Toward Normalization of the Tumor Microenvironment for Cancer Therapy
Identifieur interne : 000317 ( Main/Exploration ); précédent : 000316; suivant : 000318Toward Normalization of the Tumor Microenvironment for Cancer Therapy
Auteurs : Jie Zheng [République populaire de Chine] ; Peng Gao [États-Unis]Source :
- Integrative Cancer Therapies [ 1534-7354 ] ; 2019.
Abstract
The tumor microenvironment (TME) is a complex ecosystem, including blood vessels, immune cells, fibroblasts, extracellular matrix, cytokines, hormones, and so on. The TME differs from the normal tissue environment (NTE) in many aspects, such as tissue architecture, chronic inflammation, level of oxygen and pH, nutritional state of the cells, as well as tissue firmness. The NTE can inhibit the growth of cancer at the early tumorigenesis phase, whereas the TME promotes the growth of cancer in general, although it may have some anticancer effects. In particular, the TME plays a crucial role in the generation and maintenance of cancer stem cells, which lie at the root of cancer growth. Therefore, normalization of the TME to the NTE may inhibit cancer growth or improve cancer therapeutic efficiency. This review focuses on the recent emerging approaches for this normalization and the action mechanisms.
Url:
DOI: 10.1177/1534735419862352
PubMed: 31282197
PubMed Central: 6614947
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Toward Normalization of the Tumor Microenvironment for Cancer
Therapy</title><author><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name><affiliation wicri:level="1"><nlm:aff id="aff1-1534735419862352">Southeast University, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Southeast University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Peng" sort="Gao, Peng" uniqKey="Gao P" first="Peng" last="Gao">Peng Gao</name><affiliation wicri:level="1"><nlm:aff id="aff2-1534735419862352">Children’s Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children’s Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31282197</idno><idno type="pmc">6614947</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614947</idno><idno type="RBID">PMC:6614947</idno><idno type="doi">10.1177/1534735419862352</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000A40</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A40</idno><idno type="wicri:Area/Pmc/Curation">000A40</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A40</idno><idno type="wicri:Area/Pmc/Checkpoint">000281</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000281</idno><idno type="wicri:Area/Ncbi/Merge">000780</idno><idno type="wicri:Area/Ncbi/Curation">000780</idno><idno type="wicri:Area/Ncbi/Checkpoint">000780</idno><idno type="wicri:doubleKey">1534-7354:2019:Zheng J:toward:normalization:of</idno><idno type="wicri:Area/Main/Merge">000317</idno><idno type="wicri:Area/Main/Curation">000317</idno><idno type="wicri:Area/Main/Exploration">000317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Toward Normalization of the Tumor Microenvironment for Cancer
Therapy</title><author><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name><affiliation wicri:level="1"><nlm:aff id="aff1-1534735419862352">Southeast University, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Southeast University, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Peng" sort="Gao, Peng" uniqKey="Gao P" first="Peng" last="Gao">Peng Gao</name><affiliation wicri:level="1"><nlm:aff id="aff2-1534735419862352">Children’s Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children’s Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Integrative Cancer Therapies</title><idno type="ISSN">1534-7354</idno><idno type="eISSN">1552-695X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The tumor microenvironment (TME) is a complex ecosystem, including blood vessels,
immune cells, fibroblasts, extracellular matrix, cytokines, hormones, and so on.
The TME differs from the normal tissue environment (NTE) in many aspects, such
as tissue architecture, chronic inflammation, level of oxygen and pH,
nutritional state of the cells, as well as tissue firmness. The NTE can inhibit
the growth of cancer at the early tumorigenesis phase, whereas the TME promotes
the growth of cancer in general, although it may have some anticancer effects.
In particular, the TME plays a crucial role in the generation and maintenance of
cancer stem cells, which lie at the root of cancer growth. Therefore,
normalization of the TME to the NTE may inhibit cancer growth or improve cancer
therapeutic efficiency. This review focuses on the recent emerging approaches
for this normalization and the action mechanisms.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vogelstein, B" uniqKey="Vogelstein B">B Vogelstein</name></author><author><name sortKey="Kinzler, Kw" uniqKey="Kinzler K">KW. Kinzler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomasetti, C" uniqKey="Tomasetti C">C Tomasetti</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Vogelstein, B" uniqKey="Vogelstein B">B. Vogelstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cullen, Kj" uniqKey="Cullen K">KJ Cullen</name></author><author><name sortKey="Smith, Hs" uniqKey="Smith H">HS Smith</name></author><author><name sortKey="Hill, S" uniqKey="Hill S">S Hill</name></author><author><name sortKey="Rosen, N" uniqKey="Rosen N">N Rosen</name></author><author><name sortKey="Lippman, Me" uniqKey="Lippman M">ME. Lippman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huijbers, Ej" uniqKey="Huijbers E">EJ Huijbers</name></author><author><name sortKey="Van Beijnum, Jr" uniqKey="Van Beijnum J">JR van Beijnum</name></author><author><name sortKey="Thijssen, Vl" uniqKey="Thijssen V">VL Thijssen</name></author><author><name sortKey="Sabrkhany, S" uniqKey="Sabrkhany S">S Sabrkhany</name></author><author><name sortKey="Nowak Sliwinska, P" uniqKey="Nowak Sliwinska P">P Nowak-Sliwinska</name></author><author><name sortKey="Griffioen, Aw" uniqKey="Griffioen A">AW. Griffioen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patsialou, A" uniqKey="Patsialou A">A Patsialou</name></author><author><name sortKey="Wyckoff, J" uniqKey="Wyckoff J">J Wyckoff</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Goswami, S" uniqKey="Goswami S">S Goswami</name></author><author><name sortKey="Stanley, Er" uniqKey="Stanley E">ER Stanley</name></author><author><name sortKey="Condeelis, Js" uniqKey="Condeelis J">JS. Condeelis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name></author><author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA. Weinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webb, Ba" uniqKey="Webb B">BA Webb</name></author><author><name sortKey="Chimenti, M" uniqKey="Chimenti M">M Chimenti</name></author><author><name sortKey="Jacobson, Mp" uniqKey="Jacobson M">MP Jacobson</name></author><author><name sortKey="Barber, Dl" uniqKey="Barber D">DL. Barber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zane, L" uniqKey="Zane L">L Zane</name></author><author><name sortKey="Sharma, V" uniqKey="Sharma V">V Sharma</name></author><author><name sortKey="Misteli, T" uniqKey="Misteli T">T. Misteli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name></author><author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A. Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, C" uniqKey="Thomas C">C Thomas</name></author><author><name sortKey="Gustafsson, J" uniqKey="Gustafsson J">JÅ. Gustafsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lackner, Mr" uniqKey="Lackner M">MR Lackner</name></author><author><name sortKey="Wilson, Tr" uniqKey="Wilson T">TR Wilson</name></author><author><name sortKey="Settleman, J" uniqKey="Settleman J">J. Settleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arts, Rj" uniqKey="Arts R">RJ Arts</name></author><author><name sortKey="Plantinga, Ts" uniqKey="Plantinga T">TS Plantinga</name></author><author><name sortKey="Tuit, S" uniqKey="Tuit S">S Tuit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sousa, S" uniqKey="Sousa S">S Sousa</name></author><author><name sortKey="Brion, R" uniqKey="Brion R">R Brion</name></author><author><name sortKey="Lintunen, M" uniqKey="Lintunen M">M Lintunen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romano, M" uniqKey="Romano M">M Romano</name></author><author><name sortKey="De Francesco, F" uniqKey="De Francesco F">F De Francesco</name></author><author><name sortKey="Zarantonello, L" uniqKey="Zarantonello L">L Zarantonello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Zern, Ma" uniqKey="Zern M">MA Zern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naini, Bv" uniqKey="Naini B">BV Naini</name></author><author><name sortKey="Souza, Rf" uniqKey="Souza R">RF Souza</name></author><author><name sortKey="Odze, Rd" uniqKey="Odze R">RD. Odze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piccard, H" uniqKey="Piccard H">H Piccard</name></author><author><name sortKey="Muschel, Rj" uniqKey="Muschel R">RJ Muschel</name></author><author><name sortKey="Opdenakker, G" uniqKey="Opdenakker G">G. Opdenakker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guerriero, Jl" uniqKey="Guerriero J">JL Guerriero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sethi, G" uniqKey="Sethi G">G Sethi</name></author><author><name sortKey="Shanmugam, Mk" uniqKey="Shanmugam M">MK Shanmugam</name></author><author><name sortKey="Ramachandran, L" uniqKey="Ramachandran L">L Ramachandran</name></author><author><name sortKey="Kumar, Ap" uniqKey="Kumar A">AP Kumar</name></author><author><name sortKey="Tergaonkar, V" uniqKey="Tergaonkar V">V. Tergaonkar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cathcart, Mc" uniqKey="Cathcart M">MC Cathcart</name></author><author><name sortKey="O Yrne, Kj" uniqKey="O Yrne K">KJ O’Byrne</name></author><author><name sortKey="Reynolds, Jv" uniqKey="Reynolds J">JV Reynolds</name></author><author><name sortKey="O Ullivan, J" uniqKey="O Ullivan J">J O’Sullivan</name></author><author><name sortKey="Pidgeon, Gp" uniqKey="Pidgeon G">GP. Pidgeon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothwell, Pm" uniqKey="Rothwell P">PM Rothwell</name></author><author><name sortKey="Wilson, M" uniqKey="Wilson M">M Wilson</name></author><author><name sortKey="Price, Jf" uniqKey="Price J">JF Price</name></author><author><name sortKey="Belch, Jf" uniqKey="Belch J">JF Belch</name></author><author><name sortKey="Meade, Tw" uniqKey="Meade T">TW Meade</name></author><author><name sortKey="Mehta, Z" uniqKey="Mehta Z">Z. Mehta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thun, Mj" uniqKey="Thun M">MJ Thun</name></author><author><name sortKey="Henley, Sj" uniqKey="Henley S">SJ Henley</name></author><author><name sortKey="Patrono, C" uniqKey="Patrono C">C. Patrono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demaria, S" uniqKey="Demaria S">S Demaria</name></author><author><name sortKey="Pikarsky, E" uniqKey="Pikarsky E">E Pikarsky</name></author><author><name sortKey="Karin, M" uniqKey="Karin M">M Karin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, Bb" uniqKey="Su B">BB Su</name></author><author><name sortKey="Chen, Jh" uniqKey="Chen J">JH Chen</name></author><author><name sortKey="Shi, H" uniqKey="Shi H">H Shi</name></author><author><name sortKey="Chen, Qq" uniqKey="Chen Q">QQ Chen</name></author><author><name sortKey="Wan, J" uniqKey="Wan J">J. Wan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, J" uniqKey="Dai J">J Dai</name></author><author><name sortKey="Huang, Yj" uniqKey="Huang Y">YJ Huang</name></author><author><name sortKey="He, X" uniqKey="He X">X He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perumal, V" uniqKey="Perumal V">V Perumal</name></author><author><name sortKey="Banerjee, S" uniqKey="Banerjee S">S Banerjee</name></author><author><name sortKey="Das, S" uniqKey="Das S">S Das</name></author><author><name sortKey="Sen, Rk" uniqKey="Sen R">RK Sen</name></author><author><name sortKey="Mandal, M" uniqKey="Mandal M">M. Mandal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, P" uniqKey="Gao P">P Gao</name></author><author><name sortKey="Guan, L" uniqKey="Guan L">L Guan</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Jy" uniqKey="Liu J">JY Liu</name></author><author><name sortKey="Chiang, T" uniqKey="Chiang T">T Chiang</name></author><author><name sortKey="Liu, Ch" uniqKey="Liu C">CH Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mao, Aw" uniqKey="Mao A">AW Mao</name></author><author><name sortKey="Jiang, Th" uniqKey="Jiang T">TH Jiang</name></author><author><name sortKey="Sun, Xj" uniqKey="Sun X">XJ Sun</name></author><author><name sortKey="Peng, J" uniqKey="Peng J">J. Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frankenberger, C" uniqKey="Frankenberger C">C Frankenberger</name></author><author><name sortKey="Rabe, D" uniqKey="Rabe D">D Rabe</name></author><author><name sortKey="Bainer, R" uniqKey="Bainer R">R Bainer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halama, N" uniqKey="Halama N">N Halama</name></author><author><name sortKey="Zoernig, I" uniqKey="Zoernig I">I Zoernig</name></author><author><name sortKey="Berthel, A" uniqKey="Berthel A">A Berthel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pyzer, Ar" uniqKey="Pyzer A">AR Pyzer</name></author><author><name sortKey="Cole, L" uniqKey="Cole L">L Cole</name></author><author><name sortKey="Rosenblatt, J" uniqKey="Rosenblatt J">J Rosenblatt</name></author><author><name sortKey="Avigan, De" uniqKey="Avigan D">DE. Avigan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blidner, Ag" uniqKey="Blidner A">AG Blidner</name></author><author><name sortKey="Salatino, M" uniqKey="Salatino M">M Salatino</name></author><author><name sortKey="Mascanfroni, Id" uniqKey="Mascanfroni I">ID Mascanfroni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name></author><author><name sortKey="Kohanbash, G" uniqKey="Kohanbash G">G Kohanbash</name></author><author><name sortKey="Fellows Mayle, W" uniqKey="Fellows Mayle W">W Fellows-Mayle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, Dk" uniqKey="Chiu D">DK Chiu</name></author><author><name sortKey="Xu, Im" uniqKey="Xu I">IM Xu</name></author><author><name sortKey="Lai, Rk" uniqKey="Lai R">RK Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Draghiciu, O" uniqKey="Draghiciu O">O Draghiciu</name></author><author><name sortKey="Nijman, Hw" uniqKey="Nijman H">HW Nijman</name></author><author><name sortKey="Hoogeboom, Bn" uniqKey="Hoogeboom B">BN Hoogeboom</name></author><author><name sortKey="Meijerhof, T" uniqKey="Meijerhof T">T Meijerhof</name></author><author><name sortKey="Daemen, T" uniqKey="Daemen T">T. Daemen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finke, Jh" uniqKey="Finke J">JH Finke</name></author><author><name sortKey="Rayman, Pa" uniqKey="Rayman P">PA Rayman</name></author><author><name sortKey="Ko, Js" uniqKey="Ko J">JS Ko</name></author><author><name sortKey="Bradley, Jm" uniqKey="Bradley J">JM Bradley</name></author><author><name sortKey="Gendler, Sj" uniqKey="Gendler S">SJ Gendler</name></author><author><name sortKey="Cohen, Pa" uniqKey="Cohen P">PA. Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koelwyn, Gj" uniqKey="Koelwyn G">GJ Koelwyn</name></author><author><name sortKey="Quail, Df" uniqKey="Quail D">DF Quail</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="White, Rm" uniqKey="White R">RM White</name></author><author><name sortKey="Jones, Lw" uniqKey="Jones L">LW. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Sc" uniqKey="Wei S">SC Wei</name></author><author><name sortKey="Duffy, Cr" uniqKey="Duffy C">CR Duffy</name></author><author><name sortKey="Allison, Jp" uniqKey="Allison J">JP. Allison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu Monette, Zy" uniqKey="Xu Monette Z">ZY Xu-Monette</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Young, Kh" uniqKey="Young K">KH. Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukumura, D" uniqKey="Fukumura D">D Fukumura</name></author><author><name sortKey="Kloepper, J" uniqKey="Kloepper J">J Kloepper</name></author><author><name sortKey="Amoozgar, Z" uniqKey="Amoozgar Z">Z Amoozgar</name></author><author><name sortKey="Duda, Dg" uniqKey="Duda D">DG Duda</name></author><author><name sortKey="Jain, Rk" uniqKey="Jain R">RK. Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laoui, D" uniqKey="Laoui D">D Laoui</name></author><author><name sortKey="Van Overmeire, E" uniqKey="Van Overmeire E">E Van Overmeire</name></author><author><name sortKey="De Baetselier, P" uniqKey="De Baetselier P">P De Baetselier</name></author><author><name sortKey="Van Ginderachter, Ja" uniqKey="Van Ginderachter J">JA Van Ginderachter</name></author><author><name sortKey="Raes, G" uniqKey="Raes G">G. Raes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koh, Yw" uniqKey="Koh Y">YW Koh</name></author><author><name sortKey="Park, C" uniqKey="Park C">C Park</name></author><author><name sortKey="Yoon, Dh" uniqKey="Yoon D">DH Yoon</name></author><author><name sortKey="Suh, C" uniqKey="Suh C">C Suh</name></author><author><name sortKey="Huh, J" uniqKey="Huh J">J. Huh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ries, Ch" uniqKey="Ries C">CH Ries</name></author><author><name sortKey="Cannarile, Ma" uniqKey="Cannarile M">MA Cannarile</name></author><author><name sortKey="Hoves, S" uniqKey="Hoves S">S Hoves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pyonteck, Sm" uniqKey="Pyonteck S">SM Pyonteck</name></author><author><name sortKey="Akkari, L" uniqKey="Akkari L">L Akkari</name></author><author><name sortKey="Schuhmacher, Aj" uniqKey="Schuhmacher A">AJ Schuhmacher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mok, S" uniqKey="Mok S">S Mok</name></author><author><name sortKey="Koya, Rc" uniqKey="Koya R">RC Koya</name></author><author><name sortKey="Tsui, C" uniqKey="Tsui C">C Tsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pathria, P" uniqKey="Pathria P">P Pathria</name></author><author><name sortKey="Louis, Tl" uniqKey="Louis T">TL Louis</name></author><author><name sortKey="Varner, Ja" uniqKey="Varner J">JA. Varner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quail, Df" uniqKey="Quail D">DF Quail</name></author><author><name sortKey="Bowman, Rl" uniqKey="Bowman R">RL Bowman</name></author><author><name sortKey="Akkari, L" uniqKey="Akkari L">L Akkari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Ncalci, M" uniqKey="D Ncalci M">M D’Incalci</name></author><author><name sortKey="Badri, N" uniqKey="Badri N">N Badri</name></author><author><name sortKey="Galmarini, Cm" uniqKey="Galmarini C">CM Galmarini</name></author><author><name sortKey="Allavena, P" uniqKey="Allavena P">P. Allavena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Germano, G" uniqKey="Germano G">G Germano</name></author><author><name sortKey="Frapolli, R" uniqKey="Frapolli R">R Frapolli</name></author><author><name sortKey="Belgiovine, C" uniqKey="Belgiovine C">C Belgiovine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alkasalias, T" uniqKey="Alkasalias T">T Alkasalias</name></author><author><name sortKey="Flaberg, E" uniqKey="Flaberg E">E Flaberg</name></author><author><name sortKey="Kashuba, V" uniqKey="Kashuba V">V Kashuba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romer, Am" uniqKey="Romer A">AM Romer</name></author><author><name sortKey="Luhr, I" uniqKey="Luhr I">I Lühr</name></author><author><name sortKey="Klein, A" uniqKey="Klein A">A Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casey, Tm" uniqKey="Casey T">TM Casey</name></author><author><name sortKey="Eneman, J" uniqKey="Eneman J">J Eneman</name></author><author><name sortKey="Crocker, A" uniqKey="Crocker A">A Crocker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sherman, Mh" uniqKey="Sherman M">MH Sherman</name></author><author><name sortKey="Yu, Rt" uniqKey="Yu R">RT Yu</name></author><author><name sortKey="Engle, Dd" uniqKey="Engle D">DD Engle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campos, Lt" uniqKey="Campos L">LT Campos</name></author><author><name sortKey="Brentani, H" uniqKey="Brentani H">H Brentani</name></author><author><name sortKey="Roela, Ra" uniqKey="Roela R">RA Roela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, N" uniqKey="Ding N">N Ding</name></author><author><name sortKey="Yu, Rt" uniqKey="Yu R">RT Yu</name></author><author><name sortKey="Subramaniam, N" uniqKey="Subramaniam N">N Subramaniam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Froeling, Fe" uniqKey="Froeling F">FE Froeling</name></author><author><name sortKey="Feig, C" uniqKey="Feig C">C Feig</name></author><author><name sortKey="Chelala, C" uniqKey="Chelala C">C Chelala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, J" uniqKey="Guan J">J Guan</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Wen, Z" uniqKey="Wen Z">Z Wen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, X" uniqKey="Han X">X Han</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Th" uniqKey="Hsu T">TH Hsu</name></author><author><name sortKey="Xiao, Jl" uniqKey="Xiao J">JL Xiao</name></author><author><name sortKey="Tsao, Yw" uniqKey="Tsao Y">YW Tsao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calon, A" uniqKey="Calon A">A Calon</name></author><author><name sortKey="Lonardo, E" uniqKey="Lonardo E">E Lonardo</name></author><author><name sortKey="Berenguer Llergo, A" uniqKey="Berenguer Llergo A">A Berenguer-Llergo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, L" uniqKey="Hu L">L Hu</name></author><author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name></author><author><name sortKey="Chen, B" uniqKey="Chen B">B Chen</name></author><author><name sortKey="Bai, Y" uniqKey="Bai Y">Y. Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yauch, Rl" uniqKey="Yauch R">RL Yauch</name></author><author><name sortKey="Gould, Se" uniqKey="Gould S">SE Gould</name></author><author><name sortKey="Scales, Sj" uniqKey="Scales S">SJ Scales</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwang, Rf" uniqKey="Hwang R">RF Hwang</name></author><author><name sortKey="Moore, Tt" uniqKey="Moore T">TT Moore</name></author><author><name sortKey="Hattersley, Mm" uniqKey="Hattersley M">MM Hattersley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olive, Kp" uniqKey="Olive K">KP Olive</name></author><author><name sortKey="Jacobetz, Ma" uniqKey="Jacobetz M">MA Jacobetz</name></author><author><name sortKey="Davidson, Cj" uniqKey="Davidson C">CJ Davidson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coude, Mm" uniqKey="Coude M">MM Coude</name></author><author><name sortKey="Braun, T" uniqKey="Braun T">T Braun</name></author><author><name sortKey="Berrou, J" uniqKey="Berrou J">J Berrou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liao, Yf" uniqKey="Liao Y">YF Liao</name></author><author><name sortKey="Wu, Yb" uniqKey="Wu Y">YB Wu</name></author><author><name sortKey="Long, X" uniqKey="Long X">X Long</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, N" uniqKey="Ding N">N Ding</name></author><author><name sortKey="Hah, N" uniqKey="Hah N">N Hah</name></author><author><name sortKey="Yu, Rt" uniqKey="Yu R">RT Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, K" uniqKey="Klein K">K Klein</name></author><author><name sortKey="Kabala, Pa" uniqKey="Kabala P">PA Kabala</name></author><author><name sortKey="Grabiec, Am" uniqKey="Grabiec A">AM Grabiec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lehtonen, St" uniqKey="Lehtonen S">ST Lehtonen</name></author><author><name sortKey="Veijola, A" uniqKey="Veijola A">A Veijola</name></author><author><name sortKey="Karvonen, H" uniqKey="Karvonen H">H Karvonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mediavilla Varela, M" uniqKey="Mediavilla Varela M">M Mediavilla-Varela</name></author><author><name sortKey="Boateng, K" uniqKey="Boateng K">K Boateng</name></author><author><name sortKey="Noyes, D" uniqKey="Noyes D">D Noyes</name></author><author><name sortKey="Antonia, Sj" uniqKey="Antonia S">SJ. Antonia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozdemir, Bc" uniqKey="Ozdemir B">BC Özdemir</name></author><author><name sortKey="Pentcheva Hoang, T" uniqKey="Pentcheva Hoang T">T Pentcheva-Hoang</name></author><author><name sortKey="Carstens, Jl" uniqKey="Carstens J">JL Carstens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loges, S" uniqKey="Loges S">S Loges</name></author><author><name sortKey="Mazzone, M" uniqKey="Mazzone M">M Mazzone</name></author><author><name sortKey="Hohensinner, P" uniqKey="Hohensinner P">P Hohensinner</name></author><author><name sortKey="Carmeliet, P" uniqKey="Carmeliet P">P. Carmeliet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, Rk" uniqKey="Jain R">RK. Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thienpont, B" uniqKey="Thienpont B">B Thienpont</name></author><author><name sortKey="Steinbacher, J" uniqKey="Steinbacher J">J Steinbacher</name></author><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arjaans, M" uniqKey="Arjaans M">M Arjaans</name></author><author><name sortKey="Schroder, Cp" uniqKey="Schroder C">CP Schröder</name></author><author><name sortKey="Oosting, Sf" uniqKey="Oosting S">SF Oosting</name></author><author><name sortKey="Dafni, U" uniqKey="Dafni U">U Dafni</name></author><author><name sortKey="Kleibeuker, Je" uniqKey="Kleibeuker J">JE Kleibeuker</name></author><author><name sortKey="De Vries, Eg" uniqKey="De Vries E">EG. de Vries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tolaney, Sm" uniqKey="Tolaney S">SM Tolaney</name></author><author><name sortKey="Boucher, Y" uniqKey="Boucher Y">Y Boucher</name></author><author><name sortKey="Duda, Dg" uniqKey="Duda D">DG Duda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorensen, Ag" uniqKey="Sorensen A">AG Sorensen</name></author><author><name sortKey="Emblem, Ke" uniqKey="Emblem K">KE Emblem</name></author><author><name sortKey="Polaskova, P" uniqKey="Polaskova P">P Polaskova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Batchelor, Tt" uniqKey="Batchelor T">TT Batchelor</name></author><author><name sortKey="Gerstner, Er" uniqKey="Gerstner E">ER Gerstner</name></author><author><name sortKey="Emblem, Ke" uniqKey="Emblem K">KE Emblem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenberg, Ji" uniqKey="Greenberg J">JI Greenberg</name></author><author><name sortKey="Shields, Dj" uniqKey="Shields D">DJ Shields</name></author><author><name sortKey="Barillas, Sg" uniqKey="Barillas S">SG Barillas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Js" uniqKey="Park J">JS Park</name></author><author><name sortKey="Kim, Ik" uniqKey="Kim I">IK Kim</name></author><author><name sortKey="Han, S" uniqKey="Han S">S Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tamada, K" uniqKey="Tamada K">K Tamada</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johansson Percival, A" uniqKey="Johansson Percival A">A Johansson-Percival</name></author><author><name sortKey="Li, Zj" uniqKey="Li Z">ZJ Li</name></author><author><name sortKey="Lakhiani, Dd" uniqKey="Lakhiani D">DD Lakhiani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, B" uniqKey="He B">B He</name></author><author><name sortKey="Jabouille, A" uniqKey="Jabouille A">A Jabouille</name></author><author><name sortKey="Steri, V" uniqKey="Steri V">V Steri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mazzone, M" uniqKey="Mazzone M">M Mazzone</name></author><author><name sortKey="Dettori, D" uniqKey="Dettori D">D Dettori</name></author><author><name sortKey="De Oliveira, Rl" uniqKey="De Oliveira R">RL de Oliveira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Oliveira, Rl" uniqKey="De Oliveira R">RL de Oliveira</name></author><author><name sortKey="Deschoemaeker, S" uniqKey="Deschoemaeker S">S Deschoemaeker</name></author><author><name sortKey="Henze, At" uniqKey="Henze A">AT Henze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madsen, Cd" uniqKey="Madsen C">CD Madsen</name></author><author><name sortKey="Pedersen, Jt" uniqKey="Pedersen J">JT Pedersen</name></author><author><name sortKey="Venning, Fa" uniqKey="Venning F">FA Venning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tian, L" uniqKey="Tian L">L Tian</name></author><author><name sortKey="Goldstein, A" uniqKey="Goldstein A">A Goldstein</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Ren, Y" uniqKey="Ren Y">Y Ren</name></author><author><name sortKey="Tang, X" uniqKey="Tang X">X Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maes, H" uniqKey="Maes H">H Maes</name></author><author><name sortKey="Kuchnio, A" uniqKey="Kuchnio A">A Kuchnio</name></author><author><name sortKey="Peric, A" uniqKey="Peric A">A Peric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klug, F" uniqKey="Klug F">F Klug</name></author><author><name sortKey="Prakash, H" uniqKey="Prakash H">H Prakash</name></author><author><name sortKey="Huber, Pe" uniqKey="Huber P">PE Huber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name></author><author><name sortKey="Dong, Y" uniqKey="Dong Y">Y Dong</name></author><author><name sortKey="Peng, F" uniqKey="Peng F">F Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kolosenko, I" uniqKey="Kolosenko I">I Kolosenko</name></author><author><name sortKey="Avnet, S" uniqKey="Avnet S">S Avnet</name></author><author><name sortKey="Baldini, N" uniqKey="Baldini N">N Baldini</name></author><author><name sortKey="Viklund, J" uniqKey="Viklund J">J Viklund</name></author><author><name sortKey="De Milito, A" uniqKey="De Milito A">A. De Milito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinheiro, C" uniqKey="Pinheiro C">C Pinheiro</name></author><author><name sortKey="Longatto Filho, A" uniqKey="Longatto Filho A">A Longatto-Filho</name></author><author><name sortKey="Azevedo Silva, J" uniqKey="Azevedo Silva J">J Azevedo-Silva</name></author><author><name sortKey="Casal, M" uniqKey="Casal M">M Casal</name></author><author><name sortKey="Schmitt, Fc" uniqKey="Schmitt F">FC Schmitt</name></author><author><name sortKey="Baltazar, F" uniqKey="Baltazar F">F. Baltazar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luong Player, A" uniqKey="Luong Player A">A Luong-Player</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Wang, Hl" uniqKey="Wang H">HL Wang</name></author><author><name sortKey="Lin, F" uniqKey="Lin F">F. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amith, Sr" uniqKey="Amith S">SR Amith</name></author><author><name sortKey="Fong, S" uniqKey="Fong S">S Fong</name></author><author><name sortKey="Baksh, S" uniqKey="Baksh S">S Baksh</name></author><author><name sortKey="Fliegel, L" uniqKey="Fliegel L">L. Fliegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amith, Sr" uniqKey="Amith S">SR Amith</name></author><author><name sortKey="Wilkinson, Jm" uniqKey="Wilkinson J">JM Wilkinson</name></author><author><name sortKey="Baksh, S" uniqKey="Baksh S">S Baksh</name></author><author><name sortKey="Fliegel, L" uniqKey="Fliegel L">L. Fliegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matthews, H" uniqKey="Matthews H">H Matthews</name></author><author><name sortKey="Ranson, M" uniqKey="Ranson M">M Ranson</name></author><author><name sortKey="Kelso, Mj" uniqKey="Kelso M">MJ. Kelso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cong, D" uniqKey="Cong D">D Cong</name></author><author><name sortKey="Zhu, W" uniqKey="Zhu W">W Zhu</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lv, C" uniqKey="Lv C">C Lv</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Yu, B" uniqKey="Yu B">B Yu</name></author><author><name sortKey="Ma, Q" uniqKey="Ma Q">Q Ma</name></author><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mentzer, Rm" uniqKey="Mentzer R">RM Mentzer</name></author><author><name sortKey="Bartels, C" uniqKey="Bartels C">C Bartels</name></author><author><name sortKey="Bolli, R" uniqKey="Bolli R">R Bolli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amiri, A" uniqKey="Amiri A">A Amiri</name></author><author><name sortKey="Le, Pu" uniqKey="Le P">PU Le</name></author><author><name sortKey="Moquin, A" uniqKey="Moquin A">A Moquin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zatovicova, M" uniqKey="Zatovicova M">M Zatovicova</name></author><author><name sortKey="Jelenska, L" uniqKey="Jelenska L">L Jelenska</name></author><author><name sortKey="Hulikova, A" uniqKey="Hulikova A">A Hulikova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bola, Bm" uniqKey="Bola B">BM Bola</name></author><author><name sortKey="Chadwick, Al" uniqKey="Chadwick A">AL Chadwick</name></author><author><name sortKey="Michopoulos, F" uniqKey="Michopoulos F">F Michopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanson, Dj" uniqKey="Hanson D">DJ Hanson</name></author><author><name sortKey="Nakamura, S" uniqKey="Nakamura S">S Nakamura</name></author><author><name sortKey="Amachi, R" uniqKey="Amachi R">R Amachi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Floch, R" uniqKey="Le Floch R">R Le Floch</name></author><author><name sortKey="Chiche, J" uniqKey="Chiche J">J Chiche</name></author><author><name sortKey="Marchiq, I" uniqKey="Marchiq I">I Marchiq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polanski, R" uniqKey="Polanski R">R Polanski</name></author><author><name sortKey="Hodgkinson, Cl" uniqKey="Hodgkinson C">CL Hodgkinson</name></author><author><name sortKey="Fusi, A" uniqKey="Fusi A">A Fusi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Cs" uniqKey="Hong C">CS Hong</name></author><author><name sortKey="Graham, Na" uniqKey="Graham N">NA Graham</name></author><author><name sortKey="Gu, W" uniqKey="Gu W">W Gu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Gao, Peng" sort="Gao, Peng" uniqKey="Gao P" first="Peng" last="Gao">Peng Gao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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