Efficacy of subcutaneous tocilizumab in patients with rheumatoid arthritis and systemic sclerosis overlap syndrome: a report of two cases and review of the literature
Identifieur interne : 000849 ( Main/Exploration ); précédent : 000848; suivant : 000850Efficacy of subcutaneous tocilizumab in patients with rheumatoid arthritis and systemic sclerosis overlap syndrome: a report of two cases and review of the literature
Auteurs : Hiroki Wakabayashi ; Hitoshi Kino ; Makoto Kondo ; Keiichi Yamanaka ; Masahiro Hasegawa ; Akihiro SudoSource :
- BMC Rheumatology [ 2520-1026 ] ; 2019.
Abstract
The details of two rheumatoid arthritis (RA) patients with systemic sclerosis (SSc) who were administered tocilizumab, an anti-interleukin-6 receptor antibody, are reported, along with a review of the literature.
Two RA patients with SSc with inadequate responses to disease-modifying antirheumatic drugs (DMARDs) were given tocilizumab 162 mg every 2 weeks for 18 months. RA disease activity was evaluated by the 28-joint disease activity score with erythrocyte sedimentation rate (DAS28-ESR) and the clinical disease activity index (CDAI). The skin condition of SSc was evaluated by pinching the skin according to the modified Rodnan total skin thickness score (mRSS). Softening of the skin and improvements of arthritis and the patient global assessment were observed during tocilizumab treatment, with reduction of not only RA disease activity, but also of the mRSS.
Tocilizumab may be effective in patients with RA and SSc overlap syndrome for which conventional treatment is inadequate. Further research is needed because this report included only two patients.
Url:
DOI: 10.1186/s41927-019-0063-x
PubMed: 31049490
PubMed Central: 6480678
Affiliations:
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syndrome: a report of two cases and review of the literature</title><author><name sortKey="Wakabayashi, Hiroki" sort="Wakabayashi, Hiroki" uniqKey="Wakabayashi H" first="Hiroki" last="Wakabayashi">Hiroki Wakabayashi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0372 555X</institution-id><institution-id institution-id-type="GRID">grid.260026.0</institution-id><institution>Department of Orthopaedic Surgery,</institution><institution>Mie University Graduate School of Medicine,</institution></institution-wrap>2-174 Edobashi, Tsu, Mie 514-8507 Japan</nlm:aff><wicri:noCountry code="subfield">Mie 514-8507 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Kino, Hitoshi" sort="Kino, Hitoshi" uniqKey="Kino H" first="Hitoshi" last="Kino">Hitoshi Kino</name><affiliation><nlm:aff id="Aff2">Kino Orthopedic Clinic, 4-1-7 Kikyogaoka, Nabari, Mie 518-0624 Japan</nlm:aff><wicri:noCountry code="subfield">Mie 518-0624 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Kondo, Makoto" sort="Kondo, Makoto" uniqKey="Kondo M" first="Makoto" last="Kondo">Makoto Kondo</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0372 555X</institution-id><institution-id institution-id-type="GRID">grid.260026.0</institution-id><institution>Department of Dermatology,</institution><institution>Mie University Graduate School of Medicine,</institution></institution-wrap>2-174 Edobashi, Tsu, Mie 514-8507 Japan</nlm:aff><wicri:noCountry code="subfield">Mie 514-8507 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Yamanaka, Keiichi" sort="Yamanaka, Keiichi" uniqKey="Yamanaka K" first="Keiichi" last="Yamanaka">Keiichi Yamanaka</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0372 555X</institution-id><institution-id institution-id-type="GRID">grid.260026.0</institution-id><institution>Department of Dermatology,</institution><institution>Mie University Graduate School of Medicine,</institution></institution-wrap>2-174 Edobashi, Tsu, Mie 514-8507 Japan</nlm:aff><wicri:noCountry code="subfield">Mie 514-8507 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Hasegawa, Masahiro" sort="Hasegawa, Masahiro" uniqKey="Hasegawa M" first="Masahiro" last="Hasegawa">Masahiro Hasegawa</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0372 