DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
Identifieur interne : 000909 ( Main/Exploration ); précédent : 000908; suivant : 000910DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
Auteurs : Margie N. Sutton ; Gilbert Y. Huang ; Xiaowen Liang ; Rajesh Sharma ; Albert S. Reger ; Weiqun Mao ; Lan Pang ; Philip J. Rask ; Kwangkook Lee ; Joshua P. Gray ; Amy M. Hurwitz ; Timothy Palzkill ; Steven W. Millward ; Choel Kim ; Zhen Lu ; Robert C. BastSource :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role in the survival of dormant, drug resistant ovarian cancer cells using human xenograft models and correlated the up-regulation of autophagy and DIRAS3 expression in clinical samples obtained during “second look” operations. DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kD GTPase with homology to RAS that inhibits cancer cell proliferation and motility. Re-expression of DIRAS3 in ovarian cancer xenografts also induces dormancy and autophagy. DIRAS3 can bind to Beclin1 forming the Autophagy Initiation Complex that triggers autophagosome formation. Both the N-terminus of DIRAS3 (residues 15–33) and the switch II region of DIRAS3 (residues 93–107) interact directly with BECN1. We have identified an autophagy-inhibiting peptide based on the switch II region of DIRAS3 linked to Tat peptide that is taken up by ovarian cancer cells, binds Beclin1 and inhibits starvation-induced DIRAS3-mediated autophagy.
Url:
DOI: 10.3390/cancers11040557
PubMed: 31003488
PubMed Central: 6521623
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1</title><author><name sortKey="Sutton, Margie N" sort="Sutton, Margie N" uniqKey="Sutton M" first="Margie N." last="Sutton">Margie N. Sutton</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Huang, Gilbert Y" sort="Huang, Gilbert Y" uniqKey="Huang G" first="Gilbert Y." last="Huang">Gilbert Y. Huang</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Liang, Xiaowen" sort="Liang, Xiaowen" uniqKey="Liang X" first="Xiaowen" last="Liang">Xiaowen Liang</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Sharma, Rajesh" sort="Sharma, Rajesh" uniqKey="Sharma R" first="Rajesh" last="Sharma">Rajesh Sharma</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Reger, Albert S" sort="Reger, Albert S" uniqKey="Reger A" first="Albert S." last="Reger">Albert S. Reger</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Mao, Weiqun" sort="Mao, Weiqun" uniqKey="Mao W" first="Weiqun" last="Mao">Weiqun Mao</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Pang, Lan" sort="Pang, Lan" uniqKey="Pang L" first="Lan" last="Pang">Lan Pang</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Rask, Philip J" sort="Rask, Philip J" uniqKey="Rask P" first="Philip J." last="Rask">Philip J. Rask</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Lee, Kwangkook" sort="Lee, Kwangkook" uniqKey="Lee K" first="Kwangkook" last="Lee">Kwangkook Lee</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Gray, Joshua P" sort="Gray, Joshua P" uniqKey="Gray J" first="Joshua P." last="Gray">Joshua P. Gray</name><affiliation><nlm:aff id="af3-cancers-11-00557">Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>jpgray@mdanderson.org</email> (J.P.G.);<email>smillward@mdanderson.org</email> (S.W.M.)</nlm:aff></affiliation></author><author><name sortKey="Hurwitz, Amy M" sort="Hurwitz, Amy M" uniqKey="Hurwitz A" first="Amy M." last="Hurwitz">Amy M. Hurwitz</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Palzkill, Timothy" sort="Palzkill, Timothy" uniqKey="Palzkill T" first="Timothy" last="Palzkill">Timothy Palzkill</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Millward, Steven W" sort="Millward, Steven W" uniqKey="Millward S" first="Steven W." last="Millward">Steven W. Millward</name><affiliation><nlm:aff id="af3-cancers-11-00557">Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>jpgray@mdanderson.org</email> (J.P.G.);<email>smillward@mdanderson.org</email> (S.W.M.)