Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux
Identifieur interne : 000504 ( Main/Exploration ); précédent : 000503; suivant : 000505Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux
Auteurs : Dong Wang [République populaire de Chine] ; Haoran Guo [République populaire de Chine] ; Huahong Yang [République populaire de Chine] ; Dongyin Wang [République populaire de Chine] ; Pujun Gao [République populaire de Chine] ; Wei Wei [République populaire de Chine]Source :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Url:
DOI: 10.3389/fphar.2019.01238
PubMed: 31695612
PubMed Central: 6817474
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000573
- to stream Pmc, to step Curation: 000573
- to stream Pmc, to step Checkpoint: 000460
- to stream Ncbi, to step Merge: 000B78
- to stream Ncbi, to step Curation: 000B78
- to stream Ncbi, to step Checkpoint: 000B78
- to stream Main, to step Merge: 000504
- to stream Main, to step Curation: 000504
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma <italic>via</italic>
Enhancing the Autophagic Flux</title>
<author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Hepatology, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Virology and AIDS Research, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Haoran" sort="Guo, Haoran" uniqKey="Guo H" first="Haoran" last="Guo">Haoran Guo</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Virology and AIDS Research, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Huahong" sort="Yang, Huahong" uniqKey="Yang H" first="Huahong" last="Yang">Huahong Yang</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Respiration, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Dongyin" sort="Wang, Dongyin" uniqKey="Wang D" first="Dongyin" last="Wang">Dongyin Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Hepatology, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gao, Pujun" sort="Gao, Pujun" uniqKey="Gao P" first="Pujun" last="Gao">Pujun Gao</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Hepatology, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Virology and AIDS Research, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31695612</idno>
<idno type="pmc">6817474</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817474</idno>
<idno type="RBID">PMC:6817474</idno>
<idno type="doi">10.3389/fphar.2019.01238</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000573</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000573</idno>
<idno type="wicri:Area/Pmc/Curation">000573</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000573</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000460</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000460</idno>
<idno type="wicri:Area/Ncbi/Merge">000B78</idno>
<idno type="wicri:Area/Ncbi/Curation">000B78</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000B78</idno>
<idno type="wicri:Area/Main/Merge">000504</idno>
<idno type="wicri:Area/Main/Curation">000504</idno>
<idno type="wicri:Area/Main/Exploration">000504</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma <italic>via</italic>
Enhancing the Autophagic Flux</title>
<author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Hepatology, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Virology and AIDS Research, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Haoran" sort="Guo, Haoran" uniqKey="Guo H" first="Haoran" last="Guo">Haoran Guo</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Virology and AIDS Research, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Huahong" sort="Yang, Huahong" uniqKey="Yang H" first="Huahong" last="Yang">Huahong Yang</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Respiration, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Dongyin" sort="Wang, Dongyin" uniqKey="Wang D" first="Dongyin" last="Wang">Dongyin Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Hepatology, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gao, Pujun" sort="Gao, Pujun" uniqKey="Gao P" first="Pujun" last="Gao">Pujun Gao</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Hepatology, The First Hospital of Jilin University, Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Virology and AIDS Research, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, The First Hospital of Jilin University</institution>
,<addr-line>Changchun</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in Pharmacology</title>
<idno type="eISSN">1663-9812</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Human cholangiocarcinoma (CCA) is a highly lethal cancer that occurs in the biliary tract. It is characterized by early invasion, poor outcomes, and resistance to current chemotherapies. To date, an effective therapeutic strategy for this devastating and deadly disease is lacking. Pterostilbene, a natural compound found in the extracts of many plants including blueberries, kino tree, or dragon blood tree, has several health benefits. However, its effects on CCA have not been clarified. Here, we investigated the potential application of pterostilbene for the treatment of human CCA <italic>in vitro</italic>
and <italic>in vivo</italic>
.</p>
<p><bold>Methods:</bold>
The effects of pterostilbene on CCA cells were determined by assessing cell viability (CCK), cell proliferation, and colony formation. Cell cycle arrest and apoptosis were measured by flow cytometric analysis, whereas proteins related to autophagy were detected by immunofluorescence and immunoblotting assays. A well-established xenograft mouse model was used to evaluate the effects of pterostilbene on tumor growth <italic>in vivo</italic>
.</p>
<p><bold>Results:</bold>
Pterostilbene induced dose-dependent and time-dependent cytotoxic effects, inhibited proliferation and colony formation, and caused S phase cell cycle arrest in CCA cells. Instead of triggering apoptotic cell death in these cells, pterostilbene was found to exert potent autophagy-inducing effects, and this correlated with p62 downregulation, elevated expression of endogenous Beclin-1, ATG5, and LC3-II, and increases in LC3 puncta. Pretreating cancer cells with the autophagy inhibitor 3-MA suppressed the induction of autophagy and antitumor activity caused by pterostilbene. Finally, we confirmed that pterostilbene inhibited tumor growth in a CCA xenograft mouse model with minimal general toxicity.</p>
<p><bold>Conclusion:</bold>
Taken together, our findings indicate that pterostilbene, through the induction of autophagic flux, acts as an anti-cancer agent against CCA cells.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Banales, J M" uniqKey="Banales J">J. M. Banales</name>
</author>
<author><name sortKey="Cardinale, V" uniqKey="Cardinale V">V. Cardinale</name>
</author>
<author><name sortKey="Carpino, G" uniqKey="Carpino G">G. Carpino</name>
</author>
<author><name sortKey="Marzioni, M" uniqKey="Marzioni M">M. Marzioni</name>
</author>
<author><name sortKey="Andersen, J B" uniqKey="Andersen J">J. B. Andersen</name>
</author>
<author><name sortKey="Invernizzi, P" uniqKey="Invernizzi P">P. Invernizzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chao En, W" uniqKey="Chao En W">W. Chao-En</name>
</author>
<author><name sortKey="Ming Huang, C" uniqKey="Ming Huang C">C. Ming-Huang</name>
</author>
<author><name sortKey="Chun Nan, Y" uniqKey="Chun Nan Y">Y. Chun-Nan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chatterjee, K" uniqKey="Chatterjee K">K. Chatterjee</name>
</author>
<author><name sortKey="Alsharif, D" uniqKey="Alsharif D">D. AlSharif</name>
</author>
<author><name sortKey="Mazza, C" uniqKey="Mazza C">C. Mazza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, R J" uniqKey="Chen R">R. J. Chen</name>
</author>
<author><name sortKey="Kuo, H C" uniqKey="Kuo H">H. C. Kuo</name>
</author>
<author><name sortKey="Cheng, L H" uniqKey="Cheng L">L. H. Cheng</name>
</author>
<author><name sortKey="Lee, Y H" uniqKey="Lee Y">Y. H. Lee</name>
</author>
<author><name sortKey="Chang, W T" uniqKey="Chang W">W. T. Chang</name>
</author>
<author><name sortKey="Wang, B J" uniqKey="Wang B">B. J. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, R J" uniqKey="Chen R">R. J. Chen</name>
</author>
<author><name sortKey="Tsai, S J" uniqKey="Tsai S">S. J. Tsai</name>
</author>
<author><name sortKey="Ho, C T" uniqKey="Ho C">C. T. Ho</name>
</author>
<author><name sortKey="Pan, M H" uniqKey="Pan M">M. H. Pan</name>
</author>
<author><name sortKey="Ho, Y S" uniqKey="Ho Y">Y. S. Ho</name>
</author>
<author><name sortKey="Wu, C H" uniqKey="Wu C">C. H. Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dhar, S" uniqKey="Dhar S">S. Dhar</name>
</author>
<author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name>
</author>
<author><name sortKey="Rimando, A M" uniqKey="Rimando A">A. M. Rimando</name>
</author>
<author><name sortKey="Lage, J M" uniqKey="Lage J">J. M. Lage</name>
</author>
<author><name sortKey="Lewin, J R" uniqKey="Lewin J">J. R. Lewin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrer, P" uniqKey="Ferrer P">P. Ferrer</name>
</author>
<author><name sortKey="Asensi, M" uniqKey="Asensi M">M. Asensi</name>
</author>
<author><name sortKey="Segarra, R" uniqKey="Segarra R">R. Segarra</name>
</author>
<author><name sortKey="Ortega, A" uniqKey="Ortega A">A. Ortega</name>
</author>
<author><name sortKey="Benlloch, M" uniqKey="Benlloch M">M. Benlloch</name>
</author>
<author><name sortKey="Obrador, E" uniqKey="Obrador E">E. Obrador</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kala, R" uniqKey="Kala R">R. Kala</name>
</author>
<author><name sortKey="Shah, H N" uniqKey="Shah H">H. N. Shah</name>
</author>
<author><name sortKey="Martin, S L" uniqKey="Martin S">S. L. Martin</name>
</author>
<author><name sortKey="Tollefsbol, T O" uniqKey="Tollefsbol T">T. O. Tollefsbol</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, K Y" uniqKey="Kang K">K. Y. Kang</name>
</author>
<author><name sortKey="Shin, J K" uniqKey="Shin J">J. K. Shin</name>
</author>
<author><name sortKey="Lee, S M" uniqKey="Lee S">S. M. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name>
</author>
<author><name sortKey="Abdalla, F C" uniqKey="Abdalla F">F. C. Abdalla</name>
</author>
<author><name sortKey="Abeliovich, H" uniqKey="Abeliovich H">H. Abeliovich</name>
</author>
<author><name sortKey="Abraham, R T" uniqKey="Abraham R">R. T. Abraham</name>
</author>
<author><name sortKey="Acevedo Arozena, A" uniqKey="Acevedo Arozena A">A. Acevedo-Arozena</name>
</author>
<author><name sortKey="Adeli, K" uniqKey="Adeli K">K. Adeli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ko, C P" uniqKey="Ko C">C. P. Ko</name>
</author>
<author><name sortKey="Lin, C W" uniqKey="Lin C">C. W. Lin</name>
</author>
<author><name sortKey="Chen, M K" uniqKey="Chen M">M. K. Chen</name>
</author>
<author><name sortKey="Yang, S F" uniqKey="Yang S">S. F. Yang</name>
</author>
<author><name sortKey="Chiou, H L" uniqKey="Chiou H">H. L. Chiou</name>
</author>
<author><name sortKey="Hsieh, M J" uniqKey="Hsieh M">M. J. Hsieh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Labib, P L" uniqKey="Labib P">P. L. Labib</name>
</author>
<author><name sortKey="Goodchild, G" uniqKey="Goodchild G">G. Goodchild</name>
</author>
<author><name sortKey="Pereira, S P" uniqKey="Pereira S">S. P. Pereira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name>
</author>
<author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name>
</author>
<author><name sortKey="Jeong, J H" uniqKey="Jeong J">J. H. Jeong</name>
</author>
<author><name sortKey="Ryu, J H" uniqKey="Ryu J">J. H. Ryu</name>
</author>
<author><name sortKey="Kim, W Y" uniqKey="Kim W">W. Y. Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy, J M M" uniqKey="Levy J">J. M. M. Levy</name>
</author>
<author><name sortKey="Towers, C G" uniqKey="Towers C">C. G. Towers</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A. Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lorente, J" uniqKey="Lorente J">J. Lorente</name>
</author>
<author><name sortKey="Velandia, C" uniqKey="Velandia C">C. Velandia</name>
</author>
<author><name sortKey="Leal, J A" uniqKey="Leal J">J. A. Leal</name>
</author>
<author><name sortKey="Garcia Mayea, Y" uniqKey="Garcia Mayea Y">Y. Garcia-Mayea</name>
</author>
<author><name sortKey="Lyakhovich, A" uniqKey="Lyakhovich A">A. Lyakhovich</name>
</author>
<author><name sortKey="Kondoh, H" uniqKey="Kondoh H">H. Kondoh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mei, H" uniqKey="Mei H">H. Mei</name>
</author>
<author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y. Xiang</name>
</author>
<author><name sortKey="Mei, H" uniqKey="Mei H">H. Mei</name>
</author>
<author><name sortKey="Fang, B" uniqKey="Fang B">B. Fang</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name>
</author>
<author><name sortKey="Cao, D" uniqKey="Cao D">D. Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Milano, V" uniqKey="Milano V">V. Milano</name>
</author>
<author><name sortKey="Piao, Y" uniqKey="Piao Y">Y. Piao</name>
</author>
<author><name sortKey="Lafortune, T" uniqKey="Lafortune T">T. LaFortune</name>
</author>
<author><name sortKey="De Groot, J" uniqKey="De Groot J">J. de Groot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagao, K" uniqKey="Nagao K">K. Nagao</name>
</author>
<author><name sortKey="Jinnouchi, T" uniqKey="Jinnouchi T">T. Jinnouchi</name>
</author>
<author><name sortKey="Kai, S" uniqKey="Kai S">S. Kai</name>
</author>
<author><name sortKey="Yanagita, T" uniqKey="Yanagita T">T. Yanagita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nikhil, K" uniqKey="Nikhil K">K. Nikhil</name>
</author>
<author><name sortKey="Sharan, S" uniqKey="Sharan S">S. Sharan</name>
</author>
<author><name sortKey="Chakraborty, A" uniqKey="Chakraborty A">A. Chakraborty</name>
</author>
<author><name sortKey="Roy, P" uniqKey="Roy P">P. Roy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rimando, A M" uniqKey="Rimando A">A. M. Rimando</name>
</author>
<author><name sortKey="Cuendet, M" uniqKey="Cuendet M">M. Cuendet</name>
</author>
<author><name sortKey="Desmarchelier, C" uniqKey="Desmarchelier C">C. Desmarchelier</name>
</author>
<author><name sortKey="Mehta, R G" uniqKey="Mehta R">R. G. Mehta</name>
</author>
<author><name sortKey="Pezzuto, J M" uniqKey="Pezzuto J">J. M. Pezzuto</name>
</author>
<author><name sortKey="Duke, S O" uniqKey="Duke S">S. O. Duke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rizvi, S" uniqKey="Rizvi S">S. Rizvi</name>
</author>
<author><name sortKey="Gores, G J" uniqKey="Gores G">G. J. Gores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rizvi, S" uniqKey="Rizvi S">S. Rizvi</name>
</author>
<author><name sortKey="Khan, S A" uniqKey="Khan S">S. A. Khan</name>
</author>
<author><name sortKey="Hallemeier, C L" uniqKey="Hallemeier C">C. L. Hallemeier</name>
</author>
<author><name sortKey="Kelley, R K" uniqKey="Kelley R">R. K. Kelley</name>
</author>
<author><name sortKey="Gores, G J" uniqKey="Gores G">G. J. Gores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rossi, M" uniqKey="Rossi M">M. Rossi</name>
</author>
<author><name sortKey="Caruso, F" uniqKey="Caruso F">F. Caruso</name>
</author>
<author><name sortKey="Antonioletti, R" uniqKey="Antonioletti R">R. Antonioletti</name>
</author>
<author><name sortKey="Viglianti, A" uniqKey="Viglianti A">A. Viglianti</name>
</author>
<author><name sortKey="Traversi, G" uniqKey="Traversi G">G. Traversi</name>
</author>
<author><name sortKey="Leone, S" uniqKey="Leone S">S. Leone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saha, S K" uniqKey="Saha S">S. K. Saha</name>
</author>
<author><name sortKey="Zhu, A X" uniqKey="Zhu A">A. X. Zhu</name>
</author>
<author><name sortKey="Fuchs, C S" uniqKey="Fuchs C">C. S. Fuchs</name>
</author>
<author><name sortKey="Brooks, G A" uniqKey="Brooks G">G. A. Brooks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shacka, J J" uniqKey="Shacka J">J. J. Shacka</name>
</author>
<author><name sortKey="Klocke, B J" uniqKey="Klocke B">B. J. Klocke</name>
</author>
<author><name sortKey="Shibata, M" uniqKey="Shibata M">M. Shibata</name>
</author>
<author><name sortKey="Uchiyama, Y" uniqKey="Uchiyama Y">Y. Uchiyama</name>
</author>
<author><name sortKey="Datta, G" uniqKey="Datta G">G. Datta</name>
</author>
<author><name sortKey="Schmidt, R E" uniqKey="Schmidt R">R. E. Schmidt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, S S" uniqKey="Singh S">S. S. Singh</name>
</author>
<author><name sortKey="Vats, S" uniqKey="Vats S">S. Vats</name>
</author>
<author><name sortKey="Chia, A Y" uniqKey="Chia A">A. Y. Chia</name>
</author>
<author><name sortKey="Tan, T Z" uniqKey="Tan T">T. Z. Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Squadroni, M" uniqKey="Squadroni M">M. Squadroni</name>
</author>
<author><name sortKey="Tondulli, L" uniqKey="Tondulli L">L. Tondulli</name>
</author>
<author><name sortKey="Gatta, G" uniqKey="Gatta G">G. Gatta</name>
</author>
<author><name sortKey="Mosconi, S" uniqKey="Mosconi S">S. Mosconi</name>
</author>
<author><name sortKey="Beretta, G" uniqKey="Beretta G">G. Beretta</name>
</author>
<author><name sortKey="Labianca, R" uniqKey="Labianca R">R. Labianca</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Ding, L" uniqKey="Ding L">L. Ding</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Han, W" uniqKey="Han W">W. Han</name>
</author>
<author><name sortKey="Feng, L" uniqKey="Feng L">L. Feng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yanala, U" uniqKey="Yanala U">U. Yanala</name>
</author>
<author><name sortKey="Malhotra, G" uniqKey="Malhotra G">G. Malhotra</name>
</author>
<author><name sortKey="Are, C" uniqKey="Are C">C. Are</name>
</author>
<author><name sortKey="Padussis, J" uniqKey="Padussis J">J. Padussis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, C L" uniqKey="Yu C">C. L. Yu</name>
</author>
<author><name sortKey="Yang, S F" uniqKey="Yang S">S. F. Yang</name>
</author>
<author><name sortKey="Hung, T W" uniqKey="Hung T">T. W. Hung</name>
</author>
<author><name sortKey="Lin, C L" uniqKey="Lin C">C. L. Lin</name>
</author>
<author><name sortKey="Hsieh, Y H" uniqKey="Hsieh Y">Y. H. Hsieh</name>
</author>
<author><name sortKey="Chiou, H L" uniqKey="Chiou H">H. L. Chiou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, G Y" uniqKey="Yu G">G. Y. Yu</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Zheng, S S" uniqKey="Zheng S">S. S. Zheng</name>
</author>
<author><name sortKey="Gao, X M" uniqKey="Gao X">X. M. Gao</name>
</author>
<author><name sortKey="Jia, Q A" uniqKey="Jia Q">Q. A. Jia</name>
</author>
<author><name sortKey="Zhu, W W" uniqKey="Zhu W">W. W. Zhu</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name>
</noRegion>
<name sortKey="Gao, Pujun" sort="Gao, Pujun" uniqKey="Gao P" first="Pujun" last="Gao">Pujun Gao</name>
<name sortKey="Guo, Haoran" sort="Guo, Haoran" uniqKey="Guo H" first="Haoran" last="Guo">Haoran Guo</name>
<name sortKey="Guo, Haoran" sort="Guo, Haoran" uniqKey="Guo H" first="Haoran" last="Guo">Haoran Guo</name>
<name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name>
<name sortKey="Wang, Dongyin" sort="Wang, Dongyin" uniqKey="Wang D" first="Dongyin" last="Wang">Dongyin Wang</name>
<name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name>
<name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name>
<name sortKey="Yang, Huahong" sort="Yang, Huahong" uniqKey="Yang H" first="Huahong" last="Yang">Huahong Yang</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000504 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000504 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:6817474 |texte= Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31695612" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |