Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor
Identifieur interne : 000735 ( Main/Exploration ); précédent : 000734; suivant : 000736Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor
Auteurs : Chang-Fang Chiu [Taïwan] ; Hsien-Kuo Chin [Taïwan] ; Wei-Jan Huang ; Li-Yuan Bai [Taïwan] ; Hao-Yu Huang [Taïwan] ; Jing-Ru Weng [Taïwan]Source :
- Biomolecules [ 2218-273X ] ; 2019.
Abstract
Epigenetic therapy has been demonstrated to be a viable strategy for breast cancer treatment. In this study, we report the anti-tumor activity of a hydroxamate-based histone deacetylase (HDAC)8-selective inhibitor, HMC, in breast cancer cells. MTT assays showed that HMC inhibited cell viability of MCF-7 and MDA-MB-231 cells with IC50 values of 7.7 μM and 9.5 μM, respectively. HMC induced caspase-dependent apoptosis in MCF-7 cells, which was associated with its ability to modulate a series of cell survival-related signaling effectors, including Akt, mTOR, Bax, Mcl-1, and Bcl-2. Additionally, HMC was capable of activating PPARγ, which was accompanied by reduced expression of PPARγ target gene products, such as cyclin D1 and CDK6. HMC increased the production of ROS in MCF-7 cells, which could be partially reversed by the cotreatment with a ROS scavenger (
Url:
DOI: 10.3390/biom9120824
PubMed: 31817161
PubMed Central: 6995545
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000429
- to stream Pmc, to step Curation: 000429
- to stream Pmc, to step Checkpoint: 000680
- to stream Ncbi, to step Merge: 000D04
- to stream Ncbi, to step Curation: 000D04
- to stream Ncbi, to step Checkpoint: 000D04
- to stream Main, to step Merge: 000735
- to stream Main, to step Curation: 000735
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor</title>
<author><name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name>
<affiliation><nlm:aff id="af1-biomolecules-09-00824">Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan;<email>d5686@mail.cmuh.org.tw</email>
(C.-F.C.);<email>lybai6@gmail.com</email>
(L.-Y.B.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-09-00824">Cancer Center, China Medical University Hospital, Taichung 40415, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Cancer Center, China Medical University Hospital, Taichung 40415</wicri:regionArea>
<wicri:noRegion>Taichung 40415</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-biomolecules-09-00824">College of Medicine, China Medical University, Taichung 40402, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>College of Medicine, China Medical University, Taichung 40402</wicri:regionArea>
<wicri:noRegion>Taichung 40402</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chin, Hsien Kuo" sort="Chin, Hsien Kuo" uniqKey="Chin H" first="Hsien-Kuo" last="Chin">Hsien-Kuo Chin</name>
<affiliation><nlm:aff id="af4-biomolecules-09-00824">Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan;<email>cvschin@gmail.com</email>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-biomolecules-09-00824">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Wei Jan" sort="Huang, Wei Jan" uniqKey="Huang W" first="Wei-Jan" last="Huang">Wei-Jan Huang</name>
<affiliation><nlm:aff id="af6-biomolecules-09-00824">Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan;<email>wjhuang@tmu.edu.tw</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bai, Li Yuan" sort="Bai, Li Yuan" uniqKey="Bai L" first="Li-Yuan" last="Bai">Li-Yuan Bai</name>
<affiliation><nlm:aff id="af1-biomolecules-09-00824">Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan;<email>d5686@mail.cmuh.org.tw</email>
(C.-F.C.);<email>lybai6@gmail.com</email>
(L.-Y.B.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-biomolecules-09-00824">College of Medicine, China Medical University, Taichung 40402, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>College of Medicine, China Medical University, Taichung 40402</wicri:regionArea>
<wicri:noRegion>Taichung 40402</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Hao Yu" sort="Huang, Hao Yu" uniqKey="Huang H" first="Hao-Yu" last="Huang">Hao-Yu Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af5-biomolecules-09-00824">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name>
<affiliation wicri:level="1"><nlm:aff id="af5-biomolecules-09-00824">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="af6-biomolecules-09-00824">Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan;<email>wjhuang@tmu.edu.tw</email>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af7-biomolecules-09-00824">Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af8-biomolecules-09-00824">Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80715, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80715</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80715</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31817161</idno>
<idno type="pmc">6995545</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995545</idno>
<idno type="RBID">PMC:6995545</idno>
<idno type="doi">10.3390/biom9120824</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000429</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000429</idno>
<idno type="wicri:Area/Pmc/Curation">000429</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000429</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000680</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000680</idno>
<idno type="wicri:Area/Ncbi/Merge">000D04</idno>
<idno type="wicri:Area/Ncbi/Curation">000D04</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D04</idno>
<idno type="wicri:Area/Main/Merge">000735</idno>
<idno type="wicri:Area/Main/Curation">000735</idno>
<idno type="wicri:Area/Main/Exploration">000735</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor</title>
<author><name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name>
<affiliation><nlm:aff id="af1-biomolecules-09-00824">Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan;<email>d5686@mail.cmuh.org.tw</email>
(C.-F.C.);<email>lybai6@gmail.com</email>
(L.-Y.B.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-biomolecules-09-00824">Cancer Center, China Medical University Hospital, Taichung 40415, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Cancer Center, China Medical University Hospital, Taichung 40415</wicri:regionArea>
<wicri:noRegion>Taichung 40415</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-biomolecules-09-00824">College of Medicine, China Medical University, Taichung 40402, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>College of Medicine, China Medical University, Taichung 40402</wicri:regionArea>
<wicri:noRegion>Taichung 40402</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chin, Hsien Kuo" sort="Chin, Hsien Kuo" uniqKey="Chin H" first="Hsien-Kuo" last="Chin">Hsien-Kuo Chin</name>
<affiliation><nlm:aff id="af4-biomolecules-09-00824">Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan;<email>cvschin@gmail.com</email>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-biomolecules-09-00824">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Wei Jan" sort="Huang, Wei Jan" uniqKey="Huang W" first="Wei-Jan" last="Huang">Wei-Jan Huang</name>
<affiliation><nlm:aff id="af6-biomolecules-09-00824">Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan;<email>wjhuang@tmu.edu.tw</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bai, Li Yuan" sort="Bai, Li Yuan" uniqKey="Bai L" first="Li-Yuan" last="Bai">Li-Yuan Bai</name>
<affiliation><nlm:aff id="af1-biomolecules-09-00824">Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan;<email>d5686@mail.cmuh.org.tw</email>
(C.-F.C.);<email>lybai6@gmail.com</email>
(L.-Y.B.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-biomolecules-09-00824">College of Medicine, China Medical University, Taichung 40402, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>College of Medicine, China Medical University, Taichung 40402</wicri:regionArea>
<wicri:noRegion>Taichung 40402</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Hao Yu" sort="Huang, Hao Yu" uniqKey="Huang H" first="Hao-Yu" last="Huang">Hao-Yu Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af5-biomolecules-09-00824">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name>
<affiliation wicri:level="1"><nlm:aff id="af5-biomolecules-09-00824">Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="af6-biomolecules-09-00824">Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan;<email>wjhuang@tmu.edu.tw</email>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af7-biomolecules-09-00824">Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80424</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af8-biomolecules-09-00824">Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80715, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80715</wicri:regionArea>
<wicri:noRegion>Kaohsiung 80715</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Biomolecules</title>
<idno type="eISSN">2218-273X</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Epigenetic therapy has been demonstrated to be a viable strategy for breast cancer treatment. In this study, we report the anti-tumor activity of a hydroxamate-based histone deacetylase (HDAC)8-selective inhibitor, HMC, in breast cancer cells. MTT assays showed that HMC inhibited cell viability of MCF-7 and MDA-MB-231 cells with IC<sub>50</sub>
values of 7.7 μM and 9.5 μM, respectively. HMC induced caspase-dependent apoptosis in MCF-7 cells, which was associated with its ability to modulate a series of cell survival-related signaling effectors, including Akt, mTOR, Bax, Mcl-1, and Bcl-2. Additionally, HMC was capable of activating PPARγ, which was accompanied by reduced expression of PPARγ target gene products, such as cyclin D1 and CDK6. HMC increased the production of ROS in MCF-7 cells, which could be partially reversed by the cotreatment with a ROS scavenger (<italic>N</italic>
-acetylcysteine or glutathione). Furthermore, HMC induced autophagy, as characterized by the formation of acidic vesicular organelles and autophagic biomarkers including LC3B-II and Atg5. Notably, pharmacological blockade of autophagy by 3-MA or CQ could attenuate HMC-induced apoptosis, suggesting that autophagy played a self-protective role in HMC-induced cell death. Together, these data suggest the translational potential of HMC to be developed into a potential therapeutic agent for breast cancer therapy.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name>
</author>
<author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J. Ferlay</name>
</author>
<author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I. Soerjomataram</name>
</author>
<author><name sortKey="Siegel, R L" uniqKey="Siegel R">R.L. Siegel</name>
</author>
<author><name sortKey="Torre, L A" uniqKey="Torre L">L.A. Torre</name>
</author>
<author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ziegler, R G" uniqKey="Ziegler R">R.G. Ziegler</name>
</author>
<author><name sortKey="Hoover, R N" uniqKey="Hoover R">R.N. Hoover</name>
</author>
<author><name sortKey="Pike, M C" uniqKey="Pike M">M.C. Pike</name>
</author>
<author><name sortKey="Hildesheim, A" uniqKey="Hildesheim A">A. Hildesheim</name>
</author>
<author><name sortKey="Nomura, A M" uniqKey="Nomura A">A.M. Nomura</name>
</author>
<author><name sortKey="West, D W" uniqKey="West D">D.W. West</name>
</author>
<author><name sortKey="Wu Williams, A H" uniqKey="Wu Williams A">A.H. Wu-Williams</name>
</author>
<author><name sortKey="Kolonel, L N" uniqKey="Kolonel L">L.N. Kolonel</name>
</author>
<author><name sortKey="Horn Ross, P L" uniqKey="Horn Ross P">P.L. Horn-Ross</name>
</author>
<author><name sortKey="Rosenthal, J F" uniqKey="Rosenthal J">J.F. Rosenthal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hurvitz, S A" uniqKey="Hurvitz S">S.A. Hurvitz</name>
</author>
<author><name sortKey="Dalenc, F" uniqKey="Dalenc F">F. Dalenc</name>
</author>
<author><name sortKey="Campone, M" uniqKey="Campone M">M. Campone</name>
</author>
<author><name sortKey="O Egan, R M" uniqKey="O Egan R">R.M. O’Regan</name>
</author>
<author><name sortKey="Tjan Heijnen, V C" uniqKey="Tjan Heijnen V">V.C. Tjan-Heijnen</name>
</author>
<author><name sortKey="Gligorov, J" uniqKey="Gligorov J">J. Gligorov</name>
</author>
<author><name sortKey="Llombart, A" uniqKey="Llombart A">A. Llombart</name>
</author>
<author><name sortKey="Jhangiani, H" uniqKey="Jhangiani H">H. Jhangiani</name>
</author>
<author><name sortKey="Mirshahidi, H R" uniqKey="Mirshahidi H">H.R. Mirshahidi</name>
</author>
<author><name sortKey="Tan Chiu, E" uniqKey="Tan Chiu E">E. Tan-Chiu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cress, W D" uniqKey="Cress W">W.D. Cress</name>
</author>
<author><name sortKey="Seto, E" uniqKey="Seto E">E. Seto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, J" uniqKey="Tang J">J. Tang</name>
</author>
<author><name sortKey="Yan, H" uniqKey="Yan H">H. Yan</name>
</author>
<author><name sortKey="Zhuang, S" uniqKey="Zhuang S">S. Zhuang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pan, L N" uniqKey="Pan L">L.N. Pan</name>
</author>
<author><name sortKey="Lu, J" uniqKey="Lu J">J. Lu</name>
</author>
<author><name sortKey="Huang, B" uniqKey="Huang B">B. Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Witt, O" uniqKey="Witt O">O. Witt</name>
</author>
<author><name sortKey="Milde, T" uniqKey="Milde T">T. Milde</name>
</author>
<author><name sortKey="Deubzer, H E" uniqKey="Deubzer H">H.E. Deubzer</name>
</author>
<author><name sortKey="Oehme, I" uniqKey="Oehme I">I. Oehme</name>
</author>
<author><name sortKey="Witt, R" uniqKey="Witt R">R. Witt</name>
</author>
<author><name sortKey="Kulozik, A" uniqKey="Kulozik A">A. Kulozik</name>
</author>
<author><name sortKey="Eisenmenger, A" uniqKey="Eisenmenger A">A. Eisenmenger</name>
</author>
<author><name sortKey="Abel, U" uniqKey="Abel U">U. Abel</name>
</author>
<author><name sortKey="Karapanagiotou Schenkel, I" uniqKey="Karapanagiotou Schenkel I">I. Karapanagiotou-Schenkel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Campanella, C" uniqKey="Campanella C">C. Campanella</name>
</author>
<author><name sortKey="D Nneo, A" uniqKey="D Nneo A">A. D’Anneo</name>
</author>
<author><name sortKey="Marino Gammazza, A" uniqKey="Marino Gammazza A">A. Marino Gammazza</name>
</author>
