The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer
Identifieur interne : 000026 ( Main/Exploration ); précédent : 000025; suivant : 000027The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer
Auteurs : Wu Sun [République populaire de Chine] ; Jialu Li [République populaire de Chine] ; Likun Zhou [République populaire de Chine] ; Jiayi Han [République populaire de Chine] ; Rui Liu [République populaire de Chine] ; Haiyang Zhang [République populaire de Chine] ; Tao Ning [République populaire de Chine] ; Zhiying Gao [République populaire de Chine] ; Baorui Liu [République populaire de Chine] ; Xi Chen [République populaire de Chine] ; Yi Ba [République populaire de Chine]Source :
- Theranostics [ 1838-7640 ] ; 2020.
Abstract
Oxaliplatin (OXA) resistance is the major obstacle to the anticancer effects of chemotherapy in colorectal cancer (CRC) patients. MicroRNAs (miRNAs) play an important role in the chemoresistance of various tumors. Our objective is to clarify the underlying mechanism of miRNAs in chemoresistance and provide a potential strategy to improve the response of CRC patients to chemotherapeutics.
Url:
DOI: 10.7150/thno.37621
PubMed: 32104496
PubMed Central: 7019154
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000827
- to stream Pmc, to step Curation: 000827
- to stream Pmc, to step Checkpoint: 000021
- to stream Ncbi, to step Merge: 000F71
- to stream Ncbi, to step Curation: 000F71
- to stream Ncbi, to step Checkpoint: 000F71
- to stream Main, to step Merge: 000026
- to stream Main, to step Curation: 000026
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer</title>
<author><name sortKey="Sun, Wu" sort="Sun, Wu" uniqKey="Sun W" first="Wu" last="Sun">Wu Sun</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jialu" sort="Li, Jialu" uniqKey="Li J" first="Jialu" last="Li">Jialu Li</name>
<affiliation wicri:level="1"><nlm:aff id="A2">State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Likun" sort="Zhou, Likun" uniqKey="Zhou L" first="Likun" last="Zhou">Likun Zhou</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Han, Jiayi" sort="Han, Jiayi" uniqKey="Han J" first="Jiayi" last="Han">Jiayi Han</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Rui" sort="Liu, Rui" uniqKey="Liu R" first="Rui" last="Liu">Rui Liu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Haiyang" sort="Zhang, Haiyang" uniqKey="Zhang H" first="Haiyang" last="Zhang">Haiyang Zhang</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ning, Tao" sort="Ning, Tao" uniqKey="Ning T" first="Tao" last="Ning">Tao Ning</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Zhiying" sort="Gao, Zhiying" uniqKey="Gao Z" first="Zhiying" last="Gao">Zhiying Gao</name>
<affiliation wicri:level="1"><nlm:aff id="A3">State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Baorui" sort="Liu, Baorui" uniqKey="Liu B" first="Baorui" last="Liu">Baorui Liu</name>
<affiliation wicri:level="1"><nlm:aff id="A4">The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A3">State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ba, Yi" sort="Ba, Yi" uniqKey="Ba Y" first="Yi" last="Ba">Yi Ba</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32104496</idno>
<idno type="pmc">7019154</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019154</idno>
<idno type="RBID">PMC:7019154</idno>
<idno type="doi">10.7150/thno.37621</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">000827</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000827</idno>
<idno type="wicri:Area/Pmc/Curation">000827</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000827</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000021</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000021</idno>
<idno type="wicri:Area/Ncbi/Merge">000F71</idno>
<idno type="wicri:Area/Ncbi/Curation">000F71</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F71</idno>
<idno type="wicri:Area/Main/Merge">000026</idno>
<idno type="wicri:Area/Main/Curation">000026</idno>
<idno type="wicri:Area/Main/Exploration">000026</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer</title>
<author><name sortKey="Sun, Wu" sort="Sun, Wu" uniqKey="Sun W" first="Wu" last="Sun">Wu Sun</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jialu" sort="Li, Jialu" uniqKey="Li J" first="Jialu" last="Li">Jialu Li</name>
<affiliation wicri:level="1"><nlm:aff id="A2">State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Likun" sort="Zhou, Likun" uniqKey="Zhou L" first="Likun" last="Zhou">Likun Zhou</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Han, Jiayi" sort="Han, Jiayi" uniqKey="Han J" first="Jiayi" last="Han">Jiayi Han</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Rui" sort="Liu, Rui" uniqKey="Liu R" first="Rui" last="Liu">Rui Liu</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Haiyang" sort="Zhang, Haiyang" uniqKey="Zhang H" first="Haiyang" last="Zhang">Haiyang Zhang</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ning, Tao" sort="Ning, Tao" uniqKey="Ning T" first="Tao" last="Ning">Tao Ning</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Zhiying" sort="Gao, Zhiying" uniqKey="Gao Z" first="Zhiying" last="Gao">Zhiying Gao</name>
<affiliation wicri:level="1"><nlm:aff id="A3">State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Baorui" sort="Liu, Baorui" uniqKey="Liu B" first="Baorui" last="Liu">Baorui Liu</name>
<affiliation wicri:level="1"><nlm:aff id="A4">The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A3">State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ba, Yi" sort="Ba, Yi" uniqKey="Ba Y" first="Yi" last="Ba">Yi Ba</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Theranostics</title>
<idno type="eISSN">1838-7640</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Oxaliplatin (OXA) resistance is the major obstacle to the anticancer effects of chemotherapy in colorectal cancer (CRC) patients. MicroRNAs (miRNAs) play an important role in the chemoresistance of various tumors. Our objective is to clarify the underlying mechanism of miRNAs in chemoresistance and provide a potential strategy to improve the response of CRC patients to chemotherapeutics.</p>
<p><bold>Methods</bold>
: MiRNA microarray and Real-time PCR were performed to compare changes in miRNA expression between oxaliplatin-resistant and the parental cells. CCK8, apoptosis assay, immunofluorescence and xenograft studies were used to elucidate the impact of miR-27b-3p on regulating chemoresistance. Luciferase reporter assay and western blot were carried to assess the regulatory role of miR-27b-3p in ATG10 expression. The effects of miR-27b-3p and ATG10 on autophagy were investigated by GFP-LC3 fluorescence microscopy, transmission electron microscopy, and western blot. ChIP assay and luciferase assay were performed to test the c-Myc's occupancy on the miR-27B promoter.</p>
<p><bold>Results</bold>
: We observed that miR-27b-3p expression was significantly downregulated in oxaliplatin-resistant cell lines (SW480-OxR and HCT116-OxR) compared to the corresponding parental cell lines and that miR-27b-3p expression was positively correlated with disease-free survival (DFS) time in colorectal cancer patients. MiR-27b-3p could sensitize colorectal cancer cells to oxaliplatin in vitro and in vivo. Under oxaliplatin treatment, chemoresistant cells showed a higher autophagy level than parental cells. Moreover, we also identified that miR-27b-3p inhibited the expression of ATG10 at the posttranscriptional level, thus inhibiting autophagy. Further study demonstrated that c-Myc can inhibit the expression of miR-27b-3p via binding to the promoter region of miR-27B gene.</p>
<p><bold>Conclusions</bold>
: Our study identifies a novel c-Myc/miR-27b-3p/ATG10 signaling pathway that regulates colorectal cancer chemoresistance. These results suggest that miR-27b-3p is not only a potential indicator for evaluating efficiency of chemotherapy, but also a valuable therapeutic target for CRC, especially for patients with chemoresistance.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name>
</author>
<author><name sortKey="Miller, Kd" uniqKey="Miller K">KD Miller</name>
</author>
<author><name sortKey="Fedewa, Sa" uniqKey="Fedewa S">SA Fedewa</name>
</author>
<author><name sortKey="Ahnen, Dj" uniqKey="Ahnen D">DJ Ahnen</name>
</author>
