Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
Identifieur interne : 000815 ( Main/Exploration ); précédent : 000814; suivant : 000816Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for Cancer Therapy
Auteurs : Zhi-Zhou Shi [République populaire de Chine] ; Ze-Wen Fan [République populaire de Chine] ; Yun-Xia Chen [République populaire de Chine] ; Xiu-Feng Xie [République populaire de Chine] ; Wen Jiang [République populaire de Chine] ; Wen-Jun Wang [République populaire de Chine] ; Yun-Tan Qiu [République populaire de Chine] ; Jie Bai [République populaire de Chine]Source :
- OncoTargets and therapy [ 1178-6930 ] ; 2019.
Abstract
Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.
Url:
DOI: 10.2147/OTT.S232852
PubMed: 31908494
PubMed Central: 6927606
Affiliations:
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Z" first="Ze-Wen" last="Fan">Ze-Wen Fan</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Medical School, Kunming University of Science and Technology</institution>,<addr-line>Kunming</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Yun Xia" sort="Chen, Yun Xia" uniqKey="Chen Y" first="Yun-Xia" last="Chen">Yun-Xia Chen</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Medical School, Kunming University of Science and Technology</institution>,<addr-line>Kunming</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Xiu Feng" sort="Xie, Xiu Feng" uniqKey="Xie X" 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W" first="Wen-Jun" last="Wang">Wen-Jun Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Medical School, Kunming University of Science and Technology</institution>,<addr-line>Kunming</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qiu, Yun Tan" sort="Qiu, Yun Tan" uniqKey="Qiu Y" first="Yun-Tan" last="Qiu">Yun-Tan Qiu</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Medical School, Kunming University of Science and Technology</institution>,<addr-line>Kunming</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bai, Jie" sort="Bai, Jie" uniqKey="Bai J" first="Jie" last="Bai">Jie Bai</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Medical School, Kunming University of Science and Technology</institution>,<addr-line>Kunming</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">OncoTargets and therapy</title><idno type="eISSN">1178-6930</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Ferroptosis is a new form of programmed cell death with characteristic accumulation of reactive oxygen species (ROS) resulting from iron accumulation and lipid peroxidation. Ferroptosis is involved in many diseases, including cancer, and induction of ferroptosis has shown attractive antitumour activities. In this review, we summarize recent findings on the regulatory mechanisms of key regulators of ferroptosis, including the catalytic subunit solute carrier family 7 member 11 (SLC7A11), the glutathione peroxidase 4 (GPX4), p53 and non-coding RNAs, the correlations between ferroptosis and iron homeostasis or autophagy, ferroptosis-inducing agents and nanomaterials and the diagnostic and prognostic value of ferroptosis-associated genes in TCGA data.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Shi, Zhi Zhou" sort="Shi, Zhi Zhou" uniqKey="Shi Z" first="Zhi-Zhou" last="Shi">Zhi-Zhou Shi</name></noRegion><name sortKey="Bai, Jie" sort="Bai, Jie" uniqKey="Bai J" first="Jie" last="Bai">Jie Bai</name><name sortKey="Chen, Yun Xia" sort="Chen, Yun Xia" uniqKey="Chen Y" first="Yun-Xia" last="Chen">Yun-Xia Chen</name><name sortKey="Fan, Ze Wen" sort="Fan, Ze Wen" uniqKey="Fan Z" first="Ze-Wen" last="Fan">Ze-Wen Fan</name><name sortKey="Jiang, Wen" sort="Jiang, Wen" uniqKey="Jiang W" first="Wen" last="Jiang">Wen Jiang</name><name sortKey="Qiu, Yun Tan" sort="Qiu, Yun Tan" uniqKey="Qiu Y" first="Yun-Tan" last="Qiu">Yun-Tan Qiu</name><name sortKey="Wang, Wen Jun" sort="Wang, Wen Jun" uniqKey="Wang W" first="Wen-Jun" last="Wang">Wen-Jun Wang</name><name sortKey="Xie, Xiu Feng" sort="Xie, Xiu Feng" uniqKey="Xie X" first="Xiu-Feng" last="Xie">Xiu-Feng Xie</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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