A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3—PBX1 and β-catenin—ABCG2 signaling
Identifieur interne : 000228 ( Main/Exploration ); précédent : 000227; suivant : 000229A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3—PBX1 and β-catenin—ABCG2 signaling
Auteurs : Chia-Hsun Fang [Taïwan] ; Yi-Te Lin [Taïwan] ; Chi-Ming Liang [Taïwan] ; Shu-Mei Liang [Taïwan]Source :
- Journal of Biomedical Science [ 1021-7770 ] ; 2020.
Abstract
The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian cancer stemness and chemotherapy resistance.
Mass spectrum analysis and an in vitro kinase assay were conducted to examine the phosphorylation of PHB at tyrosine 259 by c-Kit. The in vitro effects of c-Kit on membrane raft-PHB in ovarian cancer were determined using tissue microarray (TMA)-based immunofluorescence, western blotting, immunoprecipitation, colony and spheroid formation, cell migration and cell viability assays. In vivo tumor initiation and carboplatin treatment were conducted in nude mice.
We found that c-Kit and PHB colocalized in the raft domain and were positively correlated in human ovarian serous carcinoma. c-Kit interacted with PHB and facilitated the phosphorylation of PHB at tyrosine 259 (phospho-PHBY259) in the membrane raft to enhance ovarian cancer cell motility. The generation of SKOV3GL-G4, a metastatic phenotype of SKOV3 green fluorescent protein and luciferase (GL) ovarian cancer cells, in xenograft murine ascites showed a correlation between metastatic potential and stem cell characteristics, as indicated by the expression of c-Kit, Notch3, Oct4, Nanog and SOX2. Further study revealed that after activation by c-Kit, raft-phospho-PHBY259 interacted with Notch3 to stabilize Notch3 and increase the downstream target PBX1. Downregulation of raft-phospho-PHBY259 increased the protein degradation of Notch3 through a lysosomal pathway and inhibited the β-catenin—ABCG2 signaling pathway. Moreover, raft-phospho-PHBY259 played an important role in ovarian cancer stemness and tumorigenicity as well as resistance to platinum drug treatment in vitro and in vivo.
These findings thus reveal a hitherto unreported interrelationship between c-Kit and PHB as well as the effects of raft-phospho-PHBY259 on ovarian cancer stemness and tumorigenicity mediated by the Notch3 and β-catenin signaling pathways. Targeting the c-Kit/raft-phospho-PHBY259 axis may provide a new therapeutic strategy for treating patients with ovarian cancer.
Url:
DOI: 10.1186/s12929-020-00638-x
PubMed: 32169072
PubMed Central: 7071647
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000098
- to stream Pmc, to step Curation: 000098
- to stream Pmc, to step Checkpoint: 000211
- to stream Ncbi, to step Merge: 001014
- to stream Ncbi, to step Curation: 001014
- to stream Ncbi, to step Checkpoint: 001014
- to stream Main, to step Merge: 000228
- to stream Main, to step Curation: 000228
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3—PBX1 and β-catenin—ABCG2 signaling</title><author><name sortKey="Fang, Chia Hsun" sort="Fang, Chia Hsun" uniqKey="Fang C" first="Chia-Hsun" last="Fang">Chia-Hsun Fang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Agricultural Biotechnology Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution>Institute of Biotechnology,</institution><institution>National Taiwan University,</institution></institution-wrap>4F, No. 81, Chang-Xing St, Taipei, 10672 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>4F, No. 81, Chang-Xing St, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yi Te" sort="Lin, Yi Te" uniqKey="Lin Y" first="Yi-Te" last="Lin">Yi-Te Lin</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Agricultural Biotechnology Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Chi Ming" sort="Liang, Chi Ming" uniqKey="Liang C" first="Chi-Ming" last="Liang">Chi-Ming Liang</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Genomics Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Shu Mei" sort="Liang, Shu Mei" uniqKey="Liang S" first="Shu-Mei" last="Liang">Shu-Mei Liang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Agricultural Biotechnology Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution>Institute of Biotechnology,</institution><institution>National Taiwan University,</institution></institution-wrap>4F, No. 81, Chang-Xing St, Taipei, 10672 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>4F, No. 81, Chang-Xing St, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32169072</idno><idno type="pmc">7071647</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071647</idno><idno type="RBID">PMC:7071647</idno><idno type="doi">10.1186/s12929-020-00638-x</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000098</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000098</idno><idno type="wicri:Area/Pmc/Curation">000098</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000098</idno><idno type="wicri:Area/Pmc/Checkpoint">000211</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000211</idno><idno type="wicri:Area/Ncbi/Merge">001014</idno><idno type="wicri:Area/Ncbi/Curation">001014</idno><idno type="wicri:Area/Ncbi/Checkpoint">001014</idno><idno type="wicri:doubleKey">1021-7770:2020:Fang C:a:novel:c</idno><idno type="wicri:Area/Main/Merge">000228</idno><idno type="wicri:Area/Main/Curation">000228</idno><idno type="wicri:Area/Main/Exploration">000228</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3—PBX1 and β-catenin—ABCG2 signaling</title><author><name sortKey="Fang, Chia Hsun" sort="Fang, Chia Hsun" uniqKey="Fang C" first="Chia-Hsun" last="Fang">Chia-Hsun Fang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Agricultural Biotechnology Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution>Institute of Biotechnology,</institution><institution>National Taiwan University,</institution></institution-wrap>4F, No. 81, Chang-Xing St, Taipei, 10672 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>4F, No. 81, Chang-Xing St, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yi Te" sort="Lin, Yi Te" uniqKey="Lin Y" first="Yi-Te" last="Lin">Yi-Te Lin</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Agricultural Biotechnology Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Chi Ming" sort="Liang, Chi Ming" uniqKey="Liang C" first="Chi-Ming" last="Liang">Chi-Ming Liang</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Genomics Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Shu Mei" sort="Liang, Shu Mei" uniqKey="Liang S" first="Shu-Mei" last="Liang">Shu-Mei Liang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.28665.3f</institution-id><institution-id institution-id-type="ISNI">0000 0001 2287 1366</institution-id><institution>Agricultural Biotechnology Research Center,</institution><institution>Academia Sinica,</institution></institution-wrap>128 Academia Rd, Sec. 2, Taipei, 11529 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>128 Academia Rd, Sec. 2, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.19188.39</institution-id><institution-id institution-id-type="ISNI">0000 0004 0546 0241</institution-id><institution>Institute of Biotechnology,</institution><institution>National Taiwan University,</institution></institution-wrap>4F, No. 81, Chang-Xing St, Taipei, 10672 Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>4F, No. 81, Chang-Xing St, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Biomedical Science</title><idno type="ISSN">1021-7770</idno><idno type="eISSN">1423-0127</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian cancer stemness and chemotherapy resistance.</p></sec><sec><title>Methods</title><p id="Par2">Mass spectrum analysis and an in vitro kinase assay were conducted to examine the phosphorylation of PHB at tyrosine 259 by c-Kit. The in vitro effects of c-Kit on membrane raft-PHB in ovarian cancer were determined using tissue microarray (TMA)-based immunofluorescence, western blotting, immunoprecipitation, colony and spheroid formation, cell migration and cell viability assays. In vivo tumor initiation and carboplatin treatment were conducted in nude mice.</p></sec><sec><title>Results</title><p id="Par3">We found that c-Kit and PHB colocalized in the raft domain and were positively correlated in human ovarian serous carcinoma. c-Kit interacted with PHB and facilitated the phosphorylation of PHB at tyrosine 259 (phospho-PHB<sup>Y259</sup>) in the membrane raft to enhance ovarian cancer cell motility. The generation of SKOV3GL-G4, a metastatic phenotype of SKOV3 green fluorescent protein and luciferase (GL) ovarian cancer cells, in xenograft murine ascites showed a correlation between metastatic potential and stem cell characteristics, as indicated by the expression of c-Kit, Notch3, Oct4, Nanog and SOX2. Further study revealed that after activation by c-Kit, raft-phospho-PHB<sup>Y259</sup> interacted with Notch3 to stabilize Notch3 and increase the downstream target PBX1. Downregulation of raft-phospho-PHB<sup>Y259</sup> increased the protein degradation of Notch3 through a lysosomal pathway and inhibited the β-catenin—ABCG2 signaling pathway. Moreover, raft-phospho-PHB<sup>Y259</sup> played an important role in ovarian cancer stemness and tumorigenicity as well as resistance to platinum drug treatment in vitro and in vivo.</p></sec><sec><title>Conclusions</title><p id="Par4">These findings thus reveal a hitherto unreported interrelationship between c-Kit and PHB as well as the effects of raft-phospho-PHB<sup>Y259</sup> on ovarian cancer stemness and tumorigenicity mediated by the Notch3 and β-catenin signaling pathways. Targeting the c-Kit/raft-phospho-PHB<sup>Y259</sup> axis may provide a new therapeutic strategy for treating patients with ovarian cancer.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vaughan, S" uniqKey="Vaughan S">S Vaughan</name></author><author><name sortKey="Coward, Ji" uniqKey="Coward J">JI Coward</name></author><author><name sortKey="Bast, Rc" uniqKey="Bast R">RC Bast</name></author><author><name sortKey="Berchuck, A" uniqKey="Berchuck A">A Berchuck</name></author><author><name sortKey="Berek, Js" uniqKey="Berek J">JS Berek</name></author><author><name sortKey="Brenton, Jd" uniqKey="Brenton J">JD Brenton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lengyel, E" uniqKey="Lengyel E">E Lengyel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Yu, Ts" uniqKey="Yu T">TS Yu</name></author><author><name sortKey="Mckay, Rm" uniqKey="Mckay R">RM McKay</name></author><author><name sortKey="Burns, Dk" uniqKey="Burns D">DK Burns</name></author><author><name sortKey="Kernie, Sg" uniqKey="Kernie S">SG Kernie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Rogoff, Ha" uniqKey="Rogoff H">HA Rogoff</name></author><author><name sortKey="Keates, S" uniqKey="Keates S">S Keates</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author><author><name sortKey="Murikipudi, S" uniqKey="Murikipudi S">S Murikipudi</name></author><author><name sortKey="Mikule, K" uniqKey="Mikule K">K Mikule</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Batlle, E" uniqKey="Batlle E">E Batlle</name></author><author><name sortKey="Clevers, H" uniqKey="Clevers H">H Clevers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cannistra, Sa" uniqKey="Cannistra S">SA Cannistra</name></author><author><name sortKey="Defranzo, B" uniqKey="Defranzo B">B DeFranzo</name></author><author><name sortKey="Niloff, J" uniqKey="Niloff J">J Niloff</name></author><author><name sortKey="Ottensmeir, C" uniqKey="Ottensmeir C">C Ottensmeir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrandina, G" uniqKey="Ferrandina G">G Ferrandina</name></author><author><name sortKey="Bonanno, G" uniqKey="Bonanno G">G Bonanno</name></author><author><name sortKey="Pierelli, L" uniqKey="Pierelli L">L Pierelli</name></author><author><name sortKey="Perillo, A" uniqKey="Perillo A">A Perillo</name></author><author><name sortKey="Procoli, A" uniqKey="Procoli A">A Procoli</name></author><author><name sortKey="Mariotti, A" uniqKey="Mariotti A">A Mariotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Balch, C" uniqKey="Balch C">C Balch</name></author><author><name sortKey="Chan, Mw" uniqKey="Chan M">MW Chan</name></author><author><name sortKey="Lai, Hc" uniqKey="Lai H">HC Lai</name></author><author><name sortKey="Matei, D" uniqKey="Matei D">D Matei</name></author><author><name sortKey="Schilder, Jm" uniqKey="Schilder J">JM Schilder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curley, Md" uniqKey="Curley M">MD Curley</name></author><author><name sortKey="Therrien, Va" uniqKey="Therrien V">VA Therrien</name></author><author><name sortKey="Cummings, Cl" uniqKey="Cummings C">CL Cummings</name></author><author><name sortKey="Sergent, Pa" uniqKey="Sergent P">PA Sergent</name></author><author><name sortKey="Koulouris, Cr" uniqKey="Koulouris C">CR Koulouris</name></author><author><name sortKey="Friel, Am" uniqKey="Friel A">AM Friel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Mq" uniqKey="Gao M">MQ Gao</name></author><author><name sortKey="Choi, Yp" uniqKey="Choi Y">YP Choi</name></author><author><name sortKey="Kang, S" uniqKey="Kang S">S Kang</name></author><author><name sortKey="Youn, Jh" uniqKey="Youn J">JH Youn</name></author><author><name sortKey="Cho, Nh" uniqKey="Cho N">NH Cho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koren, E" uniqKey="Koren E">E Koren</name></author><author><name sortKey="Fuchs, Y" uniqKey="Fuchs Y">Y Fuchs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stimpfel, M" uniqKey="Stimpfel M">M Stimpfel</name></author><author><name sortKey="Virant Klun, I" uniqKey="Virant Klun I">I Virant-Klun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurman, Rj" uniqKey="Kurman R">RJ Kurman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mills, Gb" uniqKey="Mills G">GB Mills</name></author><author><name sortKey="May, C" uniqKey="May C">C May</name></author><author><name sortKey="Hill, M" uniqKey="Hill M">M Hill</name></author><author><name sortKey="Campbell, S" uniqKey="Campbell S">S Campbell</name></author><author><name sortKey="Shaw, P" uniqKey="Shaw P">P Shaw</name></author><author><name sortKey="Marks, A" uniqKey="Marks A">A Marks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, L" uniqKey="Hu L">L Hu</name></author><author><name sortKey="Mcarthur, C" uniqKey="Mcarthur C">C McArthur</name></author><author><name sortKey="Jaffe, Rb" uniqKey="Jaffe R">RB Jaffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmandt, Re" uniqKey="Schmandt R">RE Schmandt</name></author><author><name sortKey="Broaddus, R" uniqKey="Broaddus R">R Broaddus</name></author><author><name sortKey="Lu, Kh" uniqKey="Lu K">KH Lu</name></author><author><name sortKey="Shvartsman, H" uniqKey="Shvartsman H">H Shvartsman</name></author><author><name sortKey="Thornton, A" uniqKey="Thornton A">A Thornton</name></author><author><name sortKey="Malpica, A" uniqKey="Malpica A">A Malpica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raspollini, Mr" uniqKey="Raspollini M">MR Raspollini</name></author><author><name sortKey="Amunni, G" uniqKey="Amunni G">G Amunni</name></author><author><name sortKey="Villanucci, A" uniqKey="Villanucci A">A Villanucci</name></author><author><name sortKey="Baroni, G" uniqKey="Baroni G">G Baroni</name></author><author><name sortKey="Taddei, A" uniqKey="Taddei A">A Taddei</name></author><author><name sortKey="Taddei, Gl" uniqKey="Taddei G">GL Taddei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brustmann, H" uniqKey="Brustmann H">H Brustmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chau, Wk" uniqKey="Chau W">WK Chau</name></author><author><name sortKey="Ip, Ck" uniqKey="Ip C">CK Ip</name></author><author><name sortKey="Mak, As" uniqKey="Mak A">AS Mak</name></author><author><name sortKey="Lai, Hc" uniqKey="Lai H">HC Lai</name></author><author><name sortKey="Wong, As" uniqKey="Wong A">AS Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lennartsson, J" uniqKey="Lennartsson J">J Lennartsson</name></author><author><name sortKey="Ronnstrand, L" uniqKey="Ronnstrand L">L Ronnstrand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yan, F" uniqKey="Yan F">F Yan</name></author><author><name sortKey="Shen, N" uniqKey="Shen N">N Shen</name></author><author><name sortKey="Pang, J" uniqKey="Pang J">J Pang</name></author><author><name sortKey="Zhao, N" uniqKey="Zhao N">N Zhao</name></author><author><name sortKey="Deng, B" uniqKey="Deng B">B Deng</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foster, Brittni" uniqKey="Foster B">Brittni Foster</name></author><author><name sortKey="Zaidi, Danish" uniqKey="Zaidi D">Danish Zaidi</name></author><author><name sortKey="Young, Tyler" uniqKey="Young T">Tyler Young</name></author><author><name sortKey="Mobley, Mary" uniqKey="Mobley M">Mary Mobley</name></author><author><name sortKey="Kerr, Bethany" uniqKey="Kerr B">Bethany Kerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mishra, S" uniqKey="Mishra S">S Mishra</name></author><author><name sortKey="Murphy, Lc" uniqKey="Murphy L">LC Murphy</name></author><author><name sortKey="Nyomba, Bl" uniqKey="Nyomba B">BL Nyomba</name></author><author><name sortKey="Murphy, Lj" uniqKey="Murphy L">LJ Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="He, Qy" uniqKey="He Q">QY He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, N" uniqKey="Patel N">N Patel</name></author><author><name sortKey="Chatterjee, Sk" uniqKey="Chatterjee S">SK Chatterjee</name></author><author><name sortKey="Vrbanac, V" uniqKey="Vrbanac V">V Vrbanac</name></author><author><name sortKey="Chung, I" uniqKey="Chung I">I Chung</name></author><author><name sortKey="Mu, Cj" uniqKey="Mu C">CJ Mu</name></author><author><name sortKey="Olsen, Rr" uniqKey="Olsen R">RR Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortiz, Mv" uniqKey="Ortiz M">MV Ortiz</name></author><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Burns, M" uniqKey="Burns M">M Burns</name></author><author><name sortKey="Henssen, Ag" uniqKey="Henssen A">AG Henssen</name></author><author><name sortKey="Hollmann, Tj" uniqKey="Hollmann T">TJ Hollmann</name></author><author><name sortKey="Macarthur, I" uniqKey="Macarthur I">I MacArthur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Begum, A" uniqKey="Begum A">A Begum</name></author><author><name sortKey="Lin, Q" uniqKey="Lin Q">Q Lin</name></author><author><name sortKey="Yu, C" uniqKey="Yu C">C Yu</name></author><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name></author><author><name sortKey="Yun, Z" uniqKey="Yun Z">Z Yun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macarthur, Ic" uniqKey="Macarthur I">IC MacArthur</name></author><author><name sortKey="Bei, Y" uniqKey="Bei Y">Y Bei</name></author><author><name sortKey="Garcia, Hd" uniqKey="Garcia H">HD Garcia</name></author><author><name sortKey="Ortiz, Mv" uniqKey="Ortiz M">MV Ortiz</name></author><author><name sortKey="Toedling, J" uniqKey="Toedling J">J Toedling</name></author><author><name sortKey="Klironomos, F" uniqKey="Klironomos F">F Klironomos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, Cf" uniqKey="Chiu C">CF Chiu</name></author><author><name sortKey="Ho, My" uniqKey="Ho M">MY Ho</name></author><author><name sortKey="Peng, Jm" uniqKey="Peng J">JM Peng</name></author><author><name sortKey="Hung, Sw" uniqKey="Hung S">SW Hung</name></author><author><name sortKey="Lee, Wh" uniqKey="Lee W">WH Lee</name></author><author><name sortKey="Liang, Cm" uniqKey="Liang C">CM Liang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, Jm" uniqKey="Peng J">JM Peng</name></author><author><name sortKey="Chen, Yh" uniqKey="Chen Y">YH Chen</name></author><author><name sortKey="Hung, Sw" uniqKey="Hung S">SW Hung</name></author><author><name sortKey="Chiu, Cf" uniqKey="Chiu C">CF Chiu</name></author><author><name sortKey="Ho, My" uniqKey="Ho M">MY Ho</name></author><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kolonin, Mg" uniqKey="Kolonin M">MG Kolonin</name></author><author><name sortKey="Saha, Pk" uniqKey="Saha P">PK Saha</name></author><author><name sortKey="Chan, L" uniqKey="Chan L">L Chan</name></author><author><name sortKey="Pasqualini, R" uniqKey="Pasqualini R">R Pasqualini</name></author><author><name sortKey="Arap, W" uniqKey="Arap W">W Arap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Staquicini, Fi" uniqKey="Staquicini F">FI Staquicini</name></author><author><name sortKey="Cardo Vila, M" uniqKey="Cardo Vila M">M Cardo-Vila</name></author><author><name sortKey="Kolonin, Mg" uniqKey="Kolonin M">MG Kolonin</name></author><author><name sortKey="Trepel, M" uniqKey="Trepel M">M Trepel</name></author><author><name sortKey="Edwards, Jk" uniqKey="Edwards J">JK Edwards</name></author><author><name sortKey="Nunes, Dn" uniqKey="Nunes D">DN Nunes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Domcke, S" uniqKey="Domcke S">S Domcke</name></author><author><name sortKey="Sinha, R" uniqKey="Sinha R">R Sinha</name></author><author><name sortKey="Levine, Da" uniqKey="Levine D">DA Levine</name></author><author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name></author><author><name sortKey="Schultz, N" uniqKey="Schultz N">N Schultz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, H" uniqKey="Kang H">H Kang</name></author><author><name sortKey="Jeong, Jy" uniqKey="Jeong J">JY Jeong</name></author><author><name sortKey="Song, Jy" uniqKey="Song J">JY Song</name></author><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name></author><author><name sortKey="Kim, G" uniqKey="Kim G">G Kim</name></author><author><name sortKey="Huh, Jh" uniqKey="Huh J">JH Huh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceccarelli, S" uniqKey="Ceccarelli S">S Ceccarelli</name></author><author><name sortKey="Megiorni, F" uniqKey="Megiorni F">F Megiorni</name></author><author><name sortKey="Bellavia, D" uniqKey="Bellavia D">D Bellavia</name></author><author><name sortKey="Marchese, C" uniqKey="Marchese C">C Marchese</name></author><author><name sortKey="Screpanti, I" uniqKey="Screpanti I">I Screpanti</name></author><author><name sortKey="Checquolo, S" uniqKey="Checquolo S">S Checquolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bapat, Sa" uniqKey="Bapat S">SA Bapat</name></author><author><name sortKey="Mali, Am" uniqKey="Mali A">AM Mali</name></author><author><name sortKey="Koppikar, Cb" uniqKey="Koppikar C">CB Koppikar</name></author><author><name sortKey="Kurrey, Nk" uniqKey="Kurrey N">NK Kurrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brabletz, T" uniqKey="Brabletz T">T Brabletz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jt" uniqKey="Park J">JT Park</name></author><author><name sortKey="Shih Ie, M" uniqKey="Shih Ie M">M Shih Ie</name></author><author><name sortKey="Wang, Tl" uniqKey="Wang T">TL Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, Jg" uniqKey="Jung J">JG Jung</name></author><author><name sortKey="Shih, Im" uniqKey="Shih I">IM Shih</name></author><author><name sortKey="Park, Jt" uniqKey="Park J">JT Park</name></author><author><name sortKey="Gerry, E" uniqKey="Gerry E">E Gerry</name></author><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name></author><author><name sortKey="Ayhan, A" uniqKey="Ayhan A">A Ayhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phi, Lth" uniqKey="Phi L">LTH Phi</name></author><author><name sortKey="Sari, In" uniqKey="Sari I">IN Sari</name></author><author><name sortKey="Yang, Y G" uniqKey="Yang Y">Y-G Yang</name></author><author><name sortKey="Lee, S H" uniqKey="Lee S">S-H Lee</name></author><author><name sortKey="Jun, N" uniqKey="Jun N">N Jun</name></author><author><name sortKey="Kim, Ks" uniqKey="Kim K">KS Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ande, Sr" uniqKey="Ande S">SR Ande</name></author><author><name sortKey="Moulik, S" uniqKey="Moulik S">S Moulik</name></author><author><name sortKey="Mishra, S" uniqKey="Mishra S">S Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ande, Sr" uniqKey="Ande S">SR Ande</name></author><author><name sortKey="Gu, Y" uniqKey="Gu Y">Y Gu</name></author><author><name sortKey="Nyomba, Bl" uniqKey="Nyomba B">BL Nyomba</name></author><author><name sortKey="Mishra, S" uniqKey="Mishra S">S Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ande, Sr" uniqKey="Ande S">SR Ande</name></author><author><name sortKey="Nguyen, Kh" uniqKey="Nguyen K">KH Nguyen</name></author><author><name sortKey="Padilla Meier, Gp" uniqKey="Padilla Meier G">GP Padilla-Meier</name></author><author><name sortKey="Nyomba, Bl" uniqKey="Nyomba B">BL Nyomba</name></author><author><name sortKey="Mishra, S" uniqKey="Mishra S">S Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ande, Sr" uniqKey="Ande S">SR Ande</name></author><author><name sortKey="Xu, Yxz" uniqKey="Xu Y">YXZ Xu</name></author><author><name sortKey="Mishra, S" uniqKey="Mishra S">S Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krishnamoorthy, N" uniqKey="Krishnamoorthy N">N Krishnamoorthy</name></author><author><name sortKey="Oriss, Tb" uniqKey="Oriss T">TB Oriss</name></author><author><name sortKey="Paglia, M" uniqKey="Paglia M">M Paglia</name></author><author><name sortKey="Fei, M" uniqKey="Fei M">M Fei</name></author><author><name sortKey="Yarlagadda, M" uniqKey="Yarlagadda M">M Yarlagadda</name></author><author><name sortKey="Vanhaesebroeck, B" uniqKey="Vanhaesebroeck B">B Vanhaesebroeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, Av" uniqKey="Das A">AV Das</name></author><author><name sortKey="James, J" uniqKey="James J">J James</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Rahnenfuhrer, J" uniqKey="Rahnenfuhrer J">J Rahnenfuhrer</name></author><author><name sortKey="Ahmad, I" uniqKey="Ahmad I">I Ahmad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ray, P" uniqKey="Ray P">P Ray</name></author><author><name sortKey="Krishnamoorthy, N" uniqKey="Krishnamoorthy N">N Krishnamoorthy</name></author><author><name sortKey="Ray, A" uniqKey="Ray A">A Ray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Mj" uniqKey="Kim M">MJ Kim</name></author><author><name sortKey="Kim, Ar" uniqKey="Kim A">AR Kim</name></author><author><name sortKey="Jeong, Jy" uniqKey="Jeong J">JY Jeong</name></author><author><name sortKey="Kim, Ki" uniqKey="Kim K">KI Kim</name></author><author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name></author><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcauliffe, Sm" uniqKey="Mcauliffe S">SM McAuliffe</name></author><author><name sortKey="Morgan, Sl" uniqKey="Morgan S">SL Morgan</name></author><author><name sortKey="Wyant, Ga" uniqKey="Wyant G">GA Wyant</name></author><author><name sortKey="Tran, Lt" uniqKey="Tran L">LT Tran</name></author><author><name sortKey="Muto, Kw" uniqKey="Muto K">KW Muto</name></author><author><name sortKey="Chen, Ys" uniqKey="Chen Y">YS Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jt" uniqKey="Park J">JT Park</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Nakayama, K" uniqKey="Nakayama K">K Nakayama</name></author><author><name sortKey="Mao, Tl" uniqKey="Mao T">TL Mao</name></author><author><name sortKey="Davidson, B" uniqKey="Davidson B">B Davidson</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Ivan, C" uniqKey="Ivan C">C Ivan</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author><author><name sortKey="Mangala, Ls" uniqKey="Mangala L">LS Mangala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jt" uniqKey="Park J">JT Park</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Trope, Cg" uniqKey="Trope C">CG Trope</name></author><author><name sortKey="Davidson, B" uniqKey="Davidson B">B Davidson</name></author><author><name sortKey="Shih Ie, M" uniqKey="Shih Ie M">M Shih Ie</name></author><author><name sortKey="Wang, Tl" uniqKey="Wang T">TL Wang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Fang, Chia Hsun" sort="Fang, Chia Hsun" uniqKey="Fang C" first="Chia-Hsun" last="Fang">Chia-Hsun Fang</name></noRegion><name sortKey="Fang, Chia Hsun" sort="Fang, Chia Hsun" uniqKey="Fang C" first="Chia-Hsun" last="Fang">Chia-Hsun Fang</name><name sortKey="Liang, Chi Ming" sort="Liang, Chi Ming" uniqKey="Liang C" first="Chi-Ming" last="Liang">Chi-Ming Liang</name><name sortKey="Liang, Shu Mei" sort="Liang, Shu Mei" uniqKey="Liang S" first="Shu-Mei" last="Liang">Shu-Mei Liang</name><name sortKey="Liang, Shu Mei" sort="Liang, Shu Mei" uniqKey="Liang S" first="Shu-Mei" last="Liang">Shu-Mei Liang</name><name sortKey="Lin, Yi Te" sort="Lin, Yi Te" uniqKey="Lin Y" first="Yi-Te" last="Lin">Yi-Te Lin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000228 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000228 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7071647
|texte= A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3—PBX1 and β-catenin—ABCG2 signaling
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32169072" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |