Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition
Identifieur interne : 000213 ( Main/Exploration ); précédent : 000212; suivant : 000214Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition
Auteurs : Bowen Yang ; Li Ding ; Yu Chen ; Jianlin ShiSource :
- Advanced Science [ 2198-3844 ] ; 2020.
Abstract
It was recently recognized that cancer therapeutic efficacy may be greatly compromised by an intrinsic protective mechanism called autophagy, by which cancer cells survive in harsh conditions such as starvation. Here, a synergetic strategy is described for cancer treatment by suppressing such a protective mechanism for augmenting tumor‐starvation therapy. The synergetic therapy is achieved by restraining glucose metabolism using an antiglycolytic agent to predispose cancer cells to severe energy deprivation; concurrently the downstream autophagic flux and compensatory energy supplies are blocked by the autophagy inhibitor black phosphorus nanosheet. Cancer cells fail to extract their own nutrient to feed themselves, finally succumbing to therapeutic interventions and starving to death. Both in vitro and in vivo results evidence the cooperative effect between the autophagy inhibitor and antiglycolytic agent, which leads to remarkable synergetic antineoplastic outcome. It is expected that such a combinational approach by concurrently blocking exogenous and endogenous nutrition supplies will be beneficial to the design of effective tumor‐specific cancer therapies in the future.
Url:
DOI: 10.1002/advs.201902847
PubMed: 32195096
PubMed Central: 7080508
Affiliations:
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Here, a synergetic strategy is described for cancer treatment by suppressing such a protective mechanism for augmenting tumor‐starvation therapy. The synergetic therapy is achieved by restraining glucose metabolism using an antiglycolytic agent to predispose cancer cells to severe energy deprivation; concurrently the downstream autophagic flux and compensatory energy supplies are blocked by the autophagy inhibitor black phosphorus nanosheet. Cancer cells fail to extract their own nutrient to feed themselves, finally succumbing to therapeutic interventions and starving to death. Both in vitro and in vivo results evidence the cooperative effect between the autophagy inhibitor and antiglycolytic agent, which leads to remarkable synergetic antineoplastic outcome. 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