Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Identifieur interne : 000E72 ( Main/Exploration ); précédent : 000E71; suivant : 000E73Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Auteurs : Liufeng Mei [République populaire de Chine] ; Yicheng Chen ; Zhimeng Wang ; Jian Wang ; Jiali Wan ; Chunrong Yu ; Xin Liu ; Wenhua LiSource :
- British journal of pharmacology [ 1476-5381 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Apoptose (), Autophagie (), Benzylisoquinoléines (pharmacologie), Caspase-3 (métabolisme), Cellules HCT116, Cellules HeLa, Charge tumorale (), Chloroquine (pharmacologie), Espèces réactives de l'oxygène (métabolisme), Facteurs temps, Humains, Inhibiteur p21 de kinase cycline-dépendante (génétique), Inhibiteur p21 de kinase cycline-dépendante (métabolisme), Mâle, Protocoles de polychimiothérapie antinéoplasique (pharmacologie), Relation dose-effet des médicaments, Souris de lignée BALB C, Souris nude, Stress oxydatif (), Survie cellulaire (), Synergie des médicaments, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal (), Transfection, Tumeurs du côlon (anatomopathologie), Tumeurs du côlon (génétique), Tumeurs du côlon (métabolisme), Tumeurs du côlon (traitement médicamenteux), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Tumeurs du poumon (métabolisme), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- anatomopathologie : Tumeurs du côlon, Tumeurs du poumon.
- génétique : Inhibiteur p21 de kinase cycline-dépendante, Tumeurs du côlon, Tumeurs du poumon.
- métabolisme : Caspase-3, Espèces réactives de l'oxygène, Inhibiteur p21 de kinase cycline-dépendante, Tumeurs du côlon, Tumeurs du poumon.
- pharmacologie : Benzylisoquinoléines, Chloroquine, Protocoles de polychimiothérapie antinéoplasique.
- traitement médicamenteux : Tumeurs du côlon, Tumeurs du poumon.
- Animaux, Apoptose, Autophagie, Cellules HCT116, Cellules HeLa, Charge tumorale, Facteurs temps, Humains, Mâle, Relation dose-effet des médicaments, Souris de lignée BALB C, Souris nude, Stress oxydatif, Survie cellulaire, Synergie des médicaments, Tests d'activité antitumorale sur modèle de xénogreffe, Transduction du signal, Transfection.
English descriptors
- KwdEn :
- Animals, Antineoplastic Combined Chemotherapy Protocols (pharmacology), Apoptosis (drug effects), Autophagy (drug effects), Benzylisoquinolines (pharmacology), Caspase 3 (metabolism), Cell Survival (drug effects), Chloroquine (pharmacology), Colonic Neoplasms (drug therapy), Colonic Neoplasms (genetics), Colonic Neoplasms (metabolism), Colonic Neoplasms (pathology), Cyclin-Dependent Kinase Inhibitor p21 (genetics), Cyclin-Dependent Kinase Inhibitor p21 (metabolism), Dose-Response Relationship, Drug, Drug Synergism, HCT116 Cells, HeLa Cells, Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Lung Neoplasms (metabolism), Lung Neoplasms (pathology), Male, Mice, Inbred BALB C, Mice, Nude, Oxidative Stress (drug effects), Reactive Oxygen Species (metabolism), Signal Transduction (drug effects), Time Factors, Transfection, Tumor Burden (drug effects), Xenograft Model Antitumor Assays.
- MESH :
- chemical , genetics : Cyclin-Dependent Kinase Inhibitor p21.
- chemical , metabolism : Caspase 3, Cyclin-Dependent Kinase Inhibitor p21, Reactive Oxygen Species.
- chemical , pharmacology : Benzylisoquinolines, Chloroquine.
- drug effects : Apoptosis, Autophagy, Cell Survival, Oxidative Stress, Signal Transduction, Tumor Burden.
- drug therapy : Colonic Neoplasms, Lung Neoplasms.
- genetics : Colonic Neoplasms, Lung Neoplasms.
- metabolism : Colonic Neoplasms, Lung Neoplasms.
- pathology : Colonic Neoplasms, Lung Neoplasms.
- pharmacology : Antineoplastic Combined Chemotherapy Protocols.
- Animals, Dose-Response Relationship, Drug, Drug Synergism, HCT116 Cells, HeLa Cells, Humans, Male, Mice, Inbred BALB C, Mice, Nude, Time Factors, Transfection, Xenograft Model Antitumor Assays.
Abstract
Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephaniae tetrandrae, has a long history in Chinese clinical applications to treat diverse diseases. Tetrandrine induced apoptosis or, at low concentrations, autophagy of human hepatocellular carcinoma cells. Here we have tested the effects of inhibitors of autophagy such as chloroquine, on the response to low concentrations of tetrandrine in cancer cells.
DOI: 10.1111/bph.13045
PubMed: 25521075
Affiliations:
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Le document en format XML
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uniqKey="Yu C" first="Chunrong" last="Yu">Chunrong Yu</name></author><author><name sortKey="Liu, Xin" sort="Liu, Xin" uniqKey="Liu X" first="Xin" last="Liu">Xin Liu</name></author><author><name sortKey="Li, Wenhua" sort="Li, Wenhua" uniqKey="Li W" first="Wenhua" last="Li">Wenhua Li</name></author></analytic><series><title level="j">British journal of pharmacology</title><idno type="eISSN">1476-5381</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antineoplastic Combined Chemotherapy Protocols (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Autophagy (drug effects)</term><term>Benzylisoquinolines (pharmacology)</term><term>Caspase 3 (metabolism)</term><term>Cell Survival (drug effects)</term><term>Chloroquine (pharmacology)</term><term>Colonic Neoplasms (drug therapy)</term><term>Colonic Neoplasms (genetics)</term><term>Colonic Neoplasms (metabolism)</term><term>Colonic Neoplasms (pathology)</term><term>Cyclin-Dependent Kinase Inhibitor p21 (genetics)</term><term>Cyclin-Dependent Kinase Inhibitor p21 (metabolism)</term><term>Dose-Response Relationship, Drug</term><term>Drug Synergism</term><term>HCT116 Cells</term><term>HeLa Cells</term><term>Humans</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (metabolism)</term><term>Lung Neoplasms (pathology)</term><term>Male</term><term>Mice, Inbred BALB C</term><term>Mice, Nude</term><term>Oxidative Stress (drug effects)</term><term>Reactive Oxygen Species (metabolism)</term><term>Signal Transduction (drug effects)</term><term>Time Factors</term><term>Transfection</term><term>Tumor Burden (drug effects)</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose ()</term><term>Autophagie ()</term><term>Benzylisoquinoléines (pharmacologie)</term><term>Caspase-3 (métabolisme)</term><term>Cellules HCT116</term><term>Cellules HeLa</term><term>Charge tumorale ()</term><term>Chloroquine (pharmacologie)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Facteurs temps</term><term>Humains</term><term>Inhibiteur p21 de kinase cycline-dépendante (génétique)</term><term>Inhibiteur p21 de kinase cycline-dépendante (métabolisme)</term><term>Mâle</term><term>Protocoles de polychimiothérapie antinéoplasique (pharmacologie)</term><term>Relation dose-effet des médicaments</term><term>Souris de lignée BALB C</term><term>Souris nude</term><term>Stress oxydatif ()</term><term>Survie cellulaire ()</term><term>Synergie des médicaments</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Transduction du signal ()</term><term>Transfection</term><term>Tumeurs du côlon (anatomopathologie)</term><term>Tumeurs du côlon (génétique)</term><term>Tumeurs du 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Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Autophagie</term><term>Cellules HCT116</term><term>Cellules HeLa</term><term>Charge tumorale</term><term>Facteurs temps</term><term>Humains</term><term>Mâle</term><term>Relation dose-effet des médicaments</term><term>Souris de lignée BALB C</term><term>Souris nude</term><term>Stress oxydatif</term><term>Survie cellulaire</term><term>Synergie des médicaments</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Transduction du signal</term><term>Transfection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephaniae tetrandrae, has a long history in Chinese clinical applications to treat diverse diseases. Tetrandrine induced apoptosis or, at low concentrations, autophagy of human hepatocellular carcinoma cells. Here we have tested the effects of inhibitors of autophagy such as chloroquine, on the response to low concentrations of tetrandrine in cancer cells.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><noCountry><name sortKey="Chen, Yicheng" sort="Chen, Yicheng" uniqKey="Chen Y" first="Yicheng" last="Chen">Yicheng Chen</name><name sortKey="Li, Wenhua" sort="Li, Wenhua" uniqKey="Li W" first="Wenhua" last="Li">Wenhua Li</name><name sortKey="Liu, Xin" sort="Liu, Xin" uniqKey="Liu X" first="Xin" last="Liu">Xin Liu</name><name sortKey="Wan, Jiali" sort="Wan, Jiali" uniqKey="Wan J" first="Jiali" last="Wan">Jiali Wan</name><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><name sortKey="Wang, Zhimeng" sort="Wang, Zhimeng" uniqKey="Wang Z" first="Zhimeng" last="Wang">Zhimeng Wang</name><name sortKey="Yu, Chunrong" sort="Yu, Chunrong" uniqKey="Yu C" first="Chunrong" last="Yu">Chunrong Yu</name></noCountry><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Mei, Liufeng" sort="Mei, Liufeng" uniqKey="Mei L" first="Liufeng" last="Mei">Liufeng Mei</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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