ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells.
Identifieur interne : 000D72 ( Main/Exploration ); précédent : 000D71; suivant : 000D73ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells.
Auteurs : Shaomin Shi [République populaire de Chine] ; Ping Tan [République populaire de Chine] ; Bingdi Yan [République populaire de Chine] ; Rong Gao [République populaire de Chine] ; Jianjun Zhao [République populaire de Chine] ; Jing Wang [République populaire de Chine] ; Jia Guo [République populaire de Chine] ; Ning Li [République populaire de Chine] ; Zhongsen Ma [République populaire de Chine]Source :
- Oncology reports [ 1791-2431 ] ; 2016.
Descripteurs français
- KwdFr :
- Adénine (analogues et dérivés), Adénine (pharmacologie), Antinéoplasiques (pharmacologie), Apoptose (), Autophagie (), Cellules A549, Chloroquine (pharmacologie), Cisplatine (pharmacologie), Concentration inhibitrice 50, Humains, Potentiel de membrane mitochondriale, Prolifération cellulaire (), Stress du réticulum endoplasmique, Tumeurs du poumon (métabolisme), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- analogues et dérivés : Adénine.
- métabolisme : Tumeurs du poumon.
- pharmacologie : Adénine, Antinéoplasiques, Chloroquine, Cisplatine.
- traitement médicamenteux : Tumeurs du poumon.
- Apoptose, Autophagie, Cellules A549, Concentration inhibitrice 50, Humains, Potentiel de membrane mitochondriale, Prolifération cellulaire, Stress du réticulum endoplasmique.
English descriptors
- KwdEn :
- A549 Cells, Adenine (analogs & derivatives), Adenine (pharmacology), Antineoplastic Agents (pharmacology), Apoptosis (drug effects), Autophagy (drug effects), Cell Proliferation (drug effects), Chloroquine (pharmacology), Cisplatin (pharmacology), Endoplasmic Reticulum Stress, Humans, Inhibitory Concentration 50, Lung Neoplasms (drug therapy), Lung Neoplasms (metabolism), Membrane Potential, Mitochondrial.
- MESH :
- chemical , analogs & derivatives : Adenine.
- chemical , pharmacology : Adenine, Antineoplastic Agents, Chloroquine, Cisplatin.
- drug effects : Apoptosis, Autophagy, Cell Proliferation.
- drug therapy : Lung Neoplasms.
- metabolism : Lung Neoplasms.
- A549 Cells, Endoplasmic Reticulum Stress, Humans, Inhibitory Concentration 50, Membrane Potential, Mitochondrial.
Abstract
Cisplatin [cis-diamminedichloroplatinum II (CDDP)] is one of the most classical and effective chemotherapeutic drugs for the treatment of cancers including lung cancer. However, the presence of cisplatin resistance in cancer lowers its curative effect and limits its usage in the clinic. The aim of the present study was to investigate the underlying mechanisms of cisplatin resistance in lung cancer involving endoplasmic reticulum (ER) stress and autophagy. In the present study, we detected the effect of cisplatin on cell viability, ER stress and autophagy in lung cancer cell lines A549 and H460. We also tested the effects of ER stress and autophagy on apoptosis induced by cisplatin. The results showed that cisplatin induced apoptosis, ER stress and autophagy in lung cancer cell lines. In addition, the inhibition of ER stress by 4-phenylbutyric acid (4-PBA) or tauroursodeoxycholic acid sodium (TUDC) enhanced cisplatin-induced apoptosis in the human lung cancer cells. Meanwhile, combination treatment with the autophagic inhibitor 3-methyladenine (3-MA) or chloroquine (CQ) further increased the apoptosis induced by cisplatin in the human lung cancer cells. The present study provides a novel treatment strategy - cisplatin in combination with an autophagic inhibitor or an ER stress inhibitor leads to increased apoptosis in human lung cancer cells.
DOI: 10.3892/or.2016.4680
PubMed: 26985651
Affiliations:
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Le document en format XML
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China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041</wicri:regionArea><wicri:noRegion>Jilin 130041</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Ping" sort="Tan, Ping" uniqKey="Tan P" first="Ping" last="Tan">Ping Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031</wicri:regionArea><wicri:noRegion>Jilin 130031</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Bingdi" sort="Yan, Bingdi" uniqKey="Yan B" first="Bingdi" last="Yan">Bingdi Yan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041</wicri:regionArea><wicri:noRegion>Jilin 130041</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Rong" sort="Gao, Rong" uniqKey="Gao R" first="Rong" last="Gao">Rong Gao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041</wicri:regionArea><wicri:noRegion>Jilin 130041</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Jianjun" sort="Zhao, Jianjun" uniqKey="Zhao J" first="Jianjun" last="Zhao">Jianjun Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031</wicri:regionArea><wicri:noRegion>Jilin 130031</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031</wicri:regionArea><wicri:noRegion>Jilin 130031</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Jia" sort="Guo, Jia" uniqKey="Guo J" first="Jia" last="Guo">Jia Guo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031</wicri:regionArea><wicri:noRegion>Jilin 130031</wicri:noRegion></affiliation></author><author><name sortKey="Li, Ning" sort="Li, Ning" uniqKey="Li N" first="Ning" last="Li">Ning Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031</wicri:regionArea><wicri:noRegion>Jilin 130031</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Zhongsen" sort="Ma, Zhongsen" uniqKey="Ma Z" first="Zhongsen" last="Ma">Zhongsen Ma</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130041</wicri:regionArea><wicri:noRegion>Jilin 130041</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncology reports</title><idno type="eISSN">1791-2431</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term><term>Adenine (analogs & derivatives)</term><term>Adenine (pharmacology)</term><term>Antineoplastic Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Autophagy (drug effects)</term><term>Cell Proliferation (drug effects)</term><term>Chloroquine (pharmacology)</term><term>Cisplatin (pharmacology)</term><term>Endoplasmic Reticulum Stress</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (metabolism)</term><term>Membrane Potential, Mitochondrial</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénine (analogues et dérivés)</term><term>Adénine (pharmacologie)</term><term>Antinéoplasiques (pharmacologie)</term><term>Apoptose ()</term><term>Autophagie ()</term><term>Cellules A549</term><term>Chloroquine (pharmacologie)</term><term>Cisplatine (pharmacologie)</term><term>Concentration inhibitrice 50</term><term>Humains</term><term>Potentiel de membrane mitochondriale</term><term>Prolifération cellulaire ()</term><term>Stress du réticulum endoplasmique</term><term>Tumeurs du poumon (métabolisme)</term><term>Tumeurs du poumon (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adenine</term><term>Antineoplastic Agents</term><term>Chloroquine</term><term>Cisplatin</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adénine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Autophagy</term><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adénine</term><term>Antinéoplasiques</term><term>Chloroquine</term><term>Cisplatine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Endoplasmic Reticulum Stress</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Membrane Potential, Mitochondrial</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term><term>Autophagie</term><term>Cellules A549</term><term>Concentration inhibitrice 50</term><term>Humains</term><term>Potentiel de membrane mitochondriale</term><term>Prolifération cellulaire</term><term>Stress du réticulum endoplasmique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cisplatin [cis-diamminedichloroplatinum II (CDDP)] is one of the most classical and effective chemotherapeutic drugs for the treatment of cancers including lung cancer. However, the presence of cisplatin resistance in cancer lowers its curative effect and limits its usage in the clinic. The aim of the present study was to investigate the underlying mechanisms of cisplatin resistance in lung cancer involving endoplasmic reticulum (ER) stress and autophagy. In the present study, we detected the effect of cisplatin on cell viability, ER stress and autophagy in lung cancer cell lines A549 and H460. We also tested the effects of ER stress and autophagy on apoptosis induced by cisplatin. The results showed that cisplatin induced apoptosis, ER stress and autophagy in lung cancer cell lines. In addition, the inhibition of ER stress by 4-phenylbutyric acid (4-PBA) or tauroursodeoxycholic acid sodium (TUDC) enhanced cisplatin-induced apoptosis in the human lung cancer cells. Meanwhile, combination treatment with the autophagic inhibitor 3-methyladenine (3-MA) or chloroquine (CQ) further increased the apoptosis induced by cisplatin in the human lung cancer cells. The present study provides a novel treatment strategy - cisplatin in combination with an autophagic inhibitor or an ER stress inhibitor leads to increased apoptosis in human lung cancer cells.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Shi, Shaomin" sort="Shi, Shaomin" uniqKey="Shi S" first="Shaomin" last="Shi">Shaomin Shi</name></noRegion><name sortKey="Gao, Rong" sort="Gao, Rong" uniqKey="Gao R" first="Rong" last="Gao">Rong Gao</name><name sortKey="Guo, Jia" sort="Guo, Jia" uniqKey="Guo J" first="Jia" last="Guo">Jia Guo</name><name sortKey="Li, Ning" sort="Li, Ning" uniqKey="Li N" first="Ning" last="Li">Ning Li</name><name sortKey="Ma, Zhongsen" sort="Ma, Zhongsen" uniqKey="Ma Z" first="Zhongsen" last="Ma">Zhongsen Ma</name><name sortKey="Tan, Ping" sort="Tan, Ping" uniqKey="Tan P" first="Ping" last="Tan">Ping Tan</name><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><name sortKey="Yan, Bingdi" sort="Yan, Bingdi" uniqKey="Yan B" first="Bingdi" last="Yan">Bingdi Yan</name><name sortKey="Zhao, Jianjun" sort="Zhao, Jianjun" uniqKey="Zhao J" first="Jianjun" last="Zhao">Jianjun Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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