Sotetsuflavone Induces Autophagy in Non-Small Cell Lung Cancer Through Blocking PI3K/Akt/mTOR Signaling Pathway in Vivo and in Vitro
Identifieur interne : 000426 ( Main/Exploration ); précédent : 000425; suivant : 000427Sotetsuflavone Induces Autophagy in Non-Small Cell Lung Cancer Through Blocking PI3K/Akt/mTOR Signaling Pathway in Vivo and in Vitro
Auteurs : Shaohui Wang [République populaire de Chine] ; Xiaoling Xu [République populaire de Chine] ; Yanlan Hu [République populaire de Chine] ; Tao Lei [République populaire de Chine] ; Tongxiang Liu [République populaire de Chine]Source :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Non-small cell lung cancer (NSCLC) is a globally scaled disease with a high incidence and high associated mortality rate. Autophagy is one of the important physiological activities that helps to control cell survival, influences the dynamics of cell death, and which plays a crucial role in the pathophysiology of NSCLC. Sotetsuflavone is a naturally derived and occurring flavonoid, and previous studies have demonstrated that sotetsuflavone possesses potential anti-cancer activities. However, whether or not sotetsuflavone induces autophagy, as well as has effects and influences cell death in NSCLC cells remains unclear. Thus, in our study, we examined and elucidated the roles and underlying mechanisms of sotetsuflavone upon the dynamics of autophagy in NSCLC
Url:
DOI: 10.3389/fphar.2019.01460
PubMed: 31920653
PubMed Central: 6915081
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sotetsuflavone Induces Autophagy in Non-Small Cell Lung Cancer Through Blocking PI3K/Akt/mTOR Signaling Pathway <italic>in Vivo</italic>
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<front><div type="abstract" xml:lang="en"><p>Non-small cell lung cancer (NSCLC) is a globally scaled disease with a high incidence and high associated mortality rate. Autophagy is one of the important physiological activities that helps to control cell survival, influences the dynamics of cell death, and which plays a crucial role in the pathophysiology of NSCLC. Sotetsuflavone is a naturally derived and occurring flavonoid, and previous studies have demonstrated that sotetsuflavone possesses potential anti-cancer activities. However, whether or not sotetsuflavone induces autophagy, as well as has effects and influences cell death in NSCLC cells remains unclear. Thus, in our study, we examined and elucidated the roles and underlying mechanisms of sotetsuflavone upon the dynamics of autophagy in NSCLC <italic>in vivo</italic>
and <italic>in vitro</italic>
. The results indicated that sotetsuflavone was able to inhibit proliferation, migration, and invasion of NSCLC cells. Mechanistically, sotetsuflavone was able to induce apoptosis by increasing the levels of expression of cytochrome C, cleaved-caspase 3, cleaved-caspase 9, and Bax, and contrastingly decreased levels of expression of Bcl-2. In addition, we also found that decreased levels of expression of cyclin D1 and CDK4 caused arrest of the G0/G1 phases of the cell cycle. Furthermore, we also found that sotetsuflavone could induce autophagy which in turn can play a cytoprotective effect on apoptosis in NSCLC. Sotetsuflavone-induced autophagy appeared related to the blocking of the PI3K/Akt/mTOR pathway. Our <italic>in vivo</italic>
study demonstrated that sotetsuflavone significantly inhibited the growth of xenograft model inoculated A549 tumor with high a degree of safety. Taken together, these findings suggest that sotetsuflavone induces autophagy in NSCLC cells through its effects upon blocking of the PI3K/Akt/mTOR signaling pathways. Our study may provide a theoretical basis for future clinical applications of sotetsuflavone and its use as a chemotherapeutic agent for treatment of NSCLC.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Aryal, P" uniqKey="Aryal P">P. Aryal</name>
</author>
<author><name sortKey="Kim, K" uniqKey="Kim K">K. Kim</name>
</author>
<author><name sortKey="Park, P H" uniqKey="Park P">P. H. Park</name>
</author>
<author><name sortKey="Ham, S" uniqKey="Ham S">S. Ham</name>
</author>
<author><name sortKey="Cho, J" uniqKey="Cho J">J. Cho</name>
</author>
<author><name sortKey="Song, K" uniqKey="Song K">K. Song</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ashwell, M A" uniqKey="Ashwell M">M. A. Ashwell</name>
</author>
<author><name sortKey="Lapierre, J M" uniqKey="Lapierre J">J. M. Lapierre</name>
</author>
<author><name sortKey="Brassard, C" uniqKey="Brassard C">C. Brassard</name>
</author>
<author><name sortKey="Bresciano, K" uniqKey="Bresciano K">K. Bresciano</name>
</author>
<author><name sortKey="Bull, C" uniqKey="Bull C">C. Bull</name>
</author>
<author><name sortKey="Cornell Kennon, S" uniqKey="Cornell Kennon S">S. Cornell-Kennon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Awan, F T" uniqKey="Awan F">F. T. Awan</name>
</author>
<author><name sortKey="Jones, J A" uniqKey="Jones J">J. A. Jones</name>
</author>
<author><name sortKey="Maddocks, K" uniqKey="Maddocks K">K. Maddocks</name>
</author>
<author><name sortKey="Poi, M" uniqKey="Poi M">M. Poi</name>
</author>
<author><name sortKey="Grever, M R" uniqKey="Grever M">M. R. Grever</name>
</author>
<author><name sortKey="Johnson, A" uniqKey="Johnson A">A. Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bakin, A V" uniqKey="Bakin A">A. V. Bakin</name>
</author>
<author><name sortKey="Tomlinson, A K" uniqKey="Tomlinson A">A. K. Tomlinson</name>
</author>
<author><name sortKey="Bhowmick, N A" uniqKey="Bhowmick N">N. A. Bhowmick</name>
</author>
<author><name sortKey="Moses, H L" uniqKey="Moses H">H. L. Moses</name>
</author>
<author><name sortKey="Arteaga, C L" uniqKey="Arteaga C">C. L. Arteaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bui, K T" uniqKey="Bui K">K. T. Bui</name>
</author>
<author><name sortKey="Cooper, W A" uniqKey="Cooper W">W. A. Cooper</name>
</author>
<author><name sortKey="Kao, S" uniqKey="Kao S">S. Kao</name>
</author>
<author><name sortKey="Boyer, M" uniqKey="Boyer M">M. Boyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y. Cao</name>
</author>
<author><name sortKey="Depinho, R A" uniqKey="Depinho R">R. A. Depinho</name>
</author>
<author><name sortKey="Ernst, M" uniqKey="Ernst M">M. Ernst</name>
</author>
<author><name sortKey="Vousden, K" uniqKey="Vousden K">K. Vousden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dela Cruz, C S" uniqKey="Dela Cruz C">C. S. Dela Cruz</name>
</author>
<author><name sortKey="Tanoue, L T" uniqKey="Tanoue L">L. T. Tanoue</name>
</author>
<author><name sortKey="Matthay, R A" uniqKey="Matthay R">R. A. Matthay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doherty, J" uniqKey="Doherty J">J. Doherty</name>
</author>
<author><name sortKey="Baehrecke, E H" uniqKey="Baehrecke E">E. H. Baehrecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J. Ferlay</name>
</author>
<author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I. Soerjomataram</name>
</author>
<author><name sortKey="Dikshit, R" uniqKey="Dikshit R">R. Dikshit</name>
</author>
<author><name sortKey="Eser, S" uniqKey="Eser S">S. Eser</name>
</author>
<author><name sortKey="Mathers, C" uniqKey="Mathers C">C. Mathers</name>
</author>
<author><name sortKey="Rebelo, M" uniqKey="Rebelo M">M. Rebelo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fu, T" uniqKey="Fu T">T. Fu</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name>
</author>
<author><name sortKey="Jin, X N" uniqKey="Jin X">X. N. Jin</name>
</author>
<author><name sortKey="Sui, H J" uniqKey="Sui H">H. J. Sui</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name>
</author>
<author><name sortKey="Jin, Y" uniqKey="Jin Y">Y. Jin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name>
</author>
<author><name sortKey="Bravosan Pedro, J M" uniqKey="Bravosan Pedro J">J. M. Bravosan Pedro</name>
</author>
<author><name sortKey="Demaria, S" uniqKey="Demaria S">S. Demaria</name>
</author>
<author><name sortKey="Formenti, S C" uniqKey="Formenti S">S. C. Formenti</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gozuacik, D" uniqKey="Gozuacik D">D. Gozuacik</name>
</author>
<author><name sortKey="Kimchi, A" uniqKey="Kimchi A">A. Kimchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, J" uniqKey="Guo J">J. Guo</name>
</author>
<author><name sortKey="Han, S" uniqKey="Han S">S. Han</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name>
</author>
<author><name sortKey="Zeng, S" uniqKey="Zeng S">S. Zeng</name>
</author>
<author><name sortKey="Zheng, X" uniqKey="Zheng X">X. Zheng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, M" uniqKey="Gupta M">M. Gupta</name>
</author>
<author><name sortKey="Sharma, R" uniqKey="Sharma R">R. Sharma</name>
</author>
<author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heras Sandoval, D" uniqKey="Heras Sandoval D">D. Heras-Sandoval</name>
</author>
<author><name sortKey="Perez Rojas, J M" uniqKey="Perez Rojas J">J. M. Perez-Rojas</name>
</author>
<author><name sortKey="Hernandez Damian, J" uniqKey="Hernandez Damian J">J. Hernandez-Damian</name>
</author>
<author><name sortKey="Pedraza Chaverri, J" uniqKey="Pedraza Chaverri J">J. Pedraza-Chaverri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hsu, K F" uniqKey="Hsu K">K. F. Hsu</name>
</author>
<author><name sortKey="Wu, C L" uniqKey="Wu C">C. L. Wu</name>
</author>
<author><name sortKey="Huang, S C" uniqKey="Huang S">S. C. Huang</name>
</author>
<author><name sortKey="Wu, C M" uniqKey="Wu C">C. M. Wu</name>
</author>
<author><name sortKey="Hsiao, J R" uniqKey="Hsiao J">J. R. Hsiao</name>
</author>
<author><name sortKey="Yo, Y T" uniqKey="Yo Y">Y. T. Yo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jmm, L" uniqKey="Jmm L">L. Jmm</name>
</author>
<author><name sortKey="Towers, C G" uniqKey="Towers C">C. G. Towers</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A. Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leonardo, F" uniqKey="Leonardo F">F. Leonardo</name>
</author>
<author><name sortKey="Ricardo, D S" uniqKey="Ricardo D">D. S. Ricardo</name>
</author>
<author><name sortKey="Glaucius, O" uniqKey="Glaucius O">O. Glaucius</name>
</author>
<author><name sortKey="Adriano, A" uniqKey="Adriano A">A. Adriano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, X" uniqKey="Luo X">X. Luo</name>
</author>
<author><name sortKey="Yu, X" uniqKey="Yu X">X. Yu</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name>
</author>
<author><name sortKey="Deng, Q" uniqKey="Deng Q">Q. Deng</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name>
</author>
<author><name sortKey="Peng, S" uniqKey="Peng S">S. Peng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maycotte, P" uniqKey="Maycotte P">P. Maycotte</name>
</author>
<author><name sortKey="Aryal, S" uniqKey="Aryal S">S. Aryal</name>
</author>
<author><name sortKey="Cummings, C T" uniqKey="Cummings C">C. T. Cummings</name>
</author>
<author><name sortKey="Thorburn, J" uniqKey="Thorburn J">J. Thorburn</name>
</author>
<author><name sortKey="Morgan, M J" uniqKey="Morgan M">M. J. Morgan</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A. Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Panche, A N" uniqKey="Panche A">A. N. Panche</name>
</author>
<author><name sortKey="Diwan, A D" uniqKey="Diwan A">A. D. Diwan</name>
</author>
<author><name sortKey="Chandra, S R" uniqKey="Chandra S">S. R. Chandra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Panda, P K" uniqKey="Panda P">P. K. Panda</name>
</author>
<author><name sortKey="Mukhopadhyay, S" uniqKey="Mukhopadhyay S">S. Mukhopadhyay</name>
</author>
<author><name sortKey="Das, D N" uniqKey="Das D">D. N. Das</name>
</author>
<author><name sortKey="Sinha, N" uniqKey="Sinha N">N. Sinha</name>
</author>
<author><name sortKey="Naik, P P" uniqKey="Naik P">P. P. Naik</name>
</author>
<author><name sortKey="Bhutia, S K" uniqKey="Bhutia S">S. K. Bhutia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Porta, C" uniqKey="Porta C">C. Porta</name>
</author>
<author><name sortKey="Paglino, C" uniqKey="Paglino C">C. Paglino</name>
</author>
<author><name sortKey="Mosca, A" uniqKey="Mosca A">A. Mosca</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prietsch, R F" uniqKey="Prietsch R">R. F. Prietsch</name>
</author>
<author><name sortKey="Monte, L G" uniqKey="Monte L">L. G. Monte</name>
</author>
<author><name sortKey="Da Silva, F A" uniqKey="Da Silva F">F. A. Da Silva</name>
</author>
<author><name sortKey="Beira, F T" uniqKey="Beira F">F. T. Beira</name>
</author>
<author><name sortKey="Del Pino, F A" uniqKey="Del Pino F">F. A. Del Pino</name>
</author>
<author><name sortKey="Campos, V F" uniqKey="Campos V">V. F. Campos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Psahoulia, F H" uniqKey="Psahoulia F">F. H. Psahoulia</name>
</author>
<author><name sortKey="Moumtzi, S" uniqKey="Moumtzi S">S. Moumtzi</name>
</author>
<author><name sortKey="Roberts, M L" uniqKey="Roberts M">M. L. Roberts</name>
</author>
<author><name sortKey="Sasazuki, T" uniqKey="Sasazuki T">T. Sasazuki</name>
</author>
<author><name sortKey="Shirasawa, S" uniqKey="Shirasawa S">S. Shirasawa</name>
</author>
<author><name sortKey="Pintzas, A" uniqKey="Pintzas A">A. Pintzas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siegel, R L" uniqKey="Siegel R">R. L. Siegel</name>
</author>
<author><name sortKey="Miller, K D" uniqKey="Miller K">K. D. Miller</name>
</author>
<author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, N" uniqKey="Song N">N. Song</name>
</author>
<author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name>
</author>
<author><name sortKey="Huang, Y H" uniqKey="Huang Y">Y. H. Huang</name>
</author>
<author><name sortKey="Huang, F Y" uniqKey="Huang F">F. Y. Huang</name>
</author>
<author><name sortKey="Mei, W L" uniqKey="Mei W">W. L. Mei</name>
</author>
<author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name>
</author>
<author><name sortKey="Wang, C C" uniqKey="Wang C">C. C. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Torre, L A" uniqKey="Torre L">L. A. Torre</name>
</author>
<author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name>
</author>
<author><name sortKey="Siegel, R L" uniqKey="Siegel R">R. L. Siegel</name>
</author>
<author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J. Ferlay</name>
</author>
<author><name sortKey="Lortet Tieulent, J" uniqKey="Lortet Tieulent J">J. Lortet-Tieulent</name>
</author>
<author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsai, J P" uniqKey="Tsai J">J. P. Tsai</name>
</author>
<author><name sortKey="Lee, C H" uniqKey="Lee C">C. H. Lee</name>
</author>
<author><name sortKey="Ying, T H" uniqKey="Ying T">T. H. Ying</name>
</author>
<author><name sortKey="Lin, C L" uniqKey="Lin C">C. L. Lin</name>
</author>
<author><name sortKey="Hsieh, Y H" uniqKey="Hsieh Y">Y. H. Hsieh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, S S" uniqKey="Wang S">S. S. Wang</name>
</author>
<author><name sortKey="Chen, Y H" uniqKey="Chen Y">Y. H. Chen</name>
</author>
<author><name sortKey="Chen, N" uniqKey="Chen N">N. Chen</name>
</author>
<author><name sortKey="Wang, L J" uniqKey="Wang L">L. J. Wang</name>
</author>
<author><name sortKey="Chen, D X" uniqKey="Chen D">D. X. Chen</name>
</author>
<author><name sortKey="Weng, H L" uniqKey="Weng H">H. L. Weng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name>
</author>
<author><name sortKey="Yan, Y" uniqKey="Yan Y">Y. Yan</name>
</author>
<author><name sortKey="Cheng, Z" uniqKey="Cheng Z">Z. Cheng</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
<author><name sortKey="Yan, Y" uniqKey="Yan Y">Y. Yan</name>
</author>
<author><name sortKey="Cheng, Z" uniqKey="Cheng Z">Z. Cheng</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, H" uniqKey="Xu H">H. Xu</name>
</author>
<author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name>
</author>
<author><name sortKey="Xu, P" uniqKey="Xu P">P. Xu</name>
</author>
<author><name sortKey="Zhang, K" uniqKey="Zhang K">K. Zhang</name>
</author>
<author><name sortKey="Lin, X" uniqKey="Lin X">X. Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, D" uniqKey="Yan D">D. Yan</name>
</author>
<author><name sortKey="Kai, R" uniqKey="Kai R">R. Kai</name>
</author>
<author><name sortKey="Dong, H" uniqKey="Dong H">H. Dong</name>
</author>
<author><name sortKey="Fei, S" uniqKey="Fei S">S. Fei</name>
</author>
<author><name sortKey="Jing, C" uniqKey="Jing C">C. Jing</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name>
</author>
<author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D. J. Klionsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, A K" uniqKey="Yang A">A. K. Yang</name>
</author>
<author><name sortKey="He, S M" uniqKey="He S">S. M. He</name>
</author>
<author><name sortKey="Liu, L" uniqKey="Liu L">L. Liu</name>
</author>
<author><name sortKey="Liu, J P" uniqKey="Liu J">J. P. Liu</name>
</author>
<author><name sortKey="Wei, M Q" uniqKey="Wei M">M. Q. Wei</name>
</author>
<author><name sortKey="Zhou, S F" uniqKey="Zhou S">S. F. Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Z J" uniqKey="Yang Z">Z. J. Yang</name>
</author>
<author><name sortKey="Chee, C E" uniqKey="Chee C">C. E. Chee</name>
</author>
<author><name sortKey="Huang, S" uniqKey="Huang S">S. Huang</name>
</author>
<author><name sortKey="Sinicrope, F A" uniqKey="Sinicrope F">F. A. Sinicrope</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name>
</author>
<author><name sortKey="Jiang, X" uniqKey="Jiang X">X. Jiang</name>
</author>
<author><name sortKey="Li, B" uniqKey="Li B">B. Li</name>
</author>
<author><name sortKey="Yang, H J" uniqKey="Yang H">H. J. Yang</name>
</author>
<author><name sortKey="Miller, M" uniqKey="Miller M">M. Miller</name>
</author>
<author><name sortKey="Yang, A" uniqKey="Yang A">A. Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, H W" uniqKey="Zhang H">H. W. Zhang</name>
</author>
<author><name sortKey="Hu, J J" uniqKey="Hu J">J. J. Hu</name>
</author>
<author><name sortKey="Fu, R Q" uniqKey="Fu R">R. Q. Fu</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name>
</author>
<author><name sortKey="Zhang, Y H" uniqKey="Zhang Y">Y. H. Zhang</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, X W" uniqKey="Zhang X">X. W. Zhang</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name>
</author>
<author><name sortKey="Jiang, H L" uniqKey="Jiang H">H. L. Jiang</name>
</author>
<author><name sortKey="Mao, B" uniqKey="Mao B">B. Mao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, G" uniqKey="Zhang G">G. Zhang</name>
</author>
<author><name sortKey="He, J" uniqKey="He J">J. He</name>
</author>
<author><name sortKey="Ye, X" uniqKey="Ye X">X. Ye</name>
</author>
<author><name sortKey="Zhu, J" uniqKey="Zhu J">J. Zhu</name>
</author>
<author><name sortKey="Hu, X" uniqKey="Hu X">X. Hu</name>
</author>
<author><name sortKey="Shen, M" uniqKey="Shen M">M. Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H. Liu</name>
</author>
<author><name sortKey="Yin, W" uniqKey="Yin W">W. Yin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, K" uniqKey="Zhao K">K. Zhao</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X. Li</name>
</author>
<author><name sortKey="Lin, B" uniqKey="Lin B">B. Lin</name>
</author>
<author><name sortKey="Yang, D" uniqKey="Yang D">D. Yang</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
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</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Shaohui" sort="Wang, Shaohui" uniqKey="Wang S" first="Shaohui" last="Wang">Shaohui Wang</name>
</noRegion>
<name sortKey="Hu, Yanlan" sort="Hu, Yanlan" uniqKey="Hu Y" first="Yanlan" last="Hu">Yanlan Hu</name>
<name sortKey="Hu, Yanlan" sort="Hu, Yanlan" uniqKey="Hu Y" first="Yanlan" last="Hu">Yanlan Hu</name>
<name sortKey="Lei, Tao" sort="Lei, Tao" uniqKey="Lei T" first="Tao" last="Lei">Tao Lei</name>
<name sortKey="Liu, Tongxiang" sort="Liu, Tongxiang" uniqKey="Liu T" first="Tongxiang" last="Liu">Tongxiang Liu</name>
<name sortKey="Liu, Tongxiang" sort="Liu, Tongxiang" uniqKey="Liu T" first="Tongxiang" last="Liu">Tongxiang Liu</name>
<name sortKey="Wang, Shaohui" sort="Wang, Shaohui" uniqKey="Wang S" first="Shaohui" last="Wang">Shaohui Wang</name>
<name sortKey="Wang, Shaohui" sort="Wang, Shaohui" uniqKey="Wang S" first="Shaohui" last="Wang">Shaohui Wang</name>
<name sortKey="Xu, Xiaoling" sort="Xu, Xiaoling" uniqKey="Xu X" first="Xiaoling" last="Xu">Xiaoling Xu</name>
</country>
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