Dual-targeting nanomicelles with CD133 and CD44 aptamers for enhanced delivery of gefitinib to two populations of lung cancer-initiating cells
Identifieur interne : 000869 ( Main/Exploration ); précédent : 000868; suivant : 000870Dual-targeting nanomicelles with CD133 and CD44 aptamers for enhanced delivery of gefitinib to two populations of lung cancer-initiating cells
Auteurs : Xiaolong Huang [République populaire de Chine] ; Jun Wan [République populaire de Chine] ; Dewen Leng [République populaire de Chine] ; Yingying Zhang [République populaire de Chine] ; Shuo Yang [République populaire de Chine]Source :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2019.
Abstract
Lung cancer is an aggressive type of cancer that is associated with a high mortality rate. Lung cancer-initiating cells are populations of self-renewing cancer cells with pluripotent differentiation ability. Cancers typically originate from multiple phenotypically distinct cancer-initiating cells. CD133 and CD44 are specific markers that maybe used to distinguish lung cancer-initiating cells. The ability to target a variety of subsets of cancer-initiating cells instead of targeting only one population of cancer initiating-cells has the potential to increase the cancer therapeutic efficacy. In the present study, CD133 and CD44 aptamer-conjugated nanomicelles loaded with gefitinib (CD133/CD44-NM-Gef) were developed to target CD133+ and CD44+ lung cancer-initiating cells. The therapeutic efficacy of CD133/CD44-NM-Gef against lung cancer-initiating cells was assessed by evaluating cell proliferation, tumorsphere formation and detection of CD44+ and CD133+ cells using flow cytometry. The results indicated that CD133/CD44-NM-Gef targeted CD133+ and CD44+ lung cancer-initiating cells and exhibited greater therapeutic efficacy against lung cancer-initiating cells than single-target and non-targeted nanomicelles, suggesting that CD133/CD44-NM-Gef represents a promising treatment for lung cancer by specifically targeting lung cancer-initiating cells. To the best of our knowledge, the present study was the first to report on drug delivery via nanomedicines targeted to multiple populations of cancer-initiating cells using aptamers. As cancer is typically derived from phenotypically distinct cancer-initiating cells, the nanomicelle-based multiple targeting strategy provided is promising for targeting multiple subsets of cancer-initiating cell within a tumor.
Url:
DOI: 10.3892/etm.2019.8220
PubMed: 31853290
PubMed Central: 6909660
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Wuhan No. 1 Hospital, Wuhan, Hubei 430022</wicri:regionArea><wicri:noRegion>Hubei 430022</wicri:noRegion></affiliation></author><author><name sortKey="Wan, Jun" sort="Wan, Jun" uniqKey="Wan J" first="Jun" last="Wan">Jun Wan</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-8220">Department of Respiratory Medicine, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Wuhan No. 1 Hospital, Wuhan, Hubei 430022</wicri:regionArea><wicri:noRegion>Hubei 430022</wicri:noRegion></affiliation></author><author><name sortKey="Leng, Dewen" sort="Leng, Dewen" uniqKey="Leng D" first="Dewen" last="Leng">Dewen Leng</name><affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-8220">Department of Critical Care Medicine, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Critical Care Medicine, Wuhan No. 1 Hospital, Wuhan, Hubei 430022</wicri:regionArea><wicri:noRegion>Hubei 430022</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yingying" sort="Zhang, Yingying" uniqKey="Zhang Y" first="Yingying" last="Zhang">Yingying Zhang</name><affiliation wicri:level="1"><nlm:aff id="af3-etm-0-0-8220">Department of Pharmacy, Naval Medical University, Shanghai 200433, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pharmacy, Naval Medical University, Shanghai 200433</wicri:regionArea><wicri:noRegion>Shanghai 200433</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Shuo" sort="Yang, Shuo" uniqKey="Yang S" first="Shuo" last="Yang">Shuo Yang</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-8220">Department of Respiratory Medicine, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, Wuhan No. 1 Hospital, Wuhan, Hubei 430022</wicri:regionArea><wicri:noRegion>Hubei 430022</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental and Therapeutic Medicine</title><idno type="ISSN">1792-0981</idno><idno type="eISSN">1792-1015</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lung cancer is an aggressive type of cancer that is associated with a high mortality