A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing
Identifieur interne : 000B39 ( Main/Exploration ); précédent : 000B38; suivant : 000B40A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing
Auteurs : Sakinah Hassan [Royaume-Uni] ; Karin J. Purdie [Royaume-Uni] ; Jun Wang [Royaume-Uni] ; Catherine A. Harwood [Royaume-Uni] ; Charlotte M. Proby [Royaume-Uni] ; Celine Pourreyron [Royaume-Uni] ; Nikol Mladkova [Royaume-Uni] ; Ai Nagano [Royaume-Uni] ; Sandeep Dhayade [Royaume-Uni] ; Dimitris Athineos [Royaume-Uni] ; Matthew Caley [Royaume-Uni] ; Viviana Mannella [Royaume-Uni] ; Karen Blyth [Royaume-Uni] ; Gareth J. Inman [Royaume-Uni] ; Irene M. Leigh [Royaume-Uni]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2019.
Abstract
Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with increasing morbidity and mortality, with limited treatment options for advanced disease. Future improvements in targeted therapy will rely on advances in genomic/transcriptomic understanding and the use of model systems for basic research. We describe here the panel of 16 primary and metastatic cSCC cell lines developed and characterised over the past three decades in our laboratory in order to provide such a resource for future preclinical research and drug screening. Methods: Primary keratinocytes were isolated from cSCC tumours and metastases, and cell lines were established. These were characterised using short tandem repeat (STR) profiling and genotyped by whole exome sequencing. Multiple in vitro assays were performed to document their morphology, growth characteristics, migration and invasion characteristics, and in vivo xenograft growth. Results: STR profiles of the cSCC lines allow the confirmation of their unique identity. Phylogenetic trees derived from exome sequence analysis of the matched primary and metastatic lines provide insight into the genetic basis of disease progression. The results of in vivo and in vitro analyses allow researchers to select suitable cell lines for specific experimentation. Conclusions: There are few well-characterised cSCC lines available for widespread preclinical experimentation and drug screening. The described cSCC cell line panel provides a critical tool for in vitro and in vivo experimentation.
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DOI: 10.3390/ijms20143428
PubMed: 31336867
PubMed Central: 6678499
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Proby</name><affiliation wicri:level="1"><nlm:aff id="af3-ijms-20-03428">Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY</wicri:regionArea><wicri:noRegion>Dundee DD1 9SY</wicri:noRegion></affiliation></author><author><name sortKey="Pourreyron, Celine" sort="Pourreyron, Celine" uniqKey="Pourreyron C" first="Celine" last="Pourreyron">Celine Pourreyron</name><affiliation wicri:level="1"><nlm:aff id="af3-ijms-20-03428">Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY</wicri:regionArea><wicri:noRegion>Dundee DD1 9SY</wicri:noRegion></affiliation></author><author><name sortKey="Mladkova, Nikol" sort="Mladkova, Nikol" uniqKey="Mladkova N" first="Nikol" last="Mladkova">Nikol Mladkova</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Nagano, Ai" sort="Nagano, Ai" uniqKey="Nagano A" first="Ai" last="Nagano">Ai Nagano</name><affiliation wicri:level="1"><nlm:aff id="af2-ijms-20-03428">Barts Cancer Institute, QMUL, London EC1M 6BQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Cancer Institute, QMUL, London EC1M 6BQ</wicri:regionArea><wicri:noRegion>London EC1M 6BQ</wicri:noRegion></affiliation></author><author><name sortKey="Dhayade, Sandeep" sort="Dhayade, Sandeep" uniqKey="Dhayade S" first="Sandeep" last="Dhayade">Sandeep Dhayade</name><affiliation wicri:level="1"><nlm:aff id="af4-ijms-20-03428">Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD</wicri:regionArea><wicri:noRegion>Glasgow G61 1BD</wicri:noRegion></affiliation></author><author><name sortKey="Athineos, Dimitris" sort="Athineos, Dimitris" uniqKey="Athineos D" first="Dimitris" last="Athineos">Dimitris Athineos</name><affiliation wicri:level="1"><nlm:aff id="af4-ijms-20-03428">Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD</wicri:regionArea><wicri:noRegion>Glasgow G61 1BD</wicri:noRegion></affiliation></author><author><name sortKey="Caley, Matthew" sort="Caley, Matthew" uniqKey="Caley M" first="Matthew" last="Caley">Matthew Caley</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Mannella, Viviana" sort="Mannella, Viviana" uniqKey="Mannella V" first="Viviana" last="Mannella">Viviana Mannella</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Blyth, Karen" sort="Blyth, Karen" uniqKey="Blyth K" first="Karen" last="Blyth">Karen Blyth</name><affiliation wicri:level="1"><nlm:aff id="af4-ijms-20-03428">Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD</wicri:regionArea><wicri:noRegion>Glasgow G61 1BD</wicri:noRegion></affiliation></author><author><name sortKey="Inman, Gareth J" sort="Inman, Gareth J" uniqKey="Inman G" first="Gareth J." last="Inman">Gareth J. 