last="Iravani">Ayda Iravani</name>
<name sortKey="Lame Rad, Behzad" sort="Lame Rad, Behzad" uniqKey="Lame Rad B" first="Behzad" last="Lame-Rad">Behzad Lame-Rad</name>
<name sortKey="Nahrevanian, Hossein" sort="Nahrevanian, Hossein" uniqKey="Nahrevanian H" first="Hossein" last="Nahrevanian">Hossein Nahrevanian</name>
<name sortKey="Pourfallah, Fatemeh" sort="Pourfallah, Fatemeh" uniqKey="Pourfallah F" first="Fatemeh" last="Pourfallah">Fatemeh Pourfallah</name>
<name sortKey="Sadeghi, Sedigheh" sort="Sadeghi, Sedigheh" uniqKey="Sadeghi S" first="Sedigheh" last="Sadeghi">Sedigheh Sadeghi</name>
<name sortKey="Tafreshi, Alireza Sadeghi" sort="Tafreshi, Alireza Sadeghi" uniqKey="Tafreshi A" first="Alireza Sadeghi" last="Tafreshi">Alireza Sadeghi Tafreshi</name>
<name sortKey="Vahabi, Farideh" sort="Vahabi, Farideh" uniqKey="Vahabi F" first="Farideh" last="Vahabi">Farideh Vahabi</name>
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