Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Identifieur interne : 001118 ( Main/Exploration ); précédent : 001117; suivant : 001119Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Auteurs : Lu Long [Royaume-Uni] ; Xudong Yang ; Mark Southwood ; Junyu Lu ; Stefan J. Marciniak ; Benjamin J. Dunmore ; Nicholas W. MorrellSource :
- Circulation research [ 1524-4571 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Autophagie (physiologie), Cellules cultivées, Chloroquine (usage thérapeutique), Hypertension pulmonaire (), Hypertension pulmonaire (anatomopathologie), Hypertension pulmonaire (métabolisme), Lysosomes (anatomopathologie), Lysosomes (métabolisme), Modèles animaux de maladie humaine, Mâle, Rat Sprague-Dawley, Rats, Récepteurs de la protéine morphogénique osseuse de type II (antagonistes et inhibiteurs), Récepteurs de la protéine morphogénique osseuse de type II (métabolisme), Transduction du signal (), Transduction du signal (physiologie), Évolution de la maladie.
- MESH :
- anatomopathologie : Hypertension pulmonaire, Lysosomes.
- antagonistes et inhibiteurs : Récepteurs de la protéine morphogénique osseuse de type II.
- métabolisme : Hypertension pulmonaire, Lysosomes, Récepteurs de la protéine morphogénique osseuse de type II.
- physiologie : Autophagie, Transduction du signal.
- usage thérapeutique : Chloroquine.
- Animaux, Cellules cultivées, Hypertension pulmonaire, Modèles animaux de maladie humaine, Mâle, Rat Sprague-Dawley, Rats, Transduction du signal, Évolution de la maladie.
English descriptors
- KwdEn :
- Animals, Autophagy (physiology), Bone Morphogenetic Protein Receptors, Type II (antagonists & inhibitors), Bone Morphogenetic Protein Receptors, Type II (metabolism), Cells, Cultured, Chloroquine (therapeutic use), Disease Models, Animal, Disease Progression, Hypertension, Pulmonary (metabolism), Hypertension, Pulmonary (pathology), Hypertension, Pulmonary (prevention & control), Lysosomes (metabolism), Lysosomes (pathology), Male, Rats, Rats, Sprague-Dawley, Signal Transduction (drug effects), Signal Transduction (physiology).
- MESH :
- chemical , antagonists & inhibitors : Bone Morphogenetic Protein Receptors, Type II.
- chemical , metabolism : Bone Morphogenetic Protein Receptors, Type II.
- drug effects : Signal Transduction.
- metabolism : Hypertension, Pulmonary, Lysosomes.
- pathology : Hypertension, Pulmonary, Lysosomes.
- physiology : Autophagy, Signal Transduction.
- prevention & control : Hypertension, Pulmonary.
- chemical , therapeutic use : Chloroquine.
- Animals, Cells, Cultured, Disease Models, Animal, Disease Progression, Male, Rats, Rats, Sprague-Dawley.
Abstract
Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation and apoptosis resistance in pulmonary artery smooth muscle cells (PASMCs).
DOI: 10.1161/CIRCRESAHA.111.300483
PubMed: 23446737
Affiliations:
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Le document en format XML
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Marciniak</name></author><author><name sortKey="Dunmore, Benjamin J" sort="Dunmore, Benjamin J" uniqKey="Dunmore B" first="Benjamin J" last="Dunmore">Benjamin J. Dunmore</name></author><author><name sortKey="Morrell, Nicholas W" sort="Morrell, Nicholas W" uniqKey="Morrell N" first="Nicholas W" last="Morrell">Nicholas W. 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Dunmore</name><name sortKey="Lu, Junyu" sort="Lu, Junyu" uniqKey="Lu J" first="Junyu" last="Lu">Junyu Lu</name><name sortKey="Marciniak, Stefan J" sort="Marciniak, Stefan J" uniqKey="Marciniak S" first="Stefan J" last="Marciniak">Stefan J. Marciniak</name><name sortKey="Morrell, Nicholas W" sort="Morrell, Nicholas W" uniqKey="Morrell N" first="Nicholas W" last="Morrell">Nicholas W. Morrell</name><name sortKey="Southwood, Mark" sort="Southwood, Mark" uniqKey="Southwood M" first="Mark" last="Southwood">Mark Southwood</name><name sortKey="Yang, Xudong" sort="Yang, Xudong" uniqKey="Yang X" first="Xudong" last="Yang">Xudong Yang</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Long, Lu" sort="Long, Lu" uniqKey="Long L" first="Lu" last="Long">Lu Long</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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