Long Non-Coding RNA: Dual Effects on Breast Cancer Metastasis and Clinical Applications
Identifieur interne : 000684 ( Main/Exploration ); précédent : 000683; suivant : 000685Long Non-Coding RNA: Dual Effects on Breast Cancer Metastasis and Clinical Applications
Auteurs : Qi-Yuan Huang [République populaire de Chine] ; Guo-Feng Liu ; Xian-Ling Qian ; Li-Bo Tang [République populaire de Chine] ; Qing-Yun Huang ; Li-Xia Xiong [République populaire de Chine]Source :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
As a highly heterogeneous malignancy, breast cancer (BC) has become the most significant threat to female health. Distant metastasis and therapy resistance of BC are responsible for most of the cases of mortality and recurrence. Distant metastasis relies on an array of processes, such as cell proliferation, epithelial-to-mesenchymal transition (EMT), mesenchymal-to-epithelial transition (MET), and angiogenesis. Long non-coding RNA (lncRNA) refers to a class of non-coding RNA with a length of over 200 nucleotides. Currently, a rising number of studies have managed to investigate the association between BC and lncRNA. In this study, we summarized how lncRNA has dual effects in BC metastasis by regulating invasion, migration, and distant metastasis of BC cells. We also emphasize that lncRNA has crucial regulatory effects in the stemness and angiogenesis of BC. Clinically, some lncRNAs can regulate chemotherapy sensitivity in BC patients and may function as novel biomarkers to diagnose or predict prognosis for BC patients. The exact impact on clinical relevance deserves further study. This review can be an approach to understanding the dual effects of lncRNAs in BC, thereby linking lncRNAs to quasi-personalized treatment in the future.
Url:
DOI: 10.3390/cancers11111802
PubMed: 31744046
PubMed Central: 6896003
Affiliations:
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330006</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author><author><name sortKey="Liu, Guo Feng" sort="Liu, Guo Feng" uniqKey="Liu G" first="Guo-Feng" last="Liu">Guo-Feng Liu</name><affiliation><nlm:aff id="af3-cancers-11-01802">First Clinical Medical College, Nanchang University, Nanchang 330006, China;<email>6302615053@email.ncu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Qian, Xian Ling" sort="Qian, Xian Ling" uniqKey="Qian X" first="Xian-Ling" last="Qian">Xian-Ling Qian</name><affiliation><nlm:aff id="af1-cancers-11-01802">Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China;<email>6301616056@email.ncu.edu.cn</email> (Q.-Y.H.);<email>6302615051@email.ncu.edu.cn</email> (X.-L.Q.);<email>lb525912836@163.com</email> (L.-B.T.);<email>401442718029@email.ncu.edu.cn</email> 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China;<email>6301616056@email.ncu.edu.cn</email> (Q.-Y.H.);<email>6302615051@email.ncu.edu.cn</email> (X.-L.Q.);<email>lb525912836@163.com</email> (L.-B.T.);<email>401442718029@email.ncu.edu.cn</email> (Q.-Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-cancers-11-01802">Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology, Nanchang 330006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology, Nanchang 330006</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31744046</idno><idno type="pmc">6896003</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896003</idno><idno type="RBID">PMC:6896003</idno><idno 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sortKey="Huang, Qi Yuan" sort="Huang, Qi Yuan" uniqKey="Huang Q" first="Qi-Yuan" last="Huang">Qi-Yuan Huang</name><affiliation><nlm:aff id="af1-cancers-11-01802">Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China;<email>6301616056@email.ncu.edu.cn</email> (Q.-Y.H.);<email>6302615051@email.ncu.edu.cn</email> (X.-L.Q.);<email>lb525912836@163.com</email> (L.-B.T.);<email>401442718029@email.ncu.edu.cn</email> (Q.-Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01802">Second Clinical Medical College, Nanchang University, Nanchang 330006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Second Clinical Medical College, Nanchang University, Nanchang 330006</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author><author><name sortKey="Liu, Guo Feng" sort="Liu, Guo Feng" uniqKey="Liu G" first="Guo-Feng" last="Liu">Guo-Feng Liu</name><affiliation><nlm:aff id="af3-cancers-11-01802">First Clinical Medical College, Nanchang University, Nanchang 330006, China;<email>6302615053@email.ncu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Qian, Xian Ling" sort="Qian, Xian Ling" uniqKey="Qian X" first="Xian-Ling" last="Qian">Xian-Ling Qian</name><affiliation><nlm:aff id="af1-cancers-11-01802">Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China;<email>6301616056@email.ncu.edu.cn</email> (Q.-Y.H.);<email>6302615051@email.ncu.edu.cn</email> (X.-L.Q.);<email>lb525912836@163.com</email> (L.-B.T.);<email>401442718029@email.ncu.edu.cn</email> (Q.-Y.H.)</nlm:aff></affiliation><affiliation><nlm:aff id="af3-cancers-11-01802">First Clinical Medical College, Nanchang University, Nanchang 330006, China;<email>6302615053@email.ncu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Tang, Li Bo" sort="Tang, Li Bo" uniqKey="Tang L" first="Li-Bo" last="Tang">Li-Bo Tang</name><affiliation><nlm:aff id="af1-cancers-11-01802">Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China;<email>6301616056@email.ncu.edu.cn</email> (Q.-Y.H.);<email>6302615051@email.ncu.edu.cn</email> (X.-L.Q.);<email>lb525912836@163.com</email> (L.-B.T.);<email>401442718029@email.ncu.edu.cn</email> (Q.-Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-01802">Second Clinical Medical College, Nanchang University, Nanchang 330006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Second Clinical Medical College, Nanchang University, Nanchang 330006</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author><author><name sortKey="Huang, Qing Yun" sort="Huang, Qing Yun" uniqKey="Huang Q" first="Qing-Yun" last="Huang">Qing-Yun Huang</name><affiliation><nlm:aff id="af1-cancers-11-01802">Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China;<email>6301616056@email.ncu.edu.cn</email> (Q.-Y.H.);<email>6302615051@email.ncu.edu.cn</email> (X.-L.Q.);<email>lb525912836@163.com</email> (L.-B.T.);<email>401442718029@email.ncu.edu.cn</email> (Q.-Y.H.)</nlm:aff></affiliation></author><author><name sortKey="Xiong, Li Xia" sort="Xiong, Li Xia" uniqKey="Xiong L" first="Li-Xia" last="Xiong">Li-Xia Xiong</name><affiliation><nlm:aff id="af1-cancers-11-01802">Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China;<email>6301616056@email.ncu.edu.cn</email> (Q.-Y.H.);<email>6302615051@email.ncu.edu.cn</email> (X.-L.Q.);<email>lb525912836@163.com</email> (L.-B.T.);<email>401442718029@email.ncu.edu.cn</email> (Q.-Y.H.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-cancers-11-01802">Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology, Nanchang 330006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology, Nanchang 330006</wicri:regionArea><placeName><settlement type="city">Nanchang</settlement><region type="province">Jiangxi</region></placeName></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="eISSN">2072-6694</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>As a highly heterogeneous malignancy, breast cancer (BC) has become the most significant threat to female health. Distant metastasis and therapy resistance of BC are responsible for most of the cases of mortality and recurrence. Distant metastasis relies on an array of processes, such as cell proliferation, epithelial-to-mesenchymal transition (EMT), mesenchymal-to-epithelial transition (MET), and angiogenesis. Long non-coding RNA (lncRNA) refers to a class of non-coding RNA with a length of over 200 nucleotides. Currently, a rising number of studies have managed to investigate the association between BC and lncRNA. In this study, we summarized how lncRNA has dual effects in BC metastasis by regulating invasion, migration, and distant metastasis of BC cells. We also emphasize that lncRNA has crucial regulatory effects in the stemness and angiogenesis of BC. Clinically, some lncRNAs can regulate chemotherapy sensitivity in BC patients and may function as novel biomarkers to diagnose or predict prognosis for BC patients. The exact impact on clinical relevance deserves further study. This review can be an approach to understanding the dual effects of lncRNAs in BC, thereby linking lncRNAs to quasi-personalized treatment in the future.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J. Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I. Soerjomataram</name></author><author><name sortKey="Siegel, R" uniqKey="Siegel R">R. Siegel</name></author><author><name sortKey="Torre, L" uniqKey="Torre L">L. Torre</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ponde, N" uniqKey="Ponde N">N. Pondé</name></author><author><name sortKey="Brandao, M" uniqKey="Brandao M">M. Brandão</name></author><author><name sortKey="El Hachem, G" uniqKey="El Hachem G">G. 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Hu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Jiangxi</li></region><settlement><li>Nanchang</li></settlement></list><tree><noCountry><name sortKey="Huang, Qing Yun" sort="Huang, Qing Yun" uniqKey="Huang Q" first="Qing-Yun" last="Huang">Qing-Yun Huang</name><name sortKey="Liu, Guo Feng" sort="Liu, Guo Feng" uniqKey="Liu G" first="Guo-Feng" last="Liu">Guo-Feng Liu</name><name sortKey="Qian, Xian Ling" sort="Qian, Xian Ling" uniqKey="Qian X" first="Xian-Ling" last="Qian">Xian-Ling Qian</name></noCountry><country name="République populaire de Chine"><region name="Jiangxi"><name sortKey="Huang, Qi Yuan" sort="Huang, Qi Yuan" uniqKey="Huang Q" first="Qi-Yuan" last="Huang">Qi-Yuan Huang</name></region><name sortKey="Tang, Li Bo" sort="Tang, Li Bo" uniqKey="Tang L" first="Li-Bo" last="Tang">Li-Bo Tang</name><name sortKey="Xiong, Li Xia" sort="Xiong, Li Xia" uniqKey="Xiong L" first="Li-Xia" last="Xiong">Li-Xia Xiong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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