AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.
Identifieur interne : 000F07 ( Main/Exploration ); précédent : 000F06; suivant : 000F08AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.
Auteurs : Hassan Chaachouay [Suisse] ; Birgit Fehrenbacher [Allemagne] ; Mahmoud Toulany [Allemagne] ; Martin Schaller [Allemagne] ; Gabriele Multhoff [Allemagne] ; H Peter Rodemann [Allemagne]Source :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [ 1879-0887 ] ; 2015.
Descripteurs français
- KwdFr :
- AMP-Activated Protein Kinases (métabolisme), Animaux, Autophagie (), Autophagie (physiologie), Carcinome pulmonaire non à petites cellules (anatomopathologie), Chloroquine (pharmacologie), Humains, Hypoxie cellulaire (), Lignée cellulaire tumorale, Petit ARN interférent (métabolisme), Radiotolérance (), Radiotolérance (physiologie), Souris, Survie cellulaire (), Transduction du signal (), Tumeurs de la tête et du cou (anatomopathologie), Tumeurs du côlon (anatomopathologie), Tumeurs du poumon (anatomopathologie).
- MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs de la tête et du cou, Tumeurs du côlon, Tumeurs du poumon.
- métabolisme : AMP-Activated Protein Kinases, Petit ARN interférent.
- pharmacologie : Chloroquine.
- physiologie : Autophagie, Radiotolérance.
- Animaux, Autophagie, Humains, Hypoxie cellulaire, Lignée cellulaire tumorale, Radiotolérance, Souris, Survie cellulaire, Transduction du signal.
English descriptors
- KwdEn :
- AMP-Activated Protein Kinases (metabolism), Animals, Autophagy (drug effects), Autophagy (physiology), Carcinoma, Non-Small-Cell Lung (pathology), Cell Hypoxia (drug effects), Cell Line, Tumor, Cell Survival (drug effects), Chloroquine (pharmacology), Colonic Neoplasms (pathology), Head and Neck Neoplasms (pathology), Humans, Lung Neoplasms (pathology), Mice, RNA, Small Interfering (metabolism), Radiation Tolerance (drug effects), Radiation Tolerance (physiology), Signal Transduction (drug effects).
- MESH :
- chemical , metabolism : AMP-Activated Protein Kinases, RNA, Small Interfering.
- drug effects : Autophagy, Cell Hypoxia, Cell Survival, Radiation Tolerance, Signal Transduction.
- pathology : Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Head and Neck Neoplasms, Lung Neoplasms.
- chemical , pharmacology : Chloroquine.
- physiology : Autophagy, Radiation Tolerance.
- Animals, Cell Line, Tumor, Humans, Mice.
Abstract
Blocking of the autophagy-signaling has the potential to improve cancer therapy. In the present study, the role of autophagy for radioresistance of human tumor cells was tested under clinically relevant hypoxia (1% O2).
DOI: 10.1016/j.radonc.2015.08.012
PubMed: 26318663
Affiliations:
- Allemagne, Suisse
- Bavière, Canton de Zurich, District de Haute-Bavière
- Munich, Zurich
- Université de Zurich, Université technique de Munich
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 000309
- to stream Ncbi, to step Curation: 000309
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Le document en format XML
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Department of Radiation Oncology, Technische Universität München (TUM), and HMGU CCG - Innate Immunity in Tumor Biology, Germany; Section of Radiation Oncology, Vetsuisse Faculty, University of Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany; Department of Radiation Oncology, Technische Universität München (TUM), and HMGU CCG - Innate Immunity in Tumor Biology, Germany; Section of Radiation Oncology, Vetsuisse Faculty, University of Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Fehrenbacher, Birgit" sort="Fehrenbacher, Birgit" uniqKey="Fehrenbacher B" first="Birgit" last="Fehrenbacher">Birgit Fehrenbacher</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, University of Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University of Tuebingen</wicri:regionArea><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Toulany, Mahmoud" sort="Toulany, Mahmoud" uniqKey="Toulany M" first="Mahmoud" last="Toulany">Mahmoud Toulany</name><affiliation wicri:level="1"><nlm:affiliation>Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen</wicri:regionArea><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Schaller, Martin" sort="Schaller, Martin" uniqKey="Schaller M" first="Martin" last="Schaller">Martin Schaller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, University of Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University of Tuebingen</wicri:regionArea><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Multhoff, Gabriele" sort="Multhoff, Gabriele" uniqKey="Multhoff G" first="Gabriele" last="Multhoff">Gabriele Multhoff</name><affiliation wicri:level="4"><nlm:affiliation>Department of Radiation Oncology, Technische Universität München (TUM), and HMGU CCG - Innate Immunity in Tumor Biology, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation Oncology, Technische Universität München (TUM), and HMGU CCG - Innate Immunity in Tumor Biology</wicri:regionArea><wicri:noRegion>and HMGU CCG - Innate Immunity in Tumor Biology</wicri:noRegion><orgName type="university">Université technique de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Rodemann, H Peter" sort="Rodemann, H Peter" uniqKey="Rodemann H" first="H Peter" last="Rodemann">H Peter Rodemann</name><affiliation wicri:level="1"><nlm:affiliation>Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany. Electronic address: hans-peter.rodemann@uni-tuebingen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Radiobiology & Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen</wicri:regionArea><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion><wicri:noRegion>University of Tuebingen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</title><idno type="eISSN">1879-0887</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AMP-Activated Protein Kinases (metabolism)</term><term>Animals</term><term>Autophagy (drug effects)</term><term>Autophagy (physiology)</term><term>Carcinoma, Non-Small-Cell Lung (pathology)</term><term>Cell Hypoxia (drug effects)</term><term>Cell Line, Tumor</term><term>Cell Survival (drug effects)</term><term>Chloroquine (pharmacology)</term><term>Colonic Neoplasms (pathology)</term><term>Head and Neck Neoplasms (pathology)</term><term>Humans</term><term>Lung Neoplasms (pathology)</term><term>Mice</term><term>RNA, Small Interfering (metabolism)</term><term>Radiation Tolerance (drug effects)</term><term>Radiation Tolerance (physiology)</term><term>Signal Transduction (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>AMP-Activated Protein Kinases (métabolisme)</term><term>Animaux</term><term>Autophagie ()</term><term>Autophagie (physiologie)</term><term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term><term>Chloroquine (pharmacologie)</term><term>Humains</term><term>Hypoxie cellulaire ()</term><term>Lignée cellulaire tumorale</term><term>Petit ARN interférent (métabolisme)</term><term>Radiotolérance ()</term><term>Radiotolérance (physiologie)</term><term>Souris</term><term>Survie cellulaire ()</term><term>Transduction du signal ()</term><term>Tumeurs de la tête et du cou (anatomopathologie)</term><term>Tumeurs du côlon (anatomopathologie)</term><term>Tumeurs du poumon (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>AMP-Activated Protein Kinases</term><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire non à petites cellules</term><term>Tumeurs de la tête et du cou</term><term>Tumeurs du côlon</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Cell Hypoxia</term><term>Cell Survival</term><term>Radiation Tolerance</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP-Activated Protein Kinases</term><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Non-Small-Cell Lung</term><term>Colonic Neoplasms</term><term>Head and Neck Neoplasms</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Autophagie</term><term>Radiotolérance</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term><term>Radiation Tolerance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Humains</term><term>Hypoxie cellulaire</term><term>Lignée cellulaire tumorale</term><term>Radiotolérance</term><term>Souris</term><term>Survie cellulaire</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Blocking of the autophagy-signaling has the potential to improve cancer therapy. In the present study, the role of autophagy for radioresistance of human tumor cells was tested under clinically relevant hypoxia (1% O2).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>Bavière</li><li>Canton de Zurich</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li><li>Zurich</li></settlement><orgName><li>Université de Zurich</li><li>Université technique de Munich</li></orgName></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Chaachouay, Hassan" sort="Chaachouay, Hassan" uniqKey="Chaachouay H" first="Hassan" last="Chaachouay">Hassan Chaachouay</name></region></country><country name="Allemagne"><noRegion><name sortKey="Fehrenbacher, Birgit" sort="Fehrenbacher, Birgit" uniqKey="Fehrenbacher B" first="Birgit" last="Fehrenbacher">Birgit Fehrenbacher</name></noRegion><name sortKey="Multhoff, Gabriele" sort="Multhoff, Gabriele" uniqKey="Multhoff G" first="Gabriele" last="Multhoff">Gabriele Multhoff</name><name sortKey="Rodemann, H Peter" sort="Rodemann, H Peter" uniqKey="Rodemann H" first="H Peter" last="Rodemann">H Peter Rodemann</name><name sortKey="Schaller, Martin" sort="Schaller, Martin" uniqKey="Schaller M" first="Martin" last="Schaller">Martin Schaller</name><name sortKey="Toulany, Mahmoud" sort="Toulany, Mahmoud" uniqKey="Toulany M" first="Mahmoud" last="Toulany">Mahmoud Toulany</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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