Strain-Dependent Porcine Circovirus Type 2 (PCV2) Entry and Replication in T-Lymphoblasts
Identifieur interne : 000423 ( Main/Exploration ); précédent : 000422; suivant : 000424Strain-Dependent Porcine Circovirus Type 2 (PCV2) Entry and Replication in T-Lymphoblasts
Auteurs : Ruifang Wei ; Nicolaas Van Renne ; Hans J. NauwynckSource :
- Viruses [ 1999-4915 ] ; 2019.
Abstract
Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied. Here, the replication cycle of PCV2 (abortion strain 1121 and PMWS strain Stoon1010) in T-lymphoblasts was examined. The expression of Rep and Cap were found for both viral strains, while progeny virus was detected for Stoon1010 but not for 1121. PCV2 attached to 11–26% (1121-Stoon1010) of the T-lymphoblasts while 2.6–12.7% of cells showed virus internalization. Chondroitin sulfate (CS) was present on 25% of T-lymphoblasts, and colocalized with PCV2 on 31–32% of the PCV2+ cells. Enzymatic removal of CS reduced PCV2 infection. PCV2 infection was decreased by chlorpromazine, cytochalasin D and
Url:
DOI: 10.3390/v11090813
PubMed: 31480752
PubMed Central: 6783876
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Strain-Dependent Porcine Circovirus Type 2 (PCV2) Entry and Replication in T-Lymphoblasts</title><author><name sortKey="Wei, Ruifang" sort="Wei, Ruifang" uniqKey="Wei R" first="Ruifang" last="Wei">Ruifang Wei</name></author><author><name sortKey="Van Renne, Nicolaas" sort="Van Renne, Nicolaas" uniqKey="Van Renne N" first="Nicolaas" last="Van Renne">Nicolaas Van Renne</name></author><author><name sortKey="Nauwynck, Hans J" sort="Nauwynck, Hans J" uniqKey="Nauwynck H" first="Hans J." last="Nauwynck">Hans J. Nauwynck</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31480752</idno><idno type="pmc">6783876</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783876</idno><idno type="RBID">PMC:6783876</idno><idno type="doi">10.3390/v11090813</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000838</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000838</idno><idno type="wicri:Area/Pmc/Curation">000838</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000838</idno><idno type="wicri:Area/Pmc/Checkpoint">000380</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000380</idno><idno type="wicri:Area/Ncbi/Merge">000990</idno><idno type="wicri:Area/Ncbi/Curation">000990</idno><idno type="wicri:Area/Ncbi/Checkpoint">000990</idno><idno type="wicri:Area/Main/Merge">000423</idno><idno type="wicri:Area/Main/Curation">000423</idno><idno type="wicri:Area/Main/Exploration">000423</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Strain-Dependent Porcine Circovirus Type 2 (PCV2) Entry and Replication in T-Lymphoblasts</title><author><name sortKey="Wei, Ruifang" sort="Wei, Ruifang" uniqKey="Wei R" first="Ruifang" last="Wei">Ruifang Wei</name></author><author><name sortKey="Van Renne, Nicolaas" sort="Van Renne, Nicolaas" uniqKey="Van Renne N" first="Nicolaas" last="Van Renne">Nicolaas Van Renne</name></author><author><name sortKey="Nauwynck, Hans J" sort="Nauwynck, Hans J" uniqKey="Nauwynck H" first="Hans J." last="Nauwynck">Hans J. Nauwynck</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied. Here, the replication cycle of PCV2 (abortion strain 1121 and PMWS strain Stoon1010) in T-lymphoblasts was examined. The expression of Rep and Cap were found for both viral strains, while progeny virus was detected for Stoon1010 but not for 1121. PCV2 attached to 11–26% (1121-Stoon1010) of the T-lymphoblasts while 2.6–12.7% of cells showed virus internalization. Chondroitin sulfate (CS) was present on 25% of T-lymphoblasts, and colocalized with PCV2 on 31–32% of the PCV2+ cells. Enzymatic removal of CS reduced PCV2 infection. PCV2 infection was decreased by chlorpromazine, cytochalasin D and <italic>Clostridium difficile</italic> toxin B for both viral strains and by amiloride for 1121 but not for Stoon1010. Inhibiting either endosome acidification or serine proteases strongly reduced PCV2 infection. Three-dimensional analysis of Cap structure demonstrated a better Cap-nucleic acid affinity for Stoon1010 than for 1121. Taken together, PCV2 binds to T-lymphoblasts partially via CS, enters via clathrin-mediated endocytosis, and disassembles under functions of a pH-drop and serine proteases. Strain Stoon1010 displayed an enhanced viral binding, a specific receptor-mediated endocytosis, an increased Cap-nucleic acid affinity, and a more productive infection in T-lymphoblasts than 1121 did, indicating an evolution from 1121 to Stoon1010.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Todd, D" uniqKey="Todd D">D. Todd</name></author><author><name sortKey="Bendinelli, M" uniqKey="Bendinelli M">M. Bendinelli</name></author><author><name sortKey="Biagini, P" uniqKey="Biagini P">P. Biagini</name></author><author><name sortKey="Hino, S" uniqKey="Hino S">S. Hino</name></author><author><name sortKey="Mankertz, A" uniqKey="Mankertz A">A. Mankertz</name></author><author><name sortKey="Mishiro, S" uniqKey="Mishiro S">S. Mishiro</name></author><author><name sortKey="Niel, C" uniqKey="Niel C">C. Niel</name></author><author><name sortKey="Okamoto, H" uniqKey="Okamoto H">H. 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