Small‐Molecule Regulators of Autophagy and Their Potential Therapeutic Applications
Identifieur interne : 001164 ( Main/Exploration ); précédent : 001163; suivant : 001165Small‐Molecule Regulators of Autophagy and Their Potential Therapeutic Applications
Auteurs : Mi Zhou [République populaire de Chine] ; Renxiao Wang [République populaire de Chine]Source :
- ChemMedChem [ 1860-7179 ] ; 2013-05.
Abstract
Autophagy is a highly conserved process in which damaged proteins and organelles are sequestered in double‐membrane autophagosomes and delivered to lysosomes for degradation and recycling. As an efficient response to cellular stress, autophagy is essential for the maintenance of cellular homeostasis. Defective autophagy is associated with a variety of diseases, including cancer. This article summarizes current knowledge about the molecular mechanism of autophagy and its role in tumorigenesis. Particular focus is placed on the development of small‐molecule regulators of autophagy and their potential application as anticancer therapeutic agents.
Self‐consumption: Autophagy plays an important role in maintaining normal cellular homeostasis. Growing evidence indicates that autophagy is associated with a variety of diseases such as cancer, making genes in autophagic pathways potential drug targets. However, given the dual role of autophagy in tumorigenesis, whether to induce or inhibit autophagy as a cancer treatment is a complicated issue that depends on tumor genotype, stage of tumor progression, and types of stress.
Url:
DOI: 10.1002/cmdc.201200560
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001918
- to stream Istex, to step Curation: 001918
- to stream Istex, to step Checkpoint: 000216
- to stream Main, to step Merge: 001165
- to stream Main, to step Curation: 001164
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Small‐Molecule Regulators of Autophagy and Their Potential Therapeutic Applications</title><author><name sortKey="Zhou, Mi" sort="Zhou, Mi" uniqKey="Zhou M" first="Mi" last="Zhou">Mi Zhou</name></author><author><name sortKey="Wang, Renxiao" sort="Wang, Renxiao" uniqKey="Wang R" first="Renxiao" last="Wang">Renxiao Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:20C520EDE71926FCE868FC7CF9E7C5C6484761BD</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/cmdc.201200560</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-HC7D2571-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001918</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001918</idno><idno type="wicri:Area/Istex/Curation">001918</idno><idno type="wicri:Area/Istex/Checkpoint">000216</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000216</idno><idno type="wicri:doubleKey">1860-7179:2013:Zhou M:small:molecule:regulators</idno><idno type="wicri:Area/Main/Merge">001165</idno><idno type="wicri:Area/Main/Curation">001164</idno><idno type="wicri:Area/Main/Exploration">001164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Small‐Molecule Regulators of Autophagy and Their Potential Therapeutic Applications</title><author><name sortKey="Zhou, Mi" sort="Zhou, Mi" uniqKey="Zhou M" first="Mi" last="Zhou">Mi Zhou</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road</wicri:regionArea><wicri:noRegion>345 Lingling Road</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Renxiao" sort="Wang, Renxiao" uniqKey="Wang R" first="Renxiao" last="Wang">Renxiao Wang</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road</wicri:regionArea><wicri:noRegion>345 Lingling Road</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Correspondence address: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road</wicri:regionArea><wicri:noRegion>345 Lingling Road</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">ChemMedChem</title><title level="j" type="alt">CHEMMEDCHEM</title><idno type="ISSN">1860-7179</idno><idno type="eISSN">1860-7187</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="694">694</biblScope><biblScope unit="page" to="707">707</biblScope><biblScope unit="page-count">14</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2013-05">2013-05</date></imprint><idno type="ISSN">1860-7179</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1860-7179</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autophagy is a highly conserved process in which damaged proteins and organelles are sequestered in double‐membrane autophagosomes and delivered to lysosomes for degradation and recycling. As an efficient response to cellular stress, autophagy is essential for the maintenance of cellular homeostasis. Defective autophagy is associated with a variety of diseases, including cancer. This article summarizes current knowledge about the molecular mechanism of autophagy and its role in tumorigenesis. Particular focus is placed on the development of small‐molecule regulators of autophagy and their potential application as anticancer therapeutic agents.</div><div type="abstract" xml:lang="en">Self‐consumption: Autophagy plays an important role in maintaining normal cellular homeostasis. Growing evidence indicates that autophagy is associated with a variety of diseases such as cancer, making genes in autophagic pathways potential drug targets. However, given the dual role of autophagy in tumorigenesis, whether to induce or inhibit autophagy as a cancer treatment is a complicated issue that depends on tumor genotype, stage of tumor progression, and types of stress.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Mi" sort="Zhou, Mi" uniqKey="Zhou M" first="Mi" last="Zhou">Mi Zhou</name></noRegion><name sortKey="Wang, Renxiao" sort="Wang, Renxiao" uniqKey="Wang R" first="Renxiao" last="Wang">Renxiao Wang</name><name sortKey="Wang, Renxiao" sort="Wang, Renxiao" uniqKey="Wang R" first="Renxiao" last="Wang">Renxiao Wang</name><name sortKey="Wang, Renxiao" sort="Wang, Renxiao" uniqKey="Wang R" first="Renxiao" last="Wang">Renxiao Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001164 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001164 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:20C520EDE71926FCE868FC7CF9E7C5C6484761BD
|texte= Small‐Molecule Regulators of Autophagy and Their Potential Therapeutic Applications
}}
| This area was generated with Dilib version V0.6.33. |  |