Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
Identifieur interne : 000147 ( Main/Exploration ); précédent : 000146; suivant : 000148Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
Auteurs : Bo Li [États-Unis] ; Sara M. Clohisey ; Bing Shao Chia [États-Unis] ; Bo Wang ; Ang Cui [États-Unis] ; Thomas Eisenhaure [États-Unis] ; Lawrence D. Schweitzer [États-Unis] ; Paul Hoover [États-Unis] ; Nicholas J. Parkinson ; Aharon Nachshon [Israël] ; Nikki Smith ; Tim Regan ; David Farr ; Michael U. Gutmann ; Syed Irfan Bukhari [États-Unis] ; Andrew Law ; Maya Sangesland [États-Unis] ; Irit Gat-Viks [États-Unis, Israël] ; Paul Digard ; Shobha Vasudevan [États-Unis] ; Daniel Lingwood [États-Unis] ; David H. Dockrell [Royaume-Uni] ; John G. Doench [États-Unis] ; J. Kenneth Baillie ; Nir Hacohen [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2020.
Abstract
Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous attempts to identify host factors have produced largely divergent results, with few overlapping hits across different studies. Here, we perform a genome-wide CRISPR/Cas9 screen and devise a new approach, meta-analysis by information content (MAIC) to systematically combine our results with prior evidence for influenza host factors. MAIC out-performs other meta-analysis methods when using our CRISPR screen as validation data. We validate the host factors,
Url:
DOI: 10.1038/s41467-019-13965-x
PubMed: 31919360
PubMed Central: 6952391
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Pmc, to step Checkpoint: 000137
- to stream Ncbi, to step Merge: 000E17
- to stream Ncbi, to step Curation: 000E17
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Le document en format XML
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<affiliation><nlm:aff id="Aff1">Harvard University Virology Program, Harvfvard Medical School, Boston, MA02142 USA</nlm:aff>
<wicri:noCountry code="subfield">MA02142 USA</wicri:noCountry>
</affiliation>
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<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>415 Main Street, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Bo" sort="Wang, Bo" uniqKey="Wang B" first="Bo" last="Wang">Bo Wang</name>
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<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cui, Ang" sort="Cui, Ang" uniqKey="Cui A" first="Ang" last="Cui">Ang Cui</name>
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<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
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<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Harvard-MIT Health Sciences and Technology,</institution>
<institution>Harvard Medical School,</institution>
</institution-wrap>
Boston, MA 02115 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Eisenhaure, Thomas" sort="Eisenhaure, Thomas" uniqKey="Eisenhaure T" first="Thomas" last="Eisenhaure">Thomas Eisenhaure</name>
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<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>415 Main Street, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schweitzer, Lawrence D" sort="Schweitzer, Lawrence D" uniqKey="Schweitzer L" first="Lawrence D." last="Schweitzer">Lawrence D. Schweitzer</name>
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<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>415 Main Street, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hoover, Paul" sort="Hoover, Paul" uniqKey="Hoover P" first="Paul" last="Hoover">Paul Hoover</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>415 Main Street, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Parkinson, Nicholas J" sort="Parkinson, Nicholas J" uniqKey="Parkinson N" first="Nicholas J." last="Parkinson">Nicholas J. Parkinson</name>
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<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Nachshon, Aharon" sort="Nachshon, Aharon" uniqKey="Nachshon A" first="Aharon" last="Nachshon">Aharon Nachshon</name>
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<institution-id institution-id-type="GRID">grid.12136.37</institution-id>
<institution>School of Molecular Cell Biology and Biotechnology, Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences,</institution>
<institution>Tel Aviv University,</institution>
</institution-wrap>
Tel Aviv, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Tel Aviv</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Nikki" sort="Smith, Nikki" uniqKey="Smith N" first="Nikki" last="Smith">Nikki Smith</name>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Regan, Tim" sort="Regan, Tim" uniqKey="Regan T" first="Tim" last="Regan">Tim Regan</name>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Farr, David" sort="Farr, David" uniqKey="Farr D" first="David" last="Farr">David Farr</name>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gutmann, Michael U" sort="Gutmann, Michael U" uniqKey="Gutmann M" first="Michael U." last="Gutmann">Michael U. Gutmann</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>School of informatics,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, EH8 9YL UK</nlm:aff>
<wicri:noCountry code="subfield">EH8 9YL UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bukhari, Syed Irfan" sort="Bukhari, Syed Irfan" uniqKey="Bukhari S" first="Syed Irfan" last="Bukhari">Syed Irfan Bukhari</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Center for Cancer Research, Massachusetts General hospital,</institution>
<institution>Harvard Medical School,</institution>
</institution-wrap>
Boston, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Law, Andrew" sort="Law, Andrew" uniqKey="Law A" first="Andrew" last="Law">Andrew Law</name>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sangesland, Maya" sort="Sangesland, Maya" uniqKey="Sangesland M" first="Maya" last="Sangesland">Maya Sangesland</name>
<affiliation wicri:level="2"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>The Ragon Institute of Massachusetts General Hospital,</institution>
<institution>MIT and Harvard University,</institution>
</institution-wrap>
Cambridge, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gat Viks, Irit" sort="Gat Viks, Irit" uniqKey="Gat Viks I" first="Irit" last="Gat-Viks">Irit Gat-Viks</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>415 Main Street, Cambridge</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1937 0546</institution-id>
<institution-id institution-id-type="GRID">grid.12136.37</institution-id>
<institution>School of Molecular Cell Biology and Biotechnology, Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences,</institution>
<institution>Tel Aviv University,</institution>
</institution-wrap>
Tel Aviv, Israel</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Tel Aviv</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Digard, Paul" sort="Digard, Paul" uniqKey="Digard P" first="Paul" last="Digard">Paul Digard</name>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vasudevan, Shobha" sort="Vasudevan, Shobha" uniqKey="Vasudevan S" first="Shobha" last="Vasudevan">Shobha Vasudevan</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>Center for Cancer Research, Massachusetts General hospital,</institution>
<institution>Harvard Medical School,</institution>
</institution-wrap>
Boston, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lingwood, Daniel" sort="Lingwood, Daniel" uniqKey="Lingwood D" first="Daniel" last="Lingwood">Daniel Lingwood</name>
<affiliation wicri:level="2"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">000000041936754X</institution-id>
<institution-id institution-id-type="GRID">grid.38142.3c</institution-id>
<institution>The Ragon Institute of Massachusetts General Hospital,</institution>
<institution>MIT and Harvard University,</institution>
</institution-wrap>
Cambridge, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dockrell, David H" sort="Dockrell, David H" uniqKey="Dockrell D" first="David H." last="Dockrell">David H. Dockrell</name>
<affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>MRC Center for Inflammation Research,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Doench, John G" sort="Doench, John G" uniqKey="Doench J" first="John G." last="Doench">John G. Doench</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>415 Main Street, Cambridge</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J. Kenneth" last="Baillie">J. Kenneth Baillie</name>
<affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7988</institution-id>
<institution-id institution-id-type="GRID">grid.4305.2</institution-id>
<institution>Roslin Institute,</institution>
<institution>University of Edinburgh,</institution>
</institution-wrap>
Easter Bush, EH25 9RG UK</nlm:aff>
<wicri:noCountry code="subfield">EH25 9RG UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0709 1919</institution-id>
<institution-id institution-id-type="GRID">grid.418716.d</institution-id>
<institution>Intensive Care Unit, Royal Infirmary Edinburgh,</institution>
</institution-wrap>
Edinburgh, EH16 5SA UK</nlm:aff>
<wicri:noCountry code="subfield">EH16 5SA UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hacohen, Nir" sort="Hacohen, Nir" uniqKey="Hacohen N" first="Nir" last="Hacohen">Nir Hacohen</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.66859.34</institution-id>
<institution>Broad Institute of MIT and Harvard,</institution>
</institution-wrap>
415 Main Street, Cambridge, MA 02142 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>415 Main Street, Cambridge</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0386 9924</institution-id>
<institution-id institution-id-type="GRID">grid.32224.35</institution-id>
<institution>Massachusetts General Hospital Cancer Center,</institution>
</institution-wrap>
Boston, MA 02129 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous attempts to identify host factors have produced largely divergent results, with few overlapping hits across different studies. Here, we perform a genome-wide CRISPR/Cas9 screen and devise a new approach, meta-analysis by information content (MAIC) to systematically combine our results with prior evidence for influenza host factors. MAIC out-performs other meta-analysis methods when using our CRISPR screen as validation data. We validate the host factors, <italic>WDR7, CCDC115</italic>
and <italic>TMEM199</italic>
, demonstrating that these genes are essential for viral entry and regulation of V-type ATPase assembly. We also find that <italic>CMTR1</italic>
, a human mRNA cap methyltransferase, is required for efficient viral cap snatching and regulation of a cell autonomous immune response, and provides synergistic protection with the influenza endonuclease inhibitor Xofluza.</p>
</div>
</front>
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</author>
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</author>
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<biblStruct><analytic><author><name sortKey="Simonsen, Lone" uniqKey="Simonsen L">Lone Simonsen</name>
</author>
<author><name sortKey="Spreeuwenberg, Peter" uniqKey="Spreeuwenberg P">Peter Spreeuwenberg</name>
</author>
<author><name sortKey="Lustig, Roger" uniqKey="Lustig R">Roger Lustig</name>
</author>
<author><name sortKey="Taylor, Robert J" uniqKey="Taylor R">Robert J. Taylor</name>
</author>
<author><name sortKey="Fleming, Douglas M" uniqKey="Fleming D">Douglas M. Fleming</name>
</author>
<author><name sortKey="Kroneman, Madelon" uniqKey="Kroneman M">Madelon Kroneman</name>
</author>
<author><name sortKey="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M">Maria D. Van Kerkhove</name>
</author>
<author><name sortKey="Mounts, Anthony W" uniqKey="Mounts A">Anthony W. Mounts</name>
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<author><name sortKey="Paget, W John" uniqKey="Paget W">W. John Paget</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, R" uniqKey="Gao R">R Gao</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yen, Hl" uniqKey="Yen H">HL Yen</name>
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<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name>
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</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
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<author><name sortKey="Klimov, Ai" uniqKey="Klimov A">AI Klimov</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Team, Ns Oiahvi" uniqKey="Team N">NS-OIAHVI Team</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Vasin, Av" uniqKey="Vasin A">AV Vasin</name>
</author>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Baillie, Jk" uniqKey="Baillie J">JK Baillie</name>
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</biblStruct>
<biblStruct></biblStruct>
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<region><li>Massachusetts</li>
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<name sortKey="Wang, Bo" sort="Wang, Bo" uniqKey="Wang B" first="Bo" last="Wang">Bo Wang</name>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Li, Bo" sort="Li, Bo" uniqKey="Li B" first="Bo" last="Li">Bo Li</name>
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<name sortKey="Bukhari, Syed Irfan" sort="Bukhari, Syed Irfan" uniqKey="Bukhari S" first="Syed Irfan" last="Bukhari">Syed Irfan Bukhari</name>
<name sortKey="Chia, Bing Shao" sort="Chia, Bing Shao" uniqKey="Chia B" first="Bing Shao" last="Chia">Bing Shao Chia</name>
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<name sortKey="Cui, Ang" sort="Cui, Ang" uniqKey="Cui A" first="Ang" last="Cui">Ang Cui</name>
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<name sortKey="Eisenhaure, Thomas" sort="Eisenhaure, Thomas" uniqKey="Eisenhaure T" first="Thomas" last="Eisenhaure">Thomas Eisenhaure</name>
<name sortKey="Gat Viks, Irit" sort="Gat Viks, Irit" uniqKey="Gat Viks I" first="Irit" last="Gat-Viks">Irit Gat-Viks</name>
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<name sortKey="Hacohen, Nir" sort="Hacohen, Nir" uniqKey="Hacohen N" first="Nir" last="Hacohen">Nir Hacohen</name>
<name sortKey="Hoover, Paul" sort="Hoover, Paul" uniqKey="Hoover P" first="Paul" last="Hoover">Paul Hoover</name>
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<name sortKey="Schweitzer, Lawrence D" sort="Schweitzer, Lawrence D" uniqKey="Schweitzer L" first="Lawrence D." last="Schweitzer">Lawrence D. Schweitzer</name>
<name sortKey="Vasudevan, Shobha" sort="Vasudevan, Shobha" uniqKey="Vasudevan S" first="Shobha" last="Vasudevan">Shobha Vasudevan</name>
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<country name="Israël"><noRegion><name sortKey="Nachshon, Aharon" sort="Nachshon, Aharon" uniqKey="Nachshon A" first="Aharon" last="Nachshon">Aharon Nachshon</name>
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<name sortKey="Gat Viks, Irit" sort="Gat Viks, Irit" uniqKey="Gat Viks I" first="Irit" last="Gat-Viks">Irit Gat-Viks</name>
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<country name="Royaume-Uni"><noRegion><name sortKey="Dockrell, David H" sort="Dockrell, David H" uniqKey="Dockrell D" first="David H." last="Dockrell">David H. Dockrell</name>
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