rate. Lung cancer-initiating cells are populations of self-renewing cancer cells with pluripotent differentiation ability. Cancers typically originate from multiple phenotypically distinct cancer-initiating cells. CD133 and CD44 are specific markers that maybe used to distinguish lung cancer-initiating cells. The ability to target a variety of subsets of cancer-initiating cells instead of targeting only one population of cancer initiating-cells has the potential to increase the cancer therapeutic efficacy. In the present study, CD133 and CD44 aptamer-conjugated nanomicelles loaded with gefitinib (CD133/CD44-NM-Gef) were developed to target CD133<sup>+</sup> and CD44<sup>+</sup> lung cancer-initiating cells. The therapeutic efficacy of CD133/CD44-NM-Gef against lung cancer-initiating cells was assessed by evaluating cell proliferation, tumorsphere formation and detection of CD44<sup>+</sup> and CD133<sup>+</sup> cells using flow cytometry. The results indicated that CD133/CD44-NM-Gef targeted CD133<sup>+</sup> and CD44<sup>+</sup> lung cancer-initiating cells and exhibited greater therapeutic efficacy against lung cancer-initiating cells than single-target and non-targeted nanomicelles, suggesting that CD133/CD44-NM-Gef represents a promising treatment for lung cancer by specifically targeting lung cancer-initiating cells. To the best of our knowledge, the present study was the first to report on drug delivery via nanomedicines targeted to multiple populations of cancer-initiating cells using aptamers. As cancer is typically derived from phenotypically distinct cancer-initiating cells, the nanomicelle-based multiple targeting strategy provided is promising for targeting multiple subsets of cancer-initiating cell within a tumor.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Zheng, R" uniqKey="Zheng R">R Zheng</name></author><author><name sortKey="Baade, Pd" uniqKey="Baade P">PD Baade</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Zeng, H" uniqKey="Zeng H">H Zeng</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Yu, Xq" uniqKey="Yu X">XQ Yu</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eramo, A" uniqKey="Eramo A">A Eramo</name></author><author><name sortKey="Lotti, F" uniqKey="Lotti F">F Lotti</name></author><author><name sortKey="Sette, G" uniqKey="Sette G">G Sette</name></author><author><name sortKey="Pilozzi, E" uniqKey="Pilozzi E">E Pilozzi</name></author><author><name sortKey="Biffoni, M" uniqKey="Biffoni M">M Biffoni</name></author><author><name sortKey="Di Virgilio, A" uniqKey="Di Virgilio A">A Di Virgilio</name></author><author><name sortKey="Conticello, C" uniqKey="Conticello C">C Conticello</name></author><author><name sortKey="Ruco, L" uniqKey="Ruco L">L Ruco</name></author><author><name sortKey="Peschle, C" uniqKey="Peschle C">C Peschle</name></author><author><name sortKey="De Maria, R" uniqKey="De Maria R">R De Maria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jj" uniqKey="Kim J">JJ Kim</name></author><author><name sortKey="Tannock, If" uniqKey="Tannock I">IF Tannock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakaria, N" uniqKey="Zakaria N">N Zakaria</name></author><author><name sortKey="Satar, Na" uniqKey="Satar N">NA Satar</name></author><author><name sortKey="Abu Halim, Nh" uniqKey="Abu Halim N">NH Abu Halim</name></author><author><name sortKey="Ngalim, Sh" uniqKey="Ngalim S">SH Ngalim</name></author><author><name sortKey="Yusoff, Nm" uniqKey="Yusoff N">NM Yusoff</name></author><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author><author><name sortKey="Yahaya, Bh" uniqKey="Yahaya B">BH Yahaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bertolini, G" uniqKey="Bertolini G">G Bertolini</name></author><author><name sortKey="Roz, L" uniqKey="Roz L">L Roz</name></author><author><name sortKey="Perego, P" uniqKey="Perego P">P Perego</name></author><author><name sortKey="Tortoreto, M" uniqKey="Tortoreto M">M Tortoreto</name></author><author><name sortKey="Fontanella, E" uniqKey="Fontanella E">E Fontanella</name></author><author><name sortKey="Gatti, L" uniqKey="Gatti L">L Gatti</name></author><author><name sortKey="Pratesi, G" uniqKey="Pratesi G">G Pratesi</name></author><author><name sortKey="Fabbri, A" uniqKey="Fabbri A">A Fabbri</name></author><author><name sortKey="Andriani, F" uniqKey="Andriani F">F Andriani</name></author><author><name sortKey="Tinelli, S" uniqKey="Tinelli S">S Tinelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author><author><name sortKey="Leng, D" uniqKey="Leng D">D Leng</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author><author><name sortKey="Yao, Q" uniqKey="Yao Q">Q Yao</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name></author><author><name sortKey="Hu, J" uniqKey="Hu J">J Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Mj" uniqKey="Meyer M">MJ Meyer</name></author><author><name sortKey="Fleming, Jm" uniqKey="Fleming J">JM Fleming</name></author><author><name sortKey="Lin, Af" uniqKey="Lin A">AF Lin</name></author><author><name sortKey="Hussnain, Sa" uniqKey="Hussnain S">SA Hussnain</name></author><author><name sortKey="Ginsburg, E" uniqKey="Ginsburg E">E Ginsburg</name></author><author><name sortKey="Vonderhaar, Bk" uniqKey="Vonderhaar B">BK Vonderhaar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stewart, Jm" uniqKey="Stewart J">JM Stewart</name></author><author><name sortKey="Shaw, Pa" uniqKey="Shaw P">PA Shaw</name></author><author><name sortKey="Gedye, C" uniqKey="Gedye C">C Gedye</name></author><author><name sortKey="Bernardini, Mq" uniqKey="Bernardini M">MQ Bernardini</name></author><author><name sortKey="Neel, Bg" uniqKey="Neel B">BG Neel</name></author><author><name sortKey="Ailles, Le" uniqKey="Ailles L">LE Ailles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, El" uniqKey="Leung E">EL Leung</name></author><author><name sortKey="Fiscus, Rr" uniqKey="Fiscus R">RR Fiscus</name></author><author><name sortKey="Tung, Jw" uniqKey="Tung J">JW Tung</name></author><author><name sortKey="Tin, Vp" uniqKey="Tin V">VP Tin</name></author><author><name sortKey="Cheng, Lc" uniqKey="Cheng L">LC Cheng</name></author><author><name sortKey="Sihoe, Ad" uniqKey="Sihoe A">AD Sihoe</name></author><author><name sortKey="Fink, Lm" uniqKey="Fink L">LM Fink</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author><author><name sortKey="Wong, Mp" uniqKey="Wong M">MP Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, Rk" uniqKey="Jain R">RK Jain</name></author><author><name sortKey="Stylianopoulos, T" uniqKey="Stylianopoulos T">T Stylianopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Xia, Y" uniqKey="Xia Y">Y Xia</name></author><author><name sortKey="Meng, Y" uniqKey="Meng Y">Y Meng</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Dai, J" uniqKey="Dai J">J Dai</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name></author><author><name sortKey="Qian, W" uniqKey="Qian W">W Qian</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Ye, Z" uniqKey="Ye Z">Z Ye</name></author><author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name></author><author><name sortKey="Xia, M" uniqKey="Xia M">M Xia</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashok, B" uniqKey="Ashok B">B Ashok</name></author><author><name sortKey="Arleth, L" uniqKey="Arleth L">L Arleth</name></author><author><name sortKey="Hjelm, Rp" uniqKey="Hjelm R">RP Hjelm</name></author><author><name sortKey="Rubinstein, I" uniqKey="Rubinstein I">I Rubinstein</name></author><author><name sortKey="Onyuksel, H" uniqKey="Onyuksel H">H Onyüksel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Bj" uniqKey="Zhao B">BJ Zhao</name></author><author><name sortKey="Ke, Xy" uniqKey="Ke X">XY Ke</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Chen, Xm" uniqKey="Chen X">XM Chen</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Zhao, Bx" uniqKey="Zhao B">BX Zhao</name></author><author><name sortKey="Lu, Wl" uniqKey="Lu W">WL Lu</name></author><author><name sortKey="Lou, Jn" uniqKey="Lou J">JN Lou</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mao, X" uniqKey="Mao X">X Mao</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Gong, Z" uniqKey="Gong Z">Z Gong</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Zou, H" uniqKey="Zou H">H Zou</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Sun, Z" uniqKey="Sun Z">Z Sun</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cushing, Bl" uniqKey="Cushing B">BL Cushing</name></author><author><name sortKey="Kolesnichenko, Vl" uniqKey="Kolesnichenko V">VL Kolesnichenko</name></author><author><name sortKey="O Connor, Cj" uniqKey="O Connor C">CJ O'Connor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Ochyl, Lj" uniqKey="Ochyl L">LJ Ochyl</name></author><author><name sortKey="Yang, E" uniqKey="Yang E">E Yang</name></author><author><name sortKey="Moon, Jj" uniqKey="Moon J">JJ Moon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Song, H" uniqKey="Song H">H Song</name></author><author><name sortKey="Su, X" uniqKey="Su X">X Su</name></author><author><name sortKey="Niu, F" uniqKey="Niu F">F Niu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Dai, J" uniqKey="Dai J">J Dai</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Passiglia, F" uniqKey="Passiglia F">F Passiglia</name></author><author><name sortKey="Listi, A" uniqKey="Listi A">A Listì</name></author><author><name sortKey="Castiglia, M" uniqKey="Castiglia M">M Castiglia</name></author><author><name sortKey="Perez, A" uniqKey="Perez A">A Perez</name></author><author><name sortKey="Rizzo, S" uniqKey="Rizzo S">S Rizzo</name></author><author><name sortKey="Bazan, V" uniqKey="Bazan V">V Bazan</name></author><author><name sortKey="Russo, A" uniqKey="Russo A">A Russo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Ew" uniqKey="Ng E">EW Ng</name></author><author><name sortKey="Shima, Dt" uniqKey="Shima D">DT Shima</name></author><author><name sortKey="Calias, P" uniqKey="Calias P">P Calias</name></author><author><name sortKey="Cunningham, Et" uniqKey="Cunningham E">ET Cunningham</name></author><author><name sortKey="Guyer, Dr" uniqKey="Guyer D">DR Guyer</name></author><author><name sortKey="Adamis, Ap" uniqKey="Adamis A">AP Adamis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Feng, Ss" uniqKey="Feng S">SS Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gong, Z" uniqKey="Gong Z">Z Gong</name></author><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name></author><author><name sortKey="Xie, F" uniqKey="Xie F">F Xie</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Zou, H" uniqKey="Zou H">H Zou</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Sun, Z" uniqKey="Sun Z">Z Sun</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, F" uniqKey="Xie F">F Xie</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Gong, Z" uniqKey="Gong Z">Z Gong</name></author><author><name sortKey="Yang, K" uniqKey="Yang K">K Yang</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Zou, H" uniqKey="Zou H">H Zou</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Xie, F" uniqKey="Xie F">F Xie</name></author><author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Zou, H" uniqKey="Zou H">H Zou</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naujokat, C" uniqKey="Naujokat C">C Naujokat</name></author><author><name sortKey="Steinhart, R" uniqKey="Steinhart R">R Steinhart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Feng, Ss" uniqKey="Feng S">SS Feng</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mamot, C" uniqKey="Mamot C">C Mamot</name></author><author><name sortKey="Ritschard, R" uniqKey="Ritschard R">R Ritschard</name></author><author><name sortKey="Wicki, A" uniqKey="Wicki A">A Wicki</name></author><author><name sortKey="Stehle, G" uniqKey="Stehle G">G Stehle</name></author><author><name sortKey="Dieterle, T" uniqKey="Dieterle T">T Dieterle</name></author><author><name sortKey="Bubendorf, L" uniqKey="Bubendorf L">L Bubendorf</name></author><author><name sortKey="Hilker, C" uniqKey="Hilker C">C Hilker</name></author><author><name sortKey="Deuster, S" uniqKey="Deuster S">S Deuster</name></author><author><name sortKey="Herrmann, R" uniqKey="Herrmann R">R Herrmann</name></author><author><name sortKey="Rochlitz, C" uniqKey="Rochlitz C">C Rochlitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, K" uniqKey="Miller K">K Miller</name></author><author><name sortKey="Cortes, J" uniqKey="Cortes J">J Cortes</name></author><author><name sortKey="Hurvitz, Sa" uniqKey="Hurvitz S">SA Hurvitz</name></author><author><name sortKey="Krop, Ie" uniqKey="Krop I">IE Krop</name></author><author><name sortKey="Tripathy, D" uniqKey="Tripathy D">D Tripathy</name></author><author><name sortKey="Verma, S" uniqKey="Verma S">S Verma</name></author><author><name sortKey="Riahi, K" uniqKey="Riahi K">K Riahi</name></author><author><name sortKey="Reynolds, Jg" uniqKey="Reynolds J">JG Reynolds</name></author><author><name sortKey="Wickham, Tj" uniqKey="Wickham T">TJ Wickham</name></author><author><name sortKey="Molnar, I" uniqKey="Molnar I">I Molnar</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Xiaolong" sort="Huang, Xiaolong" uniqKey="Huang X" first="Xiaolong" last="Huang">Xiaolong Huang</name></noRegion><name sortKey="Leng, Dewen" sort="Leng, Dewen" uniqKey="Leng D" first="Dewen" last="Leng">Dewen Leng</name><name sortKey="Wan, Jun" sort="Wan, Jun" uniqKey="Wan J" first="Jun" last="Wan">Jun Wan</name><name sortKey="Yang, Shuo" sort="Yang, Shuo" uniqKey="Yang S" first="Shuo" last="Yang">Shuo Yang</name><name sortKey="Zhang, Yingying" sort="Zhang, Yingying" uniqKey="Zhang Y" first="Yingying" 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