555X</institution-id><institution-id institution-id-type="GRID">grid.260026.0</institution-id><institution>Department of Orthopaedic Surgery,</institution><institution>Mie University Graduate School of Medicine,</institution></institution-wrap>2-174 Edobashi, Tsu, Mie 514-8507 Japan</nlm:aff><wicri:noCountry code="subfield">Mie 514-8507 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Sudo, Akihiro" sort="Sudo, Akihiro" uniqKey="Sudo A" first="Akihiro" last="Sudo">Akihiro Sudo</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0372 555X</institution-id><institution-id institution-id-type="GRID">grid.260026.0</institution-id><institution>Department of Orthopaedic Surgery,</institution><institution>Mie University Graduate School of Medicine,</institution></institution-wrap>2-174 Edobashi, Tsu, Mie 514-8507 Japan</nlm:aff><wicri:noCountry code="subfield">Mie 514-8507 Japan</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Rheumatology</title><idno type="eISSN">2520-1026</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">The details of two rheumatoid arthritis (RA) patients with systemic sclerosis (SSc) who were administered tocilizumab, an anti-interleukin-6 receptor antibody, are reported, along with a review of the literature.</p></sec><sec><title>Case presentation</title><p id="Par2">Two RA patients with SSc with inadequate responses to disease-modifying antirheumatic drugs (DMARDs) were given tocilizumab 162 mg every 2 weeks for 18 months. RA disease activity was evaluated by the 28-joint disease activity score with erythrocyte sedimentation rate (DAS28-ESR) and the clinical disease activity index (CDAI). The skin condition of SSc was evaluated by pinching the skin according to the modified Rodnan total skin thickness score (mRSS). Softening of the skin and improvements of arthritis and the patient global assessment were observed during tocilizumab treatment, with reduction of not only RA disease activity, but also of the mRSS.</p></sec><sec><title>Conclusion</title><p id="Par3">Tocilizumab may be effective in patients with RA and SSc overlap syndrome for which conventional treatment is inadequate. Further research is needed because this report included only two patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barsotti, S" uniqKey="Barsotti S">S Barsotti</name></author><author><name sortKey="Stagnaro, C" uniqKey="Stagnaro C">C Stagnaro</name></author><author><name sortKey="Della Rossa, A" uniqKey="Della Rossa A">A Della Rossa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubio Rivas, M" uniqKey="Rubio Rivas M">M Rubio-Rivas</name></author><author><name sortKey="Corbella, X" uniqKey="Corbella X">X Corbella</name></author><author><name sortKey="Pesta A Fernandez, M" uniqKey="Pesta A Fernandez M">M Pestaña-Fernández</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mihai, C" uniqKey="Mihai C">C Mihai</name></author><author><name sortKey="Antic, M" uniqKey="Antic M">M Antic</name></author><author><name sortKey="Dobrota, R" uniqKey="Dobrota 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Atsumi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hasegawa, Masahiro" sort="Hasegawa, Masahiro" uniqKey="Hasegawa M" first="Masahiro" last="Hasegawa">Masahiro Hasegawa</name><name sortKey="Kino, Hitoshi" sort="Kino, Hitoshi" uniqKey="Kino H" first="Hitoshi" last="Kino">Hitoshi Kino</name><name sortKey="Kondo, Makoto" sort="Kondo, Makoto" uniqKey="Kondo M" first="Makoto" last="Kondo">Makoto Kondo</name><name sortKey="Sudo, Akihiro" sort="Sudo, Akihiro" uniqKey="Sudo A" first="Akihiro" last="Sudo">Akihiro Sudo</name><name sortKey="Wakabayashi, Hiroki" sort="Wakabayashi, Hiroki" uniqKey="Wakabayashi H" first="Hiroki" last="Wakabayashi">Hiroki Wakabayashi</name><name sortKey="Yamanaka, Keiichi" sort="Yamanaka, Keiichi" uniqKey="Yamanaka K" first="Keiichi" last="Yamanaka">Keiichi Yamanaka</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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