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Purdie</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation wicri:level="1"><nlm:aff id="af2-ijms-20-03428">Barts Cancer Institute, QMUL, London EC1M 6BQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Cancer Institute, QMUL, London EC1M 6BQ</wicri:regionArea><wicri:noRegion>London EC1M 6BQ</wicri:noRegion></affiliation></author><author><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A." last="Harwood">Catherine A. Harwood</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M." last="Proby">Charlotte M. Proby</name><affiliation wicri:level="1"><nlm:aff id="af3-ijms-20-03428">Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY</wicri:regionArea><wicri:noRegion>Dundee DD1 9SY</wicri:noRegion></affiliation></author><author><name sortKey="Pourreyron, Celine" sort="Pourreyron, Celine" uniqKey="Pourreyron C" first="Celine" last="Pourreyron">Celine Pourreyron</name><affiliation wicri:level="1"><nlm:aff id="af3-ijms-20-03428">Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY</wicri:regionArea><wicri:noRegion>Dundee DD1 9SY</wicri:noRegion></affiliation></author><author><name sortKey="Mladkova, Nikol" sort="Mladkova, Nikol" uniqKey="Mladkova N" first="Nikol" last="Mladkova">Nikol Mladkova</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Nagano, Ai" sort="Nagano, Ai" uniqKey="Nagano A" first="Ai" last="Nagano">Ai Nagano</name><affiliation wicri:level="1"><nlm:aff id="af2-ijms-20-03428">Barts Cancer Institute, QMUL, London EC1M 6BQ, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Barts Cancer Institute, QMUL, London EC1M 6BQ</wicri:regionArea><wicri:noRegion>London EC1M 6BQ</wicri:noRegion></affiliation></author><author><name sortKey="Dhayade, Sandeep" sort="Dhayade, Sandeep" uniqKey="Dhayade S" first="Sandeep" last="Dhayade">Sandeep Dhayade</name><affiliation wicri:level="1"><nlm:aff id="af4-ijms-20-03428">Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD</wicri:regionArea><wicri:noRegion>Glasgow G61 1BD</wicri:noRegion></affiliation></author><author><name sortKey="Athineos, Dimitris" sort="Athineos, Dimitris" uniqKey="Athineos D" first="Dimitris" last="Athineos">Dimitris Athineos</name><affiliation wicri:level="1"><nlm:aff id="af4-ijms-20-03428">Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD</wicri:regionArea><wicri:noRegion>Glasgow G61 1BD</wicri:noRegion></affiliation></author><author><name sortKey="Caley, Matthew" sort="Caley, Matthew" uniqKey="Caley M" first="Matthew" last="Caley">Matthew Caley</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Mannella, Viviana" sort="Mannella, Viviana" uniqKey="Mannella V" first="Viviana" last="Mannella">Viviana Mannella</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation></author><author><name sortKey="Blyth, Karen" sort="Blyth, Karen" uniqKey="Blyth K" first="Karen" last="Blyth">Karen Blyth</name><affiliation wicri:level="1"><nlm:aff id="af4-ijms-20-03428">Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD</wicri:regionArea><wicri:noRegion>Glasgow G61 1BD</wicri:noRegion></affiliation></author><author><name sortKey="Inman, Gareth J" sort="Inman, Gareth J" uniqKey="Inman G" first="Gareth J." last="Inman">Gareth J. Inman</name><affiliation wicri:level="1"><nlm:aff id="af4-ijms-20-03428">Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD</wicri:regionArea><wicri:noRegion>Glasgow G61 1BD</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="af5-ijms-20-03428">Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1GH, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1GH</wicri:regionArea><orgName type="university">Université de Glasgow</orgName><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Leigh, Irene M" sort="Leigh, Irene M" uniqKey="Leigh I" first="Irene M." last="Leigh">Irene M. Leigh</name><affiliation wicri:level="1"><nlm:aff id="af1-ijms-20-03428">Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Blizard Institute, Barts and the London School of Medicine and Dentistry, QMUL, London E1 2AT</wicri:regionArea><wicri:noRegion>London E1 2AT</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-20-03428">Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cancer, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY</wicri:regionArea><wicri:noRegion>Dundee DD1 9SY</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with increasing morbidity and mortality, with limited treatment options for advanced disease. Future improvements in targeted therapy will rely on advances in genomic/transcriptomic understanding and the use of model systems for basic research. We describe here the panel of 16 primary and metastatic cSCC cell lines developed and characterised over the past three decades in our laboratory in order to provide such a resource for future preclinical research and drug screening. Methods: Primary keratinocytes were isolated from cSCC tumours and metastases, and cell lines were established. These were characterised using short tandem repeat (STR) profiling and genotyped by whole exome sequencing. Multiple in vitro assays were performed to document their morphology, growth characteristics, migration and invasion characteristics, and in vivo xenograft growth. Results: STR profiles of the cSCC lines allow the confirmation of their unique identity. Phylogenetic trees derived from exome sequence analysis of the matched primary and metastatic lines provide insight into the genetic basis of disease progression. The results of in vivo and in vitro analyses allow researchers to select suitable cell lines for specific experimentation. Conclusions: There are few well-characterised cSCC lines available for widespread preclinical experimentation and drug screening. The described cSCC cell line panel provides a critical tool for in vitro and in vivo experimentation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Venables, Z C" uniqKey="Venables Z">Z.C. Venables</name></author><author><name sortKey="Autier, P" uniqKey="Autier P">P. Autier</name></author><author><name sortKey="Nijsten, T" uniqKey="Nijsten T">T. Nijsten</name></author><author><name sortKey="Wong, K F" uniqKey="Wong K">K.F. Wong</name></author><author><name sortKey="Langan, S M" uniqKey="Langan S">S.M. 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Dinkova-Kostova</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Écosse</li></region><settlement><li>Glasgow</li></settlement><orgName><li>Université de Glasgow</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Hassan, Sakinah" sort="Hassan, Sakinah" uniqKey="Hassan S" first="Sakinah" last="Hassan">Sakinah Hassan</name></noRegion><name sortKey="Athineos, Dimitris" sort="Athineos, Dimitris" uniqKey="Athineos D" first="Dimitris" last="Athineos">Dimitris Athineos</name><name sortKey="Blyth, Karen" sort="Blyth, Karen" uniqKey="Blyth K" first="Karen" last="Blyth">Karen Blyth</name><name sortKey="Caley, Matthew" sort="Caley, Matthew" uniqKey="Caley M" first="Matthew" last="Caley">Matthew Caley</name><name sortKey="Dhayade, Sandeep" sort="Dhayade, Sandeep" uniqKey="Dhayade S" first="Sandeep" last="Dhayade">Sandeep Dhayade</name><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A." last="Harwood">Catherine A. Harwood</name><name sortKey="Inman, Gareth J" sort="Inman, Gareth J" uniqKey="Inman G" first="Gareth J." last="Inman">Gareth J. Inman</name><name sortKey="Inman, Gareth J" sort="Inman, Gareth J" uniqKey="Inman G" first="Gareth J." last="Inman">Gareth J. Inman</name><name sortKey="Leigh, Irene M" sort="Leigh, Irene M" uniqKey="Leigh I" first="Irene M." last="Leigh">Irene M. Leigh</name><name sortKey="Leigh, Irene M" sort="Leigh, Irene M" uniqKey="Leigh I" first="Irene M." last="Leigh">Irene M. Leigh</name><name sortKey="Mannella, Viviana" sort="Mannella, Viviana" uniqKey="Mannella V" first="Viviana" last="Mannella">Viviana Mannella</name><name sortKey="Mladkova, Nikol" sort="Mladkova, Nikol" uniqKey="Mladkova N" first="Nikol" last="Mladkova">Nikol Mladkova</name><name sortKey="Nagano, Ai" sort="Nagano, Ai" uniqKey="Nagano A" first="Ai" last="Nagano">Ai Nagano</name><name sortKey="Pourreyron, Celine" sort="Pourreyron, Celine" uniqKey="Pourreyron C" first="Celine" last="Pourreyron">Celine Pourreyron</name><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M." last="Proby">Charlotte M. Proby</name><name sortKey="Purdie, Karin J" sort="Purdie, Karin J" uniqKey="Purdie K" first="Karin J." last="Purdie">Karin J. Purdie</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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