</nlm:aff></affiliation></author><author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Lu, Zhen" sort="Lu, Zhen" uniqKey="Lu Z" first="Zhen" last="Lu">Zhen Lu</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Bast, Robert C" sort="Bast, Robert C" uniqKey="Bast R" first="Robert C." last="Bast">Robert C. Bast</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31003488</idno><idno type="pmc">6521623</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521623</idno><idno type="RBID">PMC:6521623</idno><idno type="doi">10.3390/cancers11040557</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000449</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000449</idno><idno type="wicri:Area/Pmc/Curation">000449</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000449</idno><idno type="wicri:Area/Pmc/Checkpoint">000848</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000848</idno><idno type="wicri:Area/Ncbi/Merge">000552</idno><idno type="wicri:Area/Ncbi/Curation">000552</idno><idno type="wicri:Area/Ncbi/Checkpoint">000552</idno><idno type="wicri:Area/Main/Merge">000909</idno><idno type="wicri:Area/Main/Curation">000909</idno><idno type="wicri:Area/Main/Exploration">000909</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1</title><author><name sortKey="Sutton, Margie N" sort="Sutton, Margie N" uniqKey="Sutton M" first="Margie N." last="Sutton">Margie N. Sutton</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Huang, Gilbert Y" sort="Huang, Gilbert Y" uniqKey="Huang G" first="Gilbert Y." last="Huang">Gilbert Y. Huang</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Liang, Xiaowen" sort="Liang, Xiaowen" uniqKey="Liang X" first="Xiaowen" last="Liang">Xiaowen Liang</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Sharma, Rajesh" sort="Sharma, Rajesh" uniqKey="Sharma R" first="Rajesh" last="Sharma">Rajesh Sharma</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Reger, Albert S" sort="Reger, Albert S" uniqKey="Reger A" first="Albert S." last="Reger">Albert S. Reger</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Mao, Weiqun" sort="Mao, Weiqun" uniqKey="Mao W" first="Weiqun" last="Mao">Weiqun Mao</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Pang, Lan" sort="Pang, Lan" uniqKey="Pang L" first="Lan" last="Pang">Lan Pang</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Rask, Philip J" sort="Rask, Philip J" uniqKey="Rask P" first="Philip J." last="Rask">Philip J. Rask</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Lee, Kwangkook" sort="Lee, Kwangkook" uniqKey="Lee K" first="Kwangkook" last="Lee">Kwangkook Lee</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Gray, Joshua P" sort="Gray, Joshua P" uniqKey="Gray J" first="Joshua P." last="Gray">Joshua P. Gray</name><affiliation><nlm:aff id="af3-cancers-11-00557">Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>jpgray@mdanderson.org</email> (J.P.G.);<email>smillward@mdanderson.org</email> (S.W.M.)</nlm:aff></affiliation></author><author><name sortKey="Hurwitz, Amy M" sort="Hurwitz, Amy M" uniqKey="Hurwitz A" first="Amy M." last="Hurwitz">Amy M. Hurwitz</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Palzkill, Timothy" sort="Palzkill, Timothy" uniqKey="Palzkill T" first="Timothy" last="Palzkill">Timothy Palzkill</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Millward, Steven W" sort="Millward, Steven W" uniqKey="Millward S" first="Steven W." last="Millward">Steven W. Millward</name><affiliation><nlm:aff id="af3-cancers-11-00557">Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>jpgray@mdanderson.org</email> (J.P.G.);<email>smillward@mdanderson.org</email> (S.W.M.)</nlm:aff></affiliation></author><author><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name><affiliation><nlm:aff id="af2-cancers-11-00557">Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA;<email>Rajesh.Sharma@bcm.edu</email> (R.S.);<email>al_reger@yahoo.com</email> (A.S.R.);<email>amymhz@gmail.com</email> (A.M.H.);<email>timothyp@bcm.edu</email> (T.P.);<email>ckim@bcm.edu</email> (C.K.)</nlm:aff></affiliation></author><author><name sortKey="Lu, Zhen" sort="Lu, Zhen" uniqKey="Lu Z" first="Zhen" last="Lu">Zhen Lu</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author><author><name sortKey="Bast, Robert C" sort="Bast, Robert C" uniqKey="Bast R" first="Robert C." last="Bast">Robert C. Bast</name><affiliation><nlm:aff id="af1-cancers-11-00557">Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA;<email>MNSutton@mdanderson.org</email> (M.N.S.);<email>gilbertyhuang@gmail.com</email> (G.Y.H.);<email>XLiang3@mdanderson.org</email> (X.L.);<email>WMao@mdanderson.org</email> (W.M.);<email>LPang@mdanderson.org</email> (L.P.);<email>pjrask@mdanderson.org</email> (P.J.R.);<email>KLEE74@mgh.harvard.edu</email> (K.L.)</nlm:aff></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="eISSN">2072-6694</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role in the survival of dormant, drug resistant ovarian cancer cells using human xenograft models and correlated the up-regulation of autophagy and DIRAS3 expression in clinical samples obtained during “second look” operations. DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kD GTPase with homology to RAS that inhibits cancer cell proliferation and motility. Re-expression of DIRAS3 in ovarian cancer xenografts also induces dormancy and autophagy. DIRAS3 can bind to Beclin1 forming the Autophagy Initiation Complex that triggers autophagosome formation. Both the N-terminus of DIRAS3 (residues 15–33) and the switch II region of DIRAS3 (residues 93–107) interact directly with BECN1. We have identified an autophagy-inhibiting peptide based on the switch II region of DIRAS3 linked to Tat peptide that is taken up by ovarian cancer cells, binds Beclin1 and inhibits starvation-induced DIRAS3-mediated autophagy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, R L" uniqKey="Siegel R">R.L. Siegel</name></author><author><name sortKey="Miller, K D" uniqKey="Miller K">K.D. Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, E" uniqKey="White E">E. White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez Vargas, J M" uniqKey="Rodriguez Vargas J">J.M. Rodriguez-Vargas</name></author><author><name sortKey="Rodriguez, M I" uniqKey="Rodriguez M">M.I. Rodriguez</name></author><author><name sortKey="Majuelos Melguizo, J" uniqKey="Majuelos Melguizo J">J. 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Huang</name><name sortKey="Hurwitz, Amy M" sort="Hurwitz, Amy M" uniqKey="Hurwitz A" first="Amy M." last="Hurwitz">Amy M. Hurwitz</name><name sortKey="Kim, Choel" sort="Kim, Choel" uniqKey="Kim C" first="Choel" last="Kim">Choel Kim</name><name sortKey="Lee, Kwangkook" sort="Lee, Kwangkook" uniqKey="Lee K" first="Kwangkook" last="Lee">Kwangkook Lee</name><name sortKey="Liang, Xiaowen" sort="Liang, Xiaowen" uniqKey="Liang X" first="Xiaowen" last="Liang">Xiaowen Liang</name><name sortKey="Lu, Zhen" sort="Lu, Zhen" uniqKey="Lu Z" first="Zhen" last="Lu">Zhen Lu</name><name sortKey="Mao, Weiqun" sort="Mao, Weiqun" uniqKey="Mao W" first="Weiqun" last="Mao">Weiqun Mao</name><name sortKey="Millward, Steven W" sort="Millward, Steven W" uniqKey="Millward S" first="Steven W." last="Millward">Steven W. Millward</name><name sortKey="Palzkill, Timothy" sort="Palzkill, Timothy" uniqKey="Palzkill T" first="Timothy" last="Palzkill">Timothy Palzkill</name><name sortKey="Pang, Lan" sort="Pang, Lan" uniqKey="Pang L" first="Lan" last="Pang">Lan Pang</name><name sortKey="Rask, Philip J" sort="Rask, Philip J" uniqKey="Rask P" first="Philip J." last="Rask">Philip J. Rask</name><name sortKey="Reger, Albert S" sort="Reger, Albert S" uniqKey="Reger A" first="Albert S." last="Reger">Albert S. Reger</name><name sortKey="Sharma, Rajesh" sort="Sharma, Rajesh" uniqKey="Sharma R" first="Rajesh" last="Sharma">Rajesh Sharma</name><name sortKey="Sutton, Margie N" sort="Sutton, Margie N" uniqKey="Sutton M" first="Margie N." last="Sutton">Margie N. Sutton</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
}}
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31003488" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
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