<author><name sortKey="Caruso Bavisotto, C" uniqKey="Caruso Bavisotto C">C. Caruso Bavisotto</name>
</author>
<author><name sortKey="Barone, R" uniqKey="Barone R">R. Barone</name>
</author>
<author><name sortKey="Emanuele, S" uniqKey="Emanuele S">S. Emanuele</name>
</author>
<author><name sortKey="Lo Cascio, F" uniqKey="Lo Cascio F">F. Lo Cascio</name>
</author>
<author><name sortKey="Mocciaro, E" uniqKey="Mocciaro E">E. Mocciaro</name>
</author>
<author><name sortKey="Fais, S" uniqKey="Fais S">S. Fais</name>
</author>
<author><name sortKey="Conway De Macario, E" uniqKey="Conway De Macario E">E. Conway De Macario</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Min, A" uniqKey="Min A">A. Min</name>
</author>
<author><name sortKey="Im, S A" uniqKey="Im S">S.A. Im</name>
</author>
<author><name sortKey="Kim, D K" uniqKey="Kim D">D.K. Kim</name>
</author>
<author><name sortKey="Song, S H" uniqKey="Song S">S.H. Song</name>
</author>
<author><name sortKey="Kim, H J" uniqKey="Kim H">H.J. Kim</name>
</author>
<author><name sortKey="Lee, K H" uniqKey="Lee K">K.H. Lee</name>
</author>
<author><name sortKey="Kim, T Y" uniqKey="Kim T">T.Y. Kim</name>
</author>
<author><name sortKey="Han, S W" uniqKey="Han S">S.W. Han</name>
</author>
<author><name sortKey="Oh, D Y" uniqKey="Oh D">D.Y. Oh</name>
</author>
<author><name sortKey="Kim, T Y" uniqKey="Kim T">T.Y. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, P N" uniqKey="Munster P">P.N. Munster</name>
</author>
<author><name sortKey="Thurn, K T" uniqKey="Thurn K">K.T. Thurn</name>
</author>
<author><name sortKey="Thomas, S" uniqKey="Thomas S">S. Thomas</name>
</author>
<author><name sortKey="Raha, P" uniqKey="Raha P">P. Raha</name>
</author>
<author><name sortKey="Lacevic, M" uniqKey="Lacevic M">M. Lacevic</name>
</author>
<author><name sortKey="Miller, A" uniqKey="Miller A">A. Miller</name>
</author>
<author><name sortKey="Melisko, M" uniqKey="Melisko M">M. Melisko</name>
</author>
<author><name sortKey="Ismail Khan, R" uniqKey="Ismail Khan R">R. Ismail-Khan</name>
</author>
<author><name sortKey="Rugo, H" uniqKey="Rugo H">H. Rugo</name>
</author>
<author><name sortKey="Moasser, M" uniqKey="Moasser M">M. Moasser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Ruijter, A J" uniqKey="De Ruijter A">A.J. De Ruijter</name>
</author>
<author><name sortKey="Van Gennip, A H" uniqKey="Van Gennip A">A.H. van Gennip</name>
</author>
<author><name sortKey="Caron, H N" uniqKey="Caron H">H.N. Caron</name>
</author>
<author><name sortKey="Kemp, S" uniqKey="Kemp S">S. Kemp</name>
</author>
<author><name sortKey="Van Kuilenburg, A B" uniqKey="Van Kuilenburg A">A.B. van Kuilenburg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakagawa, M" uniqKey="Nakagawa M">M. Nakagawa</name>
</author>
<author><name sortKey="Oda, Y" uniqKey="Oda Y">Y. Oda</name>
</author>
<author><name sortKey="Eguchi, T" uniqKey="Eguchi T">T. Eguchi</name>
</author>
<author><name sortKey="Aishima, S" uniqKey="Aishima S">S. Aishima</name>
</author>
<author><name sortKey="Yao, T" uniqKey="Yao T">T. Yao</name>
</author>
<author><name sortKey="Hosoi, F" uniqKey="Hosoi F">F. Hosoi</name>
</author>
<author><name sortKey="Basaki, Y" uniqKey="Basaki Y">Y. Basaki</name>
</author>
<author><name sortKey="Ono, M" uniqKey="Ono M">M. Ono</name>
</author>
<author><name sortKey="Kuwano, M" uniqKey="Kuwano M">M. Kuwano</name>
</author>
<author><name sortKey="Tanaka, M" uniqKey="Tanaka M">M. Tanaka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="An, P" uniqKey="An P">P. An</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
<author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name>
</author>
<author><name sortKey="Ling, Y" uniqKey="Ling Y">Y. Ling</name>
</author>
<author><name sortKey="Du, J" uniqKey="Du J">J. Du</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuo, Y H" uniqKey="Kuo Y">Y.H. Kuo</name>
</author>
<author><name sortKey="Huang, W J" uniqKey="Huang W">W.J. Huang</name>
</author>
<author><name sortKey="Chung, I C" uniqKey="Chung I">I.C. Chung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kee, H J" uniqKey="Kee H">H.J. Kee</name>
</author>
<author><name sortKey="Ryu, Y" uniqKey="Ryu Y">Y. Ryu</name>
</author>
<author><name sortKey="Seok, Y M" uniqKey="Seok Y">Y.M. Seok</name>
</author>
<author><name sortKey="Choi, S Y" uniqKey="Choi S">S.Y. Choi</name>
</author>
<author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name>
</author>
<author><name sortKey="Kim, G R" uniqKey="Kim G">G.R. Kim</name>
</author>
<author><name sortKey="Jeong, M H" uniqKey="Jeong M">M.H. Jeong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fuino, L" uniqKey="Fuino L">L. Fuino</name>
</author>
<author><name sortKey="Bali, P" uniqKey="Bali P">P. Bali</name>
</author>
<author><name sortKey="Wittmann, S" uniqKey="Wittmann S">S. Wittmann</name>
</author>
<author><name sortKey="Donapaty, S" uniqKey="Donapaty S">S. Donapaty</name>
</author>
<author><name sortKey="Guo, F" uniqKey="Guo F">F. Guo</name>
</author>
<author><name sortKey="Yamaguchi, H" uniqKey="Yamaguchi H">H. Yamaguchi</name>
</author>
<author><name sortKey="Wang, H G" uniqKey="Wang H">H.G. Wang</name>
</author>
<author><name sortKey="Atadja, P" uniqKey="Atadja P">P. Atadja</name>
</author>
<author><name sortKey="Bhalla, K" uniqKey="Bhalla K">K. Bhalla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name>
</author>
<author><name sortKey="Radisky, D C" uniqKey="Radisky D">D.C. Radisky</name>
</author>
<author><name sortKey="Nelson, C M" uniqKey="Nelson C">C.M. Nelson</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name>
</author>
<author><name sortKey="Fata, J E" uniqKey="Fata J">J.E. Fata</name>
</author>
<author><name sortKey="Roth, R A" uniqKey="Roth R">R.A. Roth</name>
</author>
<author><name sortKey="Bissell, M J" uniqKey="Bissell M">M.J. Bissell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miard, S" uniqKey="Miard S">S. Miard</name>
</author>
<author><name sortKey="Fajas, L" uniqKey="Fajas L">L. Fajas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saito, S" uniqKey="Saito S">S. Saito</name>
</author>
<author><name sortKey="Zhuang, Y" uniqKey="Zhuang Y">Y. Zhuang</name>
</author>
<author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T. Suzuki</name>
</author>
<author><name sortKey="Ota, Y" uniqKey="Ota Y">Y. Ota</name>
</author>
<author><name sortKey="Bateman, M E" uniqKey="Bateman M">M.E. Bateman</name>
</author>
<author><name sortKey="Alkhatib, A L" uniqKey="Alkhatib A">A.L. Alkhatib</name>
</author>
<author><name sortKey="Morris, G F" uniqKey="Morris G">G.F. Morris</name>
</author>
<author><name sortKey="Lasky, J A" uniqKey="Lasky J">J.A. Lasky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weng, J R" uniqKey="Weng J">J.R. Weng</name>
</author>
<author><name sortKey="Bai, L Y" uniqKey="Bai L">L.Y. Bai</name>
</author>
<author><name sortKey="Lin, W Y" uniqKey="Lin W">W.Y. Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toyota, M" uniqKey="Toyota M">M. Toyota</name>
</author>
<author><name sortKey="Miyazaki, Y" uniqKey="Miyazaki Y">Y. Miyazaki</name>
</author>
<author><name sortKey="Kitamura, S" uniqKey="Kitamura S">S. Kitamura</name>
</author>
<author><name sortKey="Nagasawa, Y" uniqKey="Nagasawa Y">Y. Nagasawa</name>
</author>
<author><name sortKey="Kiyohara, T" uniqKey="Kiyohara T">T. Kiyohara</name>
</author>
<author><name sortKey="Shinomura, Y" uniqKey="Shinomura Y">Y. Shinomura</name>
</author>
<author><name sortKey="Matsuzawa, Y" uniqKey="Matsuzawa Y">Y. Matsuzawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, H N" uniqKey="Yu H">H.N. Yu</name>
</author>
<author><name sortKey="Lee, Y R" uniqKey="Lee Y">Y.R. Lee</name>
</author>
<author><name sortKey="Noh, E M" uniqKey="Noh E">E.M. Noh</name>
</author>
<author><name sortKey="Lee, K S" uniqKey="Lee K">K.S. Lee</name>
</author>
<author><name sortKey="Kim, J S" uniqKey="Kim J">J.S. Kim</name>
</author>
<author><name sortKey="Song, E K" uniqKey="Song E">E.K. Song</name>
</author>
<author><name sortKey="Han, M K" uniqKey="Han M">M.K. Han</name>
</author>
<author><name sortKey="Lee, Y C" uniqKey="Lee Y">Y.C. Lee</name>
</author>
<author><name sortKey="Kwon, K B" uniqKey="Kwon K">K.B. Kwon</name>
</author>
<author><name sortKey="Lee, S J" uniqKey="Lee S">S.J. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruefli, A A" uniqKey="Ruefli A">A.A. Ruefli</name>
</author>
<author><name sortKey="Ausserlechner, M J" uniqKey="Ausserlechner M">M.J. Ausserlechner</name>
</author>
<author><name sortKey="Bernhard, D" uniqKey="Bernhard D">D. Bernhard</name>
</author>
<author><name sortKey="Sutton, V R" uniqKey="Sutton V">V.R. Sutton</name>
</author>
<author><name sortKey="Tainton, K M" uniqKey="Tainton K">K.M. Tainton</name>
</author>
<author><name sortKey="Kofler, R" uniqKey="Kofler R">R. Kofler</name>
</author>
<author><name sortKey="Smyth, M J" uniqKey="Smyth M">M.J. Smyth</name>
</author>
<author><name sortKey="Johnstone, R W" uniqKey="Johnstone R">R.W. Johnstone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wasim, L" uniqKey="Wasim L">L. Wasim</name>
</author>
<author><name sortKey="Chopra, M" uniqKey="Chopra M">M. Chopra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tanaka, T" uniqKey="Tanaka T">T. Tanaka</name>
</author>
<author><name sortKey="Halicka, H D" uniqKey="Halicka H">H.D. Halicka</name>
</author>
<author><name sortKey="Huang, X" uniqKey="Huang X">X. Huang</name>
</author>
<author><name sortKey="Traganos, F" uniqKey="Traganos F">F. Traganos</name>
</author>
<author><name sortKey="Darzynkiewicz, Z" uniqKey="Darzynkiewicz Z">Z. Darzynkiewicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mrakovcic, M" uniqKey="Mrakovcic M">M. Mrakovcic</name>
</author>
<author><name sortKey="Kleinheinz, J" uniqKey="Kleinheinz J">J. Kleinheinz</name>
</author>
<author><name sortKey="Frohlich, L F" uniqKey="Frohlich L">L.F. Frohlich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mrakovcic, M" uniqKey="Mrakovcic M">M. Mrakovcic</name>
</author>
<author><name sortKey="Kleinheinz, J" uniqKey="Kleinheinz J">J. Kleinheinz</name>
</author>
<author><name sortKey="Frohlich, L F" uniqKey="Frohlich L">L.F. Frohlich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paglin, S" uniqKey="Paglin S">S. Paglin</name>
</author>
<author><name sortKey="Hollister, T" uniqKey="Hollister T">T. Hollister</name>
</author>
<author><name sortKey="Delohery, T" uniqKey="Delohery T">T. Delohery</name>
</author>
<author><name sortKey="Hackett, N" uniqKey="Hackett N">N. Hackett</name>
</author>
<author><name sortKey="Mcmahill, M" uniqKey="Mcmahill M">M. McMahill</name>
</author>
<author><name sortKey="Sphicas, E" uniqKey="Sphicas E">E. Sphicas</name>
</author>
<author><name sortKey="Domingo, D" uniqKey="Domingo D">D. Domingo</name>
</author>
<author><name sortKey="Yahalom, J" uniqKey="Yahalom J">J. Yahalom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barth, S" uniqKey="Barth S">S. Barth</name>
</author>
<author><name sortKey="Glick, D" uniqKey="Glick D">D. Glick</name>
</author>
<author><name sortKey="Macleod, K F" uniqKey="Macleod K">K.F. Macleod</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pyo, J O" uniqKey="Pyo J">J.-O. Pyo</name>
</author>
<author><name sortKey="Yoo, S M" uniqKey="Yoo S">S.-M. Yoo</name>
</author>
<author><name sortKey="Ahn, H H" uniqKey="Ahn H">H.-H. Ahn</name>
</author>
<author><name sortKey="Nah, J" uniqKey="Nah J">J. Nah</name>
</author>
<author><name sortKey="Hong, S H" uniqKey="Hong S">S.-H. Hong</name>
</author>
<author><name sortKey="Kam, T I" uniqKey="Kam T">T.-I. Kam</name>
</author>
<author><name sortKey="Jung, S" uniqKey="Jung S">S. Jung</name>
</author>
<author><name sortKey="Jung, Y K" uniqKey="Jung Y">Y.-K. Jung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deng, Z" uniqKey="Deng Z">Z. Deng</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name>
</author>
<author><name sortKey="Jin, J" uniqKey="Jin J">J. Jin</name>
</author>
<author><name sortKey="Xu, H" uniqKey="Xu H">H. Xu</name>
</author>
<author><name sortKey="Gao, Q" uniqKey="Gao Q">Q. Gao</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="You, B R" uniqKey="You B">B.R. You</name>
</author>
<author><name sortKey="Han, B R" uniqKey="Han B">B.R. Han</name>
</author>
<author><name sortKey="Park, W H" uniqKey="Park W">W.H. Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Emmans, V C" uniqKey="Emmans V">V.C. Emmans</name>
</author>
<author><name sortKey="Rodway, H A" uniqKey="Rodway H">H.A. Rodway</name>
</author>
<author><name sortKey="Hunt, A N" uniqKey="Hunt A">A.N. Hunt</name>
</author>
<author><name sortKey="Lillycrop, K A" uniqKey="Lillycrop K">K.A. Lillycrop</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nebbioso, A" uniqKey="Nebbioso A">A. Nebbioso</name>
</author>
<author><name sortKey="Dell Versana, C" uniqKey="Dell Versana C">C. Dell’Aversana</name>
</author>
<author><name sortKey="Bugge, A" uniqKey="Bugge A">A. Bugge</name>
</author>
<author><name sortKey="Sarno, R" uniqKey="Sarno R">R. Sarno</name>
</author>
<author><name sortKey="Valente, S" uniqKey="Valente S">S. Valente</name>
</author>
<author><name sortKey="Rotili, D" uniqKey="Rotili D">D. Rotili</name>
</author>
<author><name sortKey="Manzo, F" uniqKey="Manzo F">F. Manzo</name>
</author>
<author><name sortKey="Teti, D" uniqKey="Teti D">D. Teti</name>
</author>
<author><name sortKey="Mandrup, S" uniqKey="Mandrup S">S. Mandrup</name>
</author>
<author><name sortKey="Ciana, P" uniqKey="Ciana P">P. Ciana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Snezhkina, A V" uniqKey="Snezhkina A">A.V. Snezhkina</name>
</author>
<author><name sortKey="Kudryavtseva, A V" uniqKey="Kudryavtseva A">A.V. Kudryavtseva</name>
</author>
<author><name sortKey="Kardymon, O L" uniqKey="Kardymon O">O.L. Kardymon</name>
</author>
<author><name sortKey="Savvateeva, M V" uniqKey="Savvateeva M">M.V. Savvateeva</name>
</author>
<author><name sortKey="Melnikova, N V" uniqKey="Melnikova N">N.V. Melnikova</name>
</author>
<author><name sortKey="Krasnov, G S" uniqKey="Krasnov G">G.S. Krasnov</name>
</author>
<author><name sortKey="Dmitriev, A A" uniqKey="Dmitriev A">A.A. Dmitriev</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, K" uniqKey="Wang K">K. Wang</name>
</author>
<author><name sortKey="Jiang, J" uniqKey="Jiang J">J. Jiang</name>
</author>
<author><name sortKey="Lei, Y" uniqKey="Lei Y">Y. Lei</name>
</author>
<author><name sortKey="Zhou, S" uniqKey="Zhou S">S. Zhou</name>
</author>
<author><name sortKey="Wei, Y" uniqKey="Wei Y">Y. Wei</name>
</author>
<author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dahabieh, M S" uniqKey="Dahabieh M">M.S. Dahabieh</name>
</author>
<author><name sortKey="Ha, Z" uniqKey="Ha Z">Z. Ha</name>
</author>
<author><name sortKey="Di Pietro, E" uniqKey="Di Pietro E">E. Di Pietro</name>
</author>
<author><name sortKey="Nichol, J N" uniqKey="Nichol J">J.N. Nichol</name>
</author>
<author><name sortKey="Bolt, A M" uniqKey="Bolt A">A.M. Bolt</name>
</author>
<author><name sortKey="Goncalves, C" uniqKey="Goncalves C">C. Goncalves</name>
</author>
<author><name sortKey="Dupere Richer, D" uniqKey="Dupere Richer D">D. Dupere-Richer</name>
</author>
<author><name sortKey="Pettersson, F" uniqKey="Pettersson F">F. Pettersson</name>
</author>
<author><name sortKey="Mann, K K" uniqKey="Mann K">K.K. Mann</name>
</author>
<author><name sortKey="Braverman, N E" uniqKey="Braverman N">N.E. Braverman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name>
</author>
<author><name sortKey="Zhu, W G" uniqKey="Zhu W">W.G. Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
<author><name sortKey="Zhou, W" uniqKey="Zhou W">W. Zhou</name>
</author>
<author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z. Zheng</name>
</author>
<author><name sortKey="Zhang, P" uniqKey="Zhang P">P. Zhang</name>
</author>
<author><name sortKey="Tu, B" uniqKey="Tu B">B. Tu</name>
</author>
<author><name sortKey="He, Q" uniqKey="He Q">Q. He</name>
</author>
<author><name sortKey="Zhu, W G" uniqKey="Zhu W">W.G. Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nencioni, A" uniqKey="Nencioni A">A. Nencioni</name>
</author>
<author><name sortKey="Cea, M" uniqKey="Cea M">M. Cea</name>
</author>
<author><name sortKey="Montecucco, F" uniqKey="Montecucco F">F. Montecucco</name>
</author>
<author><name sortKey="Longo, V D" uniqKey="Longo V">V.D. Longo</name>
</author>
<author><name sortKey="Patrone, F" uniqKey="Patrone F">F. Patrone</name>
</author>
<author><name sortKey="Carella, A M" uniqKey="Carella A">A.M. Carella</name>
</author>
<author><name sortKey="Holyoake, T L" uniqKey="Holyoake T">T.L. Holyoake</name>
</author>
<author><name sortKey="Helgason, G V" uniqKey="Helgason G">G.V. Helgason</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eskelinen, E L" uniqKey="Eskelinen E">E.L. Eskelinen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kundu, M" uniqKey="Kundu M">M. Kundu</name>
</author>
<author><name sortKey="Thompson, C B" uniqKey="Thompson C">C.B. Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ahn, M Y" uniqKey="Ahn M">M.Y. Ahn</name>
</author>
<author><name sortKey="Yoon, J H" uniqKey="Yoon J">J.H. Yoon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lopez, G" uniqKey="Lopez G">G. Lopez</name>
</author>
<author><name sortKey="Torres, K" uniqKey="Torres K">K. Torres</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name>
</author>
<author><name sortKey="Hernandez, B" uniqKey="Hernandez B">B. Hernandez</name>
</author>
<author><name sortKey="Young, E" uniqKey="Young E">E. Young</name>
</author>
<author><name sortKey="Belousov, R" uniqKey="Belousov R">R. Belousov</name>
</author>
<author><name sortKey="Bolshakov, S" uniqKey="Bolshakov S">S. Bolshakov</name>
</author>
<author><name sortKey="Lazar, A J" uniqKey="Lazar A">A.J. Lazar</name>
</author>
<author><name sortKey="Slopis, J M" uniqKey="Slopis J">J.M. Slopis</name>
</author>
<author><name sortKey="Mccutcheon, I E" uniqKey="Mccutcheon I">I.E. McCutcheon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Ng, S" uniqKey="Ng S">S. Ng</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J. Zhou</name>
</author>
<author><name sortKey="Tan, S H" uniqKey="Tan S">S.H. Tan</name>
</author>
<author><name sortKey="Yang, N" uniqKey="Yang N">N. Yang</name>
</author>
<author><name sortKey="Lin, Q" uniqKey="Lin Q">Q. Lin</name>
</author>
<author><name sortKey="Xia, D" uniqKey="Xia D">D. Xia</name>
</author>
<author><name sortKey="Shen, H M" uniqKey="Shen H">H.M. Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y L" uniqKey="Liu Y">Y.L. Liu</name>
</author>
<author><name sortKey="Yang, P M" uniqKey="Yang P">P.M. Yang</name>
</author>
<author><name sortKey="Shun, C T" uniqKey="Shun C">C.T. Shun</name>
</author>
<author><name sortKey="Wu, M S" uniqKey="Wu M">M.S. Wu</name>
</author>
<author><name sortKey="Weng, J R" uniqKey="Weng J">J.R. Weng</name>
</author>
<author><name sortKey="Chen, C C" uniqKey="Chen C">C.C. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gammoh, N" uniqKey="Gammoh N">N. Gammoh</name>
</author>
<author><name sortKey="Lam, D" uniqKey="Lam D">D. Lam</name>
</author>
<author><name sortKey="Puente, C" uniqKey="Puente C">C. Puente</name>
</author>
<author><name sortKey="Ganley, I" uniqKey="Ganley I">I. Ganley</name>
</author>
<author><name sortKey="Marks, P A" uniqKey="Marks P">P.A. Marks</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, S" uniqKey="Song S">S. Song</name>
</author>
<author><name sortKey="Tan, J" uniqKey="Tan J">J. Tan</name>
</author>
<author><name sortKey="Miao, Y" uniqKey="Miao Y">Y. Miao</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M. Li</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Janku, F" uniqKey="Janku F">F. Janku</name>
</author>
<author><name sortKey="Mcconkey, D J" uniqKey="Mcconkey D">D.J. McConkey</name>
</author>
<author><name sortKey="Hong, D S" uniqKey="Hong D">D.S. Hong</name>
</author>
<author><name sortKey="Kurzrock, R" uniqKey="Kurzrock R">R. Kurzrock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shao, Y" uniqKey="Shao Y">Y. Shao</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z. Gao</name>
</author>
<author><name sortKey="Marks, P A" uniqKey="Marks P">P.A. Marks</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X. Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mukhopadhyay, S" uniqKey="Mukhopadhyay S">S. Mukhopadhyay</name>
</author>
<author><name sortKey="Panda, P K" uniqKey="Panda P">P.K. Panda</name>
</author>
<author><name sortKey="Sinha, N" uniqKey="Sinha N">N. Sinha</name>
</author>
<author><name sortKey="Das, D N" uniqKey="Das D">D.N. Das</name>
</author>
<author><name sortKey="Bhutia, S K" uniqKey="Bhutia S">S.K. Bhutia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, C W" uniqKey="Lin C">C.W. Lin</name>
</author>
<author><name sortKey="Chin, H K" uniqKey="Chin H">H.K. Chin</name>
</author>
<author><name sortKey="Lee, S L" uniqKey="Lee S">S.L. Lee</name>
</author>
<author><name sortKey="Chiu, C F" uniqKey="Chiu C">C.F. Chiu</name>
</author>
<author><name sortKey="Chung, J G" uniqKey="Chung J">J.G. Chung</name>
</author>
<author><name sortKey="Lin, Z Y" uniqKey="Lin Z">Z.Y. Lin</name>
</author>
<author><name sortKey="Wu, C Y" uniqKey="Wu C">C.Y. Wu</name>
</author>
<author><name sortKey="Liu, Y C" uniqKey="Liu Y">Y.C. Liu</name>
</author>
<author><name sortKey="Hsiao, Y T" uniqKey="Hsiao Y">Y.T. Hsiao</name>
</author>
<author><name sortKey="Feng, C H" uniqKey="Feng C">C.H. Feng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hsiao, Y C" uniqKey="Hsiao Y">Y.C. Hsiao</name>
</author>
<author><name sortKey="Peng, S F" uniqKey="Peng S">S.F. Peng</name>
</author>
<author><name sortKey="Lai, K C" uniqKey="Lai K">K.C. Lai</name>
</author>
<author><name sortKey="Liao, C L" uniqKey="Liao C">C.L. Liao</name>
</author>
<author><name sortKey="Huang, Y P" uniqKey="Huang Y">Y.P. Huang</name>
</author>
<author><name sortKey="Lin, C C" uniqKey="Lin C">C.C. Lin</name>
</author>
<author><name sortKey="Lin, M L" uniqKey="Lin M">M.L. Lin</name>
</author>
<author><name sortKey="Liu, K C" uniqKey="Liu K">K.C. Liu</name>
</author>
<author><name sortKey="Tsai, C C" uniqKey="Tsai C">C.C. Tsai</name>
</author>
<author><name sortKey="Ma, Y S" uniqKey="Ma Y">Y.S. Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weng, J R" uniqKey="Weng J">J.R. Weng</name>
</author>
<author><name sortKey="Bai, L Y" uniqKey="Bai L">L.Y. Bai</name>
</author>
<author><name sortKey="Chiu, S J" uniqKey="Chiu S">S.J. Chiu</name>
</author>
<author><name sortKey="Chiu, C F" uniqKey="Chiu C">C.F. Chiu</name>
</author>
<author><name sortKey="Lin, W Y" uniqKey="Lin W">W.Y. Lin</name>
</author>
<author><name sortKey="Hu, J L" uniqKey="Hu J">J.L. Hu</name>
</author>
<author><name sortKey="Shieh, T M" uniqKey="Shieh T">T.M. Shieh</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><noCountry><name sortKey="Huang, Wei Jan" sort="Huang, Wei Jan" uniqKey="Huang W" first="Wei-Jan" last="Huang">Wei-Jan Huang</name>
</noCountry>
<country name="Taïwan"><noRegion><name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name>
</noRegion>
<name sortKey="Bai, Li Yuan" sort="Bai, Li Yuan" uniqKey="Bai L" first="Li-Yuan" last="Bai">Li-Yuan Bai</name>
<name sortKey="Chin, Hsien Kuo" sort="Chin, Hsien Kuo" uniqKey="Chin H" first="Hsien-Kuo" last="Chin">Hsien-Kuo Chin</name>
<name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name>
<name sortKey="Huang, Hao Yu" sort="Huang, Hao Yu" uniqKey="Huang H" first="Hao-Yu" last="Huang">Hao-Yu Huang</name>
<name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name>
<name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name>
<name sortKey="Weng, Jing Ru" sort="Weng, Jing Ru" uniqKey="Weng J" first="Jing-Ru" last="Weng">Jing-Ru Weng</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000735 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000735 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6995545 |texte= Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31817161" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |