Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni
Identifieur interne : 000B16 ( Main/Exploration ); précédent : 000B15; suivant : 000B17Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni
Auteurs : Matthew V. X. Whelan ; Laura Ardill ; Kentaro Koide [Japon] ; Chie Nakajima [Japon] ; Yasuhiko Suzuki [Japon] ; Jeremy C. Simpson ; Tadhg Cr InínSource :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
The World Health Organization has listed
Url:
DOI: 10.1038/s41598-019-54620-1
PubMed: 31796849
PubMed Central: 6890674
Affiliations:
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X." last="Whelan">Matthew V. X. Whelan</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0768 2743</institution-id><institution-id institution-id-type="GRID">grid.7886.1</institution-id><institution>School of Biomolecular and Biomedical Science,</institution><institution>University College Dublin,</institution></institution-wrap>Belfield, Dublin 4 Ireland</nlm:aff><wicri:noCountry code="subfield">Dublin 4 Ireland</wicri:noCountry></affiliation></author><author><name sortKey="Ardill, Laura" sort="Ardill, Laura" uniqKey="Ardill L" first="Laura" last="Ardill">Laura Ardill</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0768 2743</institution-id><institution-id institution-id-type="GRID">grid.7886.1</institution-id><institution>School of Biomolecular and Biomedical Science,</institution><institution>University College Dublin,</institution></institution-wrap>Belfield, Dublin 4 Ireland</nlm:aff><wicri:noCountry code="subfield">Dublin 4 Ireland</wicri:noCountry></affiliation></author><author><name sortKey="Koide, Kentaro" sort="Koide, Kentaro" uniqKey="Koide K" first="Kentaro" last="Koide">Kentaro Koide</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2173 7691</institution-id><institution-id institution-id-type="GRID">grid.39158.36</institution-id><institution>Division of Bioresources,</institution><institution>Hokkaido University Research Center for Zoonosis Control,</institution></institution-wrap>Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sapporo</wicri:regionArea></affiliation></author><author><name sortKey="Nakajima, Chie" sort="Nakajima, Chie" uniqKey="Nakajima C" first="Chie" last="Nakajima">Chie Nakajima</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2173 7691</institution-id><institution-id institution-id-type="GRID">grid.39158.36</institution-id><institution>Division of Bioresources,</institution><institution>Hokkaido University Research Center for Zoonosis Control,</institution></institution-wrap>Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sapporo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2173 7691</institution-id><institution-id institution-id-type="GRID">grid.39158.36</institution-id><institution>The Global Station for Zoonosis Control,</institution><institution>Hokkaido University Global Institution for Collaborative Research and Education,</institution></institution-wrap>Kita 20 Nishi 10, Kita-ku, Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kita 20 Nishi 10, Kita-ku, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Yasuhiko" sort="Suzuki, Yasuhiko" uniqKey="Suzuki Y" first="Yasuhiko" last="Suzuki">Yasuhiko Suzuki</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2173 7691</institution-id><institution-id institution-id-type="GRID">grid.39158.36</institution-id><institution>Division of Bioresources,</institution><institution>Hokkaido University Research Center for Zoonosis Control,</institution></institution-wrap>Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Sapporo</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2173 7691</institution-id><institution-id institution-id-type="GRID">grid.39158.36</institution-id><institution>The Global Station for Zoonosis Control,</institution><institution>Hokkaido University Global Institution for Collaborative Research and Education,</institution></institution-wrap>Kita 20 Nishi 10, Kita-ku, Sapporo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Kita 20 Nishi 10, Kita-ku, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Simpson, Jeremy C" sort="Simpson, Jeremy C" uniqKey="Simpson J" first="Jeremy C." last="Simpson">Jeremy C. Simpson</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0768 2743</institution-id><institution-id institution-id-type="GRID">grid.7886.1</institution-id><institution>School of Biology and Environmental Science,</institution><institution>University College Dublin,</institution></institution-wrap>Belfield, Dublin 4 Ireland</nlm:aff><wicri:noCountry code="subfield">Dublin 4 Ireland</wicri:noCountry></affiliation></author><author><name sortKey=" Cr Inin, Tadhg" sort=" Cr Inin, Tadhg" uniqKey=" Cr Inin T" first="Tadhg" last=" Cr Inín">Tadhg Cr Inín</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0768 2743</institution-id><institution-id institution-id-type="GRID">grid.7886.1</institution-id><institution>School of Biomolecular and Biomedical Science,</institution><institution>University College Dublin,</institution></institution-wrap>Belfield, Dublin 4 Ireland</nlm:aff><wicri:noCountry code="subfield">Dublin 4 Ireland</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The World Health Organization has listed <italic>C</italic>. <italic>jejuni</italic> as one of 12 microorganisms on a global priority list for antibiotic resistance due to a rapid increase in strains resistant to fluoroquinolone antibiotics. This fluoroquinolone resistance is conferred through a single point mutation in the QRDR region within the <italic>gyrA</italic> gene known to be involved in DNA supercoiling. We have previously revealed that changes in DNA supercoilikng play a major role in the regulation of virulence in <italic>C</italic>. <italic>jejuni</italic> with relaxation of DNA supercoiling associated with increased attachment to and invasion of human epithelial cells. The aim of this study was to investigate whether fluoroquinolone resistant strains of <italic>C</italic>. <italic>jejuni</italic> displayed altered supercoiling associated phenotypes. A panel of fluoroquinolone resistant mutants were derived and shown to have a greater ability to form viable biofilms under aerobic conditions, invade epithelial cells and promote virulence in the <italic>Galleria mellonella</italic> model of infection. We thus report for the first time that fluoroquinolone resistance in <italic>C</italic>. <italic>jejuni</italic> is associated with an increase in virulence and the ability to form viable biofilms in oxygen rich environments. These altered phenotypes likely play a critical role in the continued increase in fluoroquinolone resistance observed for this important pathogen.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Young, Kt" uniqKey="Young K">KT Young</name></author><author><name sortKey="Davis, Lm" uniqKey="Davis L">LM Davis</name></author><author><name sortKey="Dirita, Vj" uniqKey="Dirita V">VJ Dirita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Croinin, T" uniqKey="O Croinin T">T O Croinin</name></author><author><name sortKey="Backert, S" uniqKey="Backert S">S Backert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, E" uniqKey="Oh E">E Oh</name></author><author><name sortKey="Mcmullen, L" uniqKey="Mcmullen L">L McMullen</name></author><author><name sortKey="Jeon, B" uniqKey="Jeon B">B Jeon</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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uniqKey="Pan X">XS Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Endtz, Hp" uniqKey="Endtz H">HP Endtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudkin, Jk" uniqKey="Rudkin J">JK Rudkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pozzi, C" uniqKey="Pozzi C">C Pozzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirakata, Y" uniqKey="Hirakata Y">Y Hirakata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geisinger, E" uniqKey="Geisinger E">E Geisinger</name></author><author><name sortKey="Isberg, Rr" uniqKey="Isberg R">RR Isberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Hl" uniqKey="Brown H">HL Brown</name></author><author><name sortKey="Hanman, K" uniqKey="Hanman K">K Hanman</name></author><author><name sortKey="Reuter, M" uniqKey="Reuter M">M Reuter</name></author><author><name sortKey="Betts, Rp" uniqKey="Betts R">RP Betts</name></author><author><name sortKey="Van Vliet, Ah" uniqKey="Van Vliet A">AH van Vliet</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Askoura, M" uniqKey="Askoura M">M Askoura</name></author><author><name sortKey="Stintzi, A" uniqKey="Stintzi A">A Stintzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibreel, A" uniqKey="Gibreel A">A Gibreel</name></author><author><name sortKey="Sjogren, E" uniqKey="Sjogren E">E Sjogren</name></author><author><name sortKey="Kaijser, B" uniqKey="Kaijser B">B Kaijser</name></author><author><name sortKey="Wretlind, B" uniqKey="Wretlind B">B Wretlind</name></author><author><name sortKey="Skold, O" uniqKey="Skold O">O Skold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Lb" uniqKey="Price L">LB Price</name></author><author><name sortKey="Lackey, Lg" uniqKey="Lackey L">LG Lackey</name></author><author><name sortKey="Vailes, R" uniqKey="Vailes R">R Vailes</name></author><author><name sortKey="Silbergeld, E" uniqKey="Silbergeld E">E Silbergeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Lb" uniqKey="Price L">LB Price</name></author><author><name sortKey="Johnson, E" uniqKey="Johnson E">E Johnson</name></author><author><name sortKey="Vailes, R" uniqKey="Vailes R">R Vailes</name></author><author><name sortKey="Silbergeld, E" uniqKey="Silbergeld E">E Silbergeld</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey=" Cr Inin, Tadhg" sort=" Cr Inin, Tadhg" uniqKey=" Cr Inin T" first="Tadhg" last=" Cr Inín">Tadhg Cr Inín</name><name sortKey="Ardill, Laura" sort="Ardill, Laura" uniqKey="Ardill L" first="Laura" last="Ardill">Laura Ardill</name><name sortKey="Simpson, Jeremy C" sort="Simpson, Jeremy C" uniqKey="Simpson J" first="Jeremy C." last="Simpson">Jeremy C. Simpson</name><name sortKey="Whelan, Matthew V X" sort="Whelan, Matthew V X" uniqKey="Whelan M" first="Matthew V. X." last="Whelan">Matthew V. X. Whelan</name></noCountry><country name="Japon"><noRegion><name sortKey="Koide, Kentaro" sort="Koide, Kentaro" uniqKey="Koide K" first="Kentaro" last="Koide">Kentaro Koide</name></noRegion><name sortKey="Nakajima, Chie" sort="Nakajima, Chie" uniqKey="Nakajima C" first="Chie" last="Nakajima">Chie Nakajima</name><name sortKey="Nakajima, Chie" sort="Nakajima, Chie" uniqKey="Nakajima C" first="Chie" last="Nakajima">Chie Nakajima</name><name sortKey="Suzuki, Yasuhiko" sort="Suzuki, Yasuhiko" uniqKey="Suzuki Y" first="Yasuhiko" last="Suzuki">Yasuhiko Suzuki</name><name sortKey="Suzuki, Yasuhiko" sort="Suzuki, Yasuhiko" uniqKey="Suzuki Y" first="Yasuhiko" last="Suzuki">Yasuhiko Suzuki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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