<author><name sortKey="Meester, R" uniqKey="Meester R">R Meester</name>
</author>
<author><name sortKey="Barzi, A" uniqKey="Barzi A">A Barzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name>
</author>
<author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name>
</author>
<author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name>
</author>
<author><name sortKey="Siegel, Rl" uniqKey="Siegel R">RL Siegel</name>
</author>
<author><name sortKey="Torre, La" uniqKey="Torre L">LA Torre</name>
</author>
<author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anderson, Rl" uniqKey="Anderson R">RL Anderson</name>
</author>
<author><name sortKey="Balasas, T" uniqKey="Balasas T">T Balasas</name>
</author>
<author><name sortKey="Callaghan, J" uniqKey="Callaghan J">J Callaghan</name>
</author>
<author><name sortKey="Coombes, Rc" uniqKey="Coombes R">RC Coombes</name>
</author>
<author><name sortKey="Evans, J" uniqKey="Evans J">J Evans</name>
</author>
<author><name sortKey="Hall, Ja" uniqKey="Hall J">JA Hall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cremolini, C" uniqKey="Cremolini C">C Cremolini</name>
</author>
<author><name sortKey="Schirripa, M" uniqKey="Schirripa M">M Schirripa</name>
</author>
<author><name sortKey="Antoniotti, C" uniqKey="Antoniotti C">C Antoniotti</name>
</author>
<author><name sortKey="Moretto, R" uniqKey="Moretto R">R Moretto</name>
</author>
<author><name sortKey="Salvatore, L" uniqKey="Salvatore L">L Salvatore</name>
</author>
<author><name sortKey="Masi, G" uniqKey="Masi G">G Masi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hewish, M" uniqKey="Hewish M">M Hewish</name>
</author>
<author><name sortKey="Cunningham, D" uniqKey="Cunningham D">D Cunningham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ciombor, Kk" uniqKey="Ciombor K">KK Ciombor</name>
</author>
<author><name sortKey="Wu, C" uniqKey="Wu C">C Wu</name>
</author>
<author><name sortKey="Goldberg, Rm" uniqKey="Goldberg R">RM Goldberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gebert, L" uniqKey="Gebert L">L Gebert</name>
</author>
<author><name sortKey="Macrae, Ij" uniqKey="Macrae I">IJ MacRae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name>
</author>
<author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Du, L" uniqKey="Du L">L Du</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Tian, H" uniqKey="Tian H">H Tian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, T" uniqKey="Yu T">T Yu</name>
</author>
<author><name sortKey="Guo, F" uniqKey="Guo F">F Guo</name>
</author>
<author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name>
</author>
<author><name sortKey="Sun, T" uniqKey="Sun T">T Sun</name>
</author>
<author><name sortKey="Ma, D" uniqKey="Ma D">D Ma</name>
</author>
<author><name sortKey="Han, J" uniqKey="Han J">J Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eastlack, Sc" uniqKey="Eastlack S">SC Eastlack</name>
</author>
<author><name sortKey="Dong, S" uniqKey="Dong S">S Dong</name>
</author>
<author><name sortKey="Ivan, C" uniqKey="Ivan C">C Ivan</name>
</author>
<author><name sortKey="Alahari, Sk" uniqKey="Alahari S">SK Alahari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Jj" uniqKey="Lee J">JJ Lee</name>
</author>
<author><name sortKey="Drakaki, A" uniqKey="Drakaki A">A Drakaki</name>
</author>
<author><name sortKey="Iliopoulos, D" uniqKey="Iliopoulos D">D Iliopoulos</name>
</author>
<author><name sortKey="Struhl, K" uniqKey="Struhl K">K Struhl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsuyama, R" uniqKey="Matsuyama R">R Matsuyama</name>
</author>
<author><name sortKey="Okuzaki, D" uniqKey="Okuzaki D">D Okuzaki</name>
</author>
<author><name sortKey="Okada, M" uniqKey="Okada M">M Okada</name>
</author>
<author><name sortKey="Oneyama, C" uniqKey="Oneyama C">C Oneyama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="He, L" uniqKey="He L">L He</name>
</author>
<author><name sortKey="Luo, L" uniqKey="Luo L">L Luo</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy, Jmm" uniqKey="Levy J">JMM Levy</name>
</author>
<author><name sortKey="Towers, Cg" uniqKey="Towers C">CG Towers</name>
</author>
<author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A Thorburn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Kc" uniqKey="Lin K">KC Lin</name>
</author>
<author><name sortKey="Lin, Mw" uniqKey="Lin M">MW Lin</name>
</author>
<author><name sortKey="Hsu, Mn" uniqKey="Hsu M">MN Hsu</name>
</author>
<author><name sortKey="Yu Chen, G" uniqKey="Yu Chen G">G Yu-Chen</name>
</author>
<author><name sortKey="Chao, Yc" uniqKey="Chao Y">YC Chao</name>
</author>
<author><name sortKey="Tuan, Hy" uniqKey="Tuan H">HY Tuan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cai, Q" uniqKey="Cai Q">Q Cai</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name>
</author>
<author><name sortKey="Weng, M" uniqKey="Weng M">M Weng</name>
</author>
<author><name sortKey="Zhou, D" uniqKey="Zhou D">D Zhou</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stramucci, L" uniqKey="Stramucci L">L Stramucci</name>
</author>
<author><name sortKey="Pranteda, A" uniqKey="Pranteda A">A Pranteda</name>
</author>
<author><name sortKey="Stravato, A" uniqKey="Stravato A">A Stravato</name>
</author>
<author><name sortKey="Amoreo, Ca" uniqKey="Amoreo C">CA Amoreo</name>
</author>
<author><name sortKey="Pennetti, A" uniqKey="Pennetti A">A Pennetti</name>
</author>
<author><name sortKey="Diodoro, Mg" uniqKey="Diodoro M">MG Diodoro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, T" uniqKey="Huang T">T Huang</name>
</author>
<author><name sortKey="Wan, X" uniqKey="Wan X">X Wan</name>
</author>
<author><name sortKey="Alvarez, Aa" uniqKey="Alvarez A">AA Alvarez</name>
</author>
<author><name sortKey="James, Cd" uniqKey="James C">CD James</name>
</author>
<author><name sortKey="Song, X" uniqKey="Song X">X Song</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name>
</author>
<author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Sun, A" uniqKey="Sun A">A Sun</name>
</author>
<author><name sortKey="Zen, K" uniqKey="Zen K">K Zen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, W" uniqKey="Sun W">W Sun</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="You, C" uniqKey="You C">C You</name>
</author>
<author><name sortKey="Lu, P" uniqKey="Lu P">P Lu</name>
</author>
<author><name sortKey="Feng, H" uniqKey="Feng H">H Feng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howells, Lm" uniqKey="Howells L">LM Howells</name>
</author>
<author><name sortKey="Sale, S" uniqKey="Sale S">S Sale</name>
</author>
<author><name sortKey="Sriramareddy, Sn" uniqKey="Sriramareddy S">SN Sriramareddy</name>
</author>
<author><name sortKey="Irving, Grb" uniqKey="Irving G">GRB Irving</name>
</author>
<author><name sortKey="Jones, Djl" uniqKey="Jones D">DJL Jones</name>
</author>
<author><name sortKey="Ottley, Cj" uniqKey="Ottley C">CJ Ottley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name>
</author>
<author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Fei, B" uniqKey="Fei B">B Fei</name>
</author>
<author><name sortKey="Quan, C" uniqKey="Quan C">C Quan</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, Jl" uniqKey="Hu J">JL Hu</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Lan, Xl" uniqKey="Lan X">XL Lan</name>
</author>
<author><name sortKey="Zeng, Zc" uniqKey="Zeng Z">ZC Zeng</name>
</author>
<author><name sortKey="Liang, Ys" uniqKey="Liang Y">YS Liang</name>
</author>
<author><name sortKey="Yan, Yr" uniqKey="Yan Y">YR Yan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agarwal, V" uniqKey="Agarwal V">V Agarwal</name>
</author>
<author><name sortKey="Bell, Gw" uniqKey="Bell G">GW Bell</name>
</author>
<author><name sortKey="Nam, Jw" uniqKey="Nam J">JW Nam</name>
</author>
<author><name sortKey="Bartel, Dp" uniqKey="Bartel D">DP Bartel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miranda, Kc" uniqKey="Miranda K">KC Miranda</name>
</author>
<author><name sortKey="Huynh, T" uniqKey="Huynh T">T Huynh</name>
</author>
<author><name sortKey="Tay, Y" uniqKey="Tay Y">Y Tay</name>
</author>
<author><name sortKey="Ang, Ys" uniqKey="Ang Y">YS Ang</name>
</author>
<author><name sortKey="Tam, Wl" uniqKey="Tam W">WL Tam</name>
</author>
<author><name sortKey="Thomson, Am" uniqKey="Thomson A">AM Thomson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Backes, C" uniqKey="Backes C">C Backes</name>
</author>
<author><name sortKey="Kehl, T" uniqKey="Kehl T">T Kehl</name>
</author>
<author><name sortKey="Stockel, D" uniqKey="Stockel D">D Stockel</name>
</author>
<author><name sortKey="Fehlmann, T" uniqKey="Fehlmann T">T Fehlmann</name>
</author>
<author><name sortKey="Schneider, L" uniqKey="Schneider L">L Schneider</name>
</author>
<author><name sortKey="Meese, E" uniqKey="Meese E">E Meese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaiser, Se" uniqKey="Kaiser S">SE Kaiser</name>
</author>
<author><name sortKey="Qiu, Y" uniqKey="Qiu Y">Y Qiu</name>
</author>
<author><name sortKey="Coats, Je" uniqKey="Coats J">JE Coats</name>
</author>
<author><name sortKey="Mao, K" uniqKey="Mao K">K Mao</name>
</author>
<author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
<author><name sortKey="Schulman, Ba" uniqKey="Schulman B">BA Schulman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, T" uniqKey="Chang T">T Chang</name>
</author>
<author><name sortKey="Yu, D" uniqKey="Yu D">D Yu</name>
</author>
<author><name sortKey="Lee, Y" uniqKey="Lee Y">Y Lee</name>
</author>
<author><name sortKey="Wentzel, Ea" uniqKey="Wentzel E">EA Wentzel</name>
</author>
<author><name sortKey="Arking, De" uniqKey="Arking D">DE Arking</name>
</author>
<author><name sortKey="West, Km" uniqKey="West K">KM West</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Donnell, Ka" uniqKey="O Donnell K">KA O'Donnell</name>
</author>
<author><name sortKey="Wentzel, Ea" uniqKey="Wentzel E">EA Wentzel</name>
</author>
<author><name sortKey="Zeller, Ki" uniqKey="Zeller K">KI Zeller</name>
</author>
<author><name sortKey="Dang, Cv" uniqKey="Dang C">CV Dang</name>
</author>
<author><name sortKey="Mendell, Jt" uniqKey="Mendell J">JT Mendell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsuyama, R" uniqKey="Matsuyama R">R Matsuyama</name>
</author>
<author><name sortKey="Okuzaki, D" uniqKey="Okuzaki D">D Okuzaki</name>
</author>
<author><name sortKey="Okada, M" uniqKey="Okada M">M Okada</name>
</author>
<author><name sortKey="Oneyama, C" uniqKey="Oneyama C">C Oneyama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, Q" uniqKey="Feng Q">Q Feng</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
<author><name sortKey="Li, F" uniqKey="Li F">F Li</name>
</author>
<author><name sortKey="Ning, B" uniqKey="Ning B">B Ning</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name>
</author>
<author><name sortKey="Si, W" uniqKey="Si W">W Si</name>
</author>
<author><name sortKey="Shen, J" uniqKey="Shen J">J Shen</name>
</author>
<author><name sortKey="Du, C" uniqKey="Du C">C Du</name>
</author>
<author><name sortKey="Lou, W" uniqKey="Lou W">W Lou</name>
</author>
<author><name sortKey="Bao, C" uniqKey="Bao C">C Bao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name>
</author>
<author><name sortKey="Ye, B" uniqKey="Ye B">B Ye</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Dong, J" uniqKey="Dong J">J Dong</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fang, Q" uniqKey="Fang Q">Q Fang</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Zhi, X" uniqKey="Zhi X">X Zhi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name>
</author>
<author><name sortKey="He, D" uniqKey="He D">D He</name>
</author>
<author><name sortKey="Bo, H" uniqKey="Bo H">H Bo</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Xiao, M" uniqKey="Xiao M">M Xiao</name>
</author>
<author><name sortKey="Xiang, L" uniqKey="Xiang L">L Xiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Shi, K" uniqKey="Shi K">K Shi</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Hu, G" uniqKey="Hu G">G Hu</name>
</author>
<author><name sortKey="Wan, J" uniqKey="Wan J">J Wan</name>
</author>
<author><name sortKey="Tang, J" uniqKey="Tang J">J Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ji, J" uniqKey="Ji J">J Ji</name>
</author>
<author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name>
</author>
<author><name sortKey="Li, Zl" uniqKey="Li Z">ZL Li</name>
</author>
<author><name sortKey="Chen, My" uniqKey="Chen M">MY Chen</name>
</author>
<author><name sortKey="Deng, R" uniqKey="Deng R">R Deng</name>
</author>
<author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name>
</author>
<author><name sortKey="Fiesel, Fc" uniqKey="Fiesel F">FC Fiesel</name>
</author>
<author><name sortKey="Belmonte, Kc" uniqKey="Belmonte K">KC Belmonte</name>
</author>
<author><name sortKey="Hudec, R" uniqKey="Hudec R">R Hudec</name>
</author>
<author><name sortKey="Wang, Wx" uniqKey="Wang W">WX Wang</name>
</author>
<author><name sortKey="Kim, C" uniqKey="Kim C">C Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jo, Yk" uniqKey="Jo Y">YK Jo</name>
</author>
<author><name sortKey="Kim, Sc" uniqKey="Kim S">SC Kim</name>
</author>
<author><name sortKey="Park, Ij" uniqKey="Park I">IJ Park</name>
</author>
<author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name>
</author>
<author><name sortKey="Jin, Dh" uniqKey="Jin D">DH Jin</name>
</author>
<author><name sortKey="Hong, Sw" uniqKey="Hong S">SW Hong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, K" uniqKey="Xie K">K Xie</name>
</author>
<author><name sortKey="Liang, C" uniqKey="Liang C">C Liang</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Yan, C" uniqKey="Yan C">C Yan</name>
</author>
<author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name>
</author>
<author><name sortKey="Gu, Y" uniqKey="Gu Y">Y Gu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castell, A" uniqKey="Castell A">A Castell</name>
</author>
<author><name sortKey="Larsson, Lg" uniqKey="Larsson L">LG Larsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ozsolak, F" uniqKey="Ozsolak F">F Ozsolak</name>
</author>
<author><name sortKey="Poling, Ll" uniqKey="Poling L">LL Poling</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Liu, Xs" uniqKey="Liu X">XS Liu</name>
</author>
<author><name sortKey="Roeder, Rg" uniqKey="Roeder R">RG Roeder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name>
</author>
<author><name sortKey="Cai, X" uniqKey="Cai X">X Cai</name>
</author>
<author><name sortKey="Yung, Mm" uniqKey="Yung M">MM Yung</name>
</author>
<author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Capizzi, M" uniqKey="Capizzi M">M Capizzi</name>
</author>
<author><name sortKey="Strappazzon, F" uniqKey="Strappazzon F">F Strappazzon</name>
</author>
<author><name sortKey="Cianfanelli, V" uniqKey="Cianfanelli V">V Cianfanelli</name>
</author>
<author><name sortKey="Papaleo, E" uniqKey="Papaleo E">E Papaleo</name>
</author>
<author><name sortKey="Cecconi, F" uniqKey="Cecconi F">F Cecconi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Zeng, W" uniqKey="Zeng W">W Zeng</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name>
</author>
<author><name sortKey="Yu, P" uniqKey="Yu P">P Yu</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Tianjin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Sun, Wu" sort="Sun, Wu" uniqKey="Sun W" first="Wu" last="Sun">Wu Sun</name>
</noRegion>
<name sortKey="Ba, Yi" sort="Ba, Yi" uniqKey="Ba Y" first="Yi" last="Ba">Yi Ba</name>
<name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name>
<name sortKey="Gao, Zhiying" sort="Gao, Zhiying" uniqKey="Gao Z" first="Zhiying" last="Gao">Zhiying Gao</name>
<name sortKey="Han, Jiayi" sort="Han, Jiayi" uniqKey="Han J" first="Jiayi" last="Han">Jiayi Han</name>
<name sortKey="Li, Jialu" sort="Li, Jialu" uniqKey="Li J" first="Jialu" last="Li">Jialu Li</name>
<name sortKey="Liu, Baorui" sort="Liu, Baorui" uniqKey="Liu B" first="Baorui" last="Liu">Baorui Liu</name>
<name sortKey="Liu, Rui" sort="Liu, Rui" uniqKey="Liu R" first="Rui" last="Liu">Rui Liu</name>
<name sortKey="Ning, Tao" sort="Ning, Tao" uniqKey="Ning T" first="Tao" last="Ning">Tao Ning</name>
<name sortKey="Zhang, Haiyang" sort="Zhang, Haiyang" uniqKey="Zhang H" first="Haiyang" last="Zhang">Haiyang Zhang</name>
<name sortKey="Zhou, Likun" sort="Zhou, Likun" uniqKey="Zhou L" first="Likun" last="Zhou">Likun Zhou</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000026 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000026 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:7019154 |texte= The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32104496" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |