Autophagy in toxicology: self‐consumption in times of stress and plenty
Identifieur interne : 001428 ( Main/Exploration ); précédent : 001427; suivant : 001429Autophagy in toxicology: self‐consumption in times of stress and plenty
Auteurs : Alicia M. Bolt [États-Unis] ; Walter T. Klimecki [États-Unis]Source :
- Journal of Applied Toxicology [ 0260-437X ] ; 2012-07.
English descriptors
- Teeft :
- Acad, Adaptive, Amino, Apoptosis, Appl, Atg5, Atg7, Autophagic, Autophagic degradation, Autophagosome, Autophagosomes, Autophagy, Autophagy induction, Beclin, Biochem, Biol, Cell biol, Cell death, Cell survival, Cellular, Cellular components, Cellular stress, Chem, Constitutive, Copyright, Cuervo, Cytoplasmic, Cytoprotective, Cytosolic, Degradation, Eif2a, Endoplasmic, Eskelinen, Exogenous, Homeostasis, Hypoxia, Intracellular, John wiley sons, Kferq, Kinase, Klimecki, Klionsky, Knockout, Komatsu, Kroemer, Lamp2a, Levine, Liang, Lysosomal, Lysosomal membrane, Lysosome, Macroautophagy, Mammalian cells, Microautophagy, Misfolded, Mitochondrial, Mitochondrion, Mitophagy, Mizushima, Mtor, Natl, Natl acad, Ogata, Ohsumi, Organelle, Oxidative, Oxidative stress, Pathway, Phagophore, Phosphorylation, Proc, Protein levels, Protein synthesis, Reticulum, Shen, Toxicity, Toxicol, Toxicology, Translational, Ueno, Vesicle, Xenobiotic, Xenobiotics, Yamamoto, Yoshimori, Zhang, Zhao.
Abstract
Autophagy is a critical cellular process orchestrating the lysosomal degradation of cellular components in order to maintain cellular homeostasis and respond to cellular stress. A growing research effort over the last decade has proven autophagy to be essential for constitutive protein and organelle turnover, for embryonic/neonatal survival and for cell survival during conditions of environmental stress. Emphasizing its biological importance, dysfunctional autophagy contributes to a diverse set of human diseases. Cellular stress induced by xenobiotic exposure typifies environmental stress, and can result in the induction of autophagy as a cytoprotective mechanism. An increasing number of xenobiotics are notable for their ability to modulate the induction or the rate of autophagy. The role of autophagy in normal cellular homeostasis, the intricate relationship between cellular stress and the induction of autophagy, and the identification of specific xenobiotics capable of modulating autophagy, point to the importance of the autophagic process in toxicology. This review will summarize the importance of autophagy and its role in cellular response to stress, including examples in which consideration of autophagy has contributed to a more complete understanding of toxicant‐perturbed systems. Copyright © 2012 John Wiley & Sons, Ltd.
Autophagy is a critical cellular process that orchestrates the lysosomal degradation of cellular components in order to maintain cellular homeostasis and to respond to environmental stress. This review will highlight the importance of autophagy, its role in environmental stress response, and the importance of autophagy to the field of toxicology.
Url:
DOI: 10.1002/jat.1787
Affiliations:
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A growing research effort over the last decade has proven autophagy to be essential for constitutive protein and organelle turnover, for embryonic/neonatal survival and for cell survival during conditions of environmental stress. Emphasizing its biological importance, dysfunctional autophagy contributes to a diverse set of human diseases. Cellular stress induced by xenobiotic exposure typifies environmental stress, and can result in the induction of autophagy as a cytoprotective mechanism. An increasing number of xenobiotics are notable for their ability to modulate the induction or the rate of autophagy. The role of autophagy in normal cellular homeostasis, the intricate relationship between cellular stress and the induction of autophagy, and the identification of specific xenobiotics capable of modulating autophagy, point to the importance of the autophagic process in toxicology. This review will summarize the importance of autophagy and its role in cellular response to stress, including examples in which consideration of autophagy has contributed to a more complete understanding of toxicant‐perturbed systems. Copyright © 2012 John Wiley & Sons, Ltd.</div><div type="abstract">Autophagy is a critical cellular process that orchestrates the lysosomal degradation of cellular components in order to maintain cellular homeostasis and to respond to environmental stress. This review will highlight the importance of autophagy, its role in environmental stress response, and the importance of autophagy to the field of toxicology.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Bolt, Alicia M" sort="Bolt, Alicia M" uniqKey="Bolt A" first="Alicia M." last="Bolt">Alicia M. Bolt</name></noRegion><name sortKey="Klimecki, Walter T" sort="Klimecki, Walter T" uniqKey="Klimecki W" first="Walter T." last="Klimecki">Walter T. Klimecki</name><name sortKey="Klimecki, Walter T" sort="Klimecki, Walter T" uniqKey="Klimecki W" first="Walter T." last="Klimecki">Walter T. Klimecki</name><name sortKey="Klimecki, Walter T" sort="Klimecki, Walter T" uniqKey="Klimecki W" first="Walter T." last="Klimecki">Walter T. Klimecki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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