Bitter tastants and artificial sweeteners activate a subset of epithelial cells in acute tissue slices of the rat trachea
Identifieur interne : 000993 ( Main/Exploration ); précédent : 000992; suivant : 000994Bitter tastants and artificial sweeteners activate a subset of epithelial cells in acute tissue slices of the rat trachea
Auteurs : Chiara Lasconi [Italie] ; Simone Pifferi [Italie] ; Andres Hernandez-Clavijo [Italie] ; Flavia Merigo [Italie] ; Maria Paola Cecchini [Italie] ; Kevin Y. Gonzalez-Velandia [Italie] ; Emilio Agostinelli [Italie] ; Andrea Sbarbati [Italie] ; Anna Menini [Italie]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Bitter and sweet receptors (T2Rs and T1Rs) are expressed in many extra-oral tissues including upper and lower airways. To investigate if bitter tastants and artificial sweeteners could activate physiological responses in tracheal epithelial cells we performed confocal Ca2+ imaging recordings on acute tracheal slices. We stimulated the cells with denatonium benzoate, a T2R agonist, and with the artificial sweeteners sucralose, saccharin and acesulfame-K. To test cell viability we measured responses to ATP. We found that 39% of the epithelial cells responding to ATP also responded to bitter stimulation with denatonium benzoate. Moreover, artificial sweeteners activated different percentages of the cells, ranging from 5% for sucralose to 26% for saccharin, and 27% for acesulfame-K. By using carbenoxolone, a gap junction blocker, we excluded that responses were mainly mediated by Ca2+ waves through cell-to-cell junctions. Pharmacological experiments showed that both denatonium and artificial sweeteners induced a PLC-mediated release of Ca2+ from internal stores. In addition, bitter tastants and artificial sweeteners activated a partially overlapping subpopulation of tracheal epithelial cells. Our results provide new evidence that a subset of ATP-responsive tracheal epithelial cells from rat are activated by both bitter tastants and artificial sweeteners.
Url:
DOI: 10.1038/s41598-019-45456-w
PubMed: 31222082
PubMed Central: 6586933
Affiliations:
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institution-id-type="ISNI">0000 0004 1763 1124</institution-id><institution-id institution-id-type="GRID">grid.5611.3</institution-id><institution>Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section,</institution><institution>University of Verona, School of Medicine,</institution></institution-wrap>Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Verona</wicri:regionArea></affiliation></author><author><name sortKey="Cecchini, Maria Paola" sort="Cecchini, Maria Paola" uniqKey="Cecchini M" first="Maria Paola" last="Cecchini">Maria Paola Cecchini</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1763 1124</institution-id><institution-id institution-id-type="GRID">grid.5611.3</institution-id><institution>Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section,</institution><institution>University of Verona, 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To investigate if bitter tastants and artificial sweeteners could activate physiological responses in tracheal epithelial cells we performed confocal Ca<sup>2+</sup> imaging recordings on acute tracheal slices. We stimulated the cells with denatonium benzoate, a T2R agonist, and with the artificial sweeteners sucralose, saccharin and acesulfame-K. To test cell viability we measured responses to ATP. We found that 39% of the epithelial cells responding to ATP also responded to bitter stimulation with denatonium benzoate. Moreover, artificial sweeteners activated different percentages of the cells, ranging from 5% for sucralose to 26% for saccharin, and 27% for acesulfame-K. By using carbenoxolone, a gap junction blocker, we excluded that responses were mainly mediated by Ca<sup>2+</sup> waves through cell-to-cell junctions. Pharmacological experiments showed that both denatonium and artificial sweeteners induced a PLC-mediated release of Ca<sup>2+</sup> from internal stores. In addition, bitter tastants and artificial sweeteners activated a partially overlapping subpopulation of tracheal epithelial cells. Our results provide new evidence that a subset of ATP-responsive tracheal epithelial cells from rat are activated by both bitter tastants and artificial sweeteners.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Carleton, A" uniqKey="Carleton A">A Carleton</name></author><author><name sortKey="Accolla, R" uniqKey="Accolla R">R Accolla</name></author><author><name sortKey="Simon, Sa" uniqKey="Simon S">SA Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avau, B" uniqKey="Avau B">B Avau</name></author><author><name sortKey="Depoortere, I" uniqKey="Depoortere I">I Depoortere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrera Moro Chao, D" uniqKey="Herrera Moro Chao D">D Herrera Moro Chao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laffitte, A" uniqKey="Laffitte A">A Laffitte</name></author><author><name 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Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welcome, Menizibeya O" uniqKey="Welcome M">Menizibeya O. Welcome</name></author><author><name sortKey="Mastorakis, Nikos E" uniqKey="Mastorakis N">Nikos E. 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Gonzalez-Velandia</name><name sortKey="Hernandez Clavijo, Andres" sort="Hernandez Clavijo, Andres" uniqKey="Hernandez Clavijo A" first="Andres" last="Hernandez-Clavijo">Andres Hernandez-Clavijo</name><name sortKey="Menini, Anna" sort="Menini, Anna" uniqKey="Menini A" first="Anna" last="Menini">Anna Menini</name><name sortKey="Merigo, Flavia" sort="Merigo, Flavia" uniqKey="Merigo F" first="Flavia" last="Merigo">Flavia Merigo</name><name sortKey="Pifferi, Simone" sort="Pifferi, Simone" uniqKey="Pifferi S" first="Simone" last="Pifferi">Simone Pifferi</name><name sortKey="Sbarbati, Andrea" sort="Sbarbati, Andrea" uniqKey="Sbarbati A" first="Andrea" last="Sbarbati">Andrea Sbarbati</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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