Conversion of Tuberculosis Screening Tests During Biologic Therapy Among Veteran Patient Population With Rheumatic Disease
Identifieur interne : 000931 ( Main/Exploration ); précédent : 000930; suivant : 000932Conversion of Tuberculosis Screening Tests During Biologic Therapy Among Veteran Patient Population With Rheumatic Disease
Auteurs : Debendra Pattanaik ; Sandeep Gupta ; Syed Islam ; Kunal Singhal ; Syed RazaSource :
- Acr Open Rheumatology [ 2578-5745 ] ; 2019.
Abstract
The optimal strategy to detect the development of tuberculosis
This is a retrospective study among veteran populations with rheumatic diseases who received various biologic agents between 2003 and 2014. Subjects who had repeated TB screening tests and adequate follow‐up periods were considered for the study.
Out of 298 subjects who received biologic agents, 123 were considered for the study. After the initial negative screening test by tuberculin skin test (TST), patients were screened on an average of 1.2 years for 4.3 to 12 years. A total of 420 tests were performed, which were combination of TST and QuantiFERON‐TB gold in‐Tube assay. Only 1 out of 123 subjects (0.8%) seroconverted to latent TB and was treated with isoniazid for 9 months.
Our results are in line with a few other studies reported from the United States. We conclude that in areas with low prevalence of TB the seroconversion rate is extremely low and annual testing is unnecessary in low‐risk patient populations.
Url:
DOI: 10.1002/acr2.11070
PubMed: 31777837
PubMed Central: 6857984
Affiliations:
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The recommendations vary because there is wide variation in the reported rate of seroconversion in various parts of the world. There is a scarcity of long‐term studies regarding seroconversion of TB in the United States among these patients.</p></sec><sec id="acr211070-sec-0002"><title>Methods</title><p>This is a retrospective study among veteran populations with rheumatic diseases who received various biologic agents between 2003 and 2014. Subjects who had repeated TB screening tests and adequate follow‐up periods were considered for the study.</p></sec><sec id="acr211070-sec-0003"><title>Results</title><p>Out of 298 subjects who received biologic agents, 123 were considered for the study. After the initial negative screening test by tuberculin skin test (TST), patients were screened on an average of 1.2 years for 4.3 to 12 years. A total of 420 tests were performed, which were combination of TST and QuantiFERON‐TB gold in‐Tube assay. Only 1 out of 123 subjects (0.8%) seroconverted to latent TB and was treated with isoniazid for 9 months.</p></sec><sec id="acr211070-sec-0004"><title>Conclusion</title><p>Our results are in line with a few other studies reported from the United States. We conclude that in areas with low prevalence of TB the seroconversion rate is extremely low and annual testing is unnecessary in low‐risk patient populations.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Gupta, Sandeep" sort="Gupta, Sandeep" uniqKey="Gupta S" first="Sandeep" last="Gupta">Sandeep Gupta</name><name sortKey="Islam, Syed" sort="Islam, Syed" uniqKey="Islam S" first="Syed" last="Islam">Syed Islam</name><name sortKey="Pattanaik, Debendra" sort="Pattanaik, Debendra" uniqKey="Pattanaik D" first="Debendra" last="Pattanaik">Debendra Pattanaik</name><name sortKey="Raza, Syed" sort="Raza, Syed" uniqKey="Raza S" first="Syed" last="Raza">Syed Raza</name><name sortKey="Singhal, Kunal" sort="Singhal, Kunal" uniqKey="Singhal K" first="Kunal" last="Singhal">Kunal Singhal</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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