Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
Identifieur interne : 000089 ( Main/Exploration ); précédent : 000088; suivant : 000090Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes
Auteurs : Shou-Di He ; Sheng-Guang Huang ; Hui-Jun Zhu ; Xiao-Guang Luo ; Kang-Han Liao ; Jie-Yao Zhang ; Ning Tan ; De-Yu LiSource :
- Pharmaceutical Biology [ 1388-0209 ] ; 2020.
Abstract
Url:
DOI: 10.1080/13880209.2020.1711783
PubMed: 31971852
PubMed Central: 7034059
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes</title>
<author><name sortKey="He, Shou Di" sort="He, Shou Di" uniqKey="He S" first="Shou-Di" last="He">Shou-Di He</name>
<affiliation><nlm:aff id="AF0001"></nlm:aff>
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<author><name sortKey="Huang, Sheng Guang" sort="Huang, Sheng Guang" uniqKey="Huang S" first="Sheng-Guang" last="Huang">Sheng-Guang Huang</name>
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<author><name sortKey="Zhu, Hui Jun" sort="Zhu, Hui Jun" uniqKey="Zhu H" first="Hui-Jun" last="Zhu">Hui-Jun Zhu</name>
<affiliation><nlm:aff id="AF0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Luo, Xiao Guang" sort="Luo, Xiao Guang" uniqKey="Luo X" first="Xiao-Guang" last="Luo">Xiao-Guang Luo</name>
<affiliation><nlm:aff id="AF0001"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liao, Kang Han" sort="Liao, Kang Han" uniqKey="Liao K" first="Kang-Han" last="Liao">Kang-Han Liao</name>
<affiliation><nlm:aff id="AF0001"></nlm:aff>
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<author><name sortKey="Zhang, Jie Yao" sort="Zhang, Jie Yao" uniqKey="Zhang J" first="Jie-Yao" last="Zhang">Jie-Yao Zhang</name>
<affiliation><nlm:aff id="AF0001"></nlm:aff>
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<author><name sortKey="Tan, Ning" sort="Tan, Ning" uniqKey="Tan N" first="Ning" last="Tan">Ning Tan</name>
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<author><name sortKey="Li, De Yu" sort="Li, De Yu" uniqKey="Li D" first="De-Yu" last="Li">De-Yu Li</name>
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<series><title level="j">Pharmaceutical Biology</title>
<idno type="ISSN">1388-0209</idno>
<idno type="eISSN">1744-5116</idno>
<imprint><date when="2020">2020</date>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold>Context:</bold>
Oridonin exhibits various pharmacological and physiological activities, including antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological effects. However, its role in rheumatoid arthritis (RA) is yet to be revealed.</p>
<p><bold>Objective:</bold>
We evaluated the effects of oridonin on the survival and autophagy of RA-fibroblast-like synoviocytes (FLSs).</p>
<p><bold>Materials and methods:</bold>
RA-FLSs were treated with oridonin at serial concentrations of 0, 2, 4, 6, 8 and 10 µg/mL for 24, 48 and 72 h. Then, cell proliferation and apoptosis were measured. A GFP-LC3 plasmid was transfected into the cells to determine autophagy.</p>
<p><bold>Results:</bold>
Oridonin suppressed RA-FLS proliferation in a dose-dependent manner. The half maximal inhibitory concentrations (IC<sub>50</sub>
) of oridonin at 24, 48 and 72 h were 8.28, 7.88 and 8.35 µg/mL, respectively. Treatment with oridonin for 24 h increased apoptosis by 4.1%, and increased the protein levels of Bax and cleaved caspase-3 but significantly decreased the levels of IL-1β in the culture supernatant (<italic>p</italic>
< 0.05). In addition, 6 h of oridonin treatment significantly decreased the number of GFP-LC3 punctate dots and inhibited the protein levels of ATG5 and Beclin1 by 80.01% and 42.12%, respectively. Chloroquine (CQ) significantly reinforced the effects of oridonin on inhibition of autophagy, suppression of proliferation, and induction of apoptosis in RA-FLSs (<italic>p</italic>
< 0.05).</p>
<p><bold>Conclusions:</bold>
Our results indicate that treatment with oridonin in combination with CQ inhibits autophagy and cell proliferation and induces apoptosis in RA-FLSs more effectively than treatment oridonin alone. This finding indicates that oridonin is a potential therapeutic agent for RA.</p>
</div>
</front>
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</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="He, Shou Di" sort="He, Shou Di" uniqKey="He S" first="Shou-Di" last="He">Shou-Di He</name>
<name sortKey="Huang, Sheng Guang" sort="Huang, Sheng Guang" uniqKey="Huang S" first="Sheng-Guang" last="Huang">Sheng-Guang Huang</name>
<name sortKey="Li, De Yu" sort="Li, De Yu" uniqKey="Li D" first="De-Yu" last="Li">De-Yu Li</name>
<name sortKey="Liao, Kang Han" sort="Liao, Kang Han" uniqKey="Liao K" first="Kang-Han" last="Liao">Kang-Han Liao</name>
<name sortKey="Luo, Xiao Guang" sort="Luo, Xiao Guang" uniqKey="Luo X" first="Xiao-Guang" last="Luo">Xiao-Guang Luo</name>
<name sortKey="Tan, Ning" sort="Tan, Ning" uniqKey="Tan N" first="Ning" last="Tan">Ning Tan</name>
<name sortKey="Zhang, Jie Yao" sort="Zhang, Jie Yao" uniqKey="Zhang J" first="Jie-Yao" last="Zhang">Jie-Yao Zhang</name>
<name sortKey="Zhu, Hui Jun" sort="Zhu, Hui Jun" uniqKey="Zhu H" first="Hui-Jun" last="Zhu">Hui-Jun Zhu</name>
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</tree>
</affiliations>
</record>
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