Challenges and future of precision medicine strategies for breast cancer based on a database on drug reactions
Identifieur interne : 000964 ( Main/Exploration ); précédent : 000963; suivant : 000965Challenges and future of precision medicine strategies for breast cancer based on a database on drug reactions
Auteurs : Xiping Zhang [République populaire de Chine] ; Hongjian Yang [République populaire de Chine] ; Ruiping Zhang [République populaire de Chine]Source :
- Bioscience Reports [ 0144-8463 ] ; 2019.
Abstract
Breast cancer (BC) is a malignancy with the highest incidence in women. Great progress has been made in research related to traditional precision medicine for BC. However, many reports have suggested that patients with BC have not benefited a lot from such progress. Thus, we analyze traditional precision medicine strategies for BC, sum up their limitations and challenges, and preliminarily propose future orientations of precision medicine strategies based on a database on drug reaction of patients with BC. According to related research, traditional precision medicine strategies for BC, which are based on molecular subtypes, perform pertinent treatments, new drug research and development according to molecular typing results. Nevertheless, these strategies still have some deficiencies. First, there are very few patients with each molecular subtype, the match ratio of drugs is low. Second, these strategies can not solve the problem of poor drug sensitivity resulting from heterogeneity. The main strategy we put forward in the present paper is based on patients’ varying drug reactions. Focusing on treating existing patients and maximizing the utilization of existing drugs, it is expected to not have deficiencies of traditional precision medicine for BC, including low match rate and poor therapeutic efficacy arising from tumor heterogeneity of BC.
Url:
DOI: 10.1042/BSR20190230
PubMed: 31387972
PubMed Central: 6732363
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Challenges and future of precision medicine strategies for breast cancer based on a database on drug reactions</title><author><name sortKey="Zhang, Xiping" sort="Zhang, Xiping" uniqKey="Zhang X" first="Xiping" last="Zhang">Xiping Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Hongjian" sort="Yang, Hongjian" uniqKey="Yang H" first="Hongjian" last="Yang">Hongjian Yang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ruiping" sort="Zhang, Ruiping" uniqKey="Zhang R" first="Ruiping" last="Zhang">Ruiping Zhang</name><affiliation wicri:level="1"><nlm:aff id="A2">Shanxi Academy of Medical Sciences, Radiology Department of Shanxi Dayi Hospital, Taiyuan, 030032, Shanxi Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanxi Academy of Medical Sciences, Radiology Department of Shanxi Dayi Hospital, 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type="wicri:Area/Ncbi/Checkpoint">000889</idno><idno type="wicri:doubleKey">0144-8463:2019:Zhang X:challenges:and:future</idno><idno type="wicri:Area/Main/Merge">000964</idno><idno type="wicri:Area/Main/Curation">000964</idno><idno type="wicri:Area/Main/Exploration">000964</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Challenges and future of precision medicine strategies for breast cancer based on a database on drug reactions</title><author><name sortKey="Zhang, Xiping" sort="Zhang, Xiping" uniqKey="Zhang X" first="Xiping" last="Zhang">Xiping Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Hongjian" sort="Yang, Hongjian" uniqKey="Yang H" first="Hongjian" last="Yang">Hongjian Yang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province</wicri:regionArea><wicri:noRegion>Zhejiang Province</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ruiping" sort="Zhang, Ruiping" uniqKey="Zhang R" first="Ruiping" last="Zhang">Ruiping Zhang</name><affiliation wicri:level="1"><nlm:aff id="A2">Shanxi Academy of Medical Sciences, Radiology Department of Shanxi Dayi Hospital, Taiyuan, 030032, Shanxi Province, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanxi Academy of Medical Sciences, Radiology Department of Shanxi Dayi Hospital, Taiyuan, 030032, Shanxi Province</wicri:regionArea><wicri:noRegion>Shanxi Province</wicri:noRegion></affiliation></author></analytic><series><title level="j">Bioscience Reports</title><idno type="ISSN">0144-8463</idno><idno type="eISSN">1573-4935</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Breast cancer (BC) is a malignancy with the highest incidence in women. Great progress has been made in research related to traditional precision medicine for BC. However, many reports have suggested that patients with BC have not benefited a lot from such progress. Thus, we analyze traditional precision medicine strategies for BC, sum up their limitations and challenges, and preliminarily propose future orientations of precision medicine strategies based on a database on drug reaction of patients with BC. According to related research, traditional precision medicine strategies for BC, which are based on molecular subtypes, perform pertinent treatments, new drug research and development according to molecular typing results. Nevertheless, these strategies still have some deficiencies. First, there are very few patients with each molecular subtype, the match ratio of drugs is low. Second, these strategies can not solve the problem of poor drug sensitivity resulting from heterogeneity. The main strategy we put forward in the present paper is based on patients’ varying drug reactions. Focusing on treating existing patients and maximizing the utilization of existing drugs, it is expected to not have deficiencies of traditional precision medicine for BC, including low match rate and poor therapeutic efficacy arising from tumor heterogeneity of BC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ashley, E A" uniqKey="Ashley E">E.A. Ashley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y. Lu</name></author><author><name sortKey="Yu, B K" uniqKey="Yu B">B.K. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, L" uniqKey="Fan L">L. Fan</name></author><author><name sortKey="Strasser Weippl, K" uniqKey="Strasser Weippl K">K. Strasser-Weippl</name></author><author><name sortKey="Li, J J" uniqKey="Li J">J.J. 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Wang</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z. Zhu</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name></author><author><name sortKey="Tan, D" uniqKey="Tan D">D. Tan</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Xiping" sort="Zhang, Xiping" uniqKey="Zhang X" first="Xiping" last="Zhang">Xiping Zhang</name></noRegion><name sortKey="Yang, Hongjian" sort="Yang, Hongjian" uniqKey="Yang H" first="Hongjian" last="Yang">Hongjian Yang</name><name sortKey="Zhang, Ruiping" sort="Zhang, Ruiping" uniqKey="Zhang R" first="Ruiping" last="Zhang">Ruiping Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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