Dl‐3n‐butylphthalide improves traumatic brain injury recovery via inhibiting autophagy‐induced blood‐brain barrier disruption and cell apoptosis
Identifieur interne : 000880 ( Main/Exploration ); précédent : 000879; suivant : 000881Dl‐3n‐butylphthalide improves traumatic brain injury recovery via inhibiting autophagy‐induced blood‐brain barrier disruption and cell apoptosis
Auteurs : Fangfang Wu ; Ke Xu ; Kebin Xu ; Chenhuai Teng ; Man Zhang ; Leilei Xia ; Kairui Zhang ; Lei Liu ; Zaifeng Chen ; Jian Xiao ; Yanqing Wu ; Hongyu Zhang ; Daqing ChenSource :
- Journal of Cellular and Molecular Medicine [ 1582-1838 ] ; 2019.
Abstract
Blood‐brain barrier (BBB) disruption and neuronal apoptosis are important pathophysiological processes after traumatic brain injury (TBI). In clinical stroke, Dl‐3n‐butylphthalide (Dl‐NBP) has a neuroprotective effect with anti‐inflammatory, anti‐oxidative, anti‐apoptotic and mitochondrion‐protective functions. However, the effect and molecular mechanism of Dl‐NBP for TBI need to be further investigated. Here, we had used an animal model of TBI and SH‐SY5Y/human brain microvascular endothelial cells to explore it. We found that Dl‐NBP administration exerts a neuroprotective effect in TBI/OGD and BBB disorder, which up‐regulates the expression of tight junction proteins and promotes neuronal survival via inhibiting mitochondrial apoptosis. The expressions of autophagy‐related proteins, including ATG7, Beclin1 and LC3II, were significantly increased after TBI/OGD, and which were reversed by Dl‐NBP treatment both in vivo and in vitro. Moreover, rapamycin treatment had abolished the effect of Dl‐NBP for TBI recovery. Collectively, our current studies indicate that Dl‐NBP treatment improved locomotor functional recovery after TBI by inhibiting the activation of autophagy and consequently blocking the junction protein loss and neuronal apoptosis. Dl‐NBP, as an anti‐inflammatory and anti‐oxidative drug, may act as an effective strategy for TBI recovery.
Url:
DOI: 10.1111/jcmm.14691
PubMed: 31840938
PubMed Central: 6991645
Affiliations:
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level="j">Journal of Cellular and Molecular Medicine</title><idno type="ISSN">1582-1838</idno><idno type="eISSN">1582-4934</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Blood‐brain barrier (BBB) disruption and neuronal apoptosis are important pathophysiological processes after traumatic brain injury (TBI). In clinical stroke, Dl‐3n‐butylphthalide (Dl‐NBP) has a neuroprotective effect with anti‐inflammatory, anti‐oxidative, anti‐apoptotic and mitochondrion‐protective functions. However, the effect and molecular mechanism of Dl‐NBP for TBI need to be further investigated. Here, we had used an animal model of TBI and SH‐SY5Y/human brain microvascular endothelial cells to explore it. We found that Dl‐NBP administration exerts a neuroprotective effect in TBI/OGD and BBB disorder, which up‐regulates the expression of tight junction proteins and promotes neuronal survival via inhibiting mitochondrial apoptosis. The expressions of autophagy‐related proteins, including ATG7, Beclin1 and LC3II, were significantly increased after TBI/OGD, and which were reversed by Dl‐NBP treatment both in vivo and in vitro. Moreover, rapamycin treatment had abolished the effect of Dl‐NBP for TBI recovery. Collectively, our current studies indicate that Dl‐NBP treatment improved locomotor functional recovery after TBI by inhibiting the activation of autophagy and consequently blocking the junction protein loss and neuronal apoptosis. Dl‐NBP, as an anti‐inflammatory and anti‐oxidative drug, may act as an effective strategy for TBI recovery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chen, Daqing" sort="Chen, Daqing" uniqKey="Chen D" first="Daqing" last="Chen">Daqing Chen</name><name sortKey="Chen, Zaifeng" sort="Chen, Zaifeng" uniqKey="Chen Z" first="Zaifeng" last="Chen">Zaifeng Chen</name><name sortKey="Liu, Lei" sort="Liu, Lei" uniqKey="Liu L" first="Lei" last="Liu">Lei Liu</name><name sortKey="Teng, Chenhuai" sort="Teng, Chenhuai" uniqKey="Teng C" first="Chenhuai" last="Teng">Chenhuai Teng</name><name sortKey="Wu, Fangfang" sort="Wu, Fangfang" uniqKey="Wu F" first="Fangfang" last="Wu">Fangfang Wu</name><name sortKey="Wu, Yanqing" sort="Wu, Yanqing" uniqKey="Wu Y" first="Yanqing" last="Wu">Yanqing Wu</name><name sortKey="Xia, Leilei" sort="Xia, Leilei" uniqKey="Xia L" first="Leilei" last="Xia">Leilei Xia</name><name sortKey="Xiao, Jian" sort="Xiao, Jian" uniqKey="Xiao J" first="Jian" last="Xiao">Jian Xiao</name><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name><name sortKey="Xu, Kebin" sort="Xu, Kebin" uniqKey="Xu K" first="Kebin" last="Xu">Kebin Xu</name><name sortKey="Zhang, Hongyu" sort="Zhang, Hongyu" uniqKey="Zhang H" first="Hongyu" last="Zhang">Hongyu Zhang</name><name sortKey="Zhang, Kairui" sort="Zhang, Kairui" uniqKey="Zhang K" first="Kairui" last="Zhang">Kairui Zhang</name><name sortKey="Zhang, Man" sort="Zhang, Man" uniqKey="Zhang M" first="Man" last="Zhang">Man Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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