Dihydromyricetin induced lncRNA MALAT1-TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma
Identifieur interne : 000883 ( Main/Exploration ); précédent : 000882; suivant : 000884Dihydromyricetin induced lncRNA MALAT1-TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma
Auteurs : Miduo Tan [République populaire de Chine] ; Bin Jiang [République populaire de Chine] ; Haihua Wang [République populaire de Chine] ; Wei Ouyang [République populaire de Chine] ; Xiang Chen [République populaire de Chine] ; Taoli Wang [République populaire de Chine] ; Dan Dong [République populaire de Chine] ; Shun Yi [République populaire de Chine] ; Jiansheng Yi [République populaire de Chine] ; Yan Huang [République populaire de Chine] ; Manling Tang [République populaire de Chine] ; Yan Xiao [République populaire de Chine] ; Zuiming Jiang [République populaire de Chine] ; Wei Zhou [République populaire de Chine]Source :
- Journal of Cancer [ 1837-9664 ] ; 2019.
Abstract
Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Dihydromyricetin (DHM), a Rattan tea extract, has been shown to have antitumor activity with no obvious toxicity to normal cells in vitro and in vivo. However, its efficacy in the treatment of CSCC and the underlying antitumor mechanism has not been fully elucidated yet. In our study, DHM increased autophagic flux in the A431 cells, as evidenced by the upregulation of LC3-II and downregulation of P62/SQSTM1. Moreover, the pharmacological or genetic blocking autophagy decreased DHM-induced cell death, indicating DHM triggered autophagic cell death in A431 cells. Specifically, DHM induced TFEB(Ser142) de-phosphorylation, activated TFEB nuclear translocation and increased of TFEB reporter activity, which contributed to the expression of autophagy-related genes and subsequent initiated autophagic cell death in A431 cells. Importantly, DHM decreased lncRNA MALAT1 expression and MALAT1 overexpression abrogated the effects of DHM on TFEB-dependent autophagy both in vitro and in vivo. Taken together, DHM induces CSCC cell death via inducing excessive autophagy, which is mediated through the
Url:
DOI: 10.7150/jca.32807
PubMed: 31413743
PubMed Central: 6691703
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000646
- to stream Pmc, to step Curation: 000646
- to stream Pmc, to step Checkpoint: 000822
- to stream Ncbi, to step Merge: 000921
- to stream Ncbi, to step Curation: 000921
- to stream Ncbi, to step Checkpoint: 000921
- to stream Main, to step Merge: 000883
- to stream Main, to step Curation: 000883
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dihydromyricetin induced lncRNA MALAT1<italic>-</italic>
TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma</title>
<author><name sortKey="Tan, Miduo" sort="Tan, Miduo" uniqKey="Tan M" first="Miduo" last="Tan">Miduo Tan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Bin" sort="Jiang, Bin" uniqKey="Jiang B" first="Bin" last="Jiang">Bin Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Plastic Surgery, The Second Hospital University of South China, Hengyang, 421001, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Plastic Surgery, The Second Hospital University of South China, Hengyang, 421001</wicri:regionArea>
<wicri:noRegion>421001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Haihua" sort="Wang, Haihua" uniqKey="Wang H" first="Haihua" last="Wang">Haihua Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Burns and Plastic Surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Burns and Plastic Surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ouyang, Wei" sort="Ouyang, Wei" uniqKey="Ouyang W" first="Wei" last="Ouyang">Wei Ouyang</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Oncology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xiang" sort="Chen, Xiang" uniqKey="Chen X" first="Xiang" last="Chen">Xiang Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Taoli" sort="Wang, Taoli" uniqKey="Wang T" first="Taoli" last="Wang">Taoli Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Pathology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dong, Dan" sort="Dong, Dan" uniqKey="Dong D" first="Dan" last="Dong">Dan Dong</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Dermatology, The Second Hospital University of South China, Hengyang, 421001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Dermatology, The Second Hospital University of South China, Hengyang, 421001</wicri:regionArea>
<wicri:noRegion>421001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yi, Shun" sort="Yi, Shun" uniqKey="Yi S" first="Shun" last="Yi">Shun Yi</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Department of General surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of General surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yi, Jiansheng" sort="Yi, Jiansheng" uniqKey="Yi J" first="Jiansheng" last="Yi">Jiansheng Yi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yan" sort="Huang, Yan" uniqKey="Huang Y" first="Yan" last="Huang">Yan Huang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tang, Manling" sort="Tang, Manling" uniqKey="Tang M" first="Manling" last="Tang">Manling Tang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiao, Yan" sort="Xiao, Yan" uniqKey="Xiao Y" first="Yan" last="Xiao">Yan Xiao</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Otolaryngology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Zuiming" sort="Jiang, Zuiming" uniqKey="Jiang Z" first="Zuiming" last="Jiang">Zuiming Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31413743</idno>
<idno type="pmc">6691703</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691703</idno>
<idno type="RBID">PMC:6691703</idno>
<idno type="doi">10.7150/jca.32807</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000646</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000646</idno>
<idno type="wicri:Area/Pmc/Curation">000646</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000646</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000822</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000822</idno>
<idno type="wicri:Area/Ncbi/Merge">000921</idno>
<idno type="wicri:Area/Ncbi/Curation">000921</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000921</idno>
<idno type="wicri:Area/Main/Merge">000883</idno>
<idno type="wicri:Area/Main/Curation">000883</idno>
<idno type="wicri:Area/Main/Exploration">000883</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dihydromyricetin induced lncRNA MALAT1<italic>-</italic>
TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma</title>
<author><name sortKey="Tan, Miduo" sort="Tan, Miduo" uniqKey="Tan M" first="Miduo" last="Tan">Miduo Tan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Bin" sort="Jiang, Bin" uniqKey="Jiang B" first="Bin" last="Jiang">Bin Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Plastic Surgery, The Second Hospital University of South China, Hengyang, 421001, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Plastic Surgery, The Second Hospital University of South China, Hengyang, 421001</wicri:regionArea>
<wicri:noRegion>421001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Haihua" sort="Wang, Haihua" uniqKey="Wang H" first="Haihua" last="Wang">Haihua Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Burns and Plastic Surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Burns and Plastic Surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ouyang, Wei" sort="Ouyang, Wei" uniqKey="Ouyang W" first="Wei" last="Ouyang">Wei Ouyang</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Oncology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Oncology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xiang" sort="Chen, Xiang" uniqKey="Chen X" first="Xiang" last="Chen">Xiang Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Taoli" sort="Wang, Taoli" uniqKey="Wang T" first="Taoli" last="Wang">Taoli Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Pathology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dong, Dan" sort="Dong, Dan" uniqKey="Dong D" first="Dan" last="Dong">Dan Dong</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Dermatology, The Second Hospital University of South China, Hengyang, 421001, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Dermatology, The Second Hospital University of South China, Hengyang, 421001</wicri:regionArea>
<wicri:noRegion>421001</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yi, Shun" sort="Yi, Shun" uniqKey="Yi S" first="Shun" last="Yi">Shun Yi</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Department of General surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of General surgery, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yi, Jiansheng" sort="Yi, Jiansheng" uniqKey="Yi J" first="Jiansheng" last="Yi">Jiansheng Yi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Yan" sort="Huang, Yan" uniqKey="Huang Y" first="Yan" last="Huang">Yan Huang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tang, Manling" sort="Tang, Manling" uniqKey="Tang M" first="Manling" last="Tang">Manling Tang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiao, Yan" sort="Xiao, Yan" uniqKey="Xiao Y" first="Yan" last="Xiao">Yan Xiao</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Otolaryngology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang, Zuiming" sort="Jiang, Zuiming" uniqKey="Jiang Z" first="Zuiming" last="Jiang">Zuiming Jiang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Clinical Laboratory Center, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Surgery Department of Galactophore, The Affiliated Zhuzhou Hospital of Xiangya Medical College CSU, Zhuzhou 412000</wicri:regionArea>
<wicri:noRegion>Zhuzhou 412000</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Cancer</title>
