Efficacy of immunosuppressants with bridge vasodilator therapy in severe lupus erythematosus‐associated pulmonary arterial hypertension
Identifieur interne : 000851 ( Main/Exploration ); précédent : 000850; suivant : 000852Efficacy of immunosuppressants with bridge vasodilator therapy in severe lupus erythematosus‐associated pulmonary arterial hypertension
Auteurs : Sébastien Sanges ; Laurent Savale ; Nicolas Lamblin ; Martine Rémy-Jardin ; Marc Humbert ; Vincent SobanskiSource :
- ESC Heart Failure [ 2055-5822 ] ; 2019.
Abstract
Optimal management of
Url:
DOI: 10.1002/ehf2.12507
PubMed: 31536678
PubMed Central: 6989275
Affiliations:
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id="ehf212507-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Lamblin, Nicolas" sort="Lamblin, Nicolas" uniqKey="Lamblin N" first="Nicolas" last="Lamblin">Nicolas Lamblin</name><affiliation><nlm:aff id="ehf212507-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Remy Ardin, Martine" sort="Remy Ardin, Martine" uniqKey="Remy Ardin M" first="Martine" last="Rémy-Jardin">Martine Rémy-Jardin</name><affiliation><nlm:aff id="ehf212507-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><affiliation><nlm:aff id="ehf212507-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Sobanski, Vincent" sort="Sobanski, Vincent" uniqKey="Sobanski V" first="Vincent" last="Sobanski">Vincent Sobanski</name><affiliation><nlm:aff id="ehf212507-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0005"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31536678</idno><idno type="pmc">6989275</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989275</idno><idno type="RBID">PMC:6989275</idno><idno type="doi">10.1002/ehf2.12507</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000292</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000292</idno><idno type="wicri:Area/Pmc/Curation">000292</idno><idno type="wicri:explorRef" wicri:stream="Pmc" 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id="ehf212507-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name><affiliation><nlm:aff id="ehf212507-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Lamblin, Nicolas" sort="Lamblin, Nicolas" uniqKey="Lamblin N" first="Nicolas" last="Lamblin">Nicolas Lamblin</name><affiliation><nlm:aff id="ehf212507-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Remy Ardin, Martine" sort="Remy Ardin, Martine" uniqKey="Remy Ardin M" first="Martine" last="Rémy-Jardin">Martine Rémy-Jardin</name><affiliation><nlm:aff id="ehf212507-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><affiliation><nlm:aff id="ehf212507-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0007"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Sobanski, Vincent" sort="Sobanski, Vincent" uniqKey="Sobanski V" first="Vincent" last="Sobanski">Vincent Sobanski</name><affiliation><nlm:aff id="ehf212507-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0004"></nlm:aff></affiliation><affiliation><nlm:aff id="ehf212507-aff-0005"></nlm:aff></affiliation></author></analytic><series><title level="j">ESC Heart Failure</title><idno type="eISSN">2055-5822</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Optimal management of <italic>systemic lupus erythematosus</italic> (SLE)‐associated pulmonary arterial hypertension (PAH) remains unclear. Our observation describes the case of a 31‐year‐old SLE patient presenting with cardiogenic shock revealing severe PAH, in which a therapeutic scheme combining immunosuppressants (pulse cyclophosphamide and corticosteroids) and PAH‐specific drugs (bosentan, tadalafil, and epoprostenol) led to a complete normalization of pulmonary haemodynamics and allowed a progressive weaning of PAH vasodilators. This case report supports the efficacy of immunosuppressants and use of PAH‐specific therapy as a bridge therapy in severe SLE‐PAH. Further studies on larger population are required to confirm these findings.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><name sortKey="Lamblin, Nicolas" sort="Lamblin, Nicolas" uniqKey="Lamblin N" first="Nicolas" last="Lamblin">Nicolas Lamblin</name><name sortKey="Remy Ardin, Martine" sort="Remy Ardin, Martine" uniqKey="Remy Ardin M" first="Martine" last="Rémy-Jardin">Martine Rémy-Jardin</name><name sortKey="Sanges, Sebastien" sort="Sanges, Sebastien" uniqKey="Sanges S" first="Sébastien" last="Sanges">Sébastien Sanges</name><name sortKey="Savale, Laurent" sort="Savale, Laurent" uniqKey="Savale L" first="Laurent" last="Savale">Laurent Savale</name><name sortKey="Sobanski, Vincent" sort="Sobanski, Vincent" uniqKey="Sobanski V" first="Vincent" last="Sobanski">Vincent Sobanski</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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