Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent
Identifieur interne : 000549 ( Main/Exploration ); précédent : 000548; suivant : 000550Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent
Auteurs : Nguyen Minh Tuan ; Chang Hoon LeeSource :
- Molecules [ 1420-3049 ] ; 2019.
Abstract
Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine. Its effects last for several days after a single oral dose and it can be administered once a week to provide better compliance and symptom control. Recently; strong antitumour effects for penfluridol were discovered in various cancer cell lines; such as breast; pancreatic; glioblastoma; and lung cancer cells via several distinct mechanisms. Therefore; penfluridol has drawn much attention as a potentially novel anti-tumour agent. In addition; the anti-cancer effects of penfluridol have been demonstrated in vivo: results showed slight changes in the volume and weight of organs at doses tested in animals. This paper outlines the potential for penfluridol to be developed as a next-generation anticancer drug.
Url:
DOI: 10.3390/molecules24203659
PubMed: 31614431
PubMed Central: 6832311
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent</title><author><name sortKey="Tuan, Nguyen Minh" sort="Tuan, Nguyen Minh" uniqKey="Tuan N" first="Nguyen Minh" last="Tuan">Nguyen Minh Tuan</name></author><author><name sortKey="Lee, Chang Hoon" sort="Lee, Chang Hoon" uniqKey="Lee C" first="Chang Hoon" last="Lee">Chang Hoon Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31614431</idno><idno type="pmc">6832311</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832311</idno><idno type="RBID">PMC:6832311</idno><idno type="doi">10.3390/molecules24203659</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A69</idno><idno type="wicri:Area/Pmc/Curation">000A69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A69</idno><idno type="wicri:Area/Pmc/Checkpoint">000501</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000501</idno><idno type="wicri:Area/Ncbi/Merge">000B03</idno><idno type="wicri:Area/Ncbi/Curation">000B03</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B03</idno><idno type="wicri:Area/Main/Merge">000549</idno><idno type="wicri:Area/Main/Curation">000549</idno><idno type="wicri:Area/Main/Exploration">000549</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent</title><author><name sortKey="Tuan, Nguyen Minh" sort="Tuan, Nguyen Minh" uniqKey="Tuan N" first="Nguyen Minh" last="Tuan">Nguyen Minh Tuan</name></author><author><name sortKey="Lee, Chang Hoon" sort="Lee, Chang Hoon" uniqKey="Lee C" first="Chang Hoon" last="Lee">Chang Hoon Lee</name></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine. Its effects last for several days after a single oral dose and it can be administered once a week to provide better compliance and symptom control. Recently; strong antitumour effects for penfluridol were discovered in various cancer cell lines; such as breast; pancreatic; glioblastoma; and lung cancer cells via several distinct mechanisms. Therefore; penfluridol has drawn much attention as a potentially novel anti-tumour agent. In addition; the anti-cancer effects of penfluridol have been demonstrated in vivo: results showed slight changes in the volume and weight of organs at doses tested in animals. This paper outlines the potential for penfluridol to be developed as a next-generation anticancer drug.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J. 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Tu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhowmik, A" uniqKey="Bhowmik A">A. Bhowmik</name></author><author><name sortKey="Khan, R" uniqKey="Khan R">R. Khan</name></author><author><name sortKey="Ghosh, M K" uniqKey="Ghosh M">M.K. Ghosh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Lee, Chang Hoon" sort="Lee, Chang Hoon" uniqKey="Lee C" first="Chang Hoon" last="Lee">Chang Hoon Lee</name><name sortKey="Tuan, Nguyen Minh" sort="Tuan, Nguyen Minh" uniqKey="Tuan N" first="Nguyen Minh" last="Tuan">Nguyen Minh Tuan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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