<idno type="eISSN">1837-9664</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Dihydromyricetin (DHM), a Rattan tea extract, has been shown to have antitumor activity with no obvious toxicity to normal cells in vitro and in vivo. However, its efficacy in the treatment of CSCC and the underlying antitumor mechanism has not been fully elucidated yet. In our study, DHM increased autophagic flux in the A431 cells, as evidenced by the upregulation of LC3-II and downregulation of P62/SQSTM1. Moreover, the pharmacological or genetic blocking autophagy decreased DHM-induced cell death, indicating DHM triggered autophagic cell death in A431 cells. Specifically, DHM induced TFEB<sup>(Ser142)</sup>
de-phosphorylation, activated TFEB nuclear translocation and increased of TFEB reporter activity, which contributed to the expression of autophagy-related genes and subsequent initiated autophagic cell death in A431 cells. Importantly, DHM decreased lncRNA MALAT1 expression and MALAT1 overexpression abrogated the effects of DHM on TFEB-dependent autophagy both in vitro and in vivo. Taken together, DHM induces CSCC cell death via inducing excessive autophagy, which is mediated through the <italic>MALAT1</italic>
-TFEB pathway. Therefore, DHM may be beneficial for the development of chemotherapy for CSCC.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Green, Ac" uniqKey="Green A">AC Green</name>
</author>
<author><name sortKey="Olsen, Cm" uniqKey="Olsen C">CM Olsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hughley, Bb" uniqKey="Hughley B">BB Hughley</name>
</author>
<author><name sortKey="Schmalbach, Ce" uniqKey="Schmalbach C">CE Schmalbach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Keyal, U" uniqKey="Keyal U">U Keyal</name>
</author>
<author><name sortKey="Bhatta, Ak" uniqKey="Bhatta A">AK Bhatta</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doherty, J" uniqKey="Doherty J">J Doherty</name>
</author>
<author><name sortKey="Baehrecke, Eh" uniqKey="Baehrecke E">EH Baehrecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy, Jmm" uniqKey="Levy J">JMM Levy</name>
</author>
<author><name sortKey="Towers, Cg" uniqKey="Towers C">CG Towers</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rybstein, Md" uniqKey="Rybstein M">MD Rybstein</name>
</author>
<author><name sortKey="Bravo San Pedro, Jm" uniqKey="Bravo San Pedro J">JM Bravo-San Pedro</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name>
</author>
<author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raben, N" uniqKey="Raben N">N Raben</name>
</author>
<author><name sortKey="Puertollano, R" uniqKey="Puertollano R">R Puertollano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C Settembre</name>
</author>
<author><name sortKey="Medina, Dl" uniqKey="Medina D">DL Medina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Napolitano, G" uniqKey="Napolitano G">G Napolitano</name>
</author>
<author><name sortKey="Ballabio, A" uniqKey="Ballabio A">A Ballabio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martini Stoica, H" uniqKey="Martini Stoica H">H Martini-Stoica</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Ballabio, A" uniqKey="Ballabio A">A Ballabio</name>
</author>
<author><name sortKey="Zheng, H" uniqKey="Zheng H">H Zheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Luo, H" uniqKey="Luo H">H Luo</name>
</author>
<author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
<author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
<author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name>
</author>
<author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name>
</author>
<author><name sortKey="Sui, H" uniqKey="Sui H">H Sui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Yao, A" uniqKey="Yao A">A Yao</name>
</author>
<author><name sortKey="Liao, Q" uniqKey="Liao Q">Q Liao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kao, Sj" uniqKey="Kao S">SJ Kao</name>
</author>
<author><name sortKey="Lee, Wj" uniqKey="Lee W">WJ Lee</name>
</author>
<author><name sortKey="Chang, Jh" uniqKey="Chang J">JH Chang</name>
</author>
<author><name sortKey="Chow, Jm" uniqKey="Chow J">JM Chow</name>
</author>
<author><name sortKey="Chung, Cl" uniqKey="Chung C">CL Chung</name>
</author>
<author><name sortKey="Hung, Wy" uniqKey="Hung W">WY Hung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, Dz" uniqKey="Zhou D">DZ Zhou</name>
</author>
<author><name sortKey="Sun, Hy" uniqKey="Sun H">HY Sun</name>
</author>
<author><name sortKey="Yue, Jq" uniqKey="Yue J">JQ Yue</name>
</author>
<author><name sortKey="Peng, Y" uniqKey="Peng Y">Y Peng</name>
</author>
<author><name sortKey="Chen, Ym" uniqKey="Chen Y">YM Chen</name>
</author>
<author><name sortKey="Zhong, Zj" uniqKey="Zhong Z">ZJ Zhong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shen, F" uniqKey="Shen F">F Shen</name>
</author>
<author><name sortKey="Zheng, H" uniqKey="Zheng H">H Zheng</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, R" uniqKey="Liu R">R Liu</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Zou, L" uniqKey="Zou L">L Zou</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fan, Tf" uniqKey="Fan T">TF Fan</name>
</author>
<author><name sortKey="Wu, Tf" uniqKey="Wu T">TF Wu</name>
</author>
<author><name sortKey="Bu, Ll" uniqKey="Bu L">LL Bu</name>
</author>
<author><name sortKey="Ma, Sr" uniqKey="Ma S">SR Ma</name>
</author>
<author><name sortKey="Li, Yc" uniqKey="Li Y">YC Li</name>
</author>
<author><name sortKey="Mao, L" uniqKey="Mao L">L Mao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, B" uniqKey="Wu B">B Wu</name>
</author>
<author><name sortKey="Tan, M" uniqKey="Tan M">M Tan</name>
</author>
<author><name sortKey="Cai, W" uniqKey="Cai W">W Cai</name>
</author>
<author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name>
</author>
<author><name sortKey="He, P" uniqKey="He P">P He</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fulda, S" uniqKey="Fulda S">S Fulda</name>
</author>
<author><name sortKey="Kogel, D" uniqKey="Kogel D">D Kogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ploper, D" uniqKey="Ploper D">D Ploper</name>
</author>
<author><name sortKey="De Robertis, Em" uniqKey="De Robertis E">EM De Robertis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rehli, M" uniqKey="Rehli M">M Rehli</name>
</author>
<author><name sortKey="Lichanska, A" uniqKey="Lichanska A">A Lichanska</name>
</author>
<author><name sortKey="Cassady, Ai" uniqKey="Cassady A">AI Cassady</name>
</author>
<author><name sortKey="Ostrowski, Mc" uniqKey="Ostrowski M">MC Ostrowski</name>
</author>
<author><name sortKey="Hume, Da" uniqKey="Hume D">DA Hume</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Slade, L" uniqKey="Slade L">L Slade</name>
</author>
<author><name sortKey="Pulinilkunnil, T" uniqKey="Pulinilkunnil T">T Pulinilkunnil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chao, X" uniqKey="Chao X">X Chao</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Zhao, K" uniqKey="Zhao K">K Zhao</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Williams, Ja" uniqKey="Williams J">JA Williams</name>
</author>
<author><name sortKey="Li, T" uniqKey="Li T">T Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name>
</author>
<author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name>
</author>
<author><name sortKey="Wen, J" uniqKey="Wen J">J Wen</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
<author><name sortKey="Peng, Wx" uniqKey="Peng W">WX Peng</name>
</author>
<author><name sortKey="Mo, Yy" uniqKey="Mo Y">YY Mo</name>
</author>
<author><name sortKey="Luo, D" uniqKey="Luo D">D Luo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
<author><name sortKey="Sun, P" uniqKey="Sun P">P Sun</name>
</author>
<author><name sortKey="Zhou, Qy" uniqKey="Zhou Q">QY Zhou</name>
</author>
<author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name>
</author>
<author><name sortKey="Han, Q" uniqKey="Han Q">Q Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Cheng, H" uniqKey="Cheng H">H Cheng</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Yu, G" uniqKey="Yu G">G Yu</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Xs" uniqKey="Wu X">XS Wu</name>
</author>
<author><name sortKey="Wang, Xa" uniqKey="Wang X">XA Wang</name>
</author>
<author><name sortKey="Wu, Wg" uniqKey="Wu W">WG Wu</name>
</author>
<author><name sortKey="Hu, Yp" uniqKey="Hu Y">YP Hu</name>
</author>
<author><name sortKey="Li, Ml" uniqKey="Li M">ML Li</name>
</author>
<author><name sortKey="Ding, Q" uniqKey="Ding Q">Q Ding</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Tan, Miduo" sort="Tan, Miduo" uniqKey="Tan M" first="Miduo" last="Tan">Miduo Tan</name>
</noRegion>
<name sortKey="Chen, Xiang" sort="Chen, Xiang" uniqKey="Chen X" first="Xiang" last="Chen">Xiang Chen</name>
<name sortKey="Dong, Dan" sort="Dong, Dan" uniqKey="Dong D" first="Dan" last="Dong">Dan Dong</name>
<name sortKey="Huang, Yan" sort="Huang, Yan" uniqKey="Huang Y" first="Yan" last="Huang">Yan Huang</name>
<name sortKey="Jiang, Bin" sort="Jiang, Bin" uniqKey="Jiang B" first="Bin" last="Jiang">Bin Jiang</name>
<name sortKey="Jiang, Zuiming" sort="Jiang, Zuiming" uniqKey="Jiang Z" first="Zuiming" last="Jiang">Zuiming Jiang</name>
<name sortKey="Ouyang, Wei" sort="Ouyang, Wei" uniqKey="Ouyang W" first="Wei" last="Ouyang">Wei Ouyang</name>
<name sortKey="Tang, Manling" sort="Tang, Manling" uniqKey="Tang M" first="Manling" last="Tang">Manling Tang</name>
<name sortKey="Wang, Haihua" sort="Wang, Haihua" uniqKey="Wang H" first="Haihua" last="Wang">Haihua Wang</name>
<name sortKey="Wang, Taoli" sort="Wang, Taoli" uniqKey="Wang T" first="Taoli" last="Wang">Taoli Wang</name>
<name sortKey="Xiao, Yan" sort="Xiao, Yan" uniqKey="Xiao Y" first="Yan" last="Xiao">Yan Xiao</name>
<name sortKey="Yi, Jiansheng" sort="Yi, Jiansheng" uniqKey="Yi J" first="Jiansheng" last="Yi">Jiansheng Yi</name>
<name sortKey="Yi, Shun" sort="Yi, Shun" uniqKey="Yi S" first="Shun" last="Yi">Shun Yi</name>
<name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000883 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000883 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6691703 |texte= Dihydromyricetin induced lncRNA MALAT1-TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31413743" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |