Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma (Review)
Identifieur interne : 000389 ( Main/Exploration ); précédent : 000388; suivant : 000390Targeting autophagy is a promising therapeutic strategy to overcome chemoresistance and reduce metastasis in osteosarcoma (Review)
Auteurs : Yu-Xin Liao ; Hai-Yang Yu ; Ji-Yang Lv [République populaire de Chine] ; Yan-Rong Cai ; Fei Liu ; Zhi-Min He ; Shi-Sheng HeSource :
- International Journal of Oncology [ 1019-6439 ] ; 2019.
Abstract
Osteosarcoma (OS) is the most common primary bone malignancy, mainly affecting children and adolescents. Currently, surgical resection combined with adjuvant chemotherapy has been standardized for OS treatment. Despite great advances in chemotherapy for OS, its clinical prognosis remains far from satisfactory; this is due to chemoresistance, which has become a major obstacle to improving OS treatment. Autophagy, a catabolic process through which cells eliminate and recycle their own damaged proteins and organelles to provide energy, can be activated by chemotherapeutic drugs. Accumulating evidence has indicated that autophagy plays the dual role in the regulation of OS chemoresistance by either promoting drug resistance or increasing drug sensitivity. The aim of the present review was to demonstrate thatautophagy has both a cytoprotective and an autophagic cell death function in OS chemoresistance. In addition, methods to detect autophagy, autophagy inducers and inhibitors, as well as autophagy-mediated metastasis, immunotherapy and clinical prognosis are also discussed.
Url:
DOI: 10.3892/ijo.2019.4902
PubMed: 31638211
PubMed Central: 6831203
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240</wicri:regionArea><wicri:noRegion>Shanghai 200240</wicri:noRegion></affiliation></author><author><name sortKey="Cai, Yan Rong" sort="Cai, Yan Rong" uniqKey="Cai Y" first="Yan-Rong" last="Cai">Yan-Rong Cai</name><affiliation><nlm:aff id="af1-ijo-55-06-1213">Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072</nlm:aff><wicri:noCountry code="subfield">Shanghai 200072</wicri:noCountry></affiliation></author><author><name sortKey="Liu, Fei" sort="Liu, Fei" uniqKey="Liu F" first="Fei" last="Liu">Fei Liu</name><affiliation><nlm:aff id="af1-ijo-55-06-1213">Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072</nlm:aff><wicri:noCountry code="subfield">Shanghai 200072</wicri:noCountry></affiliation></author><author><name sortKey="He, Zhi Min" sort="He, Zhi Min" uniqKey="He Z" first="Zhi-Min" last="He">Zhi-Min He</name><affiliation><nlm:aff id="af1-ijo-55-06-1213">Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072</nlm:aff><wicri:noCountry code="subfield">Shanghai 200072</wicri:noCountry></affiliation></author><author><name sortKey="He, Shi Sheng" sort="He, Shi Sheng" uniqKey="He S" first="Shi-Sheng" last="He">Shi-Sheng He</name><affiliation><nlm:aff id="af1-ijo-55-06-1213">Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072</nlm:aff><wicri:noCountry code="subfield">Shanghai 200072</wicri:noCountry></affiliation></author></analytic><series><title level="j">International Journal of Oncology</title><idno type="ISSN">1019-6439</idno><idno type="eISSN">1791-2423</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Osteosarcoma (OS) is the most common primary bone malignancy, mainly affecting children and adolescents. Currently, surgical resection combined with adjuvant chemotherapy has been standardized for OS treatment. Despite great advances in chemotherapy for OS, its clinical prognosis remains far from satisfactory; this is due to chemoresistance, which has become a major obstacle to improving OS treatment. Autophagy, a catabolic process through which cells eliminate and recycle their own damaged proteins and organelles to provide energy, can be activated by chemotherapeutic drugs. Accumulating evidence has indicated that autophagy plays the dual role in the regulation of OS chemoresistance by either promoting drug resistance or increasing drug sensitivity. The aim of the present review was to demonstrate thatautophagy has both a cytoprotective and an autophagic cell death function in OS chemoresistance. In addition, methods to detect autophagy, autophagy inducers and inhibitors, as well as autophagy-mediated metastasis, immunotherapy and clinical prognosis are also discussed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morrow, Jj" uniqKey="Morrow J">JJ Morrow</name></author><author><name sortKey="Bayles, I" uniqKey="Bayles I">I Bayles</name></author><author><name sortKey="Funnell, Apw" uniqKey="Funnell A">APW Funnell</name></author><author><name sortKey="Miller, Te" uniqKey="Miller T">TE Miller</name></author><author><name sortKey="Saiakhova, A" uniqKey="Saiakhova A">A Saiakhova</name></author><author><name sortKey="Lizardo, Mm" uniqKey="Lizardo M">MM Lizardo</name></author><author><name sortKey="Bartels, Cf" uniqKey="Bartels C">CF Bartels</name></author><author><name sortKey="Kapteijn, My" uniqKey="Kapteijn M">MY Kapteijn</name></author><author><name sortKey="Hung, S" uniqKey="Hung S">S Hung</name></author><author><name 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sort="Liu, Fei" uniqKey="Liu F" first="Fei" last="Liu">Fei Liu</name><name sortKey="Yu, Hai Yang" sort="Yu, Hai Yang" uniqKey="Yu H" first="Hai-Yang" last="Yu">Hai-Yang Yu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Lv, Ji Yang" sort="Lv, Ji Yang" uniqKey="Lv J" first="Ji-Yang" last="Lv">Ji-Yang Lv</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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